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Volumn 27, Issue 2, 2013, Pages 237-250

The Significance of Stereotyped B-Cell Receptors in Chronic Lymphocytic Leukemia

Author keywords

Antigen; CDR3; CLL; Immunoglobulin gene; Somatic hypermutation; Stereotype; Subset

Indexed keywords

B LYMPHOCYTE RECEPTOR; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN RECEPTOR; MONOCLONAL ANTIBODY;

EID: 84875783393     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2012.12.001     Document Type: Review
Times cited : (15)

References (84)
  • 1
    • 0003807468 scopus 로고    scopus 로고
    • WH Freeman, San Francisco, CA
    • Kuby J. Immunobiology 2001, WH Freeman, San Francisco, CA. 4th edition.
    • (2001) Immunobiology
    • Kuby, J.1
  • 5
    • 80355122714 scopus 로고    scopus 로고
    • V(D)J recombination: mechanisms of initiation
    • Schatz D.G., Swanson P.C. V(D)J recombination: mechanisms of initiation. Annu Rev Genet 2011, 45:167-202.
    • (2011) Annu Rev Genet , vol.45 , pp. 167-202
    • Schatz, D.G.1    Swanson, P.C.2
  • 6
    • 0242468050 scopus 로고    scopus 로고
    • Regulating antigen-receptor gene assembly
    • Schlissel M.S. Regulating antigen-receptor gene assembly. Nat Rev Immunol 2003, 3:890-899.
    • (2003) Nat Rev Immunol , vol.3 , pp. 890-899
    • Schlissel, M.S.1
  • 7
    • 27644489367 scopus 로고    scopus 로고
    • Immunoglobulin gene diversification
    • Maizels N. Immunoglobulin gene diversification. Annu Rev Genet 2005, 39:23-46.
    • (2005) Annu Rev Genet , vol.39 , pp. 23-46
    • Maizels, N.1
  • 9
    • 84859717525 scopus 로고    scopus 로고
    • Germinal center selection and the development of memory B and plasma cells
    • Shlomchik M.J., Weisel F. Germinal center selection and the development of memory B and plasma cells. Immunol Rev 2012, 247:52-63.
    • (2012) Immunol Rev , vol.247 , pp. 52-63
    • Shlomchik, M.J.1    Weisel, F.2
  • 10
    • 84862865669 scopus 로고    scopus 로고
    • Immunoglobulin class-switch DNA recombination: induction, targeting and beyond
    • Xu Z., Zan H., Pone E.J., et al. Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat Rev Immunol 2012, 12:517-531.
    • (2012) Nat Rev Immunol , vol.12 , pp. 517-531
    • Xu, Z.1    Zan, H.2    Pone, E.J.3
  • 11
    • 0028355650 scopus 로고
    • The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire
    • Schroeder H.W., Dighiero G. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol Today 1994, 15:288-294.
    • (1994) Immunol Today , vol.15 , pp. 288-294
    • Schroeder, H.W.1    Dighiero, G.2
  • 12
    • 0029665035 scopus 로고    scopus 로고
    • Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia
    • Efremov D.G., Ivanovski M., Siljanovski N., et al. Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia. Blood 1996, 87:3869-3876.
    • (1996) Blood , vol.87 , pp. 3869-3876
    • Efremov, D.G.1    Ivanovski, M.2    Siljanovski, N.3
  • 13
    • 0028945621 scopus 로고
    • Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells
    • Hashimoto S., Dono M., Wakai M., et al. Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells. J Exp Med 1995, 181:1507-1517.
    • (1995) J Exp Med , vol.181 , pp. 1507-1517
    • Hashimoto, S.1    Dono, M.2    Wakai, M.3
  • 14
    • 0030639650 scopus 로고    scopus 로고
    • Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features
    • Johnson T.A., Rassenti L.Z., Kipps T.J. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997, 158:235-246.
    • (1997) J Immunol , vol.158 , pp. 235-246
    • Johnson, T.A.1    Rassenti, L.Z.2    Kipps, T.J.3
  • 15
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Fais F., Ghiotto F., Hashimoto S., et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998, 102:1515-1525.
    • (1998) J Clin Invest , vol.102 , pp. 1515-1525
    • Fais, F.1    Ghiotto, F.2    Hashimoto, S.3
  • 16
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin T.J., Davis Z., Gardiner A., et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999, 94:1848-1854.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3
  • 17
    • 0036624881 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
    • Damle R.N., Ghiotto F., Valetto A., et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood 2002, 99:4087-4093.
    • (2002) Blood , vol.99 , pp. 4087-4093
    • Damle, R.N.1    Ghiotto, F.2    Valetto, A.3
  • 18
    • 84859413533 scopus 로고    scopus 로고
    • Using the biology of chronic lymphocytic leukemia to choose treatment
    • Hillmen P. Using the biology of chronic lymphocytic leukemia to choose treatment. Hematology Am Soc Hematol Educ Program 2011, 2011:104-109.
    • (2011) Hematology Am Soc Hematol Educ Program , vol.2011 , pp. 104-109
    • Hillmen, P.1
  • 19
    • 0037085801 scopus 로고    scopus 로고
    • Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
    • Tobin G., Thunberg U., Johnson A., et al. Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002, 99:2262-2264.
    • (2002) Blood , vol.99 , pp. 2262-2264
    • Tobin, G.1    Thunberg, U.2    Johnson, A.3
  • 20
    • 33645507226 scopus 로고    scopus 로고
    • Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-utilizing chronic lymphocytic leukemia independent of geographical origin and mutational status
    • Thorselius M., Krober A., Murray F., et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-utilizing chronic lymphocytic leukemia independent of geographical origin and mutational status. Blood 2006, 107:2889-2894.
    • (2006) Blood , vol.107 , pp. 2889-2894
    • Thorselius, M.1    Krober, A.2    Murray, F.3
  • 21
    • 33846108722 scopus 로고    scopus 로고
    • Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
    • Stamatopoulos K., Belessi C., Moreno C., et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007, 109:259-270.
    • (2007) Blood , vol.109 , pp. 259-270
    • Stamatopoulos, K.1    Belessi, C.2    Moreno, C.3
  • 22
    • 58549100059 scopus 로고    scopus 로고
    • Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study
    • Bomben R., Dal Bo M., Capello D., et al. Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study. Br J Haematol 2009, 144:492-506.
    • (2009) Br J Haematol , vol.144 , pp. 492-506
    • Bomben, R.1    Dal Bo, M.2    Capello, D.3
  • 23
    • 77957809872 scopus 로고    scopus 로고
    • Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation
    • Oscier D., Wade R., Davis Z., et al. Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation. Haematologica 2010, 95:1705-1712.
    • (2010) Haematologica , vol.95 , pp. 1705-1712
    • Oscier, D.1    Wade, R.2    Davis, Z.3
  • 24
    • 10744230550 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope
    • Tobin G., Thunberg U., Johnson A., et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood 2003, 101:4952-4957.
    • (2003) Blood , vol.101 , pp. 4952-4957
    • Tobin, G.1    Thunberg, U.2    Johnson, A.3
  • 25
    • 4344704897 scopus 로고    scopus 로고
    • Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
    • Messmer B.T., Albesiano E., Efremov D.G., et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 2004, 200:519-525.
    • (2004) J Exp Med , vol.200 , pp. 519-525
    • Messmer, B.T.1    Albesiano, E.2    Efremov, D.G.3
  • 26
    • 4944244255 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
    • Widhopf G.F., Rassenti L.Z., Toy T.L., et al. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 2004, 104:2499-2504.
    • (2004) Blood , vol.104 , pp. 2499-2504
    • Widhopf, G.F.1    Rassenti, L.Z.2    Toy, T.L.3
  • 27
    • 7244232709 scopus 로고    scopus 로고
    • Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia
    • Tobin G., Thunberg U., Karlsson K., et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 2004, 104:2879-2885.
    • (2004) Blood , vol.104 , pp. 2879-2885
    • Tobin, G.1    Thunberg, U.2    Karlsson, K.3
  • 28
    • 27744598787 scopus 로고    scopus 로고
    • Immunoglobulin light chain repertoire in chronic lymphocytic leukemia
    • Stamatopoulos K., Belessi C., Hadzidimitriou A., et al. Immunoglobulin light chain repertoire in chronic lymphocytic leukemia. Blood 2005, 106:3575-3583.
    • (2005) Blood , vol.106 , pp. 3575-3583
    • Stamatopoulos, K.1    Belessi, C.2    Hadzidimitriou, A.3
  • 29
    • 79951498701 scopus 로고    scopus 로고
    • Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities
    • Chiorazzi N., Ferrarini M. Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood 2011, 117:1781-1791.
    • (2011) Blood , vol.117 , pp. 1781-1791
    • Chiorazzi, N.1    Ferrarini, M.2
  • 30
    • 74249107417 scopus 로고    scopus 로고
    • A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence
    • Darzentas N., Hadzidimitriou A., Murray F., et al. A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia 2010, 24(1):125-132.
    • (2010) Leukemia , vol.24 , Issue.1 , pp. 125-132
    • Darzentas, N.1    Hadzidimitriou, A.2    Murray, F.3
  • 31
    • 84861033763 scopus 로고    scopus 로고
    • Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
    • Agathangelidis A., Darzentas N., Hadzidimitriou A., et al. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood 2012, 119:4467-4475.
    • (2012) Blood , vol.119 , pp. 4467-4475
    • Agathangelidis, A.1    Darzentas, N.2    Hadzidimitriou, A.3
  • 32
    • 38949203770 scopus 로고    scopus 로고
    • Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
    • Murray F., Darzentas N., Hadzidimitriou A., et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 2008, 111(3):1524-1533.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1524-1533
    • Murray, F.1    Darzentas, N.2    Hadzidimitriou, A.3
  • 33
    • 0026592314 scopus 로고
    • Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding
    • Kirkham P.M., Mortari F., Newton J.A., et al. Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding. EMBO J 1992, 11:603-609.
    • (1992) EMBO J , vol.11 , pp. 603-609
    • Kirkham, P.M.1    Mortari, F.2    Newton, J.A.3
  • 34
    • 0031466643 scopus 로고    scopus 로고
    • Evolution of the structural repertoire of the human V(H) and Vkappa germline genes
    • Vargas-Madrazo E., Lara-Ochoa F., Ramirez-Benites M.C., et al. Evolution of the structural repertoire of the human V(H) and Vkappa germline genes. Int Immunol 1997, 9:1801-1815.
    • (1997) Int Immunol , vol.9 , pp. 1801-1815
    • Vargas-Madrazo, E.1    Lara-Ochoa, F.2    Ramirez-Benites, M.C.3
  • 35
    • 0024590614 scopus 로고
    • Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia
    • Sthoeger Z.M., Wakai M., Tse D.B., et al. Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia. J Exp Med 1989, 169:255-268.
    • (1989) J Exp Med , vol.169 , pp. 255-268
    • Sthoeger, Z.M.1    Wakai, M.2    Tse, D.B.3
  • 36
    • 0025035702 scopus 로고
    • Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies
    • Borche L., Lim A., Binet J.L., et al. Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies. Blood 1990, 76:562-569.
    • (1990) Blood , vol.76 , pp. 562-569
    • Borche, L.1    Lim, A.2    Binet, J.L.3
  • 37
    • 20444454585 scopus 로고    scopus 로고
    • Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
    • Herve M., Xu K., Ng Y.S., et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest 2005, 115:1636-1643.
    • (2005) J Clin Invest , vol.115 , pp. 1636-1643
    • Herve, M.1    Xu, K.2    Ng, Y.S.3
  • 38
    • 0024159308 scopus 로고
    • Genetics of the phosphocholine-specific antibody response to Streptococcus pneumoniae. Germ-line but not mutated T15 antibodies are dominantly selected
    • Claflin J.L., Berry J. Genetics of the phosphocholine-specific antibody response to Streptococcus pneumoniae. Germ-line but not mutated T15 antibodies are dominantly selected. J Immunol 1988, 141:4012-4019.
    • (1988) J Immunol , vol.141 , pp. 4012-4019
    • Claflin, J.L.1    Berry, J.2
  • 39
    • 0342939538 scopus 로고    scopus 로고
    • Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
    • Shaw P.X., Horkko S., Chang M.K., et al. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J Clin Invest 2000, 105:1731-1740.
    • (2000) J Clin Invest , vol.105 , pp. 1731-1740
    • Shaw, P.X.1    Horkko, S.2    Chang, M.K.3
  • 40
    • 16344380083 scopus 로고    scopus 로고
    • Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion
    • Baumgarth N., Tung J.W., Herzenberg L.A. Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion. Springer Semin Immunopathol 2005, 26:347-362.
    • (2005) Springer Semin Immunopathol , vol.26 , pp. 347-362
    • Baumgarth, N.1    Tung, J.W.2    Herzenberg, L.A.3
  • 41
    • 0027739749 scopus 로고
    • Autoimmunity-prone B-1 (CD5 B) cells, natural antibodies and self recognition
    • Kasaian M.T., Casali P. Autoimmunity-prone B-1 (CD5 B) cells, natural antibodies and self recognition. Autoimmunity 1993, 15:315-329.
    • (1993) Autoimmunity , vol.15 , pp. 315-329
    • Kasaian, M.T.1    Casali, P.2
  • 42
    • 0029008056 scopus 로고
    • Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults
    • Mouthon L., Nobrega A., Nicolas N., et al. Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults. Proc Natl Acad Sci U S A 1995, 92:3839-3843.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3839-3843
    • Mouthon, L.1    Nobrega, A.2    Nicolas, N.3
  • 43
    • 0033515101 scopus 로고    scopus 로고
    • Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system
    • Baumgarth N., Herman O.C., Jager G.C., et al. Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system. Proc Natl Acad Sci U S A 1999, 96:2250-2255.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2250-2255
    • Baumgarth, N.1    Herman, O.C.2    Jager, G.C.3
  • 44
    • 0033514512 scopus 로고    scopus 로고
    • Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites
    • Seidl K., Wilshire J., MacKenzie J., et al. Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites. Proc Natl Acad Sci U S A 1999, 96:2262-2267.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2262-2267
    • Seidl, K.1    Wilshire, J.2    MacKenzie, J.3
  • 45
    • 0030994404 scopus 로고    scopus 로고
    • Frequent occurrence of identical heavy and light chain Ig rearrangements
    • Seidl K., MacKenzie J., Wang D., et al. Frequent occurrence of identical heavy and light chain Ig rearrangements. Int Immunol 1997, 9:689-702.
    • (1997) Int Immunol , vol.9 , pp. 689-702
    • Seidl, K.1    MacKenzie, J.2    Wang, D.3
  • 46
    • 16344385845 scopus 로고    scopus 로고
    • Human innate B cells: a link between host defense and autoimmunity?
    • Milner E.C., Anolik J., Cappione A., et al. Human innate B cells: a link between host defense and autoimmunity?. Springer Semin Immunopathol 2005, 26:433-452.
    • (2005) Springer Semin Immunopathol , vol.26 , pp. 433-452
    • Milner, E.C.1    Anolik, J.2    Cappione, A.3
  • 47
    • 0032581610 scopus 로고    scopus 로고
    • Exploiting sequence space: shuffling in vivo formed complementarity determining regions into a master framework
    • Jirholt P., Ohlin M., Borrebaeck C.A., et al. Exploiting sequence space: shuffling in vivo formed complementarity determining regions into a master framework. Gene 1998, 215:471-476.
    • (1998) Gene , vol.215 , pp. 471-476
    • Jirholt, P.1    Ohlin, M.2    Borrebaeck, C.A.3
  • 48
    • 80052925616 scopus 로고    scopus 로고
    • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
    • Scheid J.F., Mouquet H., Ueberheide B., et al. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 2011, 333:1633-1637.
    • (2011) Science , vol.333 , pp. 1633-1637
    • Scheid, J.F.1    Mouquet, H.2    Ueberheide, B.3
  • 49
    • 0037076279 scopus 로고    scopus 로고
    • Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
    • Bichi R., Shinton S.A., Martin E.S., et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci U S A 2002, 99:6955-6960.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 6955-6960
    • Bichi, R.1    Shinton, S.A.2    Martin, E.S.3
  • 50
    • 67651037334 scopus 로고    scopus 로고
    • A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen
    • ter Brugge P.J., Ta V.B., de Bruijn M.J., et al. A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood 2009, 114:119-127.
    • (2009) Blood , vol.114 , pp. 119-127
    • ter Brugge, P.J.1    Ta, V.B.2    de Bruijn, M.J.3
  • 51
    • 77949890578 scopus 로고    scopus 로고
    • A novel Rag2-/-gammac-/- xenograft model of human CLL
    • Bertilaccio M.T., Scielzo C., Simonetti G., et al. A novel Rag2-/-gammac-/- xenograft model of human CLL. Blood 2010, 115:1605-1609.
    • (2010) Blood , vol.115 , pp. 1605-1609
    • Bertilaccio, M.T.1    Scielzo, C.2    Simonetti, G.3
  • 52
    • 77956602603 scopus 로고    scopus 로고
    • The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia
    • Salerno E., Yuan Y., Scaglione B., et al. The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia. Cytometry B Clin Cytom 2010, 78(Suppl 1):S98-S109.
    • (2010) Cytometry B Clin Cytom , vol.78 , Issue.SUPPL. 1
    • Salerno, E.1    Yuan, Y.2    Scaglione, B.3
  • 53
    • 84859205415 scopus 로고    scopus 로고
    • Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines
    • Lia M., Carette A., Tang H., et al. Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines. Blood 2012, 119:2981-2990.
    • (2012) Blood , vol.119 , pp. 2981-2990
    • Lia, M.1    Carette, A.2    Tang, H.3
  • 54
    • 33746817989 scopus 로고    scopus 로고
    • B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia
    • Yan X.J., Albesiano E., Zanesi N., et al. B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2006, 103:11713-11718.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11713-11718
    • Yan, X.J.1    Albesiano, E.2    Zanesi, N.3
  • 55
    • 0024323796 scopus 로고
    • Restricted immunoglobulin variable region gene usage by normal Ly-1 (CD5+) B cells that recognize phosphatidyl choline
    • Mercolino T.J., Locke A.L., Afshari A., et al. Restricted immunoglobulin variable region gene usage by normal Ly-1 (CD5+) B cells that recognize phosphatidyl choline. J Exp Med 1989, 169(6):1869-1877.
    • (1989) J Exp Med , vol.169 , Issue.6 , pp. 1869-1877
    • Mercolino, T.J.1    Locke, A.L.2    Afshari, A.3
  • 56
    • 33747761954 scopus 로고    scopus 로고
    • B-1 B cell development
    • Hardy R.R. B-1 B cell development. J Immunol 2006, 177(5):2749-2754.
    • (2006) J Immunol , vol.177 , Issue.5 , pp. 2749-2754
    • Hardy, R.R.1
  • 57
    • 0346996872 scopus 로고    scopus 로고
    • Evidence for a ligand-mediated positive selection signal in differentiation to a mature B cell
    • Wang H., Clarke S. Evidence for a ligand-mediated positive selection signal in differentiation to a mature B cell. J Immunol 2003, 171:6381-6388.
    • (2003) J Immunol , vol.171 , pp. 6381-6388
    • Wang, H.1    Clarke, S.2
  • 58
    • 0942301190 scopus 로고    scopus 로고
    • Positive selection focuses the VH12 B-cell repertoire towards a single B1 specificity with survival function
    • Wang H., Clarke S.H. Positive selection focuses the VH12 B-cell repertoire towards a single B1 specificity with survival function. Immunol Rev 2004, 197:51-59.
    • (2004) Immunol Rev , vol.197 , pp. 51-59
    • Wang, H.1    Clarke, S.H.2
  • 59
    • 43549093570 scopus 로고    scopus 로고
    • A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
    • Lanemo Myhrinder A., Hellqvist E., Sidorova E., et al. A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood 2008, 111:3838-3848.
    • (2008) Blood , vol.111 , pp. 3838-3848
    • Lanemo Myhrinder, A.1    Hellqvist, E.2    Sidorova, E.3
  • 60
    • 34547866658 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia (B-CLL) cells express antibodies reactive with antigenic epitopes expressed on the surface of common bacteria
    • Hatzi K., Catera R., Ferrarini M., et al. B-cell chronic lymphocytic leukemia (B-CLL) cells express antibodies reactive with antigenic epitopes expressed on the surface of common bacteria. Blood 2006, 108:12a.
    • (2006) Blood , vol.108
    • Hatzi, K.1    Catera, R.2    Ferrarini, M.3
  • 61
    • 55749114077 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation
    • Catera R., Silverman G.J., Hatzi K., et al. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol Med 2008, 14:665-674.
    • (2008) Mol Med , vol.14 , pp. 665-674
    • Catera, R.1    Silverman, G.J.2    Hatzi, K.3
  • 62
    • 55749091407 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
    • Chu C.C., Catera R., Hatzi K., et al. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood 2008, 112:5122-5129.
    • (2008) Blood , vol.112 , pp. 5122-5129
    • Chu, C.C.1    Catera, R.2    Hatzi, K.3
  • 63
    • 77952965028 scopus 로고    scopus 로고
    • Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed non-muscle myosin heavy chain IIA: implications for patient outcome and cell of origin
    • Chu C.C., Catera R., Zhang L., et al. Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed non-muscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood 2010, 115:3907-3915.
    • (2010) Blood , vol.115 , pp. 3907-3915
    • Chu, C.C.1    Catera, R.2    Zhang, L.3
  • 64
    • 33847373538 scopus 로고    scopus 로고
    • Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
    • Landgren O., Rapkin J., Caporaso N., et al. Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia. Blood 2007, 109:2198-2201.
    • (2007) Blood , vol.109 , pp. 2198-2201
    • Landgren, O.1    Rapkin, J.2    Caporaso, N.3
  • 65
    • 67349164793 scopus 로고    scopus 로고
    • Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors
    • Kostareli E., Hadzidimitriou A., Stavroyianni N., et al. Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Leukemia 2009, 23:919-924.
    • (2009) Leukemia , vol.23 , pp. 919-924
    • Kostareli, E.1    Hadzidimitriou, A.2    Stavroyianni, N.3
  • 66
    • 0037298948 scopus 로고    scopus 로고
    • Anti-DNA antibodies: aspects of structure and pathogenicity
    • Jang Y.J., Stollar B.D. Anti-DNA antibodies: aspects of structure and pathogenicity. Cell Mol Life Sci 2003, 60:309-320.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 309-320
    • Jang, Y.J.1    Stollar, B.D.2
  • 67
    • 58849160942 scopus 로고    scopus 로고
    • Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia
    • Hadzidimitriou A., Darzentas N., Murray F., et al. Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia. Blood 2009, 113:403-411.
    • (2009) Blood , vol.113 , pp. 403-411
    • Hadzidimitriou, A.1    Darzentas, N.2    Murray, F.3
  • 68
    • 0035696023 scopus 로고    scopus 로고
    • Editors and editing of anti-DNA receptors
    • Li H., Jiang Y., Prak E.L., et al. Editors and editing of anti-DNA receptors. Immunity 2001, 15:947-957.
    • (2001) Immunity , vol.15 , pp. 947-957
    • Li, H.1    Jiang, Y.2    Prak, E.L.3
  • 69
    • 55749095746 scopus 로고    scopus 로고
    • Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells
    • Zhang J., Jacobi A.M., Wang T., et al. Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells. Mol Med 2008, 14:675-681.
    • (2008) Mol Med , vol.14 , pp. 675-681
    • Zhang, J.1    Jacobi, A.M.2    Wang, T.3
  • 70
    • 0036785583 scopus 로고    scopus 로고
    • Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen
    • Potter K., Hobby P., Klijn S., et al. Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen. J Immunol 2002, 169:3777-3782.
    • (2002) J Immunol , vol.169 , pp. 3777-3782
    • Potter, K.1    Hobby, P.2    Klijn, S.3
  • 71
    • 73349090583 scopus 로고    scopus 로고
    • Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen
    • Sutton L.A., Kostareli E., Hadzidimitriou A., et al. Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen. Blood 2009, 114:4460-4468.
    • (2009) Blood , vol.114 , pp. 4460-4468
    • Sutton, L.A.1    Kostareli, E.2    Hadzidimitriou, A.3
  • 72
    • 77954658052 scopus 로고    scopus 로고
    • Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution
    • Kostareli E., Sutton L., Hadzidimitriou A., et al. Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution. Leukemia 2010, 24:1317-1324.
    • (2010) Leukemia , vol.24 , pp. 1317-1324
    • Kostareli, E.1    Sutton, L.2    Hadzidimitriou, A.3
  • 73
    • 79955628617 scopus 로고    scopus 로고
    • Innate control of B cell responses
    • Cerutti A., Puga I., Cols M. Innate control of B cell responses. Trends Immunol 2011, 32:202-211.
    • (2011) Trends Immunol , vol.32 , pp. 202-211
    • Cerutti, A.1    Puga, I.2    Cols, M.3
  • 74
    • 37549034962 scopus 로고    scopus 로고
    • B cell intrinsic TLR signals amplify but are not required for humoral immunity
    • Meyer-Bahlburg A., Khim S., Rawlings D.J. B cell intrinsic TLR signals amplify but are not required for humoral immunity. J Exp Med 2007, 204:3095-3101.
    • (2007) J Exp Med , vol.204 , pp. 3095-3101
    • Meyer-Bahlburg, A.1    Khim, S.2    Rawlings, D.J.3
  • 75
    • 80355126549 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenetic significance in specific subsets of patients
    • Arvaniti E., Ntoufa S., Papakonstantinou N., et al. Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenetic significance in specific subsets of patients. Haematologica 2011, 96:1644-1652.
    • (2011) Haematologica , vol.96 , pp. 1644-1652
    • Arvaniti, E.1    Ntoufa, S.2    Papakonstantinou, N.3
  • 76
    • 84870314626 scopus 로고    scopus 로고
    • Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors
    • Ntoufa S., Vardi A., Papakonstantinou N., et al. Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors. Mol Med 2012, 18:1281-1291.
    • (2012) Mol Med , vol.18 , pp. 1281-1291
    • Ntoufa, S.1    Vardi, A.2    Papakonstantinou, N.3
  • 77
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    • Minden M.D., Ubelhart R., Schneider D., et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 2012, 489:309-312.
    • (2012) Nature , vol.489 , pp. 309-312
    • Minden, M.D.1    Ubelhart, R.2    Schneider, D.3
  • 78
    • 51349126920 scopus 로고    scopus 로고
    • Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing
    • Campbell P., Pleasance E., Stephens P., et al. Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing. Proc Natl Acad Sci U S A 2008, 105:13081-13086.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13081-13086
    • Campbell, P.1    Pleasance, E.2    Stephens, P.3
  • 79
    • 74549167744 scopus 로고    scopus 로고
    • Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features
    • Bomben R., Dal-Bo M., Benedetti D., et al. Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features. Clin Cancer Res 2010, 16:620-628.
    • (2010) Clin Cancer Res , vol.16 , pp. 620-628
    • Bomben, R.1    Dal-Bo, M.2    Benedetti, D.3
  • 80
    • 33845189398 scopus 로고    scopus 로고
    • V(H)3-48 and V(H)3-53, as well as V(H)3-21, gene rearrangements define unique subgroups in CLL and are associated with biased lambda light chain restriction, homologous LCDR3 sequences and poor prognosis
    • Matthews C., Catherwood M., Morris T., et al. V(H)3-48 and V(H)3-53, as well as V(H)3-21, gene rearrangements define unique subgroups in CLL and are associated with biased lambda light chain restriction, homologous LCDR3 sequences and poor prognosis. Leuk Res 2007, 31:231-234.
    • (2007) Leuk Res , vol.31 , pp. 231-234
    • Matthews, C.1    Catherwood, M.2    Morris, T.3
  • 81
    • 13544275555 scopus 로고    scopus 로고
    • Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene
    • Ghia P., Stamatopoulos K., Belessi C., et al. Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood 2005, 105:1678-1685.
    • (2005) Blood , vol.105 , pp. 1678-1685
    • Ghia, P.1    Stamatopoulos, K.2    Belessi, C.3
  • 82
    • 11144356992 scopus 로고    scopus 로고
    • Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
    • Ghiotto F., Fais F., Valetto A., et al. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest 2004, 113:1008-1016.
    • (2004) J Clin Invest , vol.113 , pp. 1008-1016
    • Ghiotto, F.1    Fais, F.2    Valetto, A.3
  • 83
    • 67650393955 scopus 로고    scopus 로고
    • Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome
    • Rossi D., Spina V., Cerri M., et al. Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. Clin Cancer Res 2009, 15:4415-4422.
    • (2009) Clin Cancer Res , vol.15 , pp. 4415-4422
    • Rossi, D.1    Spina, V.2    Cerri, M.3
  • 84
    • 33645679597 scopus 로고    scopus 로고
    • Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia
    • Potter K.N., Mockridge C.I., Neville L., et al. Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia. Clin Cancer Res 2006, 12:1672-1679.
    • (2006) Clin Cancer Res , vol.12 , pp. 1672-1679
    • Potter, K.N.1    Mockridge, C.I.2    Neville, L.3


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