Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia

Blood

Volumn 87, Issue 9, 1996, Pages 3869-3876

  Efremov, Dimitar G ^b   Ivanovski, Martin ^b   Siljanovski, Nikola ^b   Pozzato, Gabriele ^b   Cevreska, Lidija ^b   Fais, Franco ^b   Chiorazzi, Nicholas ^b   Batista, Facundo D ^b   Burrone, Oscar R ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN;

AMINO ACID SEQUENCE; ARTICLE; AUTOIMMUNITY; CHRONIC LYMPHATIC LEUKEMIA; GENE REARRANGEMENT; GENETICS; HEMOLYTIC ANEMIA; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE ANALYSIS; AUTOIMMUNE HEMOLYTIC ANEMIA; CLINICAL ARTICLE; DISEASE ASSOCIATION; GENE SEQUENCE; HUMAN CELL; MOLECULAR CLONING; PATHOGENESIS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANEMIA, HEMOLYTIC; AUTOANTIBODIES; AUTOIMMUNITY; BASE SEQUENCE; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS;

EID: 0029665035     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.9.3869.bloodjournal8793869     Document Type: Article

References (31)

1. Foon KA, Rai KR, Gale RP: Chronic lymphocytic leukemia: New insights into biology and therapy. Ann Intern Med 113:525, 1990
2. Dighiero G, Travade P, Chevret S, Fenaux P, Chastang C, Binet J-L, French Cooperative Group on CLL: B-cell chronic lymphocytic leukemia: Present status and future directions. Blood 78:1901, 1991
3. Faguet GB: Chronic lymphocytic leukemia: An updated review. J Clin Oncol 12:1974, 1994
4. Hamblin TJ, Oscier DJ, Young BJ: Autoimmunity in chronic lymphocytic leukemia. J Clin Pathol 39:713, 1986
5. Sthoeger ZM, Sthoeger D, Shtalrid M, Sigler E, Geltner D, Berrebi A: Mechanism of autoimmune hemolytic anemia in chronic lymphocytic leukemia. Am J Hematol 43:259, 1993
6. Feizi T, Wernet P, Kunkel HG, Douglas SD: Lymphocytes forming red cell rosettes in the cold in patients with chronic cold agglutinin disease. Blood 42:753, 1983
7. Engelfriet CP, Overbeeke MAM, von dem Borne AEGK: Autoimmune hemolytic anemia. Semin Hematol 29:3, 1992
8. Kipps TJ, Carson DA: Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases. Blood 81:2475, 1993
9. Kobayashi R, Picchio G, Kirven M, Meisenholder G, Baird S, Carson DA, Mosier DE, Kipps TJ: Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency. Leuk Res 16:1013, 1992
10. Dighiero G: An attempt to explain disordered immunity and hypogammaglobulinemia in B-CLL. Nouv Rev Fr Hematol 30:283, 1988
11. International Workshop on Chronic Lymphocytic Leukemia: Chronic lymphocytic leukemia: Recommendations for diagnosis, staging and response criteria. Ann Intern Med 110:236, 1989
12. Chomzynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
13. Campbell MJ, Zelenetz AD, Levy S, Levy R: Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire. Mol Immunol 29:193, 1992
14. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C: Sequences of proteins of immunological interest (ed 5). Bethesda, MD, US Department of Health and Human Services, 1991
15. Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G: Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 173:395, 1991
16. Franzin F, Efremov DG, Pozzato G, Tulissi P, Batista F, Burrone OR: Clonal B-cell expansions in peripheral blood of HCV infected patients. Br J Haematol 90:548, 1995
17. Schroeder HW Jr, Dighiero G: The pathogenesis of chronic lymphocytic leukemia: Analysis of the antibody repertoire. Immunol Today 15:288, 1994
18. + B-cell chronic lymphocytic leukemia and displaying autoantibody activity. Blood 82:3103, 1993
19. H5 gene in human B cell chronic lymphocytic leukemia. J Exp Med 176:1073, 1992
20. Pascual V, Capra JD: VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire. Arthritis Rheum 35:11, 1992
21. Schutte MEM, van Es JH, Silberstein LE, Logtenberg T: VH4.21-encoded natural autoantibodies with anti-i specificity mirror those associated with cold hemagglutinin disease. J Immunol 151:6569, 1993
22. Kipps TJ: Immunoglobulin genes in chronic lymphocytic leukemia. Blood Cells 19:615, 1993
23. Bye JM, Carter C, Cui Y, Gorick BD, Songsivilai S, Winter G, Hughes-Jones NC, Marks JD: Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies: Evidence for affinity maturation by somatic hypermutation and repertoire shift. J Clin Invest 90:2481, 1992
24. Martin T, Crouzier R, Weber J-C, Kipps TJ, Pasquali J-L: Structure-function studies on a polyreactive (natural) autoantibody: Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain. J Immunol 152:5988, 1994
25. Crouzier R, Martin T, Pasquali J-L: Heavy chain variable region, light chain variable region, and heavy chain CDR3 influences on the mono- and polyreactivity and on the affinity of human monoclonal rheumatoid factors. J Immunol 154:4526, 1995
26. Hardy RR, Hayakawa K: CD5 B cells, a fetal B cell lineage. Adv Immunol 55:297, 1994
27. Izui S: Autoimmune hemolytic anemia. Curr Opin Immunol 6:926, 1994
28. Reininger L, Ollier P, Poncet P, Kaushik A, Jaton J-C: Novel V genes encode virtually identical variable regions of six murine monoclonal anti-bromelain-treated red blood cell autoantibodies. J Immunol 138:316, 1987
29. H11 family. J Immunol 142:3643, 1989
30. Kaushik A, Matthes T, Dighiero G: Do natural autoantibodies play an important role in the elimination of senescent or damaged red blood cells? Blood Cells 14:161, 1988
31. Masouredis SP, Branks MJ, Victoria EJ: Antiidiotypic IgG crossreactive with Rh alloantibodies in red cell autoimmuniry. Blood 70:710, 1987