메뉴 건너뛰기




Volumn 96, Issue 11, 2011, Pages 1644-1652

Toll-like receptor signaling pathway in chronic lymphocytic leukemia: Distinct gene expression profiles of potential pathogenic significance in specific subsets of patients

Author keywords

Chronic lymphocytic leukemia; Gene expression profiling; Signaling pathway; Toll like receptor

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD180 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR; INTERLEUKIN 6; LYMPHOCYTE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 80355126549     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.044792     Document Type: Article
Times cited : (74)

References (49)
  • 1
    • 52449121246 scopus 로고    scopus 로고
    • Novel insights in chronic lymphocytic leukemia: Are we getting closer to understanding the pathogenesis of the disease?
    • Caligaris-Cappio F, Ghia P. Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol 2008; 26(27):4497-503.
    • (2008) J Clin Oncol , vol.26 , Issue.27 , pp. 4497-4503
    • Caligaris-Cappio, F.1    Ghia, P.2
  • 2
    • 77956646833 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia: A disease of activated monoclonal B cells
    • Damle RN, Calissano C, Chiorazzi N. Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells. Best Pract Res Clin Haematol. 2010;23(1):33-45.
    • (2010) Best Pract Res Clin Haematol , vol.23 , Issue.1 , pp. 33-45
    • Damle, R.N.1    Calissano, C.2    Chiorazzi, N.3
  • 3
    • 74249107417 scopus 로고    scopus 로고
    • A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: Molecular and computational evidence
    • Darzentas N, Hadzidimitriou A, Murray F, Hatzi K, Josefsson P, Laoutaris N, et al. A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia. 2010;24(1):125-32.
    • (2010) Leukemia , vol.24 , Issue.1 , pp. 125-132
    • Darzentas, N.1    Hadzidimitriou, A.2    Murray, F.3    Hatzi, K.4    Josefsson, P.5    Laoutaris, N.6
  • 4
    • 78649786581 scopus 로고    scopus 로고
    • Antigens in chronic lymphocytic leukemia-implications for cell origin and leukemogenesis
    • Rosen A, Murray F, Evaldsson C, Rosenquist R. Antigens in chronic lymphocytic leukemia-implications for cell origin and leukemogenesis. Semin Cancer Biol. 2010;20(6):400-6.
    • (2010) Semin Cancer Biol , vol.20 , Issue.6 , pp. 400-406
    • Rosen, A.1    Murray, F.2    Evaldsson, C.3    Rosenquist, R.4
  • 5
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: The virtues of a nonclonal system of recognition
    • Medzhitov R, Janeway CA Jr. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 1997;91(3):295-8.
    • (1997) Cell , vol.91 , Issue.3 , pp. 295-298
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 7
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2001; 11(5):373-84.
    • (2001) Nat Immunol , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 8
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2(8):675-80.
    • (2001) Nat Immunol , vol.2 , Issue.8 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 9
    • 16644366474 scopus 로고    scopus 로고
    • Toll-like receptors: Linking innate and adaptive immunity
    • Pasare C, Medzhitov R. Toll-like receptors: linking innate and adaptive immunity. Microbes Infect. 2004;6(15):1382-7.
    • (2004) Microbes Infect , vol.6 , Issue.15 , pp. 1382-1387
    • Pasare, C.1    Medzhitov, R.2
  • 10
    • 75749128201 scopus 로고    scopus 로고
    • Innate pathways to B-cell activation and tolerance
    • Crampton SP, Voynova E, Bolland S. Innate pathways to B-cell activation and tolerance. Ann NY Acad Sci. 2010;1183:58-68.
    • (2010) Ann NY Acad Sci , vol.1183 , pp. 58-68
    • Crampton, S.P.1    Voynova, E.2    Bolland, S.3
  • 11
    • 18844380660 scopus 로고    scopus 로고
    • Signaling in B cells via Toll-like receptors
    • Peng SL. Signaling in B cells via Toll-like receptors. Curr Opin Immunol 2005;17(3): 230-6.
    • (2005) Curr Opin Immunol , vol.17 , Issue.3 , pp. 230-236
    • Peng, S.L.1
  • 12
    • 0038142387 scopus 로고    scopus 로고
    • A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi NL, Onai N, Lanzavecchia A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood. 2003;101(11):4500-4.
    • (2003) Blood , vol.101 , Issue.11 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 13
    • 0041743207 scopus 로고    scopus 로고
    • The toll-like receptor repertoire of human B lymphocytes: Inducible and selective expression of TLR9 and TLR10 in normal and transformed cells
    • Bourke E, Bosisio D, Golay J, Polentarutti N, Mantovani A. The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood. 2003;102(3):956-63.
    • (2003) Blood , vol.102 , Issue.3 , pp. 956-963
    • Bourke, E.1    Bosisio, D.2    Golay, J.3    Polentarutti, N.4    Mantovani, A.5
  • 15
    • 77950967415 scopus 로고    scopus 로고
    • Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: Rele vance to microbial antibody responses
    • Pone EJ, Zan H, Zhang J, Al-Qahtani A, Xu Z, Casali P. Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: rele vance to microbial antibody responses. Crit Rev Immunol. 2010;30(1):1-29.
    • (2010) Crit Rev Immunol , vol.30 , Issue.1 , pp. 1-29
    • Pone, E.J.1    Zan, H.2    Zhang, J.3    Al-Qahtani, A.4    Xu, Z.5    Casali, P.6
  • 16
    • 34249707214 scopus 로고    scopus 로고
    • Nuclear factorkappa B: Activation and regulation during toll-like receptor signaling
    • Carmody RJ, Chen YH. Nuclear factorkappa B: activation and regulation during toll-like receptor signaling. Cell Mol Immunol. 2007;4(1):31-41.
    • (2007) Cell Mol Immunol , vol.4 , Issue.1 , pp. 31-41
    • Carmody, R.J.1    Chen, Y.H.2
  • 17
    • 67349090990 scopus 로고    scopus 로고
    • HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation
    • Park SR, Zan H, Pal Z, Zhang J, Al-Qahtani A, Pone EJ, et al. HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nat Immunol. 2009;10(5):540-50.
    • (2009) Nat Immunol , vol.10 , Issue.5 , pp. 540-550
    • Park, S.R.1    Zan, H.2    Pal, Z.3    Zhang, J.4    Al-Qahtani, A.5    Pone, E.J.6
  • 18
    • 65749104837 scopus 로고    scopus 로고
    • How location governs toll-like receptor signaling
    • Chaturvedi A, Pierce SK. How location governs toll-like receptor signaling. Traffic. 2009;10(6):621-8.
    • (2009) Traffic , vol.10 , Issue.6 , pp. 621-628
    • Chaturvedi, A.1    Pierce, S.K.2
  • 20
    • 65449118056 scopus 로고    scopus 로고
    • BCR-mediated uptake of antigen linked to TLR9-ligand stimulates B-cell proliferation and antigenspecific plasma cell formation
    • Eckl-Dorna J, Batista FD. BCR-mediated uptake of antigen linked to TLR9-ligand stimulates B-cell proliferation and antigenspecific plasma cell formation. Blood. 2009;113(17):3969-77.
    • (2009) Blood , vol.113 , Issue.17 , pp. 3969-3977
    • Eckl-Dorna, J.1    Batista, F.D.2
  • 21
    • 39549105619 scopus 로고    scopus 로고
    • B cell autonomous TLR signaling and autoimmunity
    • Meyer-Bahlburg A, Rawlings DJ. B cell autonomous TLR signaling and autoimmunity. Autoimmun Rev. 2008;7(4):313-6.
    • (2008) Autoimmun Rev , vol.7 , Issue.4 , pp. 313-316
    • Meyer-Bahlburg, A.1    Rawlings, D.J.2
  • 22
    • 33645956556 scopus 로고    scopus 로고
    • Toll-like receptor stimulation as a third signal required for activation of human naive B cells
    • Ruprecht CR, Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol. 2006;36(4):810-6.
    • (2006) Eur J Immunol , vol.36 , Issue.4 , pp. 810-816
    • Ruprecht, C.R.1    Lanzavecchia, A.2
  • 23
    • 70349251459 scopus 로고    scopus 로고
    • Antigen receptor signals rescue B cells from TLR tolerance
    • Poovassery JS, Vanden Bush TJ, Bishop GA. Antigen receptor signals rescue B cells from TLR tolerance. J Immunol. 2009;183(5): 2974-83.
    • (2009) J Immunol , vol.183 , Issue.5 , pp. 2974-2983
    • Poovassery, J.S.1    Vanden, B.T.J.2    Bishop, G.A.3
  • 24
    • 33845542139 scopus 로고    scopus 로고
    • Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia
    • Spaner DE, Masellis A. Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia. Leukemia. 2007;21(1): 53-60.
    • (2007) Leukemia , vol.21 , Issue.1 , pp. 53-60
    • Spaner, D.E.1    Masellis, A.2
  • 25
    • 36348953188 scopus 로고    scopus 로고
    • Expression of functional toll-like receptors by B-chronic lymphocytic leukemia cells
    • Grandjenette C, Kennel A, Faure GC, Béné MC FP. Expression of functional toll-like receptors by B-chronic lymphocytic leukemia cells. Haematologica. 2007;92(9): 1279-81.
    • (2007) Haematologica , vol.92 , Issue.9 , pp. 1279-1281
    • Grandjenette, C.1    Kennel, A.2    Faure, G.C.3    Béné, M.C.F.P.4
  • 26
    • 74049096598 scopus 로고    scopus 로고
    • Toll-like receptors on B-CLL cells: Expression and functional consequences of their stimulation
    • Rozková D, Novotná L, Pytlík R, Hochová I, Kozák T, Bartůnková J, et al. Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation. Int J Cancer. 2010;126(5):1132-43.
    • (2010) Int J Cancer , vol.126 , Issue.5 , pp. 1132-1143
    • Rozková, D.1    Novotná, L.2    Pytlík, R.3    Hochová, I.4    Kozák, T.5    Bartůnková, J.6
  • 28
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111 (12):5446-56.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3    Caligaris-Cappio, F.4    Dighiero, G.5    Döhner, H.6
  • 29
    • 33846108722 scopus 로고    scopus 로고
    • Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations
    • Stamatopoulos K, Belessi C, Moreno C, Boudjograh M, Guida G, Smilevska T, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood. 2007;109(1):259-70.
    • (2007) Blood , vol.109 , Issue.1 , pp. 259-270
    • Stamatopoulos, K.1    Belessi, C.2    Moreno, C.3    Boudjograh, M.4    Guida, G.5    Smilevska, T.6
  • 30
    • 48449094247 scopus 로고    scopus 로고
    • IMGT/V-QUEST: The highly customized andintegrated system for IG and TR standardized V-J and V-D-J sequence analysis
    • (Web Server issue)
    • Brochet X, Lefranc MP, Giudicelli V. IMGT/V-QUEST: the highly customized andintegrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 2008;36(Web Server issue):W503-W8.
    • (2008) Nucleic Acids Res , vol.36
    • Brochet, X.1    Lefranc, M.P.2    Giudicelli, V.3
  • 32
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402-8.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 33
    • 0034141541 scopus 로고    scopus 로고
    • Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells
    • Decker T, Schneller F, Sparwasser T, Tretter T, Lipford GB, Wagner H, et al. Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood. 2000; 95(3):999-1006.
    • (2000) Blood , vol.95 , Issue.3 , pp. 999-1006
    • Decker, T.1    Schneller, F.2    Sparwasser, T.3    Tretter, T.4    Lipford, G.B.5    Wagner, H.6
  • 34
    • 77954662424 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells
    • Liang X, Moseman EA, Farrar MA, Bachanova V, Weisdorf DJ, Blazar BR, et al. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood. 2010;115(24):5041-52.
    • (2010) Blood , vol.115 , Issue.24 , pp. 5041-5052
    • Liang, X.1    Moseman, E.A.2    Farrar, M.A.3    Bachanova, V.4    Weisdorf, D.J.5    Blazar, B.R.6
  • 35
    • 33845526567 scopus 로고    scopus 로고
    • The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease
    • Longo PG, Laurenti L, Gobessi S, Petlickovski A, Pelosi M, Chiusolo P, et al. The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease. Leukemia. 2007;21(1):110-20.
    • (2007) Leukemia , vol.21 , Issue.1 , pp. 110-120
    • Longo, P.G.1    Laurenti, L.2    Gobessi, S.3    Petlickovski, A.4    Pelosi, M.5    Chiusolo, P.6
  • 36
    • 31444457097 scopus 로고    scopus 로고
    • Immunomodulatory effects of Toll-like receptor-7 activation on CLL cells
    • Spaner DE, Shi Y, White D, Mena J, Hammond C, Tomic J, et al. Immunomodulatory effects of Toll-like receptor-7 activation on CLL cells. Leukemia. 2006;20(2):286-95.
    • (2006) Leukemia , vol.20 , Issue.2 , pp. 286-295
    • Spaner, D.E.1    Shi, Y.2    White, D.3    Mena, J.4    Hammond, C.5    Tomic, J.6
  • 37
    • 33847702017 scopus 로고    scopus 로고
    • Toll-like receptor-7 tolerizes malignant B cells and enhances klling by cytotoxic agents
    • Shi Y, White D, He L, Miller RL, Spaner DE. Toll-like receptor-7 tolerizes malignant B cells and enhances klling by cytotoxic agents. Cancer Res. 2007;67(4):1823-31.
    • (2007) Cancer Res , vol.67 , Issue.4 , pp. 1823-1831
    • Shi, Y.1    White, D.2    He, L.3    Miller, R.L.4    Spaner, D.E.5
  • 38
    • 47049101962 scopus 로고    scopus 로고
    • Resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kB activation
    • Hammadi A, Billard C, Faussat AM, Kolb JP. Resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kB activation. Nitric Oxide. 2008;19: 138-45.
    • (2008) Nitric Oxide , vol.19 , pp. 138-145
    • Hammadi, A.1    Billard, C.2    Faussat, A.M.3    Kolb, J.P.4
  • 39
    • 33644800269 scopus 로고    scopus 로고
    • Differential expression of CD180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes
    • Porakishvili N, Kulikova N, Jewell AP, Youinou PY, Yong K, Nathwani A, et al. Differential expression of CD180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes. Br J Haematol. 2005;131(3):313-9.
    • (2005) Br J Haematol , vol.131 , Issue.3 , pp. 313-319
    • Porakishvili, N.1    Kulikova, N.2    Jewell, A.P.3    Youinou, P.Y.4    Yong, K.5    Nathwani, A.6
  • 40
    • 10744226156 scopus 로고    scopus 로고
    • Post- transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions
    • Tiscornia AC, Cayota A, Landon AI, Brito C, Oppezzo P, Vuillier F, et al. Post- transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions. Leukemia. 2004;18(1): 48-56.
    • (2004) Leukemia , vol.18 , Issue.1 , pp. 48-56
    • Tiscornia, A.C.1    Cayota, A.2    Landon, A.I.3    Brito, C.4    Oppezzo, P.5    Vuillier, F.6
  • 41
    • 48749109814 scopus 로고    scopus 로고
    • Predominantly post-transcriptional regulation of activation molecules in chronic lymphocytic leukemia: The case of transferrin receptors
    • Chiotoglou I, Smilevska T, Samara M, Likousi S, Belessi C, Athanasiadou I, et al. Predominantly post-transcriptional regulation of activation molecules in chronic lymphocytic leukemia: the case of transferrin receptors. Blood Cells Mol Dis. 2008; 41(2):203-9.
    • (2008) Blood Cells Mol Dis , vol.41 , Issue.2 , pp. 203-209
    • Chiotoglou, I.1    Smilevska, T.2    Samara, M.3    Likousi, S.4    Belessi, C.5    Athanasiadou, I.6
  • 42
    • 77952965028 scopus 로고    scopus 로고
    • Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: Implications for patient outcome and cell of origin
    • Chu CC, Catera R, Zhang L, Didier S, Agagnina BM, Damle RN, et al. Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood. 2010;115(19):3907-15.
    • (2010) Blood , vol.115 , Issue.19 , pp. 3907-3915
    • Chu, C.C.1    Catera, R.2    Zhang, L.3    Didier, S.4    Agagnina, B.M.5    Damle, R.N.6
  • 43
    • 0035803464 scopus 로고    scopus 로고
    • Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
    • Klein U, Tu Y, Stolovitzky GA, Mattioli M, Cattoretti G, Husson H, et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med. 2001;194(11):1625-38.
    • (2001) J Exp Med , vol.194 , Issue.11 , pp. 1625-1638
    • Klein, U.1    Tu, Y.2    Stolovitzky, G.A.3    Mattioli, M.4    Cattoretti, G.5    Husson, H.6
  • 44
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • Rosenwald A, Alizadeh AA, Widhopf G, Simon R, Davis RE, Yu X, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med. 2001;194(11):1639-47.
    • (2001) J Exp Med , vol.194 , Issue.11 , pp. 1639-1647
    • Rosenwald, A.1    Alizadeh, A.A.2    Widhopf, G.3    Simon, R.4    Davis, R.E.5    Yu, X.6
  • 45
    • 0030989818 scopus 로고    scopus 로고
    • CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules
    • Van den Hove LE, Van Gool SW, Vandenberghe P, Bakkus M, Thielemans K, Boogaerts MA, et al. CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules. Leukemia. 1997;11(4): 572-80.
    • (1997) Leukemia , vol.11 , Issue.4 , pp. 572-580
    • van den Hove, L.E.1    van Gool, S.W.2    Vandenberghe, P.3    Bakkus, M.4    Thielemans, K.5    Boogaerts, M.A.6
  • 46
    • 78649833413 scopus 로고    scopus 로고
    • Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors
    • Marincevic M, Mansouri M, Kanduri M, Isaksson A, Göransson H, Smedby KE, et al. Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Haematologica. 2010;95(12): 2072-9.
    • (2010) Haematologica , vol.95 , Issue.12 , pp. 2072-2079
    • Marincevic, M.1    Mansouri, M.2    Kanduri, M.3    Isaksson, A.4    Göransson, H.5    Smedby, K.E.6
  • 47
    • 77956865697 scopus 로고    scopus 로고
    • High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4- 34 B-cell receptors
    • Marincevic M, Cahill N, Gunnarsson R, Isaksson A, Mansouri M, Göransson H, et al. High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4- 34 B-cell receptors. Haematologica. 2010;95(9):1519-25.
    • (2010) Haematologica , vol.95 , Issue.9 , pp. 1519-1525
    • Marincevic, M.1    Cahill, N.2    Gunnarsson, R.3    Isaksson, A.4    Mansouri, M.5    Göransson, H.6
  • 48
    • 55949116983 scopus 로고    scopus 로고
    • Microenvironmental influences in chronic lymphocytic leukaemia: Therole of antigen stimulation
    • Ghia P, Chiorazzi N, Stamatopoulos K. Microenvironmental influences in chronic lymphocytic leukaemia: therole of antigen stimulation. J Intern Med. 2008;264(6):549- 62.
    • (2008) J Intern Med , vol.264 , Issue.6 , pp. 549-562
    • Ghia, P.1    Chiorazzi, N.2    Stamatopoulos, K.3
  • 49
    • 43549093570 scopus 로고    scopus 로고
    • A new perspective: Molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
    • Lanemo Myhrinder A, Hellqvist E, Sidorova E, Söderberg A, Baxendale H, Dahle C, et al. A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood. 2008; 111(7):3838-48.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3838-3848
    • Lanemo Myhrinder, A.1    Hellqvist, E.2    Sidorova, E.3    Söderberg, A.4    Baxendale, H.5    Dahle, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.