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Volumn 18, Issue 9, 2012, Pages 1281-1291

Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors

Author keywords

[No Author keywords available]

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; IMMUNOGLOBULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR;

EID: 84870314626     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00480     Document Type: Article
Times cited : (60)

References (51)
  • 1
    • 79951498701 scopus 로고    scopus 로고
    • Cellular origin(s) of chronic lymphocytic leukemia: Cautionary notes and additional considerations and possibilities
    • Chiorazzi N, Ferrarini M. (2010) Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood. 117:1781-91.
    • (2010) Blood , vol.117 , pp. 1781-1791
    • Chiorazzi, N.1    Ferrarini, M.2
  • 2
    • 0042971643 scopus 로고    scopus 로고
    • B cell chronic lymphocytic leukemia: Lessons learned from studies of the B cell antigen receptor
    • Chiorazzi N, Ferrarini M. (2003) B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu. Rev. Immunol. 21:841-94.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 841-894
    • Chiorazzi, N.1    Ferrarini, M.2
  • 3
    • 33846108722 scopus 로고    scopus 로고
    • Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations
    • Stamatopoulos K, et al. (2007) Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood. 109:259-70.
    • (2007) Blood , vol.109 , pp. 259-270
    • Stamatopoulos, K.1
  • 4
    • 38949203770 scopus 로고    scopus 로고
    • Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: Implications for the role of antigen selection in leukemogenesis
    • Murray F, et al. (2008) Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood. 111:1524-33.
    • (2008) Blood , vol.111 , pp. 1524-1533
    • Murray, F.1
  • 5
    • 58549100059 scopus 로고    scopus 로고
    • Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: Results from an Italian multicentre study
    • Bomben R, et al. (2009) Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study. Br. J. Haematol. 144:492-506.
    • (2009) Br. J. Haematol. , vol.144 , pp. 492-506
    • Bomben, R.1
  • 6
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Fais F, et al. (1998) Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J. Clin. Invest. 102:1515-25.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1515-1525
    • Fais, F.1
  • 7
    • 74249107417 scopus 로고    scopus 로고
    • A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: Molecular and computational evidence
    • Darzentas N, et al. (2010) A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia. 24:125-32.
    • (2010) Leukemia , vol.24 , pp. 125-132
    • Darzentas, N.1
  • 8
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, et al. (1999) Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 94:1840-47.
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1
  • 9
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. (1999) Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 94:1848-54.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 11
    • 84870311404 scopus 로고    scopus 로고
    • Stereotyped B-cell receptors in chronic lymphocytic leukemia
    • In: Stamatopoulos K GP, Rosenquist R, et al. (ed.), Milan, Italy
    • Belessi C, Stamatopoulos K. (2010) Stereotyped B-cell receptors in chronic lymphocytic leukemia. In: Stamatopoulos K GP, Rosenquist R, et al. (ed.) WKHealth Books, Milan, Italy, pp. 119-34.
    • (2010) WKHealth Books , pp. 119-134
    • Belessi, C.1    Stamatopoulos, K.2
  • 12
    • 43549093570 scopus 로고    scopus 로고
    • A new perspective: Molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
    • Lanemo Myhrinder A, et al. (2008) A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood. 111:3838-48.
    • (2008) Blood , vol.111 , pp. 3838-3848
    • Lanemo Myhrinder, A.1
  • 13
    • 55749114077 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation
    • Catera R, et al. (2008) Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol. Med. 14:665-74.
    • (2008) Mol. Med. , vol.14 , pp. 665-674
    • Catera, R.1
  • 14
    • 55749091407 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
    • Chu CC, et al. (2008) Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood. 112:5122-9.
    • (2008) Blood , vol.112 , pp. 5122-5129
    • Chu, C.C.1
  • 15
    • 70449506033 scopus 로고    scopus 로고
    • Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells
    • Seiler T, et al. (2009) Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells. Blood. 114:3615-24.
    • (2009) Blood , vol.114 , pp. 3615-3624
    • Seiler, T.1
  • 16
    • 77952965028 scopus 로고    scopus 로고
    • Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: Implications for patient outcome and cell of origin
    • Chu CC, et al. (2010) Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood. 115:3907-15.
    • (2010) Blood , vol.115 , pp. 3907-3915
    • Chu, C.C.1
  • 17
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. (2006) Pathogen recognition and innate immunity. Cell. 124:783-801.
    • (2006) Cell. , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 19
    • 20544474210 scopus 로고    scopus 로고
    • Pathogen recognition with Toll-like receptors
    • Kawai T, Akira S. (2005) Pathogen recognition with Toll-like receptors. Curr. Opin. Immunol. 17:338-44.
    • (2005) Curr. Opin. Immunol. , vol.17 , pp. 338-344
    • Kawai, T.1    Akira, S.2
  • 21
    • 0038142387 scopus 로고    scopus 로고
    • A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi NL, Onai N, Lanzavecchia A. (2003) A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood. 101:4500-4.
    • (2003) Blood , vol.101 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 22
    • 0041743207 scopus 로고    scopus 로고
    • The toll-like receptor repertoire of human B lymphocytes: Inducible and selective expression of TLR9 and TLR10 in normal and transformed cells
    • Bourke E, Bosisio D, Golay J, Polentarutti N, Mantovani A. (2003) The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood. 102:956-63.
    • (2003) Blood , vol.102 , pp. 956-963
    • Bourke, E.1    Bosisio, D.2    Golay, J.3    Polentarutti, N.4    Mantovani, A.5
  • 23
    • 37549034962 scopus 로고    scopus 로고
    • B cell intrinsic TLR signals amplify but are not required for humoral immunity
    • Meyer-Bahlburg A, Khim S, Rawlings DJ. (2007) B cell intrinsic TLR signals amplify but are not required for humoral immunity. J. Exp. Med. 204:3095-101.
    • (2007) J. Exp. Med. , vol.204 , pp. 3095-3101
    • Meyer-Bahlburg, A.1    Khim, S.2    Rawlings, D.J.3
  • 24
    • 33645956556 scopus 로고    scopus 로고
    • Toll-like receptor stimulation as a third signal required for activation of human naive B cells
    • Ruprecht CR, Lanzavecchia A. (2006) Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur. J. Immunol. 36:810-6.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 810-816
    • Ruprecht, C.R.1    Lanzavecchia, A.2
  • 25
    • 79951844253 scopus 로고    scopus 로고
    • Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors
    • Petterson T, et al. (2011) Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors. J. Leukoc. Biol. 89:177-87.
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 177-187
    • Petterson, T.1
  • 26
    • 0037061453 scopus 로고    scopus 로고
    • Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    • Leadbetter EA, et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 416:603-7.
    • (2002) Nature. , vol.416 , pp. 603-607
    • Leadbetter, E.A.1
  • 27
    • 27744444832 scopus 로고    scopus 로고
    • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    • Lau CM, et al. (2005) RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202:1171-7.
    • (2005) J. Exp. Med. , vol.202 , pp. 1171-1177
    • Lau, C.M.1
  • 28
    • 70349251459 scopus 로고    scopus 로고
    • Antigen receptor signals rescue B cells from TLR tolerance
    • Poovassery JS, Vanden Bush TJ, Bishop GA. (2009) Antigen receptor signals rescue B cells from TLR tolerance. J. Immunol. 183:2974-83.
    • (2009) J. Immunol. , vol.183 , pp. 2974-2983
    • Poovassery, J.S.1    Vanden Bush, T.J.2    Bishop, G.A.3
  • 29
    • 36348953188 scopus 로고    scopus 로고
    • Expression of functional tolllike receptors by B-chronic lymphocytic leukemia cells
    • Grandjenette C, Kennel A, Faure GC, Bene MC, Feugier P. (2007) Expression of functional tolllike receptors by B-chronic lymphocytic leukemia cells. Haematologica. 92:1279-81.
    • (2007) Haematologica , vol.92 , pp. 1279-1281
    • Grandjenette, C.1    Kennel, A.2    Faure, G.C.3    Bene, M.C.4    Feugier, P.5
  • 30
    • 74049096598 scopus 로고    scopus 로고
    • Toll-like receptors on B-CLL cells: Expression and functional consequences of their stimulation
    • Rozkova D, et al. (2010) Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation. Int. J. Cancer. 126:1132-43.
    • (2010) Int. J. Cancer , vol.126 , pp. 1132-1143
    • Rozkova, D.1
  • 31
    • 58549120954 scopus 로고    scopus 로고
    • Expression and function of toll like receptors in chronic lymphocytic leukaemia cells
    • Muzio M, et al. (2009) Expression and function of toll like receptors in chronic lymphocytic leukaemia cells. Br. J. Haematol. 144:507-16.
    • (2009) Br. J. Haematol. , vol.144 , pp. 507-516
    • Muzio, M.1
  • 32
    • 80355126549 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathway in chronic lymphocytic leukemia: Distinct gene expression profiles of potential pathogenetic significance in specific subsets of patients
    • Arvaniti E, et al. (2011) Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenetic significance in specific subsets of patients. Haematologica. 96:1644-52.
    • (2011) Haematologica , vol.96 , pp. 1644-1652
    • Arvaniti, E.1
  • 33
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M, et al. (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 111:5446-56.
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1
  • 34
    • 58149316094 scopus 로고    scopus 로고
    • IMGT, the international ImMunoGeneTics information system
    • Lefranc MP, et al. (2009) IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res. 37: D1006-12.
    • (2009) Nucleic Acids Res. , vol.37
    • Lefranc, M.P.1
  • 35
    • 48449094247 scopus 로고    scopus 로고
    • IMGT/V-QUEST: The highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
    • Brochet X, Lefranc MP, Giudicelli V. (2008) IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 36: W503-8.
    • (2008) Nucleic Acids Res. , vol.36
    • Brochet, X.1    Lefranc, M.P.2    Giudicelli, V.3
  • 36
    • 0034141541 scopus 로고    scopus 로고
    • Immunostimulatory CpGoligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells
    • Decker T, et al. (2000) Immunostimulatory CpGoligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood. 95:999-1006.
    • (2000) Blood , vol.95 , pp. 999-1006
    • Decker, T.1
  • 37
    • 11144356992 scopus 로고    scopus 로고
    • Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
    • Ghiotto F, et al. (2004) Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J. Clin. Invest. 113:1008-16.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1008-1016
    • Ghiotto, F.1
  • 38
    • 33847702017 scopus 로고    scopus 로고
    • Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents
    • Shi Y, White D, He L, Miller RL, Spaner DE. (2007) Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents. Cancer Res. 67:1823-31.
    • (2007) Cancer Res. , vol.67 , pp. 1823-1831
    • Shi, Y.1    White, D.2    He, L.3    Miller, R.L.4    Spaner, D.E.5
  • 39
    • 33845526567 scopus 로고    scopus 로고
    • The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease
    • Longo PG, et al. (2007) The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease. Leukemia 21:110-20.
    • (2007) Leukemia , vol.21 , pp. 110-120
    • Longo, P.G.1
  • 40
    • 0037306842 scopus 로고    scopus 로고
    • Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia
    • Lanham S, et al. (2003) Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood. 101:1087-93.
    • (2003) Blood , vol.101 , pp. 1087-1093
    • Lanham, S.1
  • 41
    • 34248354409 scopus 로고    scopus 로고
    • Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
    • Mockridge CI, et al. (2007) Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood. 109:4424-31.
    • (2007) Blood , vol.109 , pp. 4424-4431
    • Mockridge, C.I.1
  • 42
    • 47249152803 scopus 로고    scopus 로고
    • Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: A molecular signature of anergy
    • Muzio M, et al. (2008) Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood. 112:188-95.
    • (2008) Blood , vol.112 , pp. 188-195
    • Muzio, M.1
  • 43
    • 13544275555 scopus 로고    scopus 로고
    • Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: The lesson of the IGHV3-21 gene
    • Ghia P, et al. (2005) Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood. 105:1678-85.
    • (2005) Blood , vol.105 , pp. 1678-1685
    • Ghia, P.1
  • 44
    • 33645679597 scopus 로고    scopus 로고
    • Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia
    • Potter KN, et al. (2006) Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia. Clin. Cancer Res. 12:1672-9.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1672-1679
    • Potter, K.N.1
  • 45
    • 0037298948 scopus 로고    scopus 로고
    • Anti-DNA antibodies: Aspects of structure and pathogenicity
    • Jang YJ, Stollar BD. (2003) Anti-DNA antibodies: aspects of structure and pathogenicity. Cell Mol. Life Sci. 60:309-20.
    • (2003) Cell Mol. Life Sci. , vol.60 , pp. 309-320
    • Jang, Y.J.1    Stollar, B.D.2
  • 46
    • 67349164793 scopus 로고    scopus 로고
    • Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors
    • Kostareli E, et al. (2009) Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Leukemia 23:919-24.
    • (2009) Leukemia , vol.23 , pp. 919-924
    • Kostareli, E.1
  • 47
    • 73349090583 scopus 로고    scopus 로고
    • Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: Implications for ongoing interactions with antigen
    • Sutton LA, et al. (2009) Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen. Blood. 114:4460-68.
    • (2009) Blood , vol.114 , pp. 4460-4468
    • Sutton, L.A.1
  • 48
    • 4344704897 scopus 로고    scopus 로고
    • Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
    • Messmer BT, et al. (2004) Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J. Exp. Med. 200:519-25.
    • (2004) J. Exp. Med. , vol.200 , pp. 519-525
    • Messmer, B.T.1
  • 49
    • 77956865697 scopus 로고    scopus 로고
    • High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors
    • Marincevic M, et al. (2010) High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors. Haematologica. 95:1519-25.
    • (2010) Haematologica. , vol.95 , pp. 1519-1525
    • Marincevic, M.1
  • 50
    • 78649833413 scopus 로고    scopus 로고
    • Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors
    • Marincevic M, et al. (2010) Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Haematologica. 95:2072-9.
    • (2010) Haematologica. , vol.95 , pp. 2072-2079
    • Marincevic, M.1
  • 51
    • 33845542139 scopus 로고    scopus 로고
    • Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia
    • Spaner DE, Masellis A. (2007) Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia Leukemia. 21:53-60.
    • (2007) Leukemia. , vol.21 , pp. 53-60
    • Spaner, D.E.1    Masellis, A.2


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