Frequent occurrence of identical heavy and light chain Ig rearrangements

International Immunology

Volumn 9, Issue 5, 1997, Pages 689-702

  Seidl, Katherine J ^a,d   MacKenzie, John D ^a   Wang, Denong ^b   Kantor, Aaron B ^a,c   Kabat, Elvin A ^b   Herzenberg, Leonard A ^a   Herzenberg, Leonore A ^a  

^a STANFORD UNIVERSITY   (United States)

^b Columbia University ^*  (United States)

^c AmCell Corporation   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

B 1 cells; CD5; Clonal expansion; Dominant idiotype; FACS; Ig sequences; Phosphatidylcholine; Single cell; V(H) region sequences; V(H)11; V(L) region sequences

Indexed keywords

AUTOANTIBODY; BROMELAIN; IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; PHOSPHATIDYLCHOLINE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CLONE; CONTROLLED STUDY; CYTOLYSIS; ERYTHROCYTE; FEMALE; GENE REARRANGEMENT; HYBRIDOMA; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BINDING SITES, ANTIBODY; CELL DIFFERENTIATION; CELL LINE; CLONE CELLS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; GERM CELLS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; LIPOSOMES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PHOSPHATIDYLCHOLINES; RECEPTORS, ANTIGEN, B-CELL; REPETITIVE SEQUENCES, NUCLEIC ACID; RESTRICTION MAPPING; SEQUENCE HOMOLOGY, NUCLEIC ACID; STAINING AND LABELING;

EID: 0030994404     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.5.689     Document Type: Article

References (83)

1. Tornberg, U. C. and Holmberg, D. 1995. B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures. EMBO J. 14:1680.
2. Hayakawa, K., Carmack, C. E., Hyman, R. and Hardy, R. R. 1990. Natural autoantibodies to thymocytes: origin, VH genes, fine specificities, and the role of Thy-1 glycoprotein. J. Exp. Med. 172:869.
3. + B cells. Immunol. Rev. 137:91.
4. Pennell, C. A, Mercolino, T. J., Grdina, T. A., Arnold, L. W., Haughton, G. and Clarke, S. H. 1969. Biased immunoglobulin variable region gene expression by Ly-1 B cells due to clonal selection. Eur J. Immunol. 19:1289.
5. Hummel, M., Ziemann, K., Lammert, H., Pileri, S., Sabattini, E. and Stein, H. 1995. Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells [see comments]. N. Engl. J. Med. 333:901.
6. Lieber, M. R. 1991. Site-specific recombination in the immune system. FASEB J. 5:2934.
7. Siekevitz, M., Kocks, C., Rajewsky, K. and Dildrop, R. 1987. Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses. Cell 48:757.
8. Berek, C. 1989. Molecular dissection of an antigen-specific immune response. J. Autoimmun. 2 Suppl:195.
9. Pennell, C. A., Arnold, L. W., Lutz, P. M., LoCascio, N. J., Willoughby, P. B. and Haughton, G. 1985. Cross-reactive idiotypes and common antigen binding specificities expressed by a series of murine B-cell lymphomas: etiological implications. Proc. Natl Acad. Sci. USA 82:3799.
10. Reininger, L., Ollier, P., Poncet, P., Kaushik, A. and Jaton, J. C. 1987. Novel V genes encode virtually identical variable regions of six murine monoclonal anti-bromelain-treated red blood cell autoantibodies. J. Immunol. 138:316.
11. Hardy, R. R., Carmack, C. E., Shinton, S. A., Riblet, R. J. and Hayakawa, K. 1989. A single VH gene is utilized predominantly in anti-BrMRBC hybridomas derived from purified Ly-1 B cells. Definition of the VH11 family. J. Immunol. 142:3643.
12. Wang, D. N., Chen, H. T., Liao, J., Akolkar, P. N., Sikder, S. K., Gruezo, F. and Kabat, E. A. 1990. Two families of monoclonal antibodies to alpha(1-6)dextran, VH19.1.2 and VH9.14.7, show distinct patterns of J kappa and JH minigene usage and amino acid substitutions in CDR3. J. Immunol 145:3002.
13. Cumano, A. and Rajewsky, K. 1985. Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice. Eur. J. Immunol. 15:512.
14. Blier, P. R. and Bothwell, A. L. 1988. The immune response to the hapten NP in C57BL/6 mice: insights into the structure of the B-cell repertoire. Immunol. Rev. 105:27.
15. Manser, T. 1990. Limits on heavy chain junctional diversity contribute to the recurrence of an antibody variable region. Mol. Immunol. 27:503.
16. Claflin, J. L., George, J., Dell, C. and Berry, J. 1989. Patterns of mutations and selection in antibodies to the phosphorylcholine-specific determinant in Proteus morganii. J. Immunol. 143:3054.
17. Poncet, P., Reininger, L., Freitas, A., Holmberg, D., Dighiero, G. and Coutinho, A. 1989. Expression of VH11-gene family in hybridoma collections from peritoneum and spleen: differential correlation with BrMRBC reactivity. Res. Immunol. 140:255.
18. Poncet, P., Huetz, F., Marcos, M. A. and Andrade, L. 1990. All VH11 genes expressed in peritoneal lymphocytes encode anti-bromelain-treated mouse red blood cell autoantibodies but other VH gene families contribute to this specificity. Eur. J. Immunol. 20:1583.
19. + B cell lymphomas. J. Immunol. 141:2788.
20. +) B cells that recognize phosphatidyl choline. J. Exp. Med. 169:1869.
21. Hardy, R. R. and Hayakawa, K. 1992. Developmental origins, specificities and immunoglobulin gene biases of murine Ly-1 B cell. Int. Rev. Immunol. 8:189.
22. Reininger, L., Kaushik, A., Izui, S. and Jaton, J. C. 1988. A member of a new VH gene family encodes antibromelinized mouse red blood cell autoantibodies. Eur. J. Immunol. 18:1521.
23. Conger, J. D., Sage, H. J. and Corley, R. B. 1989. Diversity in the available repertoire of murine antibodies reactive with bromelain-treated isologous erythrocytes. J. Immunol. 143:4044.
24. + murine B cell lymphomas specific for erythrocyte membranes. J. Exp. Med. 163:155.
25. + (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes. J. Exp. Med. 168:687.
26. Kantor, A. B. and Herzenberg, L. A. 1993. Origin of murine B cell lineages. Annu. Rev. Immunol. 11:501.
27. Cunningham, A. J. 1974. Large numbers of cells in normal mice produce antibody components of isologous erythrocytes. Nature 252:749.
28. Arnold, L. W., Spencer, D. H., Clarke, S. H. and Haughton, G. 1993. Mechanisms that limit the diversity of antibody: three sequentially acting mechanisms that favor the spontaneous production of germline encoded anti-phosphatidyl choline. Int. Immunol. 5:1365.
29. Arnold, L. W. and Haughton, G. 1992. Autoantibodies to phosphatidylcholine. The murine antibromelain RBC response Ann. NY Acad. Sci. 651:354.
30. Itohara, S., Mombaerts, P., Lafaille, J., Iacomini, J., Nelson, A., Clarke, A. R., Hooper, M. L., Farr, A. and Tonegawa, S. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72:337.
31. Alt, F. W. and Baltimore, D. 1982. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc. Natl Acad. Sci. USA 79:4118.
32. Feeney, A. J. 1992. Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies. J. Immunol. 149:222.
33. Ichihara, Y., Hayashida, H., Miyazawa, S. and Kurosawa, Y. 1989. Only DFL16, DSP2, and DQ52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which DFL16 and DSP2 originate from the same primordial DH gene. Eur. J. Immunol. 19:1849.
34. Gu, H., Forster, I. and Rajewsky, K. 1990. Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation. EMBO J. 9:2133.
35. Klinman, N. R. and Stone, M. R. 1983. Role of variable region gene expression and environmental selection in determining the anti-phosphorylcholine B cell repertoire. J. Exp. Med. 158:1948.
36. Kantor, A. B., Stall, A. M., Adams, S., Watanabe, K. and Herzenberg, L. A. 1995. De novo development and self-replenishment of B cells. Int. Immunol. 11:55.
37. Parks, D. R., Lanier, L. L. and Herzenberg, L. A. 1986. Flow cytometry and fluorescence activated cell sorting. In Weir, D. M., Herzenberg, L. A., Blackwell, C. C. and Herzenberg, L. A., eds, The Handbook of Experimental Immunology, p. 29.1. Blackwell Scientific, Edinburgh.
38. Lee, K. D., Kantor, A. B., Nir, S. and Owicki, J. C. 1993. Aggregation of hapten-bearing liposomes mediated by specific antibodies. Biophys. J. 64:905.
39. Kantor, A. B. 1988. Monoclonal antibody interactions with hapten-bearing liposomes. PhD Dissertation. University of California at Berkeley.
40. Kantor, A. B., Merrill, C. E., MacKenzie, J. D., Herzenberg, L. A. and Hillson, J. E. 1995. Development of the antibody repertoire as revealed by single cell PCR of FACS-Sorted B cell subsets. Ann. NY Acad. Sci. 764:224.
41. Kantor, A. B., Merrill, C. E. and Hillson, J. L. 1996. Construction of cDNA from Single Unstimulated B Lymphocytes: Method and Application to the Study of Expressed Antibody Repertoires in FACS-sorted B Cell Subsets. The Handbook of Experimental Immunology, Vol. 1, Immunochemistry and Molecular Immunology. Blackwell Scientific, Boston, MA, in press.
42. Kantor, A. B., Merrill, C. E., Herzenberg, L. A. and Hillson, J. L. 1996. The first unbiased analysis of VH-D-JH Sequences from B-1a, B-1b, and conventional B cells. J. Immunol. 158:1175.
43. Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, K. S. and Foeller, C. 1991. Sequences of Proteins of Immunological Interest, 5th edn, p. 1250. US Department of Health and Human Services, National Institutes of Health, Bethesda, MD.
44. Gu, H., Tarlinton, D., Muller, W., Rajewsky, K. and Forster, I. 1991. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173:1357.
45. Winter, D., Diamond, M., Abu-hadid, M., Falkenberg, S and Bankert, R. 1995. Allelic differences in the VHOx-1 gene explain the absence of a B cell clonal dominance in the primary response of C57BL/6 mice to phthalate. J. Immunol. 155:2445.
46. Dzierzak, E. A., Janeway, C., Jr, Richard, N. and Bothwell, A. 1986. Molecular characterization of antibodies bearing Id-460. I. The structure of two highly homologous VH genes used to produce idiotype positive immunoglobulins. J. Immunol. 136:1864.
47. Heinrich, G., Traunecker, A. and Tonegawa, S. 1984. Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains. J. Exp. Med. 159:417.
48. Even, J., Griffiths, G. M., Berek, C. and Milstein, C. 1985. Light chain germ-line genes and the immune response to 2-phenyloxazolone. EMBO J. 4:3439.
49. Hayakawa, K., Carmack, C. E., Shinton, S. A. and Hardy, R. R. 1992. Selection of Autoantibody specificities in the Ly-1 B subset. Ann. NY Acad. Sci. 651:346.
50. Riggs, J. E., Feeney, A. J., Kirven, M. and Mosier, D. E. 1994. VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer. Mol. Immunol. 31:783.
51. Osmond, D. G. 1990. B cell development in the bone marrow. Semin. Immunol. 2:173.
52. Decker, D. J., Boyle, N. E. and Klinman, N. R. 1991. Predominance of nonproductive rearrangements of VH81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains. J. Immunol. 147:1406.
53. Tiegs, S. L., Russell, D. M. and Nemazee, D. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009.
54. Levy, S., Campbell, M. J. and Levy, R, 1989. Functional immunoglobulin light chain genes are replaced by ongoing rearrangements of germline V kappa genes to downstream J kappa segments in a murine B cell line. J. Exp. Med. 170:1.
55. Prak, E. L., Trounstine, M., Huszar, D. and Weigert, M. 1994. Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance. J. Exp. Med. 180:1805.
56. Clarke, S. H. and McCray, S. K. 1993. VH CDR3-dependent positive selection of murine VH12-expressing B cells in the neonate. Eur. J. Immunol. 23:3327.
57. Pennell, C., McCray, S. and Clarke, S. 1992. VH12 rearrangements in adult peritoneal B cells. Ann. NY Acad. Sci. 651:311.
58. Kofler, R., Geley, S., Kofler, H. and Helmberg, A. 1992. Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses. Immunol. Rev. 128:5.
59. Feeney, A. J. 1992. Comparison of junctional diversity in the neonatal and adult immunoglobulin repertoires. Int. Rev. Immunol. 8:113.
60. Zhang, Y., Cado, D., Asarnow, D. M., Kmori, T., Alt, F., Raulet, D. H. and Allison, J. P. 1995. The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus. Immunity 3:439.
61. Gerstein, R. M. and Lieber, M. R. 1993. Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination. Nature 363:625.
62. Morris, D. L. and Rothstein, T. L. 1994. Decreased surface IgM receptor-mediated activation of phospholipase C gamma 2 in B-1 lymphocytes. Int. Immunol. 6:1011.
63. Lam, K. and Stall, A. M. 1994. Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny. J. Exp. Med. 180:507.
64. Tarlinton, D. 1993. Direct demonstration of MHC class II surface expression on murine pre-B cells. Int. Immunol. 12:1629.
65. Tarakhovsky, A., Turner, M., Schaal, S., Mee, P. J., Duddy, L. P., Rajewsky, K. and Tybulewicz, V. L. 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374:467.
66. Zhang, R., Alt, F. W., Davidson, L , Orkin, S. H and Swat, W. 1995. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470.
67. Ahearn, J. M., Fischer, M. B., Croix, D., Goerg, S., Ma, M., Xia, J., Zhou, X., Howard, R. G., Rothstein, T. L. and Carroll, M. C. 1996. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an imparied B cell response to T-dependent antigen. Immunity 4:251.
68. Krop, I., Shaffer, A. L., Fearon, D. T. and Schlissel, M. S. 1996. The signaling activity of murine CD19 is regulated during B cell development. J. Immunol. 157:48.
69. + B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity 4:15.
70. Kitamura, D., Kudo, A., Schaal, S., Muller, W., Melchers, F. and Rajewsky, K. 1992. A critical role of λ5 in B cell development. Cell 69:823.
71. Rolink, A., Karasuyama, H., Grawunder, U., Haasner, D., Kudo, A. and Melchers, F. 1993. B cell development in mice with a defective lambda 5 gene. Eur. J. Immunol. 23:1284.
72. Berek, C. and Milstein, C. 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96:23.
73. Forster, I. and Rajewsky, K. 1987. Expansion and functional activity of Ly-1+ B cells upon transfer of peritoneal cells into allotype-congenic, newborn mice. Eur. J. Immunol. 17:521.
74. + B lymphocytes. Int. Immunol. 2:515.
75. Schilling, J., Clevinger, B., Davie, J. M. and Hood, L. 1980. Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangements in heavy chain V-region gene segments. Nature 283:35.
76. Feeney, A. J. 1990. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences. J. Exp. Med. 172:1377.
77. + Ly-1 B clones of (NZB×NZW)F1 mice. EMBO J. 7:3705.
78. Forster, I., Gu, H. and Rajewsky, K. 1988. Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment. EMBO J. 7:3693.
79. + normal B cells. Immunol. Rev. 93:35.
80. Kipps, T. J., Tomhave, E., Chen, P. P. and Carson, D. A. 1988. Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy. J. Exp. Med. 167:840.
81. Linke, B., Pyttlich, J., Tiemann, M., Suttorp, M., Parwaresch, R., Hiddemann, W. and Kneba, M. 1995. Identification and structural analysis of rearranged immunoglobulin heavy chain genes in lymphomas and leukemias. Leukemia 9:840.
82. Aubin, J., Davi, F., Nguyen-Salomon, F., Leboeuf, D., Debert, C., Taher, M., Valensi, F., Canioni, D., Brousse, N., Varet, B., et al. 1995. Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies for the detection of clonality in B cell malignancies. Leukemia 9:471.
83. Segal, G. H., Jorgensen, T., Scott, M. and Braylan, R. C. 1994. Optimal primer selection for clonality assessment by polymerase chain reaction analysis: II. Follicular lymphomas. Hum. Pathol. 25:1276.