Innate control of B cell responses

Trends in Immunology

Volumn 32, Issue 5, 2011, Pages 202-211

  Cerutti, Andrea ^a,b,c   Puga, Irene ^b   Cols, Montserrat ^c  

^a INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^b HOSPITAL DEL MAR   (Spain)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; IMMUNOGLOBULIN;

B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; GENE REARRANGEMENT; HUMAN; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL MEMORY; INNATE IMMUNITY; NONHUMAN; REVIEW; SOMATIC HYPERMUTATION; T LYMPHOCYTE;

B-CELL ACTIVATING FACTOR; B-LYMPHOCYTES; GENE EXPRESSION REGULATION; GENES, IMMUNOGLOBULIN; IMMUNITY, INNATE; LIGANDS; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13;

EID: 79955628617     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2011.02.004     Document Type: Review

References (122)

1. Sansonetti P.J. War and peace at mucosal surfaces. Nat. Rev. Immunol. 2004, 4:953-964.
2. Janeway C.A., Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002, 20:197-216.
3. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 2001, 1:135-145.
4. Cooper M.D., Alder M.N. The evolution of adaptive immune systems. Cell 2006, 124:815-822.
5. Medzhitov R., Janeway C.A. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997, 91:295-298.
6. Pasare C., Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004, 21:733-741.
7. Pasare C., Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 2005, 438:364-368.
8. Gavin A.L., et al. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science 2006, 314:1936-1938.
9. Medzhitov R. Approaching the asymptote: 20 years later. Immunity 2009, 30:766-775.
10. Lanzavecchia A., Sallusto F. Toll-like receptors and innate immunity in B-cell activation and antibody responses. Curr. Opin. Immunol. 2007, 19:268-274.
11. Bernasconi N.L., et al. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002, 298:2199-2202.
12. He B., et al. CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10. J. Immunol. 2004, 173:4479-4491.
13. Xu W., et al. Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF. J. Immunol. 2008, 181:276-287.
14. Weill J.C., et al. Human marginal zone B cells. Annu. Rev. Immunol. 2009, 27:267-285.
15. Fagarasan S., et al. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu. Rev. Immunol. 2010, 28:243-273.
16. Fagarasan S., Honjo T. T-Independent immune response: new aspects of B cell biology. Science 2000, 290:89-92.
17. Baumgarth N. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat. Rev. Immunol. 2011, 11:34-46.
18. -. J. Exp. Med. 2011, 208:67-80.
19. Bendelac A., et al. Autoreactivity by design: innate B and T lymphocytes. Nat. Rev. Immunol. 2001, 1:177-186.
20. Martin F., Kearney J.F. Marginal-zone B cells. Nat. Rev. Immunol. 2002, 2:323-335.
21. Mond J.J., et al. T cell independent antigens. Curr. Opin. Immunol. 1995, 7:349-354.
22. Balazs M., et al. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 2002, 17:341-352.
23. Ng L.G., et al. BAFF costimulation of Toll-like receptor-activated B-1 cells. Eur. J. Immunol. 2006, 36:1837-1846.
24. Dillon S.R., et al. An APRIL to remember: novel TNF ligands as therapeutic targets. Nat. Rev. Drug Discov. 2006, 5:235-246.
25. Cerutti A. The regulation of IgA class switching. Nat. Rev. Immunol. 2008, 8:421-434.
26. Mackay F., Schneider P. Cracking the BAFF code. Nat. Rev. Immunol. 2009, 9:491-502.
27. Tsuji M., et al. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity 2008, 29:261-271.
28. Suzuki K., et al. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity 2010, 33:71-83.
29. Honjo T., et al. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol. 2002, 20:165-196.
30. Peled J.U., et al. The biochemistry of somatic hypermutation. Annu. Rev. Immunol. 2008, 26:481-511.
31. Stavnezer J., et al. Mechanism and regulation of class switch recombination. Annu. Rev. Immunol. 2008, 26:261-292.
32. Chen K., et al. Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. Nat. Immunol. 2009, 10:889-898.
33. Klein U., Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat. Rev. Immunol. 2008, 8:22-33.
34. King C., et al. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 2008, 26:741-766.
35. Bishop G.A. The multifaceted roles of TRAFs in the regulation of B-cell function. Nat. Rev. Immunol. 2004, 4:775-786.
36. Siebenlist U., et al. Control of lymphocyte development by nuclear factor-κB. Nat. Rev. Immunol. 2005, 5:435-445.
37. Chen K., Cerutti A. New insights into the enigma of immunoglobulin D. Immunol. Rev. 2010, 237:1-20.
38. McHeyzer-Williams L.J., McHeyzer-Williams M.G. Antigen-specific memory B cell development. Annu. Rev. Immunol. 2005, 23:487-513.
39. He B., et al. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat. Immunol. 2010, 11:836-845.
40. Vinuesa C.G., Goodnow C.C. Immunology: DNA drives autoimmunity. Nature 2002, 416:595-598.
41. Cerutti A., et al. Immunoglobulin responses at the mucosal interface. Annu. Rev. Immunol. 2010, 10.1146/annurev-immunol-031210-101317.
42. Weller S., et al. Human blood IgM " memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004, 104:3647-3654.
43. Weller S., et al. CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:1166-1170.
44. Lin L., et al. CpG DNA redirects class-switching towards " Th1-like" Ig isotype production via TLR9 and MyD88. Eur. J. Immunol. 2004, 34:1483-1487.
45. Xu W., et al. Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. Nat. Immunol. 2007, 8:294-303.
46. Ueda Y., et al. T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. J. Immunol. 2007, 178:3593-3601.
47. Capolunghi F., et al. CpG drives human transitional B cells to terminal differentiation and production of natural antibodies. J. Immunol. 2008, 180:800-808.
48. Aranburu A., et al. TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells. J. Immunol. 2010, 185:7293-7301.
49. William J., et al. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 2002, 297:2066-2070.
50. Herlands R.A., et al. T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity 2008, 29:249-260.
51. Mao C., et al. T cell-independent somatic hypermutation in murine B cells with an immature phenotype. Immunity 2004, 20:133-144.
52. Han J.H., et al. Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and toll-like receptors. Immunity 2007, 27:64-75.
53. He B., et al. Intestinal bacteria trigger T cell-independent immunoglobulin A2 class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity 2007, 26:812-826.
54. Delgado M.F., et al. Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease. Nat. Med. 2009, 15:34-41.
55. Ichinohe T., et al. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J. Exp. Med. 2009, 206:79-87.
56. Lee B.O., et al. CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection. J. Immunol. 2005, 175:5827-5838.
57. He B., et al. HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors. J. Immunol. 2006, 176:3931-3941.
58. Pulendran B., et al. Division of labor, plasticity, and crosstalk between dendritic cell subsets. Curr. Opin. Immunol. 2008, 20:61-67.
59. Scapini P., et al. G-CSF-stimulated neutrophils are a prominent source of functional BLyS. J .Exp. Med. 2003, 197:297-302.
60. Chen K., Cerutti A. Vaccination strategies to promote mucosal antibody responses. Immunity 2010, 33:479-491.
61. Gardby E., et al. Strong differential regulation of serum and mucosal IgA responses as revealed in CD28-deficient mice using cholera toxin adjuvant. J. Immunol. 2003, 170:55-63.
62. Casola S., et al. B cell receptor signal strength determines B cell fate. Nat. Immunol. 2004, 5:317-327.
63. Bergqvist P., et al. Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers. J. Immunol. 2006, 177:7772-7783.
64. Tezuka H., et al. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature 2007, 448:929-933.
65. Mora J.R., et al. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat. Rev. Immunol. 2008, 8:685-698.
66. Massacand J.C., et al. Intestinal bacteria condition dendritic cells to promote IgA production. PLoS ONE 2008, 3:e2588.
67. Bessa J., et al. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J. Immunol. 2009, 183:3788-3799.
68. Serbina N.V., et al. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 2003, 19:59-70.
69. Crouch E.E., et al. Regulation of AID expression in the immune response. J. Exp. Med. 2007, 204:1145-1156.
70. Uematsu S., et al. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat. Immunol. 2008, 9:769-776.
71. Fagarasan S., et al. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Nature 2001, 413:639-643.
72. Liu Y.J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 2005, 23:275-306.
73. Litinskiy M.B., et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 2002, 3:822-829.
74. Bekeredjian-Ding I.B., et al. Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN. J. Immunol. 2005, 174:4043-4050.
75. Fink K., et al. Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses. Eur. J. Immunol. 2006, 36:2094-2105.
76. Ziegler S.F., Liu Y.J. Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. Nat. Immunol. 2006, 7:709-714.
77. Xu W., et al. HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits. Nat. Immunol. 2009, 10:1008-1017.
78. Castigli E., et al. TACI and BAFF-R mediate isotype switching in B cells. J. Exp. Med. 2005, 201:35-39.
79. Castigli E., et al. Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation. J. Allergy Clin. Immunol. 2007, 120:885-891.
80. Mantchev G.T., et al. TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens. J. Immunol. 2007, 179:2282-2288.
81. Katsenelson N., et al. Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion. Eur. J. Immunol. 2007, 37:1785-1795.
82. Treml L.S., et al. TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells. J. Immunol. 2007, 178:7531-7539.
83. Groom J.R., et al. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J. Exp. Med. 2007, 204:1959-1971.
84. Xia X.Z., et al. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. J. Exp. Med. 2000, 192:137-143.
85. Jabara H., et al. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity 2002, 17:265-276.
86. Rahman Z.S., et al. Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J. Exp. Med. 2003, 198:1157-1169.
87. Shulga-Morskaya S., et al. B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J. Immunol. 2004, 173:2331-2341.
88. Xu L.G., Shu H.B. TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production. J. Immunol. 2002, 169:6883-6889.
89. Xie P., et al. Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. Immunity 2007, 27:253-267.
90. Gardam S., et al. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 2008, 28:391-401.
91. Tusche M.W., et al. Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets. J. Exp. Med. 2009, 206:2671-2683.
92. Claudio E., et al. BAFF-induced NEMO-independent processing of NF-kappaB2 in maturing B cells. Nat. Immunol. 2002, 3:958-965.
93. Kayagaki N., et al. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity 2002, 17:515-524.
94. Stavnezer J. Antibody class switching. Adv. Immunol. 1996, 61:79-146.
95. Hatada E.N., et al. NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cells. J. Immunol. 2003, 171:761-768.
96. Hatzoglou A., et al. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. J. Immunol. 2000, 165:1322-1330.
97. Avery D.T., et al. BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J. Clin. Invest. 2003, 112:286-297.
98. Yang M., et al. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. J. Immunol. 2005, 175:2814-2824.
99. Hapfelmeier S., et al. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science 2010, 328:1705-1709.
100. O'Connor B.P., et al. BCMA is essential for the survival of long-lived bone marrow plasma cells. J. Exp. Med. 2004, 199:91-98.
101. Huard B., et al. APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa. J. Clin. Invest. 2008, 118:2887-2895.
102. Salzer U., et al. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat. Genet. 2005, 37:820-828.
103. Zhang L., et al. Transmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immunodeficiency: clinical and immunologic outcomes in heterozygotes. J. Allergy Clin. Immunol. 2007, 120:1178-1185.
104. Castigli E., et al. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat. Genet. 2005, 37:829-834.
105. Warnatz K., et al. B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:13945-13950.
106. Picard C., et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 2003, 299:2076-2079.
107. von Bernuth H., et al. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 2008, 321:691-696.
108. von Bulow G.U., et al. Regulation of the T-independent humoral response by TACI. Immunity 2001, 14:573-582.
109. Neves P., et al. Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity 2010, 33:777-790.
110. Mackay F., Tangye S.G. The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers. Curr. Opin. Pharmacol. 2004, 4:347-354.
111. Yan M., et al. Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat. Immunol. 2000, 1:37-41.
112. Yu G., et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat. Immunol. 2000, 1:252-256.
113. Castigli E., Geha R.S. TACI, isotype switching, CVID and IgAD. Immunol. Res. 2007, 38:102-111.
114. Castigli E., et al. Impaired IgA class switching in APRIL-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:3903-3908.
115. Stein J.V., et al. APRIL modulates B and T cell immunity. J. Clin. Invest. 2002, 109:1587-1598.
116. Seshasayee D., et al. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 2003, 18:279-288.
117. Sakurai D., et al. TACI attenuates antibody production costimulated by BAFF-R and CD40. Eur. J. Immunol. 2007, 37:110-118.
118. Salzer U., et al. Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes. Blood 2009, 113:1967-1976.
119. Castigli E., et al. Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency. Nat. Genet. 2007, 39:430-431.
120. Woodland R.T., et al. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood 2008, 111:750-760.
121. Patke A., et al. BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism. J. Exp. Med. 2006, 203:2551-2562.
122. Thomson A.W., et al. Immunoregulatory functions of mTOR inhibition. Nat. Rev. Immunol. 2009, 9:324-337.