A model of peptide triazole entry inhibitor binding to HIV-1 gp120 and the mechanism of bridging sheet disruption

Biochemistry

Volumn 52, Issue 13, 2013, Pages 2245-2261

  Emileh, Ali ^a,b   Tuzer, Ferit ^b   Yeh, Herman ^d   Umashankara, Muddegowda ^b   Moreira, Diogo R M ^b   Lalonde, Judith M ^c   Bewley, Carole A ^d   Abrams, Cameron F ^a   Chaiken, Irwin M ^b  

^a Drexel University   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c BRYN MAWR COLLEGE   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX STABILITY; DOMAIN INTERFACES; ENCOUNTER COMPLEX; EXPLICIT SOLVENT MOLECULAR DYNAMICS; HYDROPHOBIC MOTIFS; MUTAGENESIS EXPERIMENT; SATURATION-TRANSFER DIFFERENCES; SIDE CHAIN HYDROGEN BONDING;

COMPUTER SIMULATION; HYDROGEN BONDS; HYDROPHOBICITY; MOLECULAR DYNAMICS; NITROGEN COMPOUNDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLATINUM COMPOUNDS;

PEPTIDES;

GLYCOPROTEIN GP 120; TRIAZOLE DERIVATIVE;

ARTICLE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; SATURATION TRANSFER DIFFERENCE NUCLEAR MAGNETIC RESONANCE;

ANTI-HIV AGENTS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN CONFORMATION; TRIAZOLES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84875762591     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400166b     Document Type: Article

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