Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 Entry Inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 9, 2012, Pages 4382-4396

  Lalonde, Judith M ^a   Kwon, Young Do ^b   Jones, David M ^c   Sun, Alexander W ^c   Courter, Joel R ^c   Soeta, Takahiro ^c   Kobayashi, Toyoharu ^c   Princiotto, Amy M ^d   Wu, Xueling ^b   Schön, Arne ^e   Freire, Ernesto ^e   Kwong, Peter D ^b   Mascola, John R ^b   Sodroski, Joseph ^d,f,g   Madani, Navid ^d   Smith, Amos B ^c  

^a BRYN MAWR COLLEGE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR;

ARTICLE; BINDING SITE; CLADISTICS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRUS ENTRY; VIRUS INFECTIVITY; VIRUS INHIBITION; VIRUS NEUTRALIZATION; X RAY CRYSTALLOGRAPHY;

ANTIGENS, CD4; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; HIV ENVELOPE PROTEIN GP120; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; INDANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NEUTRALIZATION TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; VIRUS INTERNALIZATION;

EID: 84861048825     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300265j     Document Type: Article

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