Contribution of fructose-6-phosphate to glucocorticoid activation in the endoplasmic reticulum: Possible implication in the metabolic syndrome

Endocrinology

Volumn 151, Issue 10, 2010, Pages 4830-4839

  Senesi, Silvia ^a   Legeza, Balázs ^b   Balázs, Zoltán ^b   Csala, Miklós ^c   Marcolongo, Paola ^a   Kereszturi, Éva ^c   Szelényi, Péter ^c   Egger, Christine ^b   Fulceri, Rosella ^a   Mandl, József ^c   Giunti, Roberta ^a   Odermatt, Alex ^b   Bánhegyi, Gábor ^a,c   Benedetti, Angelo ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF BASEL   (Switzerland)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CORTISONE; FRUCTOSE 6 PHOSPHATE; GLUCOCORTICOID; GLUCOSE; GLUCOSE 6 PHOSPHATE; HEXOSE PHOSPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; FRUCTOSE PHOSPHATE; FRUCTOSE-6-PHOSPHATE;

ANIMAL TISSUE; ARTICLE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GLUCONEOGENESIS; LIVER MICROSOME; MALE; METABOLIC SYNDROME X; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; ADIPOSE TISSUE; ANIMAL; CELL CULTURE; DOWN REGULATION; DRUG EFFECTS; HUMAN; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADIPOSE TISSUE; ANIMALS; CELLS, CULTURED; CORTISONE; DOWN-REGULATION; ENDOPLASMIC RETICULUM; FRUCTOSEPHOSPHATES; GLUCOCORTICOIDS; GLUCOSE; HUMANS; MALE; METABOLIC SYNDROME X; MICROSOMES, LIVER; NADP; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77957258654     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0614     Document Type: Article

References (39)

1. Havel PJ 2005 Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 63:133-157
2. Montonen J, Järvinen R, Knekt P, Heliövaara M, Reunanen A 2007 Consumption of sweetened beverages and intakes of fructose and glucose predict type 2 diabetes occurrence. J Nutr 137:1447-1454
3. Stanhope KL, Havel PJ 2008 Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Curr Opin Lipidol 19:16-24
4. Stanhope KL, Havel PJ 2009 Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans. J Nutr 139:1236S-1241S
5. Tomlinson JW, Finney J, Gay C, Hughes BA, Hughes SV, Stewart PM 2008 Impaired glucose tolerance and insulin resistance are associated with increased adipose 11β-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5α-reductase activity. Diabetes 57:2652-2660
6. Bujalska IJ, Hewitt KN, Hauton D, Lavery GG, Tomlinson JW, Walker EA, Stewart PM 2008 Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue. Endocrinology 149:2584-2591 (Pubitemid 351574493)
7. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ 2002 Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76:911-922 (Pubitemid 35244659)
8. Agius L 1998 The physiological role of glucokinase binding and translocation in hepatocytes. Adv Enzyme Regul 38:303-331 (Pubitemid 28381397)
9. Van Schaftingen E, Detheux M, Veiga da Cunha M 1994 Short-term control of glucokinase activity: role of a regulatory protein. FASEB J 8:414-419 (Pubitemid 24155954)
10. Froesch ER, Ginsberg JL 1962 Fructose metabolism of adipose tissue. I. Comparison of fructose and glucose metabolism in epididymal adipose tissue of normal rats. J Biol Chem 237:3317-3324
11. Mziaut H, Korza G, Hand AR, Gerard C, Ozols J 1999 Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11β-hydroxysteroid dehydrogenase and the 50-kDa esterase. J Biol Chem 274:14122-14129 (Pubitemid 129518720)
12. Odermatt A, Arnold P, Stauffer A, Frey BM, Frey FJ 1999 The N-terminal anchor sequences of 11β-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane. J Biol Chem 274:28762-28770
13. Atanasov AG, Nashev LG, Gelman L, Legeza B, Sack R, Portmann R, Odermatt A 2008 Direct protein-protein interaction of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen. Biochim Biophys Acta 1783:1536-1543
14. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ 2009 Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119: 1322-1334
15. Bánhegyi G, Benedetti A, Fulceri R, Senesi S 2004 Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum. J Biol Chem 279:27017-27021 (Pubitemid 38812537)
16. Marcolongo P, Piccirella S, Senesi S, Wunderlich L, Gerin I, Mandl J, Fulceri R, Bánhegyi G, Benedetti A 2007 The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11β-hydroxysteroid dehydrogenase type 1 system of the adipose tissue. Endocrinology 148:2487-2495 (Pubitemid 46997033)
17. Atanasov AG, Nashev LG, Schweizer RA, Frick C, Odermatt A 2004 Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase. FEBS Lett 571:129-133 (Pubitemid 38992936)
18. Simpson IA, Yver DR, Hissin PJ, Wardzala LJ, Karnieli E, Salans LB, Cushman SW 1983 Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: characterization of subcellular fractions. Biochim Biophys Acta 763:393-407
19. Bánhegyi G, Csala M, Nagy G, Sorrentino V, Fulceri R, Benedetti A 2003 Evidence for the transport of glutathione through ryanodine receptor channel type 1. Biochem J 376:807-812 (Pubitemid 38058082)
20. Fulceri R, Bánhegyi G, Gamberucci A, Giunti R, Mandl J, Benedetti A 1994 Evidence for the intraluminal positioning of p-nitrophenol UDP-glucuronosyltransferase activity in rat liver microsomal vesicles. Arch Biochem Biophys 309:43-46
21. Bánhegyi G, Braun L, Marcolongo P, Csala M, Fulceri R, Mandl J, BenedettiA1996 Evidence for an UDP-glucuronic acid/phenol glucuronide antiport in rat liver microsomal vesicles. Biochem J 315: 171-176
22. McCormick KL, Wang X, Mick GJ 2008 Modification of microsomal 11β-HSD1 activity by cytosolic compounds: glutathione and hexose phosphoesters. J Steroid Biochem Mol Biol 111:18-23
23. Fairbank M, St-Pierre P, Nabi IR 2009 The complex biology of autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and its receptor, the gp78/AMFR E3 ubiquitin ligase. Mol Biosyst 5:793-801
24. Clarke JL, Mason PJ 2003 Murine hexose-6-phosphate dehydrogenase: a bifunctional enzyme with broad substrate specificity and 6- phosphogluconolactonase activity. Arch Biochem Biophys 415: 229-234
25. Bánhegyi G, Marcolongo P, Fulceri R, Hinds C, Burchell A, Benedetti A 1997 Demonstration of a metabolically active glucose-6-phosphate pool in the lumen of liver microsomal vesicles. J Biol Chem 272:13584-13590 (Pubitemid 27224789)
26. Gerin I, Van Schaftingen E 2002 Evidence for glucose-6-phosphate transport in rat liver microsomes. FEBS Lett 517:257-260 (Pubitemid 34327670)
27. Gerin I, Veiga-da-Cunha M, Achouri Y, Collet JF, Van Schaftingen E 1997 Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib. FEBS Lett 419:235-238 (Pubitemid 28010817)
28. Arion WJ, Canfield WK, Ramos FC, Su ML, Burger HJ, Hemmerle H, Schubert G, Below P, Herling AW 1998 Chlorogenic acid analogue S 3483: a potent competitive inhibitor of the hepatic and renal glucose-6-phosphatase systems. Arch Biochem Biophys 351:279-285 (Pubitemid 28368637)
29. Leuzzi R, Fulceri R, Marcolongo P, Bánhegyi G, Zammarchi E, Stafford K, Burchell A, Benedetti A 2001 Glucose-6-phosphate transport in fibroblast microsomes from glycogen storage disease type 1b patients: evidence for multiple glucose-6-phosphate transport sytems. Biochem J 357:557-562 (Pubitemid 32701795)
30. Chirgwin JM, Parsons TF, Noltmann EA 1975 Mechanistic implications of the pH independence of inhibition of phosphoglucose isomerase by neutral sugar phosphates. J Biol Chem 250:7277-7279
31. Tappy L, Lê KA 2010 Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 90:23-46
32. Darakhshan F, Hajduch E, Kristiansen S, Richter EA, Hundal HS 1998 Biochemical and functional characterization of the GLUT5 fructose transporter in rat skeletal muscle. Biochem J 336:361-366 (Pubitemid 28564392)
33. Hajduch E, Darakhshan F, Hundal HS 1998 Fructose uptake in rat adipocytes: GLUT5 expression and the effects of streptozotocin-induced diabetes. Diabetologia 41:821-828 (Pubitemid 28313716)
34. Hems DA, Brosnan JT 1970 Effects of ischaemia on content of metabolites in rat liver and kidney in vivo. Biochem J 120:105-111
35. van Schaftingen E, Gerin I 2002 The glucose-6-phosphatase system. Biochem J 362:513-532
36. Basu R, Singh R, Basu A, Johnson CM, Rizza RA 2006 Effect of nutrient ingestion on total-body and splanchnic cortisol production in humans. Diabetes 55:667-674 (Pubitemid 43343222)
37. Stimson RH, Lobley GE, Maraki I, Morton NM, Andrew R, Walker BR 2010 Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats. PLoS One 5:e8779
38. Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, Shafiu M, Segal M, Glassock RJ, Shimada M, Roncal C, Nakagawa T 2009 Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev 30:96-116
39. Prieto PG, Cancelas J, Villanueva-Peñacarrillo ML, Valverde I, Malaisse WJ 2004 Plasma D-glucose, D-fructose and insulin responses after oral administration of D-glucose, D-fructose and sucrose to normal rats. J Am Coll Nutr 23:414-419