Polysulfated xanthones: Multipathway development of a new generation of dual anticoagulant/antiplatelet agents

Journal of Medicinal Chemistry

Volumn 54, Issue 15, 2011, Pages 5373-5384

  Correia Da Silva, Marta ^a   Sousa, Emília ^a   Duarte, Bárbara ^a   Marques, Franklim ^a   Carvalho, Félix ^a   Cunha Ribeiro, Luís M ^b   Pinto, Madalena M M ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b HOSPITAL DE SÃO JOÃO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

3,6 (O BETA GLUCOPYRANOSYL)XANTHONE; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; ALANINE AMINOTRANSFERASE; ANTICOAGULANT AGENT; ANTITHROMBIN III; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; ASPARTATE AMINOTRANSFERASE; COLLAGEN; DIOSMIN HEXASULFATE; HESPERIDIN HEXASULFATE; MANGIFERIN 2',3,3',4',6,6',7 HEPTASULFATE; MANGIFERIN 2',3,3',4',6,6',7 O HEPTASULFATE; MANGIFERIN HEPTASULFATE; PROSTAGLANDIN E1; PROTHROMBIN; SULFATED XANTHONOSIDE DERIVATIVE; THROMBIN RECEPTOR ACTIVATING PEPTIDE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTERY THROMBOSIS; ARTICLE; BLOOD; BLOOD CLOTTING TIME; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STABILITY; DRUG SULFATION; DRUG SYNTHESIS; FUNGUS; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MOLECULE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; SINGLE DRUG DOSE; THROMBOCYTE AGGREGATION; THROMBOELASTOGRAPHY; TRICHOTHECIUM ROSEUM; VEIN THROMBOSIS;

ADULT; ANIMALS; ANTICOAGULANTS; FACTOR XA; GLUCOSIDES; HUMANS; MICE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; SULFURIC ACID ESTERS; THROMBOSIS; XANTHONES;

EID: 79961228634     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2006589     Document Type: Article

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