Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Starowicz, Katarzyna ^a   Makuch, Wioletta ^a   Korostynski, Michal ^a   Malek, Natalia ^a   Slezak, Michal ^a   Zychowska, Magdalena ^a   Petrosino, Stefania ^b   De Petrocellis, Luciano ^c   Cristino, Luigia ^c   Przewlocka, Barbara ^a   Di Marzo, Vincenzo ^b  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b CNR Consiglio Nazionale delle Ricerche   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY ANANDAMIDE; AMIDE; ANANDAMIDE; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; BAICALEIN; CALCIUM ION; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; FATTY ACID AMIDASE; LIPOXYGENASE; MESSENGER RNA; N OLEOYLETHANOLAMINE; PALMIDROL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ALLODYNIA; ALOX12 GENE; ALOX15 GENE; ALOX5 GENE; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CALCIUM CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID METABOLISM; GENE; GENE EXPRESSION; HYPERALGESIA; IMMUNOFLUORESCENCE; NEUROPATHIC PAIN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

AMIDOHYDROLASES; ANALGESIA; ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONIC ACIDS; BENZAMIDES; CALCIUM SIGNALING; CARBAMATES; DITERPENES; ENDOCANNABINOIDS; ETHANOLAMINES; FLAVANONES; GLYCERIDES; HEK293 CELLS; HUMANS; HYPERALGESIA; INJECTIONS, SPINAL; LIPOXYGENASE INHIBITORS; MALE; NEURALGIA; OLEIC ACIDS; PALMITIC ACIDS; POLYUNSATURATED ALKAMIDES; POSTERIOR HORN CELLS; RATS; RATS, WISTAR; SCIATIC NERVE; SPINAL CORD; TRPV CATION CHANNELS;

RATTUS;

EID: 84875724383     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060040     Document Type: Article

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