15-Lipoxygenase eicosanoids are the putative ligands for vanilloid receptors and peroxisome proliferator-activated receptors (PPARs)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 1, 2012, Pages

  Mabalirajan, Ulaganathan ^a   Agrawal, Anurag ^a   Ghosh, Balaram ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; ICOSANOID; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; ENZYME ACTIVATION; HUMAN; INFLAMMATION; LETTER; MACROPHAGE; PRIORITY JOURNAL; RECEPTOR BINDING; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; SPUTUM CULTURE;

ARACHIDONATE 15-LIPOXYGENASE; BRONCHI; EPITHELIAL CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN;

EID: 84856013252     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118477109     Document Type: Letter

References (5)

1. Zhao J, et al. (2011) 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proc Natl Acad Sci USA 108:14246-14251.
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3. Caterina MJ, Julius D (2001) The vanilloid receptor: A molecular gateway to the pain pathway. Annu Rev Neurosci 24:487-517. (Pubitemid 32695237)
4. Subbarayan V, et al. (2006) 15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma. Oncogene 25:6015-6025. (Pubitemid 44477295)
5. Mabalirajan U, Aich J, Agrawal A, Ghosh B (2009) Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma. Am J Physiol Lung Cell Mol Physiol 297: L411-L419.