Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display

Protein Engineering, Design and Selection

Volumn 26, Issue 4, 2013, Pages 255-265

  Traxlmayr, Michael W ^a   Lobner, Elisabeth ^a   Antes, Bernhard ^b   Kainer, Manuela ^b   Wiederkum, Susanne ^b   Hasenhindl, Christoph ^a   Stadlmayr, Gerhard ^a   Rüker, Florian ^a   Woisetschläger, Max ^b   Moulder, Kevin ^b   Obinger, Christian ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b Babraham Research Campus   (Austria)

Author keywords

conformational stability; directed evolution; IgG1 Fc; protein aggregation; yeast surface display

Indexed keywords

CONFORMATIONAL STABILITIES; DIRECTED EVOLUTION; IGG1-FC; PROTEIN AGGREGATION; YEAST SURFACE DISPLAYS;

ANTIGENS; BINDERS; REPAIR; STABILITY; YEAST;

ANTIBODIES;

ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; IMMUNOGLOBULIN FC FRAGMENT;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; DIRECTED MOLECULAR EVOLUTION; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN STABILITY;

ANTIBODIES, MONOCLONAL; ANTIGENS; DIRECTED MOLECULAR EVOLUTION; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; PICHIA; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR, ERBB-2;

PICHIA PASTORIS;

EID: 84875681317     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs102     Document Type: Article

References (37)

1. M.K., B.A. and F.R. hold stock in F-star. M.W. and K.M. are employees of F-star. No disclosures by M.W.T., E.L., S.W., C.H., G.S. and C.O.
2. Aggen,D.H., Chervin,A.S., Insaidoo,F.K., Piepenbrink,K.H., Baker,B.M. and Kranz,D.M. (2011) Protein Eng. Des. Sel., 24, 361-372. First published, doi:gzq113 [ pii] 10.1093/protein/gzq113.
3. Balint,R.F. and Larrick,J.W. (1993) Gene, 137, 109-118. First published, doi:0378-1119(93)90258-5 [ pii].
4. Bloom,J.D., Labthavikul,S.T., Otey,C.R. and Arnold,F.H. (2006) Proc. Natl Acad. Sci. USA, 103, 5869-5874. First published, doi:0510098103 [ pii] 10.1073/pnas.0510098103.
5. Braun,A., Kwee,L., Labow,M.A. and Alsenz,J. (1997) Pharm. Res., 14, 1472-1478. First published.
6. Chao,G., Lau,W.L., Hackel,B.J., Sazinsky,S.L., Lippow,S.M. and Wittrup,K.D. (2006) Nat. Protoc., 1, 755-768. First published, doi:nprot. 2006.94 [ pii] 10.1038/nprot.2006.94.
7. Dall'Acqua,W., Simon,A.L., Mulkerrin,M.G. and Carter,P. (1998) Biochemistry, 37, 9266-9273. First published, doi:10.1021/bi980270i bi980270i [ pii].
8. Famm,K., Hansen,L., Christ,D. and Winter,G. (2008) J. Mol. Biol., 376, 926-931. First published, doi:S0022-2836(07)01434-9 [ pii] 10.1016/ j.jmb.2007.10.075.
9. Felgenhauer,M., Kohl,J. and Ruker,F. (1990) Nucleic Acids Res., 18, 4927. First published.
10. Gai,S.A. and Wittrup,K.D. (2007) Curr. Opin. Struct. Biol., 17, 467-473. First published, doi:S0959-440X(07)00119-4 [pii] 10.1016/j.sbi.2007.08.012.
11. Ghirlando,R., Lund,J., Goodall,M. and Jefferis,R. (1999) Immunol. Lett., 68, 47-52. First published, doi:S0165-2478(99)00029-2 [ pii].
12. Gietz,R.D. and Schiestl,R.H. (2007) Nat. Protoc., 2, 31-34. First published, doi:nprot.2007.13 [ pii] 10.1038/nprot.2007.13.
13. Halaby,D.M., Poupon,A. and Mornon,J. (1999) Protein Eng, 12, 563-571. First published.
14. Hermeling,S., Crommelin,D.J., Schellekens,H. and Jiskoot,W. (2004) Pharm Res, 21, 897-903. First published.
15. Jespers,L., Schon,O., Famm,K. and Winter,G. (2004) Nat. Biotechnol., 22, 1161-1165. First published, doi:10.1038/nbt1000 nbt1000 [ pii].
16. Jones,L.L., Brophy,S.E., Bankovich,A.J., Colf,L.A., Hanick,N.A., Garcia,K.C. and Kranz,D.M. (2006) J. Biol. Chem., 281, 25734-25744. First published, doi:M604343200 [ pii] 10.1074/jbc.M604343200.
17. Jung,S., Honegger,A. and Pluckthun,A. (1999) J. Mol. Biol., 294, 163-180. First published, doi:10.1006/jmbi.1999.3196 S0022-2836(99)93196-0 [ pii].
18. Kabat,E.A., Wu,T.T., Perry,H.M., Gottesman,K.S. and Foeller,C. (1991) Sequences of proteins of immunological interest, 5th ed. National Institutes of Health, Bethesda, MD, 688-696. First published.
19. Kubota,T., Niwa,R., Satoh,M., Akinaga,S., Shitara,K. and Hanai,N. (2009) Cancer Sci., 100, 1566-1572. First published, doi:CAS1222 [ pii] 10.1111/j.1349-7006.2009.01222.x.
20. Moore,W.V. and Leppert,P. (1980) J. Clin. Endocrinol. Metab., 51, 691-697. First published.
21. Nelson,A.L., Dhimolea,E. and Reichert,J.M. (2010) Nat. Rev. Drug Discov., 9, 767-774. First published, doi:nrd3229 [ pii] 10.1038/nrd3229.
22. Pavoor,T.V., Cho,Y.K. and Shusta,E.V. (2009) Proc. Natl Acad. Sci. USA, 106, 11895-11900. First published, DOl 0902828106 [ pii] 10.1073/ pnas.0902828106.
23. Pavoor,T.V., Wheasler,J.A., Kamat,V. and Shusta,E.V. (2012) Protein Eng. Des. Sel., 25, 625-630. First published, doi:gzs041 [ pii] 10.1093/protein/ gzs041.
24. Pepper,L.R., Cho,Y.K., Boder,E.T. and Shusta,E.V. (2008) Comb. Chem. High Throughput Screen, 11, 127-134. First published.
25. Schaefer,J.V. and Pluckthun,A. (2012) J Mol Biol, 417, 309-335. First published, doi:S0022-2836(12)00081-2 [ pii] 10.1016/j.jmb.2012.01.027.
26. Schmidt,M.M. and Wittrup,K.D. (2009) Mol. Cancer Ther., 8, 2861-2871. First published, doi:8/10/2861 [ pii] 10.1158/1535-7163.MCT-09-0195.
27. Shusta,E.V., Holler,P.D., Kieke,M.C., Kranz,D.M. and Wittrup,K.D. (2000) Nat. Biotechnol., 18, 754-759. First published, doi:10.1038/77325.
28. Tischenko,V.M., Abramov,V.M. and Zav'yalov,V.P. (1998) Biochemistry, 37, 5576-5581. First published, doi:10.1021/bi972647a bi972647a [ pii].
29. Traxlmayr,M.W., Faissner,M., Stadlmayr,G., Hasenhindl,C., Antes,B., Ruker,F. and Obinger,C. (2012a) Biochim. Biophys. Acta, 1824, 542-549. First published, doi:S1570-9639(12)00009-X [pii] 10.1016/j.bbapap.2012.01.006.
30. Traxlmayr,M.W., Hasenhindl,C., Hackl,M., Stadlmayr,G., Rybka,J.D., Borth,N., Grillari,J., Ruker,F. and Obinger,C. (2012b) J. Mol. Biol., 423, 397-412. First published, doi:S0022-2836(12)00584-0 [ pii] 10.1016/ j.jmb.2012.07.017.
31. Traxlmayr,M.W. and Obinger,C. (2012) Arch. Biochem. Biophys., 526, 174-180. First published, doi:S0003-9861(12)00161-0 [ pii] 10.1016/ j.abb.2012.04.022
32. Traxlmayr,M.W., Wozniak-Knopp,G., Antes,B., Stadlmayr,G., Ruker,F. and Obinger,C. (2011) J. Biotechnol., 155, 193-202. First published, doi:S0168-1656(11)00374-9 [ pii] 10.1016/j.jbiotec.2011.06.042.
33. Weber,K.S., Donermeyer,D.L., Allen,P.M. and Kranz,D.M. (2005) Proc. Natl Acad. Sci. USA, 102, 19033-19038. First published, doi:0507554102 [ pii] 10.1073/pnas.0507554102.
34. Willuda,J., Honegger,A., Waibel,R., Schubiger,P.A., Stahel,R., Zangemeister-Wittke,U. and Pluckthun,A. (1999) Cancer Res., 59, 5758-5767. First published.
35. Wozniak-Knopp,G., Bartl,S., Bauer,A., et al. (2010) Protein Eng. Des. Sel., 23, 289-297. First published, doi:gzq005 [ pii] 10.1093/protein/gzq005.
36. Wozniak-Knopp,G. and Ruker,F. (2012) Arch. Biochem. Biophys. First published, doi:S0003-9861(12)00115-4 [ pii] 10.1016/j.abb.2012.03.024.
37. Wozniak-Knopp,G., Stadlmann,J. and Ruker,F. (2012) PLoS One, 7, e30083. First published, doi:10.1371/journal.pone.0030083 PONE-D-11-14922 [ pii].