Capillary electrophoresis-mass spectrometry methods for tryptic peptide mapping of therapeutic antibodies

Electrophoresis

Volumn 33, Issue 11, 2012, Pages 1550-1556

  Whitmore, Colin D ^a   Gennaro, Lynn A ^a  

^a GENENTECH INC   (United States)

Author keywords

Capillary electrophoresis; Mass spectrometry; Therapeutic antibodies; Tryptic peptide mapping

Indexed keywords

CAPILLARY ELECTROPHORESIS; CELL CULTURE; LIQUID CHROMATOGRAPHY; MAPPING; MASS SPECTROMETERS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES;

BIOTECH INDUSTRY; CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRIES; PEPTIDE ANALYSIS; PEPTIDE MAPPING; PRIMARY SEQUENCES; SEQUENCE COVERAGES; THERAPEUTIC ANTIBODIES; TRYPTIC DIGESTS; TRYPTIC PEPTIDE MAPPING; TRYPTIC PEPTIDES;

PEPTIDES;

MONOCLONAL ANTIBODY; PEPTIDE DERIVATIVE; TRYPSIN;

AMINO ACID COMPOSITION; ARTICLE; CAPILLARY ELECTROPHORESIS; DRUG DETERMINATION; EQUIPMENT DESIGN; LIMIT OF DETECTION; MASS SPECTROMETER; MASS SPECTROMETRY; NOISE REDUCTION; OPTICAL RESOLUTION; PEPTIDE MAPPING; PROCESS DEVELOPMENT; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SYSTEM ANALYSIS; TRYPTIC PEPTIDE MAPPING;

EID: 84862896818     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201200066     Document Type: Article

References (23)

1. Harris, R. J., Murnane, A. A., Utter, S. L., Wagner, K. L., Cox, E. T., Polastri, G. D., Helder, J. C., and Sliwkowski, M. B., Biotechnology 1993, 11, 1293-1297.
2. Kleemann, G. R., Beierle, J., Nichols, A. C., Dillon, T. M., Pipes, G. D., Bondarenko, P. V., Anal. Chem. 2008, 80, 2001-2009.
3. Yan, B. X., Valliere-Douglass, J., Brady, L., Steen, S., Han, M., Pace, D., Elliott, S., Yates, Z., Han, Y. H., Balland, A., Wang, W. C., Pettit, D. J., J. Chromatogr. A 2007, 1164, 153-161.
4. Barnes, C. A. S., Lim, A., Mass Spectrom. Rev. 2007, 26, 370-388.
5. Chelius, D., Xiao, G., Nichols, A. C., Vizel, A., He, B., Dillon, T. M., Rehder, D. S., Pipes, G. D., Kraft, E., Oroska, A., Treuheit, M. J., Bondarenko, P. V., J. Pharm. Biomed. Anal. 2008, 47, 285-294.
6. Julka, S., Regnier, F. E., Anal. Chem. 2004, 76, 5799-5806.
7. Forbes, A. J., Mazur, M. T., Kelleher, N. L., Patel, H. M., Walsh, C. T., Eur. J. Mass Spectrom. 2001, 7, 81-87.
8. Srebalus Barnes, C. A., Lim, A., Mass Spectrom. Rev. 2007, 26, 370-388.
9. Chin, E. T., Papac, D. I., Anal. Biochem. 1999, 273, 179-185.
10. Roturier, J. M., Lebars, D., Gripon, J. C., J. Chromatogr. A 1995, 696, 209-217.
11. Kadlcik, V., Strohalm, M., Kodicek, M., Biochem. Biophys. Res. Commun. 2003, 305, 1091-1093.
12. Cobb, K. A., Novotny, M. V., Anal. Chem. 1992, 64, 879-886.
13. Novotny, M. V., Cobb, K. A., Liu, J. P., Electrophoresis 1990, 11, 735-749.
14. Busnel, J. M., Lion, N., Girault, H. H., Electrophoresis 2008, 29, 1565-1572.
15. Herrero, M., Ibanez, E., Cifuentes, A., Electrophoresis 2008, 29, 2148-2160.
16. Smith, R. D., Barinaga, C. J., Udseth, H. R., Anal. Chem. 1988, 60, 1948-1952.
17. Schmitt-Kopplin, P., Frommberger, M., Electrophoresis 2003, 24, 3837-3867.
18. Hernandez-Borges, J., Neususs, C., Cifuentes, A., Pelzing, M., Electrophoresis 2004, 25, 2257-2281.
19. Gennaro, L. A., Salas-Solano, O., Ma, S., Anal. Biochem. 2006, 355, 249-258.
20. Moini, M., Whitt, J. T., Anal. Chem. 2003, 75, 2188-2191.
21. Moini, M., Anal. Chem. 2007, 79, 4241-4246.
22. Busnel, J. M., Schoenmaker, B., Ramautar, R., Carrasco-Pancorbo, A., Ratnayake, C., Feitelson, J. S., Chapman, J. D., Deelder, A. M., Mayboroda, O. A., Anal. Chem. 2010, 82, 9476-9483.
23. Keller, B. O., Suj, J., Young, A. B., Whittal, R. M., Anal. Chim. Acta 2008, 627, 71-81.