Characterization of drug-lysozyme conjugates by sheathless capillary electrophoresis-time-of-flight mass spectrometry

Analytica Chimica Acta

Volumn 698, Issue 1-2, 2011, Pages 77-83

  Haselberg, R ^a   Harmsen, S ^a   Dolman, M E M ^a   de Jong, G J ^a   Kok, R J ^a   Somsen, G W ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Capillary electrophoresis; Drug protein conjugates; Electrospray ionization; Mass spectrometry; Sheathless interfacing

Indexed keywords

BACK GROUND ELECTROLYTE; CAPILLARY COATINGS; CAPILLARY WALL; DRUG LOADING; DRUG MOLECULES; DRUG-PROTEIN CONJUGATES; DRUG-TARGETING; ERLOTINIB; HYDROXYSUCCINIMIDE; INDIVIDUAL COMPONENTS; KINASE INHIBITORS; LYSINE RESIDUES; MIGRATION TIME; PEAK AREA; POLYETHYLENIMINES; POSITIVELY CHARGED; SHEATHLESS INTERFACING; TUBULAR CELLS;

ADSORPTION; AMINO ACIDS; CAPILLARY ELECTROPHORESIS; ELECTROSPRAY IONIZATION; ENZYMES; INDUCTIVELY COUPLED PLASMA; IONIZATION; MASS SPECTROMETERS; MASS SPECTROMETRY; PLATINUM; PROTEINS;

DRUG PRODUCTS;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ERLOTINIB; LY 364947; LYSINE; LYSOZYME; METHIONINE; N HYDROXYSUCCINIMIDE; POLYETHYLENEIMINE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; CAPILLARY ELECTROPHORESIS; CAPILLARY WALL; CHEMICAL REACTION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG STRUCTURE; MOLECULAR WEIGHT; PH; POROSITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

ELECTROPHORESIS, CAPILLARY; MASS SPECTROMETRY; MURAMIDASE; PHARMACEUTICAL PREPARATIONS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 79958005259     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2011.04.050     Document Type: Article

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