Use of CE-SDS gel for characterization of monoclonal antibody hinge region clipping due to copper and high pH stress

Electrophoresis

Volumn 32, Issue 21, 2011, Pages 3078-3084

  Rustandi, Richard R ^a   Wang, Yang ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Sino Biological Inc ^*  (China)

Author keywords

CE SDS gel; Copper induced cleavage; EDTA and high pH stress; MAb hinge region; Transition metals

Indexed keywords

COPPER;

CE-SDS GEL; COPPER-INDUCED CLEAVAGE; EDTA AND HIGH PH STRESS; GEL TECHNIQUE; HIGH PH; HIGHEST TEMPERATURE; MAB HINGE REGION; PH STRESS; PRODUCT CHARACTERIZATIONS; PRODUCT STABILITY;

MONOCLONAL ANTIBODIES;

COPPER; IRON; METAL; MONOCLONAL ANTIBODY; ZINC;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHEMICAL ANALYSIS; CONTROLLED STUDY; HEAT STRESS; HIGH TEMPERATURE; MASS SPECTROMETRY; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; TEMPERATURE STRESS; ULTRAVIOLET RADIATION;

EID: 80054969608     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201100186     Document Type: Article

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