Locating sweet spots for screening hits and evaluating pan-assay interference filters from the performance analysis of two lead-like libraries

Journal of Chemical Information and Modeling

Volumn 53, Issue 3, 2013, Pages 534-544

  Mok, N Yi ^a,b   Maxe, Sara ^a   Brenk, Ruth ^a,c  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC COMPOUNDS; CHEMICAL ANALYSIS; EFFICIENCY; LIBRARIES;

CHEMICAL DIVERSITY; CHEMICAL SPACE; COMPOUND SCREENINGS; INTERFERENCE FILTERS; LIPOPHILICITY; PERFORMANCE ANALYSIS; STRUCTURAL MOTIFS; VARIABLE CONCENTRATION;

LEAD COMPOUNDS;

ENZYME; LIGAND;

ALGORITHM; ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPUTER PROGRAM; DRUG DEVELOPMENT; FACTUAL DATABASE; HIGH THROUGHPUT SCREENING; METABOLISM; METHODOLOGY; MOLECULAR LIBRARY; MOLECULAR WEIGHT; PRINCIPAL COMPONENT ANALYSIS;

ALGORITHMS; COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, FACTUAL; DRUG DISCOVERY; ENZYMES; HIGH-THROUGHPUT SCREENING ASSAYS; LIGANDS; MODELS, CHEMICAL; MOLECULAR WEIGHT; PRINCIPAL COMPONENT ANALYSIS; SMALL MOLECULE LIBRARIES; SOFTWARE;

EID: 84875421001     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci300382f     Document Type: Article

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