Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: Discovery, synthesis, and characterization of their binding mode by protein crystallography

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6514-6530

  Patterson, Stephen ^a   Alphey, Magnus S ^a   Jones, Deuan C ^a   Shanks, Emma J ^a   Street, Ian P ^b   Frearson, Julie A ^a   Wyatt, Paul G ^a   Gilbert, Ian H ^a   Fairlamb, Alan H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROQUINAZOLINE; ANTIPROTOZOAL AGENT; DIHYDROQUINAZOLINE DERIVATIVE; TRYPANOTHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; LIGAND BINDING; NONHUMAN; TRYPANOSOMA BRUCEI;

CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; LIGANDS; NADH, NADPH OXIDOREDUCTASES; PROTEIN BINDING; PROTEIN CONFORMATION; QUINAZOLINES; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 80053920610     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200312v     Document Type: Article

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