Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes

Journal of Biological Chemistry

Volumn 288, Issue 12, 2013, Pages 8445-8455

  Tsutakawa, Susan E ^a   Shin, David S ^b   Mol, Clifford D ^b   Izumi, Tadahide ^c,d   Arvai, Andrew S ^b   Mantha, Anil K ^d,h   Szczesny, Bartosz ^d   Ivanov, Ivaylo N ^e   Hosfield, David J ^b   Maiti, Buddhadev ^e   Pique, Mike E ^b   Frankel, Kenneth A ^a   Hitomi, Kenichi ^a,b,f   Cunningham, Richard P ^g   Mitra, Sankar ^d   Tainer, John A ^a,b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^e GEORGIA STATE UNIVERSITY   (United States)

^f OSAKA UNIVERSITY   (Japan)

^g STATE UNIVERSITY OF NEW YORK   (United States)

^h CENTRAL UNIVERSITY OF PUNJAB   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE STRUCTURE; BASE EXCISION REPAIRS; CATALYTIC REACTIONS; COMPUTATIONAL ANALYSIS; DNA-REPAIR ENZYMES; FUNCTIONAL EQUIVALENCE; GEOMETRIC CONSERVATIONS; STRUCTURAL CHEMISTRY;

CATALYSIS; DNA; ENZYMES; METAL IONS;

REPAIR;

DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DOUBLE STRANDED DNA; ENDONUCLEASE; ENDONUCLEASE 4 DNA REPAIR ENZYME; ENDONUCLEASE APE1; GLUTAMINE; LYSINE; MAGNESIUM; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TETRAHYDROFURAN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; EXCISION REPAIR; GEOMETRY; HUMAN; HYDROGEN BOND; MESOPHILE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SEQUENCE ALIGNMENT; THERMOPHILE; THERMOTOGA MARITIMA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ESCHERICHIA COLI; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURAL HOMOLOGY, PROTEIN; THERMOTOGA MARITIMA;

BACTERIA (MICROORGANISMS);

EID: 84875412272     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.422774     Document Type: Article

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