A "moving metal mechanism" for substrate cleavage by the DNA repair endonuclease APE-1

Proteins: Structure, Function and Genetics

Volumn 68, Issue 1, 2007, Pages 313-323

  Oezguen, Numan ^a   Schein, Catherine H ^a   Peddi, Srinivasa R ^b   Power, Trevor D ^a   Izumi, Tadahide ^b   Braun, Werner ^a,c  

^a University of Texas Medical Branch School of Medicine   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

BER pathway; Divalent metal ion; Molecular dynamic simulation

Indexed keywords

CALCIUM ION; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; ENDONUCLEASE; MAGNESIUM ION; METAL ION; OXYGEN; PHOSPHATE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DNA CLEAVAGE; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; EXCISION REPAIR; MOLECULAR DYNAMICS; PHOSPHORYLATION; PRIORITY JOURNAL;

COMPUTER SIMULATION; DNA; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HUMANS; MAGNESIUM; MODELS, MOLECULAR;

EID: 34249905486     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21397     Document Type: Article

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