Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function

Free Radical Biology and Medicine

Volumn 60, Issue , 2013, Pages 201-210

  Cho, Kumsun ^a   Shin, Hyun Woo ^a   Kim, Young Im ^a   Cho, Chung Hyun ^a   Chun, Yang Sook ^a,b   Kim, Tae You ^a   Park, Jong Wan ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Colon cancer; Doxorubicin; Free radicals; Mad1; Mitochondria; ROS

Indexed keywords

CASPASE 3; CASPASE 9; DOXORUBICIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN MAD1; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL; CELL FUNCTION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; COLON CANCER; CONTROLLED STUDY; GENE; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRION; MOLECULARLY TARGETED THERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR RESISTANCE; WESTERN BLOTTING;

ANOXIA; APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MITOCHONDRIA; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; REACTIVE OXYGEN SPECIES;

EID: 84875384007     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.02.022     Document Type: Article

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