메뉴 건너뛰기




Volumn 7, Issue 5, 2012, Pages

Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE; MULTIENZYME COMPLEX; OXYGEN;

EID: 84860535468     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036801     Document Type: Article
Times cited : (73)

References (43)
  • 1
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    • Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, et al. (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12: 149-162.
    • (1998) Genes Dev , vol.12 , pp. 149-162
    • Iyer, N.V.1    Kotch, L.E.2    Agani, F.3    Leung, S.W.4    Laughner, E.5
  • 2
    • 0034682786 scopus 로고    scopus 로고
    • Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing
    • Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, et al. (2000) Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 275: 25130-25138.
    • (2000) J Biol Chem , vol.275 , pp. 25130-25138
    • Chandel, N.S.1    McClintock, D.S.2    Feliciano, C.E.3    Wood, T.M.4    Melendez, J.A.5
  • 3
    • 33845741242 scopus 로고    scopus 로고
    • The cellular basis for diverse responses to oxygen
    • Chandel NS, Budinger GR, (2007) The cellular basis for diverse responses to oxygen. Free Radic Biol Med 42: 165-174.
    • (2007) Free Radic Biol Med , vol.42 , pp. 165-174
    • Chandel, N.S.1    Budinger, G.R.2
  • 4
    • 70549092785 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate hypoxic signaling
    • Hamanaka RB, Chandel NS, (2009) Mitochondrial reactive oxygen species regulate hypoxic signaling. Curr Opin Cell Biol 21: 894-899.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 894-899
    • Hamanaka, R.B.1    Chandel, N.S.2
  • 5
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst MW, Cao Y, Moeller B, (2008) Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8: 425-437.
    • (2008) Nat Rev Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 6
    • 34347227058 scopus 로고    scopus 로고
    • Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
    • Semenza GL, (2007) Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem J 405: 1-9.
    • (2007) Biochem J , vol.405 , pp. 1-9
    • Semenza, G.L.1
  • 7
    • 77951961591 scopus 로고    scopus 로고
    • Mechanisms of intermittent hypoxia induced hypertension
    • Bosc LV, Resta T, Walker B, Kanagy NL, (2010) Mechanisms of intermittent hypoxia induced hypertension. J Cell Mol Med 14: 3-17.
    • (2010) J Cell Mol Med , vol.14 , pp. 3-17
    • Bosc, L.V.1    Resta, T.2    Walker, B.3    Kanagy, N.L.4
  • 8
    • 77952592310 scopus 로고    scopus 로고
    • Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction
    • Douglas RM, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan LL, et al. (2010) Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. Am J Physiol Cell Physiol 298: C1594-1602.
    • (2010) Am J Physiol Cell Physiol , vol.298
    • Douglas, R.M.1    Ryu, J.2    Kanaan, A.3    Del Carmen, R.M.4    Dugan, L.L.5
  • 9
    • 0037203544 scopus 로고    scopus 로고
    • Cellular and molecular pathways of ischemic neuronal death
    • Won SJ, Kim DY, Gwag BJ, (2002) Cellular and molecular pathways of ischemic neuronal death. J Biochem Mol Biol 35: 67-86.
    • (2002) J Biochem Mol Biol , vol.35 , pp. 67-86
    • Won, S.J.1    Kim, D.Y.2    Gwag, B.J.3
  • 10
    • 0022590628 scopus 로고
    • Defense strategies against hypoxia and hypothermia
    • Hochachka PW, (1986) Defense strategies against hypoxia and hypothermia. Science 231: 234-241.
    • (1986) Science , vol.231 , pp. 234-241
    • Hochachka, P.W.1
  • 12
    • 77953931313 scopus 로고    scopus 로고
    • Inter-connection between mitochondria and HIFs
    • Tormos KV, Chandel NS, (2010) Inter-connection between mitochondria and HIFs. J Cell Mol Med.
    • (2010) J Cell Mol Med
    • Tormos, K.V.1    Chandel, N.S.2
  • 13
    • 52449106053 scopus 로고    scopus 로고
    • Experimental selection for Drosophila survival in extremely low O2 environment
    • Zhou D, Xue J, Chen J, Morcillo P, Lambert JD, et al. (2007) Experimental selection for Drosophila survival in extremely low O2 environment. PLoS One 2: e490.
    • (2007) PLoS One , vol.2
    • Zhou, D.1    Xue, J.2    Chen, J.3    Morcillo, P.4    Lambert, J.D.5
  • 14
    • 79952291784 scopus 로고    scopus 로고
    • Experimental selection of hypoxia-tolerant Drosophila melanogaster
    • Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, et al. (2011) Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A 108: 2349-2354.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2349-2354
    • Zhou, D.1    Udpa, N.2    Gersten, M.3    Visk, D.W.4    Bashir, A.5
  • 15
    • 55449113035 scopus 로고    scopus 로고
    • Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch
    • Zhou D, Xue J, Lai JC, Schork NJ, White KP, et al. (2008) Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet 4: e1000221.
    • (2008) PLoS Genet , vol.4
    • Zhou, D.1    Xue, J.2    Lai, J.C.3    Schork, N.J.4    White, K.P.5
  • 16
    • 71049135169 scopus 로고    scopus 로고
    • Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis
    • Feala JD, Coquin L, Zhou D, Haddad GG, Paternostro G, et al. (2009) Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. BMC Syst Biol 3: 91.
    • (2009) BMC Syst Biol , vol.3 , pp. 91
    • Feala, J.D.1    Coquin, L.2    Zhou, D.3    Haddad, G.G.4    Paternostro, G.5
  • 17
    • 25144463436 scopus 로고    scopus 로고
    • Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster
    • Ferguson M, Mockett RJ, Shen Y, Orr WC, Sohal RS, (2005) Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster. Biochem J 390: 501-511.
    • (2005) Biochem J , vol.390 , pp. 501-511
    • Ferguson, M.1    Mockett, R.J.2    Shen, Y.3    Orr, W.C.4    Sohal, R.S.5
  • 18
    • 0036938302 scopus 로고    scopus 로고
    • 5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties
    • Chalier F, Tordo P, (2002) 5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties. J Chem Soc, Perkin Trans 2 12: 2110-2117.
    • (2002) J Chem Soc, Perkin Trans 2 , vol.12 , pp. 2110-2117
    • Chalier, F.1    Tordo, P.2
  • 19
    • 0034669528 scopus 로고    scopus 로고
    • Spin trapping of lipid radicals with DEPMPO-derived spin traps: detection of superoxide, alkyl and alkoxyl radicals in aqueous and lipid phase
    • Stolze K, Udilova N, Nohl H, (2000) Spin trapping of lipid radicals with DEPMPO-derived spin traps: detection of superoxide, alkyl and alkoxyl radicals in aqueous and lipid phase. Free Radic Biol Med 29: 1005-1014.
    • (2000) Free Radic Biol Med , vol.29 , pp. 1005-1014
    • Stolze, K.1    Udilova, N.2    Nohl, H.3
  • 21
    • 0015882341 scopus 로고
    • The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
    • Boveris A, Chance B, (1973) The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 134: 707-716.
    • (1973) Biochem J , vol.134 , pp. 707-716
    • Boveris, A.1    Chance, B.2
  • 22
    • 26844552854 scopus 로고    scopus 로고
    • Mechanism of mitochondrial uncouplers, inhibitors, and toxins: focus on electron transfer, free radicals, and structure-activity relationships
    • Kovacic P, Pozos RS, Somanathan R, Shangari N, O'Brien PJ, (2005) Mechanism of mitochondrial uncouplers, inhibitors, and toxins: focus on electron transfer, free radicals, and structure-activity relationships. Curr Med Chem 12: 2601-2623.
    • (2005) Curr Med Chem , vol.12 , pp. 2601-2623
    • Kovacic, P.1    Pozos, R.S.2    Somanathan, R.3    Shangari, N.4    O'Brien, P.J.5
  • 23
    • 0141815741 scopus 로고    scopus 로고
    • Production of reactive oxygen species by mitochondria: central role of complex III
    • Chen Q, Vazquez EJ, Moghaddas S, Hoppel CL, Lesnefsky EJ, (2003) Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem 278: 36027-36031.
    • (2003) J Biol Chem , vol.278 , pp. 36027-36031
    • Chen, Q.1    Vazquez, E.J.2    Moghaddas, S.3    Hoppel, C.L.4    Lesnefsky, E.J.5
  • 24
    • 0024281056 scopus 로고
    • Mechanism of O2- generation in reduction and oxidation cycle of ubiquinones in a model of mitochondrial electron transport systems
    • Sugioka K, Nakano M, Totsune-Nakano H, Minakami H, Tero-Kubota S, et al. (1988) Mechanism of O2- generation in reduction and oxidation cycle of ubiquinones in a model of mitochondrial electron transport systems. Biochim Biophys Acta 936: 377-385.
    • (1988) Biochim Biophys Acta , vol.936 , pp. 377-385
    • Sugioka, K.1    Nakano, M.2    Totsune-Nakano, H.3    Minakami, H.4    Tero-Kubota, S.5
  • 25
    • 79961123240 scopus 로고    scopus 로고
    • Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis
    • Biniecka M, Fox E, Gao W, Ng CT, Veale DJ, et al. (2011) Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis. Arthritis Rheum 63: 2172-2182.
    • (2011) Arthritis Rheum , vol.63 , pp. 2172-2182
    • Biniecka, M.1    Fox, E.2    Gao, W.3    Ng, C.T.4    Veale, D.J.5
  • 26
    • 0038476368 scopus 로고    scopus 로고
    • Effect of age and hypoxia/reoxygenation on mRNA expression of antioxidative enzymes in rat liver and kidneys
    • Martin R, Fitzl G, Mozet C, Martin H, Welt K, et al. (2002) Effect of age and hypoxia/reoxygenation on mRNA expression of antioxidative enzymes in rat liver and kidneys. Exp Gerontol 37: 1481-1487.
    • (2002) Exp Gerontol , vol.37 , pp. 1481-1487
    • Martin, R.1    Fitzl, G.2    Mozet, C.3    Martin, H.4    Welt, K.5
  • 27
    • 78650406045 scopus 로고    scopus 로고
    • Oxidative stress status in rats after intermittent exposure to hypobaric hypoxia
    • Esteva S, Pedret R, Fort N, Torrella JR, Pages T, et al. (2010) Oxidative stress status in rats after intermittent exposure to hypobaric hypoxia. Wilderness Environ Med 21: 325-331.
    • (2010) Wilderness Environ Med , vol.21 , pp. 325-331
    • Esteva, S.1    Pedret, R.2    Fort, N.3    Torrella, J.R.4    Pages, T.5
  • 28
    • 77953935500 scopus 로고    scopus 로고
    • Tumor hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
    • Chiche J, Brahimi-Horn MC, Pouyssegur J, (2010) Tumor hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med 14: 771-794.
    • (2010) J Cell Mol Med , vol.14 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouyssegur, J.3
  • 29
    • 34548317034 scopus 로고    scopus 로고
    • Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
    • Gatenby RA, Smallbone K, Maini PK, Rose F, Averill J, et al. (2007) Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer 97: 646-653.
    • (2007) Br J Cancer , vol.97 , pp. 646-653
    • Gatenby, R.A.1    Smallbone, K.2    Maini, P.K.3    Rose, F.4    Averill, J.5
  • 30
    • 0017406503 scopus 로고
    • Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria
    • Cadenas E, Boveris A, Ragan CI, Stoppani AO, (1977) Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch Biochem Biophys 180: 248-257.
    • (1977) Arch Biochem Biophys , vol.180 , pp. 248-257
    • Cadenas, E.1    Boveris, A.2    Ragan, C.I.3    Stoppani, A.O.4
  • 31
    • 0030969868 scopus 로고    scopus 로고
    • Superoxide production by the mitochondrial respiratory chain
    • Turrens JF, (1997) Superoxide production by the mitochondrial respiratory chain. Biosci Rep 17: 3-8.
    • (1997) Biosci Rep , vol.17 , pp. 3-8
    • Turrens, J.F.1
  • 32
    • 0033396970 scopus 로고    scopus 로고
    • Fundamental aspects of reactive oxygen species, or what's the matter with oxygen?
    • Fridovich I, (1999) Fundamental aspects of reactive oxygen species, or what's the matter with oxygen? Ann N Y Acad Sci 893: 13-18.
    • (1999) Ann N Y Acad Sci , vol.893 , pp. 13-18
    • Fridovich, I.1
  • 33
    • 0021351203 scopus 로고
    • Oxygen toxicity, oxygen radicals, transition metals and diseases
    • Halliwell B, Gutteridge JM, (1984) Oxygen toxicity, oxygen radicals, transition metals and diseases. Biochem J 219: 1-14.
    • (1984) Biochem J , vol.219 , pp. 1-14
    • Halliwell, B.1    Gutteridge, J.M.2
  • 34
    • 0037144396 scopus 로고    scopus 로고
    • Exposure of yeast cells to anoxia induces transient oxidative stress. Implications for the induction of hypoxic genes
    • Dirmeier R, O'Brien KM, Engle M, Dodd A, Spears E, et al. (2002) Exposure of yeast cells to anoxia induces transient oxidative stress. Implications for the induction of hypoxic genes. J Biol Chem 277: 34773-34784.
    • (2002) J Biol Chem , vol.277 , pp. 34773-34784
    • Dirmeier, R.1    O'Brien, K.M.2    Engle, M.3    Dodd, A.4    Spears, E.5
  • 35
    • 0035348181 scopus 로고    scopus 로고
    • Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene
    • Grishko V, Solomon M, Breit JF, Killilea DW, Ledoux SP, et al. (2001) Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene. Faseb J 15: 1267-1269.
    • (2001) Faseb J , vol.15 , pp. 1267-1269
    • Grishko, V.1    Solomon, M.2    Breit, J.F.3    Killilea, D.W.4    Ledoux, S.P.5
  • 36
    • 0030809576 scopus 로고    scopus 로고
    • Reactive oxygen species, mitochondria, apoptosis and aging
    • Papa S, Skulachev VP, (1997) Reactive oxygen species, mitochondria, apoptosis and aging. Mol Cell Biochem 174: 305-319.
    • (1997) Mol Cell Biochem , vol.174 , pp. 305-319
    • Papa, S.1    Skulachev, V.P.2
  • 37
    • 0015911233 scopus 로고
    • The mechanism of action of the respiratory inhibitor, antimycin
    • Slater EC, (1973) The mechanism of action of the respiratory inhibitor, antimycin. Biochim Biophys Acta 301: 129-154.
    • (1973) Biochim Biophys Acta , vol.301 , pp. 129-154
    • Slater, E.C.1
  • 39
    • 24144493814 scopus 로고    scopus 로고
    • Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    • Guzy RD, Hoyos B, Robin E, Chen H, Liu L, et al. (2005) Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 1: 401-408.
    • (2005) Cell Metab , vol.1 , pp. 401-408
    • Guzy, R.D.1    Hoyos, B.2    Robin, E.3    Chen, H.4    Liu, L.5
  • 40
    • 24144447915 scopus 로고    scopus 로고
    • Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
    • Mansfield KD, Guzy RD, Pan Y, Young RM, Cash TP, et al. (2005) Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab 1: 393-399.
    • (2005) Cell Metab , vol.1 , pp. 393-399
    • Mansfield, K.D.1    Guzy, R.D.2    Pan, Y.3    Young, R.M.4    Cash, T.P.5
  • 41
    • 37849022071 scopus 로고    scopus 로고
    • Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis
    • Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT, (2008) Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol 28: 718-731.
    • (2008) Mol Cell Biol , vol.28 , pp. 718-731
    • Guzy, R.D.1    Sharma, B.2    Bell, E.3    Chandel, N.S.4    Schumacker, P.T.5
  • 42
    • 44949127039 scopus 로고    scopus 로고
    • PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
    • Wigfield SM, Winter SC, Giatromanolaki A, Taylor J, Koukourakis ML, et al. (2008) PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer. Br J Cancer 98: 1975-1984.
    • (2008) Br J Cancer , vol.98 , pp. 1975-1984
    • Wigfield, S.M.1    Winter, S.C.2    Giatromanolaki, A.3    Taylor, J.4    Koukourakis, M.L.5
  • 43
    • 34250361521 scopus 로고    scopus 로고
    • Cytochrome C oxidase activity and oxygen tolerance
    • Campian JL, Gao X, Qian M, Eaton JW, (2007) Cytochrome C oxidase activity and oxygen tolerance. J Biol Chem 282: 12430-12438.
    • (2007) J Biol Chem , vol.282 , pp. 12430-12438
    • Campian, J.L.1    Gao, X.2    Qian, M.3    Eaton, J.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.