Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model

Pharmacology Biochemistry and Behavior

Volumn 103, Issue 2, 2012, Pages 187-196

  Gao, Fei ^a,b   Liu, Yangfeng ^a,c   Li, Xiaowei ^a   Wang, Ying ^a   Wei, Dong ^a   Jiang, Wen ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^c People's Liberation Army No 451 Hospital   (China)

Author keywords

Epileptogenesis; FTY720; Hippocampus; Inflammation; Mossy fiber sprouting; Neuroprotection

Indexed keywords

FINGOLIMOD; INTERLEUKIN 1BETA; LITHIUM; PILOCARPINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; CONVULSION; DISEASE SEVERITY; EPILEPTIC STATE; HIPPOCAMPUS; MALE; MICROGLIA; MOSSY FIBER; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ASTROCYTES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; LITHIUM COMPOUNDS; MALE; PILOCARPINE; PROPYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOSINE; STATUS EPILEPTICUS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 84866095781     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.08.025     Document Type: Article

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