Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

Genome Biology

Volumn 14, Issue 3, 2013, Pages

  Reddington, James P ^a   Perricone, Sara M ^a   Nestor, Colm E ^a,b   Reichmann, Judith ^a   Youngson, Neil A ^c   Suzuki, Masako ^d   Reinhardt, Diana ^a   Dunican, Donncha S ^a   Prendergast, James G ^a   Mjoseng, Heidi ^a   Ramsahoye, Bernard H ^b   Whitelaw, Emma ^c   Greally, John M ^d   Adams, Ian R ^a   Bickmore, Wendy A ^a   Meehan, Richard R ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

DNA methylation; H3K27me3; Polycomb; PRC2; Regulation of transcription

Indexed keywords

HISTONE H3; POLYCOMB REPRESSIVE COMPLEX 2; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; HISTONE; LYSINE; REPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEVELOPMENT; DISEASES; DNA METHYLATION; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENE MAPPING; GENE REPRESSION; GENE TARGETING; HISTONE METHYLATION; HOX GENE; MOUSE; NONHUMAN; PROMOTER REGION; SOMATIC CELL; TRANSCRIPTION REGULATION; ANIMAL; ANIMAL EMBRYO; BIOLOGICAL MODEL; CYTOLOGY; DEFICIENCY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HOMEOBOX; METABOLISM; MULTIGENE FAMILY;

ANIMALS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EMBRYO, MAMMALIAN; EPIGENESIS, GENETIC; FIBROBLASTS; GENE EXPRESSION REGULATION; GENES, HOMEOBOX; HISTONES; LYSINE; MICE; MODELS, GENETIC; MULTIGENE FAMILY; POLYCOMB REPRESSIVE COMPLEX 2; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS;

EID: 84875333893     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2013-14-3-r25     Document Type: Article

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