-
1
-
-
0037026489
-
The voltage-gated potassium channels and their relatives
-
Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419(6902):35-42.
-
(2002)
Nature
, vol.419
, Issue.6902
, pp. 35-42
-
-
Yellen, G.1
-
2
-
-
36248982122
-
Atomic structure of a voltagedependent K+ channel in a lipid membrane-like environment
-
Long SB, Tao X, Campbell EB, MacKinnon R (2007) Atomic structure of a voltagedependent K+ channel in a lipid membrane-like environment. Nature 450(7168): 376-382.
-
(2007)
Nature
, vol.450
, Issue.7168
, pp. 376-382
-
-
Long, S.B.1
Tao, X.2
Campbell, E.B.3
MacKinnon, R.4
-
3
-
-
79958072421
-
Intrinsically disordered proteins: Regulation and disease
-
Babu MM, van der Lee R, de Groot NS, Gsponer J (2011) Intrinsically disordered proteins: Regulation and disease. Curr Opin Struct Biol 21(3):432-440.
-
(2011)
Curr Opin Struct Biol
, vol.21
, Issue.3
, pp. 432-440
-
-
Babu, M.M.1
Van Der Lee, R.2
De Groot, N.S.3
Gsponer, J.4
-
4
-
-
80053441923
-
Dynamic protein-DNA recognition: Beyond what can be seen
-
Fuxreiter M, Simon I, Bondos S (2011) Dynamic protein-DNA recognition: Beyond what can be seen. Trends Biochem Sci 36(8):415-423.
-
(2011)
Trends Biochem Sci
, vol.36
, Issue.8
, pp. 415-423
-
-
Fuxreiter, M.1
Simon, I.2
Bondos, S.3
-
5
-
-
79952959945
-
Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21
-
Wang Y, et al. (2011) Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21. Nat Chem Biol 7(4):214-221.
-
(2011)
Nat Chem Biol
, vol.7
, Issue.4
, pp. 214-221
-
-
Wang, Y.1
-
6
-
-
34250821717
-
Mechanism of coupled folding and binding of an intrinsically disordered protein
-
Sugase K, Dyson HJ, Wright PE (2007) Mechanism of coupled folding and binding of an intrinsically disordered protein. Nature 447(7147):1021-1025.
-
(2007)
Nature
, vol.447
, Issue.7147
, pp. 1021-1025
-
-
Sugase, K.1
Dyson, H.J.2
Wright, P.E.3
-
7
-
-
14644435825
-
Intrinsically unstructured proteins and their functions
-
Dyson HJ, Wright PE (2005) Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol 6(3):197-208.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, Issue.3
, pp. 197-208
-
-
Dyson, H.J.1
Wright, P.E.2
-
8
-
-
39049162291
-
Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1
-
Galea CA, et al. (2008) Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1. J Mol Biol 376(3):827-838.
-
(2008)
J Mol Biol
, vol.376
, Issue.3
, pp. 827-838
-
-
Galea, C.A.1
-
9
-
-
0029796983
-
Small-conductance, calcium-activated potassium channels from mammalian brain
-
Köhler M, et al. (1996) Small-conductance, calcium-activated potassium channels from mammalian brain. Science 273(5282):1709-1714.
-
(1996)
Science
, vol.273
, Issue.5282
, pp. 1709-1714
-
-
Köhler, M.1
-
10
-
-
34547985303
-
Functions of SK channels in central neurons
-
Faber ESL, Sah P (2007) Functions of SK channels in central neurons. Clin Exp Pharmacol Physiol 34(10):1077-1083.
-
(2007)
Clin Exp Pharmacol Physiol
, vol.34
, Issue.10
, pp. 1077-1083
-
-
Faber, E.S.L.1
Sah, P.2
-
11
-
-
5044238460
-
Ca(2+)-activated K+ channels: Molecular determinants and function of the SK family
-
Stocker M (2004) Ca(2+)-activated K+ channels: Molecular determinants and function of the SK family. Nat Rev Neurosci 5(10):758-770.
-
(2004)
Nat Rev Neurosci
, vol.5
, Issue.10
, pp. 758-770
-
-
Stocker, M.1
-
12
-
-
1542467647
-
Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts
-
Xu Y, et al. (2003) Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts. J Biol Chem 278(49):49085-49094.
-
(2003)
J Biol Chem
, vol.278
, Issue.49
, pp. 49085-49094
-
-
Xu, Y.1
-
13
-
-
84857254665
-
Small-conductance Ca2+-activated K+ channels: Form and function
-
Adelman JP, Maylie J, Sah P (2012) Small-conductance Ca2+-activated K+ channels: Form and function. Annu Rev Physiol 74:245-269.
-
(2012)
Annu Rev Physiol
, vol.74
, pp. 245-269
-
-
Adelman, J.P.1
Maylie, J.2
Sah, P.3
-
14
-
-
84861045290
-
Structural basis for calmodulin as a dynamic calcium sensor
-
Zhang M, et al. (2012) Structural basis for calmodulin as a dynamic calcium sensor. Structure 20(5):911-923.
-
(2012)
Structure
, vol.20
, Issue.5
, pp. 911-923
-
-
Zhang, M.1
-
15
-
-
53849127475
-
Molecular and cellular basis of small - And intermediateconductance, calcium-activated potassium channel function in the brain
-
Pedarzani P, Stocker M (2008) Molecular and cellular basis of small - and intermediateconductance, calcium-activated potassium channel function in the brain. Cell Mol Life Sci 65(20):3196-3217.
-
(2008)
Cell Mol Life Sci
, vol.65
, Issue.20
, pp. 3196-3217
-
-
Pedarzani, P.1
Stocker, M.2
-
16
-
-
84863823979
-
SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells
-
Ohtsuki G, Piochon C, Adelman JP, Hansel C (2012) SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells. Neuron 75(1):108-120.
-
(2012)
Neuron
, vol.75
, Issue.1
, pp. 108-120
-
-
Ohtsuki, G.1
Piochon, C.2
Adelman, J.P.3
Hansel, C.4
-
17
-
-
0141565369
-
Role of endothelial intermediate conductance KCa channels in cerebral EDHF-mediated dilations
-
Marrelli SP, Eckmann MS, Hunte MS (2003) Role of endothelial intermediate conductance KCa channels in cerebral EDHF-mediated dilations. Am J Physiol Heart Circ Physiol 285(4):H1590-H1599.
-
(2003)
Am J Physiol Heart Circ Physiol
, vol.285
, Issue.4
-
-
Marrelli, S.P.1
Eckmann, M.S.2
Hunte, M.S.3
-
18
-
-
33748345798
-
Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediateconductance Ca2+-activated K+ channel
-
Si H, et al. (2006) Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediateconductance Ca2+-activated K+ channel. Circ Res 99(5):537-544.
-
(2006)
Circ Res
, vol.99
, Issue.5
, pp. 537-544
-
-
Si, H.1
-
19
-
-
22044451572
-
Possible role for K+ in endothelium-derived hyperpolarizing factor-linked dilatation in rat middle cerebral artery
-
McNeish AJ, Dora KA, Garland CJ (2005) Possible role for K+ in endothelium-derived hyperpolarizing factor-linked dilatation in rat middle cerebral artery. Stroke 36(7): 1526-1532.
-
(2005)
Stroke
, vol.36
, Issue.7
, pp. 1526-1532
-
-
McNeish, A.J.1
Dora, K.A.2
Garland, C.J.3
-
20
-
-
66349089328
-
Genetic deficit of SK3 and IK1 channels disrupts the endothelium- derived hyperpolarizing factor vasodilator pathway and causes hypertension
-
Brähler S, et al. (2009) Genetic deficit of SK3 and IK1 channels disrupts the endothelium- derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119(17):2323-2332.
-
(2009)
Circulation
, vol.119
, Issue.17
, pp. 2323-2332
-
-
Brähler, S.1
-
21
-
-
77952825712
-
Compromised vascular endothelial cell SK(Ca) activity: A fundamental aspect of hypertension?
-
Garland CJ (2010) Compromised vascular endothelial cell SK(Ca) activity: A fundamental aspect of hypertension? Br J Pharmacol 160(4):833-835.
-
(2010)
Br J Pharmacol
, vol.160
, Issue.4
, pp. 833-835
-
-
Garland, C.J.1
-
22
-
-
77955565266
-
Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease
-
Köhler R (2010) Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease. Pflugers Arch 460(2):343-351.
-
(2010)
Pflugers Arch
, vol.460
, Issue.2
, pp. 343-351
-
-
Köhler, R.1
-
23
-
-
82555194074
-
SK2 channels are neuroprotective for ischemia-induced neuronal cell death
-
Allen D, et al. (2011) SK2 channels are neuroprotective for ischemia-induced neuronal cell death. J Cereb Blood Flow Metab 31(12):2302-2312.
-
(2011)
J Cereb Blood Flow Metab
, vol.31
, Issue.12
, pp. 2302-2312
-
-
Allen, D.1
-
24
-
-
41549129593
-
KCa3.1: Target and marker for cancer, autoimmune disorder and vascular inflammation?
-
Chou CC, Lunn CA, Murgolo NJ (2008) KCa3.1: Target and marker for cancer, autoimmune disorder and vascular inflammation? Expert Rev Mol Diagn 8(2):179-187.
-
(2008)
Expert Rev Mol Diagn
, vol.8
, Issue.2
, pp. 179-187
-
-
Chou, C.C.1
Lunn, C.A.2
Murgolo, N.J.3
-
25
-
-
77649191092
-
Common variants in KCNN3 are associated with lone atrial fibrillation
-
Ellinor PT, et al. (2010) Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet 42(3):240-244.
-
(2010)
Nat Genet
, vol.42
, Issue.3
, pp. 240-244
-
-
Ellinor, P.T.1
-
26
-
-
77649085090
-
Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence
-
Hopf FW, et al. (2010) Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence. Neuron 65(5):682-694.
-
(2010)
Neuron
, vol.65
, Issue.5
, pp. 682-694
-
-
Hopf, F.W.1
-
27
-
-
84868015420
-
Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2
-
Kasumu AW, et al. (2012) Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol 19(10):1340-1353.
-
(2012)
Chem Biol
, vol.19
, Issue.10
, pp. 1340-1353
-
-
Kasumu, A.W.1
-
28
-
-
84857731900
-
Targeting SKCa channels in cancer: Potential new therapeutic approaches
-
Girault A, et al. (2012) Targeting SKCa channels in cancer: Potential new therapeutic approaches. Curr Med Chem 19(5):697-713.
-
(2012)
Curr Med Chem
, vol.19
, Issue.5
, pp. 697-713
-
-
Girault, A.1
-
29
-
-
3042846773
-
Small conductance Ca2+-activated K+ channels as targets of CNS drug development
-
Blank T, Nijholt I, Kye M-J, Spiess J (2004) Small conductance Ca2+-activated K+ channels as targets of CNS drug development. Curr Drug Targets CNS Neurol Disord 3(3):161-167.
-
(2004)
Curr Drug Targets CNS Neurol Disord
, vol.3
, Issue.3
, pp. 161-167
-
-
Blank, T.1
Nijholt, I.2
Kye, M.-J.3
Spiess, J.4
-
30
-
-
0037230389
-
Modulation of small conductance calcium-activated potassium (SK) channels: A new challenge in medicinal chemistry
-
Liégeois JF, et al. (2003) Modulation of small conductance calcium-activated potassium (SK) channels: A new challenge in medicinal chemistry. Curr Med Chem 10(8): 625-647.
-
(2003)
Curr Med Chem
, vol.10
, Issue.8
, pp. 625-647
-
-
Liégeois, J.F.1
-
31
-
-
44849093511
-
K+ channel modulators for the treatment of neurological disorders and autoimmune diseases
-
Wulff H, Zhorov BS (2008) K+ channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev 108(5):1744-1773.
-
(2008)
Chem Rev
, vol.108
, Issue.5
, pp. 1744-1773
-
-
Wulff, H.1
Zhorov, B.S.2
-
32
-
-
0034608869
-
Design of a potent and selective inhibitor of the intermediateconductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant
-
Wulff H, et al. (2000) Design of a potent and selective inhibitor of the intermediateconductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant. Proc Natl Acad Sci USA 97(14):8151-8156.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.14
, pp. 8151-8156
-
-
Wulff, H.1
-
33
-
-
0032189766
-
Mechanism of calcium gating in small-conductance calciumactivated potassium channels
-
Xia XM, et al. (1998) Mechanism of calcium gating in small-conductance calciumactivated potassium channels. Nature 395(6701):503-507.
-
(1998)
Nature
, vol.395
, Issue.6701
, pp. 503-507
-
-
Xia, X.M.1
-
34
-
-
70349641039
-
EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK-calmodulin interaction
-
Li W, Halling DB, Hall AW, Aldrich RW(2009) EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK-calmodulin interaction. J Gen Physiol 134(4):281-293.
-
(2009)
J Gen Physiol
, vol.134
, Issue.4
, pp. 281-293
-
-
Li, W.1
Halling, D.B.2
Hall, A.W.3
Aldrich, R.W.4
-
35
-
-
0026794065
-
Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex
-
Meador WE, Means AR, Quiocho FA (1992) Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex. Science 257(5074):1251-1255.
-
(1992)
Science
, vol.257
, Issue.5074
, pp. 1251-1255
-
-
Meador, W.E.1
Means, A.R.2
Quiocho, F.A.3
-
36
-
-
2342513320
-
Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex
-
Schumacher MA, Crum M, Miller MC (2004) Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex. Structure 12(5): 849-860.
-
(2004)
Structure
, vol.12
, Issue.5
, pp. 849-860
-
-
Schumacher, M.A.1
Crum, M.2
Miller, M.C.3
-
37
-
-
0035953757
-
Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin
-
Schumacher MA, Rivard AF, Bächinger HP, Adelman JP (2001) Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. Nature 410(6832):1120-1124.
-
(2001)
Nature
, vol.410
, Issue.6832
, pp. 1120-1124
-
-
Schumacher, M.A.1
Rivard, A.F.2
Bächinger, H.P.3
Adelman, J.P.4
-
38
-
-
4644325419
-
Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6, 7-dichloro-1H-indole-2, 3-dione 3-oxime)
-
Strøbaek D, et al. (2004) Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6, 7-dichloro-1H-indole-2, 3-dione 3-oxime). Biochim Biophys Acta 1665(1-2):1-5.
-
(2004)
Biochim Biophys Acta
, vol.1665
, Issue.1-2
, pp. 1-5
-
-
Strøbaek, D.1
-
39
-
-
29244437522
-
Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons
-
Pedarzani P, et al. (2005) Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons. J Biol Chem 280(50):41404-41411.
-
(2005)
J Biol Chem
, vol.280
, Issue.50
, pp. 41404-41411
-
-
Pedarzani, P.1
-
40
-
-
84859517054
-
Intrinsic protein flexibility in regulation of cell proliferation: Advantages for signaling and opportunities for novel therapeutics
-
Follis AV, Galea CA, Kriwacki RW (2012) Intrinsic protein flexibility in regulation of cell proliferation: Advantages for signaling and opportunities for novel therapeutics. Adv Exp Med Biol 725:27-49.
-
(2012)
Adv Exp Med Biol
, vol.725
, pp. 27-49
-
-
Follis, A.V.1
Galea, C.A.2
Kriwacki, R.W.3
-
41
-
-
0030021584
-
Molecular basis of charge movement in voltage- gated sodium channels
-
Yang N, George AL, Jr., Horn R (1996) Molecular basis of charge movement in voltage- gated sodium channels. Neuron 16(1):113-122.
-
(1996)
Neuron
, vol.16
, Issue.1
, pp. 113-122
-
-
Yang, N.1
George Jr., A.L.2
Horn, R.3
-
42
-
-
0030064382
-
Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis
-
Ranganathan R, Lewis JH, MacKinnon R (1996) Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron 16(1):131-139.
-
(1996)
Neuron
, vol.16
, Issue.1
, pp. 131-139
-
-
Ranganathan, R.1
Lewis, J.H.2
MacKinnon, R.3
-
43
-
-
0028987938
-
Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor
-
Hidalgo P, MacKinnon R (1995) Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science 268(5208):307-310.
-
(1995)
Science
, vol.268
, Issue.5208
, pp. 307-310
-
-
Hidalgo, P.1
MacKinnon, R.2
-
44
-
-
84866074628
-
Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels
-
Zhang M, Pascal JM, Schumann M, Armen RS, Zhang JF (2012) Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels. Nat Commun 3:1021.
-
(2012)
Nat Commun
, vol.3
, pp. 1021
-
-
Zhang, M.1
Pascal, J.M.2
Schumann, M.3
Armen, R.S.4
Zhang, J.F.5
-
45
-
-
77953940694
-
An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing
-
Yang J, et al. (2010) An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. Neuron 66(6):871-883.
-
(2010)
Neuron
, vol.66
, Issue.6
, pp. 871-883
-
-
Yang, J.1
-
46
-
-
8844263765
-
Structural basis of ligand activation in a cyclic nucleotide regulated potassiumchannel
-
Clayton GM, Silverman WR, Heginbotham L, Morais-Cabral JH (2004) Structural basis of ligand activation in a cyclic nucleotide regulated potassiumchannel. Cell 119(5):615-627.
-
(2004)
Cell
, vol.119
, Issue.5
, pp. 615-627
-
-
Clayton, G.M.1
Silverman, W.R.2
Heginbotham, L.3
Morais-Cabral, J.H.4
-
47
-
-
33645313112
-
CNG and HCN channels: Two peas, one pod
-
Craven KB, Zagotta WN (2006) CNG and HCN channels: Two peas, one pod. Annu Rev Physiol 68:375-401.
-
(2006)
Annu Rev Physiol
, vol.68
, pp. 375-401
-
-
Craven, K.B.1
Zagotta, W.N.2
-
48
-
-
67349260120
-
Convergent evolution of alternative splices at domain boundaries of the BK channel
-
Fodor AA, Aldrich RW (2009) Convergent evolution of alternative splices at domain boundaries of the BK channel. Annu Rev Physiol 71:19-36.
-
(2009)
Annu Rev Physiol
, vol.71
, pp. 19-36
-
-
Fodor, A.A.1
Aldrich, R.W.2
-
49
-
-
34249869012
-
Gating of HCN channels by cyclic nucleotides: Residue contacts that underlie ligand binding, selectivity, and efficacy
-
Zhou L, Siegelbaum SA (2007) Gating of HCN channels by cyclic nucleotides: Residue contacts that underlie ligand binding, selectivity, and efficacy. Structure 15(6):655-670.
-
(2007)
Structure
, vol.15
, Issue.6
, pp. 655-670
-
-
Zhou, L.1
Siegelbaum, S.A.2
-
50
-
-
84856234056
-
Structure of the carboxyterminal region of a KCNH channel
-
Brelidze TI, Carlson AE, Sankaran B, Zagotta WN (2012) Structure of the carboxyterminal region of a KCNH channel. Nature 481(7382):530-533.
-
(2012)
Nature
, vol.481
, Issue.7382
, pp. 530-533
-
-
Brelidze, T.I.1
Carlson, A.E.2
Sankaran, B.3
Zagotta, W.N.4
-
51
-
-
4544271696
-
Protein kinase CK2 is coassembled with small conductance Ca(2+)- activated K+ channels and regulates channel gating
-
Bildl W, et al. (2004) Protein kinase CK2 is coassembled with small conductance Ca(2+)- activated K+ channels and regulates channel gating. Neuron 43(6):847-858.
-
(2004)
Neuron
, vol.43
, Issue.6
, pp. 847-858
-
-
Bildl, W.1
-
52
-
-
48749109072
-
Neurotransmitter modulation of small-conductance Ca2+- activated K+ channels by regulation of Ca2+ gating
-
Maingret F, et al. (2008) Neurotransmitter modulation of small-conductance Ca2+- activated K+ channels by regulation of Ca2+ gating. Neuron 59(3):439-449.
-
(2008)
Neuron
, vol.59
, Issue.3
, pp. 439-449
-
-
Maingret, F.1
-
53
-
-
80051984832
-
Role of Ca2+-sensitive K+ currents in controlling ventricular repolarization: Possible implications for future antiarrhytmic drug therapy
-
Nagy N, et al. (2011) Role of Ca2+-sensitive K+ currents in controlling ventricular repolarization: Possible implications for future antiarrhytmic drug therapy. Curr Med Chem 18(24):3622-3639.
-
(2011)
Curr Med Chem
, vol.18
, Issue.24
, pp. 3622-3639
-
-
Nagy, N.1
|