Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2

Chemistry and Biology

Volumn 19, Issue 10, 2012, Pages 1340-1353

  Kasumu, Adebimpe W ^a   Hougaard, Charlotte ^c   Rode, Frederik ^c   Jacobsen, Thomas A ^c   Sabatier, Jean Marc ^d   Eriksen, Birgitte L ^c   Strobæk, Dorte ^c   Liang, Xia ^a   Egorova, Polina ^b   Vorontsova, Dasha ^b   Christophersen, Palle ^c   Ronn, Lars Christian B ^c,e   Bezprozvanny, Ilya ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b PETER THE GREAT ST PETERSBURG POLYTECHNIC UNIVERSITY   (Russian Federation)

^c NEUROSEARCH A S   (Denmark)

^d AIX MARSEILLE UNIVERSITY   (France)

^e H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 2 BENZIMIDAZOLINONE; 3 OXIME 6,7 DICHLORO 1H INDOLE 2,3 DIONE; 4 CHLOROPHENYL [2 (3,5 DIMETHYLPYRAZOL 1 YL) 9 METHYL 9H PURIN 6 YL] AMINE; CHLORZOXAZONE; CYCLOHEXYL [2 (3,5 DIMETHYLPYRAZOL 1 YL) 6 METHYL PYRIMIDIN 4 YL] AMINE; NAPHTHOL[1,2 D]THIAZOL 2 YLAMINE; NS 13001; NS 309; POTASSIUM CHANNEL BLOCKING AGENT; RILUZOLE; SKA 31; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL TYPE 2; UNCLASSIFIED DRUG;

AGING; ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL ACTIVITY; CEREBELLUM; CONTROLLED STUDY; DRUG EFFECT; DRUG SPECIFICITY; EMBRYO; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PACEMAKER NERVE CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PURKINJE CELL; RAT; SPINOCEREBELLAR ATAXIA TYPE 2; SPINOCEREBELLAR DEGENERATION;

ADENINE; ANIMALS; CALCIUM; CEREBELLUM; DISEASE MODELS, ANIMAL; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; PATCH-CLAMP TECHNIQUES; PURKINJE CELLS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; SPINOCEREBELLAR ATAXIAS;

MUS; MUS MUSCULUS;

EID: 84868015420     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.07.013     Document Type: Article

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