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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 2106-2110

A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors

(10) Atobe, Masakazu a Maekawara, Naomi a Ishiguro, Noriko a Sogame, Shinya a Suenaga, Yoshihito a Kawanishi, Masashi a Suzuki, Hiroko a Jinno, Norimasa a Tanaka, Eiichi a Miyoshi, Shiro a

a ASAHI KASEI PHARMA CORPORATION (Japan)

Author keywords

ADAMTS 5; Non competitive inhibitor; Osteoarthritis; Thiazole; Thiazolidin 4 one

Indexed keywords

1 BENZYL 4 [[4 (4 CHLOROPHENOXY) PHENYL] SULFONYL] N HYDROXYPIPERIDINE 4 CARBOXAMIDE; AGGRECANASE 2; METALLOPROTEINASE INHIBITOR; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL INTERACTION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG SCREENING; HIGH THROUGHPUT SCREENING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADAM PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84875222719 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.01.121 Document Type: Article

Times cited : (13)

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