Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1735-1748

  Imramovský, Aleš ^a   Pejchal, Vladimír ^a   Štěpánková, Šárka ^a   Vorčáková, Katarína ^a   Jampílek, Josef ^b   Vančo, Ján ^b   Šimůnek, Petr ^a   Královec, Karel ^a   Brůčková, Lenka ^a   Mandíková, Jana ^c   Trejtnar, František ^c  

^a UNIVERSITY OF PARDUBICE   (Czech Republic)

^b UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^c Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

6 Fluorobenzo d thiazole; Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase inhibition; In vitro cytotoxicity; Lipophilicity; Molecular docking; Structure activity relationships

Indexed keywords

2 BROMOETHYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL] 2 METHYLPROPYLCARBAMIC ACID; 2 CHLOROETHYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL] 2 METHYLPROPYLCARBAMIC ACID; 2 CHLOROETHYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; 2 SUBSTITUTED 6 FLUOROBENZO[D]THIAZOLE DERIVATIVE; 2,2,2 TRICHLOROETHYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL] 2 METHYLPROPYLCARBAMIC ACID; 2,2,2 TRICHLOROETHYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; 2,2,2 TRIFLUOROETHYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]2 METHYLPROPYLCARBAMIC ACID; 2,2,2 TRIFLUOROETHYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; 2,2,3,3 TETRAFLUOROPROPYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]2 METHYLPROPYLCARBAMIC ACID; 2,2,3,3 TETRAFLUOROPROPYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; 2,2,3,3,4,4,4 HEPTAFLUOROBUTYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]2 METHYLPROPYLCARBAMIC ACID; 2,2,3,3,4,4,4 HEPTAFLUOROBUTYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; ACETYLCHOLINESTERASE; BUTYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL] 2 METHYLPROPYLCARBAMIC ACID; BUTYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; CARBAMIC ACID DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; ETHYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; GALANTAMINE; ISOBUTYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL] 2 METHYLPROPYLCARBAMIC ACID; ISOBUTYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; ISOPROPYL 1 [1 (6 FLUOROBENZO[D]THIAZOL 2 YL)ETHYLCARBAMOYL] 2 METHYLPROPYLCARBAMIC ACID; ISOPROPYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; METHYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; PROPYL 1 [1 (6 FLUOROBENZO[D]THIAZOLE)ETHYLCARBAMOYL]BUTYLCARBAMIC ACID; RIVASTIGMINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; LIVER CELL CARCINOMA; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CARBAMATES; CELL LINE, TUMOR; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; HALOGENATION; HEP G2 CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84875221505     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.052     Document Type: Article

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