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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4839-4843

Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV

(3) Karle, Michael a Knecht, Wolfgang a Xue, Yafeng a

a ASTRAZENECA R AND D (Sweden)

Author keywords

Benzothiazole guanidine; Fragment screening; Thrombin; Trypsin IV; WaterLOGSY

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; GUANIDINE DERIVATIVE; THROMBIN; THROMBIN INHIBITOR; TRYPSIN; TRYPSIN I; TRYPSIN INHIBITOR; TRYPSIN IV; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; HYDROPHOBICITY; LIPOPHILICITY; MEASUREMENT; MOLECULAR DOCKING; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE; PKA; SURFACE PLASMON RESONANCE; WATER LIGAND OBSERVED VIA GRADIENT SPECTROSCOPY;

BENZOTHIAZOLES; GUANIDINE; HYDROGEN BONDING; MODELS, MOLECULAR; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TRYPSIN; TRYPSIN INHIBITORS;

EID: 84863451192 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.05.046 Document Type: Article

Times cited : (24)

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