Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols')

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 19, 2006, Pages 5005-5008

  Lion, Cedric J ^a   Matthews, Charles S ^a   Wells, Geoffrey ^a   Bradshaw, Tracey D ^a   Stevens, Malcolm F G ^a   Westwell, Andrew D ^a,b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Antitumour agents; Fluorinated benzothiazoles; Thioredoxin

Indexed keywords

2 (3,4 DIMETHOXYPHENYL) 5 FLUOROBENZOTHIAZOLE; 2 (4 AMINO 3 METHYLPHENYL)BENZOTHIAZOLE; 4 (BENZOTHIAZOL 2 YL) 4 HYDROXYCYCLOHEXA 2,5 DIENONE; 5 FLUORO 2 (4 LYSYLAMINO 3 METHYLPHENYL)BENZOTHIAZOLE; AJM 290; ANTINEOPLASTIC AGENT; AW 464; BENZOTHIAZOLE DERIVATIVE; GW 610; PMX 464; THIOREDOXIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FLUORINATION; HUMAN; HUMAN CELL; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROQUINONES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXIN;

EID: 33747507687     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.072     Document Type: Article

References (26)

1. Chew E.-H., Matthews C.S., Zhang J., McCarroll A.J., Hagen T., Stevens M.F.G., Westwell A.D., and Bradshaw T.D. Biochem. Biophys. Res. Commun. 346 (2006) 242
2. Böhn H.-J., Banner D., Bendels S., Kansy M., Kuhn B., Müller K., Obst-Sander U., and Stahl M. ChemBioChem 5 (2004) 637
3. Czernin J., Weber W.A., and Herschman J.R. Ann. Rev. Med. 57 (2006) 99
4. Wright D.H., Brown G.H., Peterson M.L., and Rotschafer J.C. J. Antimicrob. Chemother. 46 (2000) 669
5. Bradshaw T.D., and Westwell A.D. Curr. Med. Chem. 11 (2004) 1009
6. Bradshaw T.D., Stevens M.F.G., and Westwell A.D. Curr. Med. Chem. 8 (2001) 203
7. Loaiza-Pérez A.I., Trapani V., Hose C., Singh S.S., Trepel J.B., Stevens M.F.G., Bradshaw T.D., and Sausville E.A. Mol. Pharmacol. 61 (2002) 13
8. Bradshaw T.D., Trapani V., Vasselin D.A., and Westwell A.D. Curr. Pharm. Des. 8 (2002) 2475
9. Chua M.-S., Kashiyama E., Bradshaw T.D., Stinson S.F., Brantley E.A., Sausville E.A., and Stevens M.F.G. Cancer Res. 60 (2000) 5196
10. Kashiyama E., Hutchinson I., Chua M.-S., Stinson S.F., Phillips L.R., Kaur G., Sausville E.A., Bradshaw T.D., Westwell A.D., and Stevens M.F.G. J. Med. Chem. 42 (1999) 4172
11. Hutchinson I., Chua M.-S., Browne H., Trapani V., Fichtner I., Bradshaw T.D., Westwell A.D., and Stevens M.F.G. J. Med. Chem. 44 (2001) 1446
12. Hutchinson I., Jennings S.A., Vishnuvajjala B.R., Westwell A.D., and Stevens M.F.G. J. Med. Chem. 45 (2002) 744
13. Bradshaw T.D., Bibby M.C., Double J.A., Fichtner I., Cooper P.A., Alley M.C., Donohue S., Stinson S.F., Tomaszwejski J.E., and Sausville E.A. Mol. Cancer Ther. 1 (2002) 239
14. Fichtner I., Monks A., Hose C., Stevens M.F.G., and Bradshaw T.D. Breast Cancer Res. Treat. 87 (2004) 97
15. Westwell A.D. Drugs Future 29 (2004) 479
16. Mortimer C.G., Wells G., Crochard J.-P., Stone E.L., Bradshaw T.D., Stevens M.F.G., and Westwell A.D. J. Med. Chem. 49 (2006) 179
17. Wells G., Berry J.M., Bradshaw T.D., Burger A.M., Seaton A., Wang B., Westwell A.D., and Stevens M.F.G. J. Med. Chem. 46 (2003) 532
18. Wells G., Bradshaw T.D., Diana P., Seaton A., Westwell A.D., and Stevens M.F.G. Bioorg. Med. Chem. Lett. 10 (2000) 513
19. Berry J.M., Bradshaw T.D., Fichtner I., Ren R., Schwalbe C.H., Wells G., Chew E.-H., Stevens M.F.G., and Westwell A.D. J. Med. Chem. 48 (2005) 639
20. Wells G., Seaton A., and Stevens M.F.G. J. Med. Chem. 43 (2000) 1550
21. Bradshaw T.D., Matthews C.S., Cookson J., Chew E.-H., Shah M., Bailey K., Monks A., Harris E., Westwell A.D., Wells G., Laughton C.A., and Stevens M.F.G. Cancer Res. 65 (2005) 3911
22. Mukherjee A., Bradshaw T.D., Westwell A.D., Stevens M.F.G., Carmichael J., and Martin S.G. Brit. J. Cancer 92 (2005) 350
23. ++1).
24. Gromer S., Urig S., and Becker K. Med. Res. Rev. 24 (2004) 40
25. Kirkpatrick D.L., Kuperus M., Dowdeswell M., Potier N., Donald L.J., Kunkel M., Berggren M., Angulo M., and Powis G. Biochem. Pharmacol. 55 (1998) 987
26. Brown G.D., Wilson H.K., Westwell A.D., Hutchinson I., Stevens M.F.G., Price P.M., Aboagye E., Luthra S.K., and Brady F. J. Labelled Compd. Radiopharm. 44 Suppl. 1 (2001) S374