Mast cells and vascular diseases

Pharmacology and Therapeutics

Volumn 138, Issue 1, 2013, Pages 53-65

  Kennedy, Simon ^a   Wu, Junxi ^b   Wadsworth, Roger M ^b   Lawrence, Catherine E ^b   Maffia, Pasquale ^a,c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Aneurysm; Atherosclerosis; Keywords; Mast cell; Restenosis; Vascular remodeling; Vein graft

Indexed keywords

CHEMOKINE RECEPTOR CXCR5; GAMMA INTERFERON; HUMAN GROWTH HORMONE; IMATINIB; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 8; KETOTIFEN; LEUKOTRIENE B4; MASITINIB; NEDOCROMIL; NERVE GROWTH FACTOR; NEUROTENSIN; PROSTAGLANDIN D2; PROTEOGLYCAN; RUPATADINE; TRANILAST; VASCULAR CELL ADHESION MOLECULE 1;

ABDOMINAL AORTA ANEURYSM; ADAPTIVE IMMUNITY; ALLERGIC CONJUNCTIVITIS; ANEURYSM; APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD VESSEL PERMEABILITY; CARDIOVASCULAR DISEASE; CELL PROLIFERATION; CORONARY ARTERY DISEASE; DRUG ELUTING STENT; GRAFT PATENCY; HUMAN; HYPER IGE SYNDROME; HYPERPLASIA; IN VITRO STUDY; ISCHEMIC HEART DISEASE; KOUNIS SYNDROME; MAST CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RESTENOSIS; REVASCULARIZATION; REVIEW; RHINITIS; SUBARACHNOID HEMORRHAGE; THORACIC AORTA ANEURYSM; TRANSLUMINAL CORONARY ANGIOPLASTY; VASCULAR DISEASE; VASCULITIS; VEIN GRAFT DISEASE;

ANIMALS; HUMANS; HYPERPLASIA; MAST CELLS; TISSUE TRANSPLANTATION; VASCULAR DISEASES; VEINS;

EID: 84875215094     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.01.001     Document Type: Review

References (180)

1. S.N. Abraham, and A.L. St John Mast cell-orchestrated immunity to pathogens Nat Rev Immunol 10 2010 440 452
2. K.J. Aichberger, S. Herndlhofer, G.H. Schernthaner, M. Schillinger, G. Mitterbauer-Hohendanner, and C. Sillaber Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML Am J Hematol 86 2011 533 539
3. M.M. Amaral, C. Davio, A. Ceballos, G. Salamone, C. Cañones, and J. Geffner Histamine improves antigen uptake and cross-presentation by dendritic cells J Immunol 179 2007 3425 3433
4. M.S. Anvari, M.A. Boroumand, E. Ameli Mojarad, A. Karimi, K. Abbasi, and M. Shirzad Do adventitial mast cells contribute to the pathogenesis of ascending thoracic aorta aneurysm? Int J Surg Pathol 20 2012 474 479
5. J.B. Atkinson, C.W. Harlan, G.C. Harlan, and R. Virmani The association of mast cells and atherosclerosis: a morphologic study of early atherosclerotic lesions in young people Hum Pathol 25 1994 154 159
6. I. Bachelet, and F. Levi-Schaffer Mast cells as effector cells: a co-stimulating question Trends Immunol 28 2007 360 365
7. L. Badimon, R.F. Storey, and G. Vilahur Update on lipids, inflammation and atherothrombosis Thromb Haemost 105 Suppl. 1 2011 S34 S42
8. R. Bafford, X.X. Sui, G. Wang, and M. Conte Angiotensin II and tumor necrosis factor-alpha upregulate survivin and Kruppel-like factor 5 in smooth muscle cells: potential relevance to vein graft hyperplasia Surgery 140 2006 289 296
9. M.L. Ballinger, N. Osman, K. Hashimura, J.B. de Haan, K. Jandeleit-Dahm, and T. Allen Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo J Cell Mol Med 14 2010 1408 1418
10. B. Bartelds, R.L. van Loon, S. Mohaupt, H. Wijnberg, M.G. Dickinson, and B. Boersma Mast cell inhibition improves pulmonary vascular remodeling in pulmonary hypertension Chest 141 2012 651 660
11. L. Bell, and J.A. Madri Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells Circ Res 65 1989 1057 1065
12. I. Bot, and E.A. Biessen Mast cells in atherosclerosis Thromb Haemost 106 2011 820 826
13. -/- mice Cardiovasc Res 89 2011 244 252
14. I. Bot, S.C. de Jager, M. Bot, S.H. van Heiningen, P. de Groot, and R.W. Veldhuizen The neuropeptide substance P mediates adventitial mast cell activation and induces intraplaque hemorrhage in advanced atherosclerosis Circ Res 106 2010 89 92
15. I. Bot, S.C. de Jager, A. Zernecke, K.A. Lindstedt, T.J. van Berkel, and C. Weber Perivascular mast cells promote atherogenesis and induce plaque destabilization in apolipoprotein E-deficient mice Circulation 115 2007 2516 2525
16. G.L. Brower, and J.S. Janicki Pharmacologic inhibition of mast cell degranulation prevents left ventricular remodeling induced by chronic volume overload in rats J Card Fail 11 2005 548 556
17. G. Caron, Y. Delneste, E. Roelandts, C. Duez, N. Herbault, and G. Magistrelli Histamine induces CD86 expression and chemokine production by human immature dendritic cells J Immunol 166 2001 6000 6006
18. M.O. Chandesris, A. Azarine, K.T. Ong, S. Taleb, P. Boutouyrie, and E. Mousseaux Frequent and widespread vascular abnormalities in human signal transducer and activator of transcription 3 deficiency Circ Cardiovasc Genet 5 2012 25 34
19. D. Chatterjea, A. Wetzel, M. Mack, C. Engblom, J. Allen, and C. Mora-Solano Mast cell degranulation mediates compound 48/80-induced hyperalgesia in mice Biochem Biophys Res Commun 425 2012 237 243
20. C.W. Choi, D.H. Kang, G.H. Kim, J.S. Eum, S.M. Lee, and G.A. Song Nafamostat mesylate in the prevention of post-ERCP pancreatitis and risk factors for post-ERCP pancreatitis Gastrointest Endosc 69 2009 e11 e18
21. S.J. Collington, T.J. Williams, and C.L. Weller Mechanisms underlying the localisation of mast cells in tissues Trends Immunol 32 2011 478 485
22. P. Conti, X. Pang, W. Boucher, R. Letourneau, M. Reale, and R.C. Barbacane Impact of Rantes and MCP-1 chemokines on in vivo basophilic cell recruitment in rat skin injection model and their role in modifying the protein and mRNA levels for histidine decarboxylase Blood 89 1997 4120 4127
23. K.S. Cross, M.N. el-Sanadiki, J.J. Murray, E.M. Mikat, R.L. McCann, and P.O. Hagen Mast cell infiltration: a possible mechanism for vein graft vasospasm Surgery 104 1988 171 177
24. A. Curcio, D. Torella, and C. Indolfi Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy Circ J 75 2011 1287 1296
25. H. Dai, and R.J. Korthuis Mast cell proteases and inflammation Drug Discov Today Dis Models 8 2011 47 55
26. M.R. de Vries, A. Wezel, A. Schepers, P.J. van Santbrink, T.M. Woodruff, and H.W. Niessen Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease Cardiovasc Res 97 2013, Nov 6 311 320
27. W.K. den Dekker, D. Tempel, I. Bot, E.A. Biessen, L.A. Joosten, and M.G. Netea Mast cells induce vascular smooth muscle cell apoptosis via a toll-like receptor 4 activation pathway Arterioscler Thromb Vasc Biol 32 2012 1960 1969
28. A. Di Gennaro, D. Wågsäter, M.I. Mäyränpää , A. Gabrielsen, J. Swedenborg, and A. Hamsten Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm Proc Natl Acad Sci U S A 107 2010 21093 21097
29. S.A. Doggrell, and J.C. Wanstall Vascular chymase: pathophysiological role and therapeutic potential of inhibition Cardiovasc Res 61 2004 653 662
30. J.S. Douglas Jr. Pharmacologic approaches to restenosis prevention Am J Cardiol 100 2007 S10 S16
31. P. Dubreuil, S. Letard, M. Ciufolini, L. Gros, M. Humbert, and N. Castéran Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT PLoS One 4 2009 e7258
32. A. Dudeck, J. Dudeck, J. Scholten, A. Petzold, S. Surianarayanan, and A. Köhler Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens Immunity 34 2011 973 984
33. A. Dudeck, M. Leist, S. Rubant, A. Zimmermann, J. Dudeck, and W.H. Boehncke Immature mast cells exhibit rolling and adhesion to endothelial cells and subsequent diapedesis triggered by E- and P-selectin, VCAM-1 and PECAM-1 Exp Dermatol 19 2010 424 434
34. J. Ejiri, N. Inoue, T. Tsukube, T. Munezane, Y. Hino, and S. Kobayashi Oxidative stress in the pathogenesis of thoracic aortic aneurysm: protective role of statin and angiotensin II type 1 receptor blocker Cardiovasc Res 59 2003 988 996
35. D.S. El-Agamy Targeting c-kit in the therapy of mast cell disorders: current update Eur J Pharmacol 690 2012 1 3
36. O. Erdogan, C. Gul, A. Altun, and G. Ozbay Increased immunoglobulin E response in acute coronary syndromes Angiology 54 2003 73 79
37. L.C. Faleiro, C.R. Machado, A. Gripp Jr., R.A. Resende, and P.A. Rodrigues Cerebral vasospasm: presence of mast cells in human cerebral arteries after aneurysm rupture J Neurosurg 54 1981 733 735
38. Y.I. Fang, H. Namiki, E. Tsunoda, S. Shioda, M. Shibata, and M. Nakatani Marked increase in the histamine content of neointima after stent implantation of pig coronary artery and growth-promoting effects of histamine in cultured smooth muscle cells Life Sci 77 2005 241 251
39. T.B. Feyerabend, A. Weiser, A. Tietz, M. Stassen, N. Harris, and M. Kopf Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity Immunity 35 2011 832 844
40. A.F. Freeman, E.M. Avila, P.A. Shaw, J. Davis, A.P. Hsu, and P. Welch Coronary artery abnormalities in Hyper-IgE syndrome J Clin Immunol 31 2011 338 345
41. D.S. Friend, N. Ghildyal, K.F. Austen, M.F. Gurish, R. Matsumoto, and R.L. Stevens Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype J Cell Biol 135 1996 279 290
42. D.S. Friend, N. Ghildyal, M.F. Gurish, J. Hunt, X. Hu, and K.F. Austen Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis J Immunol 160 1998 5537 5545
43. H. Fujita, R. Sakuma, S. Fujimoto, Y. Hazama, C. Ohtake, and A. Moriyama Nafamostat mesilate, a noncalcium compound, as an anticoagulant, induces calcium-dependent haemolysis when infused with packed erythrocytes Transfus Med 22 2012 186 191
44. G.J. Fulton, M.G. Davies, L. Barber, E. Svendsen, and P.O. Hagen Localized versus systemic angiotensin II receptor inhibition of intimal hyperplasia in experimental vein grafts by the specific angiotensin II receptor inhibitor L158,809 Surgery 123 1998 218 227
45. C.D. Funk, R.Y. Cao, L. Zhao, and A.J. Habenicht Is there a role for the macrophage 5-lipoxygenase pathway in aortic aneurysm development in apolipoprotein E-deficient mice? Ann N Y Acad Sci 1085 2006 151 160
46. E. Galkina, and K. Ley Immune and inflammatory mechanisms of atherosclerosis Annu Rev Immunol 27 2009 165 197
47. S.J. Galli, and Y. Kitamura Genetically mast-cell-deficient W/Wv and Sl/Sld mice. Their value for the analysis of the roles of mast cells in biologic responses in vivo Am J Pathol 127 1987 191 198
48. S.J. Galli, and M. Tsai IgE and mast cells in allergic disease Nat Med 18 2012 693 704
49. S.J. Galli, M. Tsai, and A.M. Piliponsky The development of allergic inflammation Nature 454 2008 445 454
50. N. Ghildyal, H.P. McNeil, M.F. Gurish, K.F. Austen, and R.L. Stevens Transcriptional regulation of the mucosal mast cell-specific protease gene, MMCP-2, by interleukin 10 and interleukin 3 J Biol Chem 267 1992 8473 8477
51. A.M. Gilfillan, and M.A. Beaven Regulation of mast cell responses in health and disease Crit Rev Immunol 31 2011 475 529
52. J. Gong, N.S. Yang, M. Croft, I.C. Weng, L. Sun, and F.T. Liu The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcepsilonRI and MHC II BMC Immunol 11 2010 34
53. K.K. Griendling, C.A. Minieri, J.D. Ollerenshaw, and R.W. Alexander Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells Circ Res 74 1994 1141 1148
54. M.A. Grimbaldeston, C.C. Chen, A.M. Piliponsky, M. Tsai, S.Y. Tam, and S.J. Galli Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo Am J Pathol 167 2005 835 848
55. A. Grützkau, S. Krüger-Krasagakes, H. Baumeister, C. Schwarz, H. Kögel, and P. Welker Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206 Mol Biol Cell 9 1998 875 884
56. T. Guo, W.Q. Chen, C. Zhang, Y.X. Zhao, and Y. Zhang Chymase activity is closely related with plaque vulnerability in a hamster model of atherosclerosis Atherosclerosis 207 2009 59 67
57. M.F. Gurish, and K.F. Austen Developmental origin and functional specialization of mast cell subsets Immunity 37 2012 25 33
58. D.R. Holmes Jr., M. Savage, J.M. LaBlanche, L. Grip, P.W. Serruys, and P. Fitzgerald Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial Circulation 106 2002 1243 1250
59. T.R. Hundley, A.M. Gilfillan, C. Tkaczyk, M.V. Andrade, D.D. Metcalfe, and M.A. Beaven Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells Blood 104 2004 2410 2417
60. A. Ialenti, G. Grassia, P. Gordon, M. Maddaluno, M.V. Di Lauro, and A.H. Baker Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries Arterioscler Thromb Vasc Biol 31 2011 2448 2454
61. M.X. Ierna, H.E. Scales, K.L. Saunders, and C.E. Lawrence Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection Mucosal Immunol 1 2008 147 155
62. M. Ihara, H. Urata, A. Kinoshita, J. Suzumiya, M. Sasaguri, and M. Kikuchi Increased chymase-dependent angiotensin II formation in human atherosclerotic aorta Hypertension 33 1999 1399 1405
63. N. Inoue, M. Muramatsu, D. Jin, S. Takai, T. Hayashi, and H. Katayama Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice Atherosclerosis 204 2009 359 364
64. M. Ishizaki, H. Tanaka, D. Kajiwara, T. Toyohara, K. Wakahara, and N. Inagaki Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma J Pharmacol Sci 108 2008 355 363
65. M. Jeziorska, C. McCollum, and D.E. Woolley Mast cell distribution, activation, and phenotype in atherosclerotic lesions of human carotid arteries J Pathol 182 1997 115 122
66. D. Jin, H. Ueda, S. Takai, M. Muramatsu, K. Furubayashi, and T. Ibaraki Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations Life Sci 81 2007 1291 1300
67. D. Jin, H. Ueda, S. Takai, Y. Okamoto, M. Muramatsu, and M. Sakaguchi Effect of chymase inhibition on the arteriovenous fistula stenosis in dogs J Am Soc Nephrol 16 2005 1024 1034
68. J.L. Johnson, C.L. Jackson, G.D. Angelini, and S.J. George Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques Arterioscler Thromb Vasc Biol 18 1998 1707 1715
69. M. Kaartinen, A. Penttilä, and P.T. Kovanen Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture Circulation 90 1994 1669 1678
70. A.M. Kabir, A. Selvarajah, and A.M. Seifalian How safe and how good are drug-eluting stents? Future Cardiol 7 2011 251 270
71. E. Kaschina, H. Scholz, U.M. Steckelings, M. Sommerfeld, U.R. Kemnitz, and M. Artuc Transition from atherosclerosis to aortic aneurysm in humans coincides with an increased expression of RAS components Atherosclerosis 205 2009 396 403
72. A. Kastrati, A. Schömig, S. Elezi, H. Schühlen, J. Dirschinger, and M. Hadamitzky Predictive factors of restenosis after coronary stent placement J Am Coll Cardiol 30 1997 1428 1436
73. T. Kawakami, and S.J. Galli Regulation of mast-cell and basophil function and survival by IgE Nat Rev Immunol 2 2002 773 786
74. M.S. Kim, and L.S. Dean In-stent restenosis Cardiovasc Ther 29 2011 190 198
75. M. Kinoshita, M. Okada, M. Hara, Y. Furukawa, and A. Matsumori Mast cell tryptase in mast cell granules enhances MCP-1 and interleukin-8 production in human endothelial cells Arterioscler Thromb Vasc Biol 25 2005 1858 1863
76. A. Kinoshita, H. Urata, F.M. Bumpus, and A. Husain Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart J Biol Chem 266 1991 19192 19197
77. K. Kishi, M. Muramatsu, D. Jin, K. Furubayashi, S. Takai, and H. Tamai The effects of chymase on matrix metalloproteinase-2 activation in neointimal hyperplasia after balloon injury in dogs Hypertens Res 30 2007 77 83
78. P.A. Knight, S.H. Wright, C.E. Lawrence, Y.Y. Paterson, and H.R. Miller Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1 J Exp Med 192 2000 1849 1856
79. H. Komatsu, M. Kojima, N. Tsutsumi, S. Hamano, H. Kusama, and A. Ujiie Study of the mechanism of inhibitory action of tranilast on chemical mediator release Jpn J Pharmacol 46 1988 43 51
80. N.G. Kounis, G. Hahalis, and T.C. Theoharides Coronary stents, hypersensitivity reactions, and the Kounis syndrome J Interv Cardiol 20 2007 314 323
81. N.G. Kounis, A. Mazarakis, G. Tsigkas, S. Giannopoulos, and J. Goudevenos Kounis syndrome: a new twist on an old disease Future Cardiol 7 2011 805 824
82. P.T. Kovanen Mast cells: multipotent local effector cells in atherothrombosis Immunol Rev 217 2007 105 122
83. P.T. Kovanen, M. Kaartinen, and T. Paavonen Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction Circulation 92 1995 1084 1088
84. P. Laine, M. Kaartinen, A. Penttilä, P. Panula, T. Paavonen, and P.T. Kovanen Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery Circulation 99 1999 361 369
85. H. Lappalainen, P. Laine, M.O. Pentikäinen, A. Sajantila, and P.T. Kovanen Mast cells in neovascularized human coronary plaques store and secrete basic fibroblast growth factor, a potent angiogenic mediator Arterioscler Thromb Vasc Biol 24 2004 1880 1885
86. J. Lappalainen, K.A. Lindstedt, R. Oksjoki, and P.T. Kovanen OxLDL-IgG immune complexes induce expression and secretion of proatherogenic cytokines by cultured human mast cells Atherosclerosis 214 2011 357 363
87. C. Larroche, M.L. Chadenat, M.P. Chaunu, S. Abad, P. Casassus, and R. Dhôte Strokes associated with cervical artery dissection, and systemic mastocytosis: an unfortuitous association? A report of two cases Rev Med Interne 26 2005 820 823
88. M. Lassila, T.J. Allen, Z. Cao, V. Thallas, K.A. Jandeleit-Dahm, and R. Candido Imatinib attenuates diabetes-associated atherosclerosis Arterioscler Thromb Vasc Biol 24 2004 935 942
89. C.E. Lawrence, Y.Y. Paterson, S.H. Wright, P.A. Knight, and H.R. Miller Mouse mast cell protease-1 is required for the enteropathy induced by gastrointestinal helminth infection in the mouse Gastroenterology 127 2004 155 165
90. M. Lee, L. Calabresi, G. Chiesa, G. Franceschini, and P.T. Kovanen Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux Arterioscler Thromb Vasc Biol 22 2002 1475 1481
91. M. Lee-Rueckert, and P.T. Kovanen Mast cell proteases: physiological tools to study functional significance of high density lipoproteins in the initiation of reverse cholesterol transport Atherosclerosis 189 2006 8 18
92. O. Leppänen, J. Rutanen, M.O. Hiltunen, T.T. Rissanen, M.P. Turunen, and T. Sjöblom Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits Circulation 109 2004 1140 1146
93. M.J. Leskinen, P.T. Kovanen, and K.A. Lindstedt Regulation of smooth muscle cell growth, function and death in vitro by activated mast cells - a potential mechanism for the weakening and rupture of atherosclerotic plaques Biochem Pharmacol 66 2003 1493 1498
94. M. Li, K. Liu, J. Michalicek, J.A. Angus, J.E. Hunt, and L.J. Dell'Italia Involvement of chymase-mediated angiotensin II generation in blood pressure regulation J Clin Invest 114 2004 112 120
95. J.N. Lilla, C.C. Chen, K. Mukai, M.J. BenBarak, C.B. Franco, and J. Kalesnikoff Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice Blood 118 2011 6930 6938
96. K.A. Lindstedt, and P.T. Kovanen Proteolysis of pericellular matrix: a process linking inflammation to plaque destabilization and rupture Arterioscler Thromb Vasc Biol 24 2004 2205 2206
97. K.A. Lindstedt, M.I. Mäyränpää, and P.T. Kovanen Mast cells in vulnerable atherosclerotic plaques - a view to a kill J Cell Mol Med 11 2007 739 758
98. S.Q. Liu Focal expression of angiotensin II type 1 receptor and smooth muscle cell proliferation in the neointima of experimental vein grafts: relation to eddy blood flow Arterioscler Thromb Vasc Biol 19 1999 2630 2639
99. N. Macritchie, G. Grassia, S.R. Sabir, M. Maddaluno, P. Welsh, and N. Sattar Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice Arterioscler Thromb Vasc Biol 32 2012 2569 2579
100. P. Maffia, B.H. Zinselmeyer, A. Ialenti, S. Kennedy, A.H. Baker, and I.B. McInnes Images in cardiovascular medicine. Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery Circulation 115 2007 e326 e328
101. L. Magnol, M.C. Chevallier, V. Nalesso, S. Retif, H. Fuchs, and M. Klempt KIT is required for hepatic function during mouse post-natal development BMC Dev Biol 7 2007 81
102. S. Masuda, K. Nakano, K. Funakoshi, G. Zhao, W. Meng, and S. Kimura Imatinib mesylate-incorporated nanoparticle-eluting stent attenuates in-stent neointimal formation in porcine coronary arteries J Atheroscler Thromb 18 2011 1043 1053
103. M. Maurer, J. Wedemeyer, M. Metz, A.M. Piliponsky, K. Weller, and D. Chatterjea Mast cells promote homeostasis by limiting endothelin-1-induced toxicity Nature 432 2004 512 516
104. M.I. Mäyränpää, J.A. Trosien, V. Fontaine, M. Folkesson, M. Kazi, and P. Eriksson Mast cells associate with neovessels in the media and adventitia of abdominal aortic aneurysms J Vasc Surg 50 2009 388 395
105. G.C. Meléndez, J. Li, B.A. Law, J.S. Janicki, S.C. Supowit, and S.P. Levick Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells Cardiovasc Res 92 2011 420 429
106. M.C. Meyer, M.H. Creer, and J. McHowat Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium Am J Physiol Cell Physiol 289 2005 C1485 C1491
107. M. Miyazaki, N. Shiota, H. Sakonjo, and S. Takai Angiotensin II type 1 receptor antagonist, TCV-116, prevents neointima formation in injured arteries in the dog Jpn J Pharmacol 79 1999 455 460
108. M. Miyazaki, S. Takai, D. Jin, and M. Muramatsu Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models Pharmacol Ther 112 2006 668 676
109. N. Miyazawa, S. Watanabe, A. Matsuda, K. Kondo, H. Hashimoto, and K. Umemura Role of histamine H1 and H2 receptor antagonists in the prevention of intimal thickening Eur J Pharmacol 362 1998 53 59
110. D. Montani, F. Perros, N. Gambaryan, B. Girerd, P. Dorfmuller, and L.C. Price C-kit-positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 184 2011 116 123
111. D.S. Moura, S. Sultan, S. Georgin-Lavialle, N. Pillet, F. Montestruc, and P. Gineste Depression in patients with mastocytosis: prevalence, features and effects of masitinib therapy PLoS One 6 2011 e26375
112. D.B. Murray, J.D. Gardner, G.L. Brower, and J.S. Janicki Endothelin-1 mediates cardiac mast cell degranulation, matrix metalloproteinase activation, and myocardial remodeling in rats Am J Physiol Heart Circ Physiol 287 2004 H2295 H2299
113. N. Nakano, C. Nishiyama, S. Kanada, Y. Niwa, N. Shimokawa, and H. Ushio Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections Blood 109 2007 4846 4855
114. T. Nakano, T. Sonoda, C. Hayashi, A. Yamatodani, Y. Kanayama, and T. Yamamura Pillars article: fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient w/wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells J Immunol 183 2009 6863 6881
115. P.A. Nigrovic, D.H. Gray, T. Jones, J. Hallgren, F.C. Kuo, and B. Chaletzky Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy Am J Pathol 173 2008 1693 1701
116. M. Nishimoto, S. Takai, H. Fukumoto, K. Tsunemi, A. Yuda, and Y. Sawada Increased local angiotensin II formation in aneurysmal aorta Life Sci 71 2002 2195 2205
117. M. Nishimoto, S. Takai, S. Kim, D. Jin, A. Yuda, and M. Sakaguchi Significance of chymase-dependent angiotensin II-forming pathway in the development of vascular proliferation Circulation 104 2001 1274 1279
118. K. Nocka, J.C. Tan, E. Chiu, T.Y. Chu, P. Ray, and P. Traktman Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W EMBO J 9 1990 1805 1813
119. H. Ohsawa, H. Noike, M. Kanai, M. Yoshinuma, K. Mineoka, and T. Hitsumoto Preventive effects of an antiallergic drug, pemirolast potassium, on restenosis after percutaneous transluminal coronary angioplasty Am Heart J 136 1998 1081 1087
120. A. Oksaharju, J. Lappalainen, A.M. Tuomainen, P.J. Pussinen, M. Puolakkainen, and P.T. Kovanen Pro-atherogenic lung and oral pathogens induce an inflammatory response in human and mouse mast cells J Cell Mol Med 13 2009 103 113
121. J.R. Ortlepp, U. Janssens, F. Bleckmann, J. Lauscher, S. Merkelbach-Bruse, and P. Hanrath A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts Coron Artery Dis 12 2001 493 497
122. M.J. Osgood, D.G. Harrison, K.W. Sexton, K.M. Hocking, I.V. Voskresensky, and P. Komalavilas Role of the renin-angiotensin system in the pathogenesis of intimal hyperplasia: therapeutic potential for prevention of vein graft failure? Ann Vasc Surg 26 2012 1130 1144
123. A. Otsuka, M. Kubo, T. Honda, G. Egawa, S. Nakajima, and H. Tanizaki Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity PLoS One 6 2011 e25538
124. T. Palmerini, G. Biondi-Zoccai, D. Della Riva, C. Stettler, D. Sangiorgi, and F. D'Ascenzo Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis Lancet 379 2012 1393 1402
125. C. Paul, B. Sans, F. Suarez, P. Casassus, S. Barete, and F. Lanternier Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: a phase 2a study Am J Hematol 85 2010 921 925
126. H.D. Pettigrew, S.S. Teuber, J.S. Kong, and M.E. Gershwin Contemporary challenges in mastocytosis Clin Rev Allergy Immunol 38 2010 125 134
127. L. Pfoch, V. Mahler, and M. Sticherling Drug-eluting coronary stents: hypersensitivity reactions to paclitaxel. A case report Dermatology 218 2009 52 55
128. A.M. Piliponsky, C.C. Chen, E.J. Rios, P.M. Treuting, A. Lahiri, and M. Abrink The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis Am J Pathol 181 2012 875 886
129. R. Ramachandran, F. Noorbakhsh, K. Defea, and M.D. Hollenberg Targeting proteinase-activated receptors: therapeutic potential and challenges Nat Rev Drug Discov 11 2012 69 86
130. L.S. Ramalho, L.F. Oliveira, C.L. Cavellani, M.L. Ferraz, F.A. de Oliveira, and R.R. Miranda Corrêa Role of mast cell chymase and tryptase in the progression of atherosclerosis: study in 44 autopsied cases Ann Diagn Pathol 17 2012 28 31
131. P. Rastogi, M.C. White, A. Rickard, and J. McHowat Potential mechanism for recruitment and migration of CD133 positive cells to areas of vascular inflammation Thromb Res 123 2008 258 266
132. L.L. Reber, T. Marichal, and S.J. Galli New models for analyzing mast cell functions in vivo Trends Immunol 33 2012 613 625
133. H.R. Rodewald, and T.B. Feyerabend Widespread immunological functions of mast cells: fact or fiction? Immunity 37 2012 13 24
134. I. Rozenberg, S.H. Sluka, L. Rohrer, J. Hofmann, B. Becher, and A. Akhmedov Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins Arterioscler Thromb Vasc Biol 30 2010 923 930
135. S.S. Saini, A.D. Klion, S.M. Holland, R.G. Hamilton, B.S. Bochner, and D.W. Macglashan Jr. The relationship between serum IgE and surface levels of FcepsilonR on human leukocytes in various diseases: correlation of expression with FcepsilonRI on basophils but not on monocytes or eosinophils J Allergy Clin Immunol 106 2000 514 520
136. R. Saluja, I. Delin, G.P. Nilsson, and M. Adner FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment PLoS One 7 2012 e43547
137. Y. Sasaguri, and A. Tanimoto Role of macrophage-derived histamine in atherosclerosis - chronic participation in the inflammatory response J Atheroscler Thromb 11 2004 122 130
138. M. Sata, A. Saiura, A. Kunisato, A. Tojo, S. Okada, and T. Tokuhisa Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis Nat Med 8 2002 403 409
139. M. Sawada, H. Yanamoto, I. Nagata, N. Hashimoto, I. Nakahara, and Y. Akiyama Prevention of neointimal formation by a serine protease inhibitor, FUT-175, after carotid balloon injury in rats Stroke 30 1999 644 650
140. M. Sawaguchi, S. Tanaka, Y. Nakatani, Y. Harada, K. Mukai, and Y. Matsunaga Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness J Immunol 188 2012 1809 1818
141. L.M. Sevigny, K.M. Austin, P. Zhang, S. Kasuda, G. Koukos, and S. Sharifi Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia Arterioscler Thromb Vasc Biol 31 2011 e100 e106
142. G.P. Shi, and J.S. Lindholt Mast Cells in Abdominal Aortic Aneurysms Curr Vasc Pharmacol 2012, Jun 22 PubMed PMID: 22724485. (Epub ahead of print)
143. N. Shiota, H. Okunishi, S. Takai, I. Mikoshiba, H. Sakonjo, and N. Shibata Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery Circulation 99 1999 1084 1090
144. I.M. Singh, and D.R. Holmes Jr. Myocardial revascularization by percutaneous coronary intervention: past, present, and the future Curr Probl Cardiol 36 2011 375 401
145. D.D. Smith, X. Tan, V.V. Raveendran, O. Tawfik, D.J. Stechschulte, and K.N. Dileepan Mast cell deficiency attenuates progression of atherosclerosis and hepatic steatosis in apolipoprotein E-null mice Am J Physiol Heart Circ Physiol 302 2012 H2612 H2621
146. K.J. Sowerwine, S.M. Holland, and A.F. Freeman Hyper-IgE syndrome update Ann N Y Acad Sci 1250 2012 25 32
147. J. Sun, G.K. Sukhova, P.J. Wolters, M. Yang, S. Kitamoto, and P. Libby Mast cells promote atherosclerosis by releasing proinflammatory cytokines Nat Med 13 2007 719 724
148. J. Sun, G.K. Sukhova, M. Yang, P.J. Wolters, L.A. MacFarlane, and P. Libby Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice J Clin Invest 117 2007 3359 3368
149. J. Sun, J. Zhang, J.S. Lindholt, G.K. Sukhova, J. Liu, and A. He Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation Circulation 120 2009 973 982
150. J. Swedenborg, M.I. Mäyränpää, and P.T. Kovanen Mast cells: important players in the orchestrated pathogenesis of abdominal aortic aneurysms Arterioscler Thromb Vasc Biol 31 2011 734 740
151. A. Takahashi, T. Taniguchi, Y. Ishikawa, and M. Yokoyama Tranilast inhibits vascular smooth muscle cell growth and intimal hyperplasia by induction of p21(waf1/cip1/sdi1) and p53 Circ Res 84 1999 543 550
152. S. Takai, and M. Miyazaki Effect of chymase inhibitor on vascular proliferation Jpn J Pharmacol 90 2002 223 227
153. S. Takai, and M. Miyazaki Application of a chymase inhibitor, NK3201, for prevention of vascular proliferation Cardiovasc Drug Rev 21 2003 185 198
154. G.M. Tennant, R.M. Wadsworth, and S. Kennedy PAR-2 mediates increased inflammatory cell adhesion and neointima formation following vascular injury in the mouse Atherosclerosis 198 2008 57 64
155. T.C. Theoharides, K.D. Alysandratos, A. Angelidou, D.A. Delivanis, N. Sismanopoulos, and B. Zhang Mast cells and inflammation Biochim Biophys Acta 1822 2012 21 33
156. T.C. Theoharides, N. Sismanopoulos, D.A. Delivanis, B. Zhang, E.E. Hatziagelaki, and D. Kalogeromitros Mast cells squeeze the heart and stretch the gird: their role in atherosclerosis and obesity Trends Pharmacol Sci 32 2011 534 542
157. N.M. Tigerstedt, E. Aavik, S. Lehti, P. Hayry, and H. Savolainen-Peltonen Mechanisms behind the synergistic effect of sirolimus and imatinib in preventing restenosis after intimal injury J Vasc Res 46 2009 240 252
158. B. Tom, I.M. Garrelds, E. Scalbert, A.P. Stegmann, F. Boomsma, and P.R. Saxena ACE-versus chymase-dependent angiotensin II generation in human coronary arteries: a matter of efficiency? Arterioscler Thromb Vasc Biol 23 2003 251 256
159. H. Toru, M. Eguchi, R. Matsumoto, M. Yanagida, J. Yata, and T. Nakahata Interleukin-4 promotes the development of tryptase and chymase double-positive human mast cells accompanied by cell maturation Blood 91 1998 187 195
160. T. Tsuruda, J. Kato, K. Hatakeyama, A. Yamashita, K. Nakamura, and T. Imamura Adrenomedullin in mast cells of abdominal aortic aneurysm Cardiovasc Res 70 2006 158 164
161. Y. Uehara, H. Urata, M. Ideishi, K. Arakawa, and K. Saku Chymase inhibition suppresses high-cholesterol diet-induced lipid accumulation in the hamster aorta Cardiovasc Res 55 2002 870 876
162. M. Vasiadi, D. Kalogeromitros, D. Kempuraj, A. Clemons, B. Zhang, and C. Chliva Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli Int Arch Allergy Immunol 151 2010 38 45
163. K.M. Vural, M.C. Oz, H. Liao, H.F. Batirel, and D.J. Pinsky Membrane stabilization in harvested vein graft storage: effects on adhesion molecule expression and nitric oxide synthesis Eur J Cardiothorac Surg 16 1999 150 155
164. D. Wågsäter, D. Johansson, V. Fontaine, E. Vorkapic, A. Bäcklund, and A. Razuvaev Serine protease inhibitor A3 in atherosclerosis and aneurysm disease Int J Mol Med 30 2012 288 294
165. D.S. Walia, M. Sharma, V.V. Raveendran, J. Zhou, R. Sharma, and D.J. Stechschulte Human mast cells (HMC-1 5C6) enhance interleukin-6 production by quiescent and lipopolysaccharide-stimulated human coronary artery endothelial cells Mediators Inflamm 2012 2012 274347
166. -/- mice J Clin Invest 121 2011 3564 3577
167. J. Wang, and G.P. Shi Mast cell stabilization: novel medication for obesity and diabetes Diabetes Metab Res Rev 27 2011 919 924
168. Y. Wang, and G.P. Shi Mast cell chymase and tryptase in abdominal aortic aneurysm formation Trends Cardiovasc Med 22 2012 150 155
169. K.Y. Wang, A. Tanimoto, X. Guo, S. Yamada, S. Shimajiri, and Y. Murata Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level Arterioscler Thromb Vasc Biol 31 2011 800 807
170. H. Wasse, A.A. Rivera, R. Huang, D.E. Martinson, Q. Long, and W. McKinnon Increased plasma chymase concentration and mast cell chymase expression in venous neointimal lesions of patients with CKD and ESRD Semin Dial 24 2011 688 693
171. K. Watanabe, D. Fujioka, Y. Saito, T. Nakamura, J.E. Obata, and K. Kawabata Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice Am J Physiol Heart Circ Physiol 302 2012 H95 H104
172. M.C. White, and J. McHowat Protease activation of calcium-independent phospholipase A2 leads to neutrophil recruitment to coronary artery endothelial cells Thromb Res 120 2007 597 605
173. M.R. Woolhiser, Y. Okayama, A.M. Gilfillan, and D.D. Metcalfe IgG-dependent activation of human mast cells following up-regulation of FcgammaRI by IFN-gamma Eur J Immunol 31 2001 3298 3307
174. W. Xing, K.F. Austen, M.F. Gurish, and T.G. Jones Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue Proc Natl Acad Sci U S A 108 2011 14210 14215
175. P. Yeong, Y. Ning, Y. Xu, X. Li, and L. Yin Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRalpha activation Biochim Biophys Acta 1801 2010 567 576
176. J. Zhang, P. Alcaide, L. Liu, J. Sun, A. He, and F.W. Luscinskas Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils PLoS One 6 2011 e14525
177. J. Zhang, H. Chen, L. Liu, J. Sun, M.A. Shi, and G.K. Sukhova Chemokine (CC motif) receptor 2 mediates mast cell migration to abdominal aortic aneurysm lesions in mice Cardiovasc Res 96 2012 543 551
178. Q.Y. Zhang, J.B. Li, Z.H. Wang, X.B. Li, L.H. Yin, and M. Wei Tranilast stabilizes the accumulation and degranulation of resident mast cells while reducing cardiomyocyte apoptosis in a swine model of coronary microembolisation Clin Exp Pharmacol Physiol 37 2010 641 646
179. J. Zhang, J. Sun, J.S. Lindholt, G.K. Sukhova, M. Sinnamon, and R.L. Stevens Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation Circ Res 108 2011 1316 1327
180. D. Zohlnhöfer, J. Hausleiter, A. Kastrati, J. Mehilli, C. Goos, and H. Schühlen A randomized, double-blind, placebo-controlled trial on restenosis prevention by the receptor tyrosine kinase inhibitor imatinib J Am Coll Cardiol 46 2005 1999 2003