Exploiting microspheres as a therapeutic proficient doer for colon delivery: A review

Expert Opinion on Drug Delivery

Volumn 10, Issue 4, 2013, Pages 545-557

  Vats, Anima ^a   Pathak, Kamla ^a  

^a NH 2   (India)

Author keywords

Colon targeted delivery; Colonic pathologies; Microspheres; Multiparticulate system

Indexed keywords

ALBENDAZOLE; AZATHIOPRINE; CAMPTOTHECIN; CURCUMIN; DEXAMETHASONE; DICHLOROMETHYLENE DIPHOSPHATE; DILTIAZEM; DRUG CARRIER; EUDRAGIT; FLUOROURACIL; FLURBIPROFEN; HYDROXYCAMPTOTHECIN; KETOPROFEN; MEBEVERINE; MESALAZINE; METHOTREXATE; METRONIDAZOLE; MICROBEAD; MICROSPHERE; MICROSPONGE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PREDNISOLONE; PYROPHOSPHATE; TACROLIMUS; TINIDAZOLE; TRAMADOL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALDECOXIB; YTTRIUM 90;

ABDOMINAL CANCER; AMEBIASIS; COLITIS; COLON CANCER; COLON CARCINOMA; CROHN DISEASE; DRUG ABSORPTION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; ENTERITIS; HUMAN; METASTASIS; MICROCAPSULE; NONHUMAN; PARASITOSIS; REVIEW; ULCERATIVE COLITIS;

ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; COLON; COLONIC DISEASES; DRUG DELIVERY SYSTEMS; HUMANS; MICROSPHERES; PHARMACEUTICAL PREPARATIONS;

EID: 84875189267     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2013.759937     Document Type: Review

References (79)

1. Mennini N, Furlanetto S, Cirri M, et al. Quality by design approach for developing chitosan-Ca-alginate microspheres for colon delivery of celecoxib-hydroxypropyl-b-cyclodextrin-PVP complex. Eur J Pharm Biopharm 2012;80(1):67-75
2. Vemula SK, Veerareddy PR. Different approaches to design and evaluation of colon specific drug delivery systems. Int J Pharm Tech 2009;1(1):1-35
3. Atyabi F, Majzooba S, Iman M, et al. In vitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water soluble macromolecules to colon. Carbohydr Polym 2005;61:39-51
4. Aurora J, Talwar N, Pathak V. Colonic drug delivery challenges and opportunities - an overview. Eur Gastroenterol Rev 2006;1:1-6
5. Rathbone MJ, Hadgraft J, Roberts MS. Modified release drug delivery technology. Marcel Dekker, Inc; New York: 2003
6. Rodriguez M, Vila-Jato JL, Torres D. Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region. J Control Release 1998;55:67-77
7. Sriamornsak P. Investigation of pectin as a carrier for oral delivery of proteins using calcium pectinate gel beads. Int J Pharm 1998;169:213-20
8. Elias P, Smart JD, Tsibouklis J. Azocrosslinked poly(acrylic acid) for colonic delivery and adhesion specificity: In vitro degradation and preliminary ex vivo bioadhesion studies. J Control Release 1998;54(1):95-9
9. Manjanna KM, Kumar SB, Kumar PTM. Diclofenac sodium microbeads for oral sustained drug delivery. Int J Pharm Tech Res 2009;1(2):317-27
10. Jain A, Gupta Y, Jain SK. Potential of calcium pectinate beads for target specific drug release to colon. J Drug Target 2007;15(4):285-94
11. Atyabi F, Inanloo K, Dinarvand R. Bovine serum albumin-loaded pectinate beads as colonic peptide delivery system: Preparation and in vitro characterization. Drug Deliv 2005;12(6):367-75
12. Ahmed IS. Effect of simulated gastrointestinal conditions on drug release from pectin/ethylcellulose as film coating for drug delivery to the colon. Drug Dev Ind Pharm 2005;31(4-5):465-70
13. Farlow SJ, Jerusalmi A, Sano T. Enhanced transduction of colonic cell lines in vitro and the inflamed colon in mice by viral vectors, derived from adeno-associated virus serotype 2, using virus-microbead conjugates bearing lectin. BMC Biotech 2007;7:83
14. Singh BN, Kwon HK. Characterization and relevance of physicochemical interactions among components of a novel multiparticulate formulation for colonic delivery. Int J Pharm 2007;341:143-51
15. Pandey AK, Choudhary N, Raj VK, et al. Fabrication and evaluation of tinidazole microbeads for colon targeting. Asian Pac J Trop Dis 2012;2(1):S197-01
16. Mishra B, Jayanth P, Sankar C. Development of chitosan - alginate microcapsules for colon specific delivery of metronidazole. Ind Drug 2003;40(12):695-700
17. Arimoto M, Fukumori Y, Fujiki J, et al. Acrylic terpolymer microcapsules for colon-specific drug delivery: Effect of molecular weight and solubility of microencapsulated drugs on their release behaviors. J Drug Deliv Sci Tech 2006;16(3):173-81
18. Singh A, Raghvendra, Kumar A, et al. Development and characterization of microcapsule of flurbiprofen for colon specific drug delivery system. Eur J Bio Sci 2011;3(2):40-5
19. Swetha A, Rao GM, Ramana VK, et al. Formulation and in-vitro evaluation of etodolac entrapped in microsponge based drug delivery system. Int J Pharm 2011;1(2):73-80
20. Comoglu T, Savaser A, Ozkan Y, et al. Enhancement of ketoprofen bioavailability by formation of microsponge tablets. Pharmazie 2007;62:51-4
21. Srivastava R, Kumar D, Pathak K. Colonic luminal surface retention of meloxicam microsponges delivered by erosion based colon targeted matrix tablet. Int J Pharm 2012;427(2):153-62
22. Jain V, Singh R. Dicyclomine-loaded eudragit-based microsponge with potential for colonic delivery: Preparation and characterization. Trop J Pharm Res 2010;9(1):67-72
23. Anderson DL, Chung-Heng C, Nacht S. Flow characteristics of loosely compacted macroporous microsponge polymeric systems. Powder Technol 1994;78(1):15-18
24. Comoglu T, Gonul N, Baykara T. Preparation and in vitro evaluation of modified release ketoprofen microsponges. Farmaco 2003;58:101-6
25. Orlu M, Erdal Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm 2006;318:103-17
26. Kawashima Y, Niwa T, Takeuchi H, et al. Hollow microspheres for use as a floating controlled drug delivery system in the stomach. J Pharm Sci 1992;82(2):135-40
27. Mishra MK, Shikhri M, Sharma R, et al. Optimization, formulation development and characterization of eudragit RS 100 loaded microsponges and subsequent colonic delivery. Int J Drug Discov Herbal Res 2011;1(1):8-13
28. Alagsundaram M, Chetty MC, Attuluri UK, et al. Microspheres-drug delivery system review. Int J Chem Tech Res 2009;1(3):526-34
29. Jain SK, Ray G, Saraf DK, et al. The preparation and evaluation of albendazole microspheres for colon delivery. Pharm Technol 2004;66-71
30. Robinson JR, Lee VHL, Hui H. Design and fabrication of oral controlled release drug delivery system. In: Robinson JR, Lee VHL, editors. Controlled drug delivery: Fundamental and applications. 2nd edition. Marcel Dekkar, New York; 1987. p. 373-374
31. Masareddy RS, George JA. An overview on polymers used in development of drug delivery systems. Ind J Pharm Edu Res 2006;40(1):45-50
32. Bajpai SK, Sonkusley J. Dynamic release of riboflavin from a colon-targeted drug delivery device: An in vitro study. React Funct Polym 2003;55(2):197-210
33. Giovannucci E, Rimm EB, Stampfer MJ, et al. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med 1994;121:241-6
34. Kune GA, Kune S, Watson LF. Colorectal cancer risk, chronic illnesses, operations, and medications: Case control results from the Melbourne colorectal cancer study. Cancer Res 1988;48:4399-404
35. Kune S, Kune GA, Watson LF. The melbourne colorectal cancer study: Incidence findings by age, sex, site, migrants and religion. Int J Epidemiol 1986;15(4):483-93
36. Thun MJ, Namboodiri MM. Aspirin use and reduced risk of fatal colon cancer. Eng J Med 1991;325:1593-6
37. Craven PA, Thornburg K, Derubertis FR. Sustained increase in the proliferation of rat colonic mucosa during chronic treatment with aspirin. Gastroenterology 1988;94:567-75
38. Chan TA. Non steroidal anti inflammatory drugs, apoptosis and colon cancer chemoprevention. Lancet Oncol 2002;3:166-74
39. Thakral NK, Ray AR, Majumdar DK. Eudragit S100 entrapped chitosan microspheres of valdecoxib for colon cancer. J Mater Sci Mater Med 2010;21:2691-9
40. Thakral NK, Ray AR, Bar- shalom D, et al. The quest for targeted delivery in colon cancer: Mucoadhesive valdecoxib microspheres. Int J Nanomed 2011;6:1057-68
41. Vats A, Pathak K. Tabletted guar gum microspheres of piroxicam for targetted adjuvant therapy for colonic adenocarcinoma. Ther Deliv 2012;3(11):1281-95
42. Rahman Z, Kohli K, Khar RK, et al. Characterization of 5- fluorouracil microspheres for colonic delivery. AAPS Pharm Sci Tech 2006;7(2):E113-21
43. Mandal TK. Development of biodegradable drug delivery system to treat addiction. Drug Dev Ind Pharm 1999;25:773-9
44. Lamprecht A, Yammoto H, Taeuchi H, et al. Microspheres design for colonic delivery of 5- fluorouracil. J Control Release 2003;90:313-22
45. Shivani N, Hetal P, Rajesh K, et al. Colon delivery of 5- fluorouracil using cross-linked chitosan microspheres coated with eudragit S 100. Int J Drug Deliv 2011;3(2):260-8
46. Ganguly K, Aminabhavi TM, Kulkarni AR. Colon targeting of 5-fluorouracil using polyethylene glycol cross-linked chitosan microspheres enteric coated with cellulose acetate phthalate. Ind Eng Chem Res 2011;50(21):11797-807
47. Chaturvedi K, Kulkarni AR, Aminabhavi TM. Blend microspheres of poly (3-hydroxybutyrate) and cellulose acetate phthalate for colon delivery of 5-fluorouracil. Ind Eng Chem Res 2011;50(18):10414-23
48. Paharia A, Yadav AK, Rai G, et al. Eudragit-coated pectin microspheres of 5-fluorouracil for colon targeting. AAPS PharmSciTech 2007;8(1):E1-7
49. Dhawale SC, Bankar AS, Patro MN. Formulation and evaluation porous microspheres of 5- fluorouracil for colon targeting. Int J Pharm Tech Res 2010;2(2):1112-18
50. Chaurasia M, Chaurasia MK, Jain NK, et al. Cross-linked guar gum microspheres: A viable approach for improved delivery of anticancer drugs for the treatment of colorectal Cancer. AAPS Pharm Sci Tech 2006;7(3):E143-51
51. Dai M, Xu X, Song J, et al. Preparation of camptothecin-loaded PCEC microspheres for the treatment of colorectal peritoneal carcinomatosis and tumor growth in mice. Cancer Lett 2011;312(2):189-96
52. Zhang L, Cao F, Ding B, et al. Eudragit S100 coated calcium pectinate microspheres of curcumin for colon targeting. J Microencapsul 2011;28(7):659-67
53. Lu B, Zhang Z. Novel colon-specific microspheres with highly dispersed hydroxyl camptothecin cores: Their preparation, release behavior, and therapeutic efficiency against colonic cancer. J Pharm Sci 2006;95(12):2619-30
54. Gao Y, Zhu C-L, Zhang X-X, et al. Lipidpolymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique. J Microencapsul 2011;28(6):549-56
55. Hardy FH, David SS, Khosala R, et al. Gastrointestinal transit of small tablets in patients with ulcerative colitis. Int J Pharmcol 1998;48:79-82
56. Lamprecht A, Yamamoto H, Takeuchi H, et al. A pH-sensitive microsphere system for colon delivery of tacrolimus containing nanoparticles. J Control Release 2005;104(2):337-46
57. Lamprecht A, Yamamoto H, Ubrich N, et al. FK506 microparticles mitigate experimental colitis with minor renal calcineurin suppression. Pharm Res 2005;22(2):193-9
58. Dandagi PM, Mastiholimath VS, Gadad AP, et al. pH-sensitive mebeverine microspheres for colon delivery. Ind J Pharm Sci 2009;71(4):464-8
59. Keitzmann D, Moulari B, Beduneau A, et al. Colonic delivery of carboxyfluorescein by pH-sensitive microspheres in experimental colitis. Eur J Pharm Biopharm 2010;76(2):290-5
60. Dubey R, Dubey R, Omrey P, et al. Development and characterization of colon specific drug delivery system bearing 5-ASA and camylofine dihydrochloride for the treatment of ulcerative colitis. J Drug Target 2010;18(8):589-601
61. Nakase H, Okazak K, Tabata Y, et al. Biodegradable microspheres targeting mucosal immune-regulating cells: New approach for treatment of inflammatory bowel disease. J Gastroenterol 2003;38(15):59-62
62. Dashora A, Jain CP. Development and characterization of pectin-prednisolone microspheres for colon targeted delivery. Int J Chem Tech Res 2009;1(3):751-7
63. Masterelli F, Zerrou KN, Cirria M, et al. Microspheres for colonic delivery of Ketoprofen-hydroxypropyl- b-cyclone dextrin complex. Eur J Pharm Biopharm 2008;34(1):1-11
64. Kushwaha P, Fareed S, Nanda S, et al. Design and fabrication of tramadol HCl loaded multiparticulate colon targeted drug delivery system. J Chem Pharm Res 2011;3(5):584-95
65. Patel MM, Amin AF. Process, optimization and characterization of mebeverine hydrochloride loaded guar gum microspheres for irritable bowel syndrome. Carbohydr Polym 2011;86(2):536-54
66. Mahajan NM, Sakarkar DMDR, Manmode AS. Therapeutic potential of biodegradable meselamine microspheres in the treatment of ulcerative colitis. Asian J Pharm Clin Res 2011;4(1):120-5
67. El- Bary AA, Aboelwafa AA, Sharabi IM. Influence of some formulation variables on the optimization of pH-dependent, colon-targeted, sustained-release mesalamine microspheres. AAPS Pharm Sci Tech 2011;13(1):75-84
68. Varshosaz J, Dehkordi JA, Golafshan S. Colon-specific delivery of mesalazine chitosan microspheres. J Microencapsul 2006;23(3):329-39
69. Chandran S, Sanjay KS, Ali Asghar LF. Microspheres with pH modulated release: Design and characterization of formulation variables for colonic delivery. J Microencapsul 2009;26(5):420-31
70. Vijay S, Sati OP, Majumdar DK. Acrylic acid-methyl methacrylate (2.5:7.5/2:8) enteric copolymer for colon targeted drug delivery. J Mater Sci Mater Med 2011;22(1):125-35
71. Kumar SR, Piyush T, Suman R, et al. Preparation and characterization of cross-linked guar gum microspheres: Optimization using factorial design. Chem Pharm Bull 2011;59(2):185-90
72. Shukla S, Jain D, Verma K, et al. Formulation and in vitro characterization of alginate microspheres loaded with diloxanide furoate for colon- specific drug delivery. Asian J Pharm 2010;4(4):199-204
73. Chourasia MK, Jain SK. Design and development of multiparticulate system for targeted drug delivery to colon. Drug Deliv 2004;11(3):201-7
74. Gray B, Van Hazel G, Hope M, et al. Randomised trial of sir-spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann Oncol 2001;12:1711-20
75. Van Hazel GA, Pavlakis N, Goldstein D, et al. Treatment of fluorouracil-refractory patients with liver metastases from colorectal cancer by using yttrium-90 resin microspheres plus concomitant systemic irinotecan chemotherapy. J Clin Oncol 2009;27(25):4089-95
76. Cosimelli M, Golfieri M, Cagol PP, et al. Multi-centre phase II clinical trial of yttrium-90 resin microspheres alone in unresectable, chemotherapy refractory colorectal liver metastases. Br J Cancer 2010;103(3):324-31
77. Gulec SA, Pennington K, Wheeler J, et al. Yttrium-90 microsphere- selective internal radiation therapy with chemotherapy (Chemo-SIRT) for colorectal cancer liver metastases: An in vivo double-arm-controlled phase II trial. Am J Clin Oncol 2012; published online\
78. Jose S, Prema MT, Chacko AJ, et al. Colon specific chitosan microspheres for chronotherapy of chronic stable angina. Eur J Pharm Biopharm 2011;89:277-83
79. Vaidya A, Jain A, Khare P, et al. Metronidazole loaded pectin microspheres for colon targeting. J Pharm Sci 2009;98(11):4229-36