Preparation and in vitro evaluation of modified release ketoprofen microsponges

Farmaco

Volumn 58, Issue 2, 2003, Pages 101-106

  Çomoǧlu, Tansel ^a   Gönül, Nurşin ^a   Baykara, Tamer ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Ketoprofen; Microsponges; Modified release; Quasi emulsion solvent diffusion method

Indexed keywords

EUDRAGIT; EUDRAGIT RS; KETOPROFEN; SOLVENT;

ARTICLE; DIFFUSION; DISSOLUTION; DRUG FORMULATION; DRUG RELEASE; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY;

ACRYLIC RESINS; DRUG CARRIERS; DRUG EVALUATION, PRECLINICAL; KETOPROFEN; MICROSPHERES;

EID: 0037320895     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)00007-1     Document Type: Article

References (21)

1. Mc Grea J.D., Telford A.M., Kaye C.M., Boyd M.W.J. A comparison of plasma and synovial fluid profiles of standard and controlled-release formulations of ketoprofen in patients with rheumatoid arthritis. Curr. Med. Res. Opin. 10:1986;73-81.
2. Oka K., Aoshima S. Highly sensitive determination of ketoprofen in human serum and urine and its application to pharmacokinetic study. J. Chromatogr. 345:1985;419-424.
3. Dennis M.J., French F.C., Crome P., Babiker M., Shillingford J., Hopkins R. Pharmacokinetic profile of controlled release ketoprofen in elderly patients. Br. J. Clin. Pharmacol. 20:1985;567-573.
4. Houghton G.W., Dennis M.J., Rigler E.D. Comparative pnarmacokinetics of ketoprofen derived from single oral doses of ketoprofen capsules or a novel sustained-release pellet formulation. Biopharmaceut. Drug Dispos. 5:1984;203-209.
5. Jamali F., Brocks D.R. Clinical pharmacokinetics of ketoprofen and its enantiomers. Clin. Pharmacokinet. 19:1990;197-217.
6. Kislalioglu M.S., Khan M.A., Blount C., Goettsch R.W., Bolton S. Physical characterization and dissolution properties of ibuprofen: Eudragit coprecipitates. J. Pharm. Sci. 80:1991;799-804.
7. Jenquin M.R., Mc Ginity J.W. Characterization of acrylic resin matrix films and mechanisms of drug-polymer interactions. Int. J. Pharm. 101:1994;23-34.
8. Kawashima Y., Iwamoto T., Niwa T., Takeuchi H., Hino T. Role of the solvent-diffusion rate modifier in a new emulsion solvent diffusion method for preparation of ketoprofen microspheres. J. Microencapsulation. 10:1993;329-340.
9. Akbuǧa J., Durmaz G. Preparation and evaluation of cross-linked chitosan microspheres containing furosemide. Int. J. Pharm. 111:1994;217-222.
10. Barkai A., Pathak Y.V., Benita S. Polyacrylate (Eudragit retard) microspheres for oral controlled release of nifedipine. I. Formulation design and process optimization. Drug Dev. Ind. Pharm. 16:1990;2057-2075.
11. Khodairy K.A., Eshra A.G., Nada A.H., Mortada S.A.M. Preparation and in vitro evaluation of slow release ketoprofen microcapsules formulated into tablets and capsules. J. Microencapsulation. 9:1992;365-373.
12. Pongpaibul Y., Price J.C., Whitworth C.W. Preparation and evaluation of controlled release indomethacin microspheres. Drug Dev. Ind. Pharm. 10:1984;1597-1616.
13. L.S.C. Wan, P.W.S. Heng, L.W. Chan, Drug encapsulation in alginate microspheres by emulsification, J. Microencapsulation (1992) 309-316.
14. Kawashima Y., Niwa T., Takeuchi H., Hino T., Ito Y. Control of prolonged drug release and compression properties of ibuprofen microsponges with acrylic polymer, Eudragit RS, by changing their interparticle porosity. Chem. Pharm. Bull. 40:1992;196-201.
15. Clarke's Isolation and Identification of Drugs, The Pharmaceutical Press, 1986, p. 697.
16. The United States Pharmacopoeia XXIII, Fourth Supplement. Easton Mack Printing Co., 1995, p. 3159.
17. Ozkan A.S., Uslu B. Rapid HPLC assay for lamivudine in pharmaceuticals and human serum. J. Liq. Chromatogr. Technol. 25:2002;1447-1456.
18. Valvo L., Alimenti R., Alimonti S., Raimondi S., Foglietta F., Campana F. Development and validation of a liquid chromatographic method for the determination of related substances in verapamil hydrochloride. J. Pharm. Biomed. Anal. 15:1987;989-996.
19. Yilmaz S., Uslu B., Ozkan A.S. Anodic oxidation of etodolac and its square wave and differential pulse voltammetric determination in pharmaceuticals and human serum. Talanta. 54:2001;351-360.
20. T. Baykara, FABAD, Biyoyararlilik ve Patent, Workshop, 17 April 2002.
21. Nacht S., Katz M. The microsponge: a novel topical programmable delivery system. Osborne D.W., Ammann A.H. Topical Drug Delivery Formulations. 1990;299-325 Marcel Dekker, New York, Basel.