Colon delivery of 5 - Fluoro uracil using cross-linked chitosan microspheres coated with eudragit S 100

International Journal of Drug Delivery

Volumn 1, Issue 2, 2011, Pages 260-268

  Shivani, Nayak ^a   Hetal, Patel ^a   Rajesh, Kesarla ^b   Murthy, Rayasa Ramachandra ^b  

^a M S UNIVERSITY OF BARODA   (India)

^b ISF COLLEGE OF PHARMACY   (India)

Author keywords

5 FU; Chitosan; Colon targeting; Eudragit S 100; Microspheres

Indexed keywords

CHITOSAN; EUDRAGIT; FLUOROURACIL; GLUTARALDEHYDE; MICROSPHERE; ALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLON; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CAPSULE; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG SOLUBILITY; DRUG TISSUE LEVEL; EMULSION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; RAT; SLOW RELEASE FORMULATION; SURFACE PROPERTY; CROSS LINKING; DRUG FORMULATION; EVAPORATION; PH MEASUREMENT; PROCESS OPTIMIZATION; SLOW DRUG RELEASE;

EID: 84855199051     PISSN: None     EISSN: 09750215     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Diasio RB, Harris BE. Clinical Pharmacology of 5-fluorouracil. Clin Pharmacokinet 1989;16:215-237.
2. Meissner Y, Lamprecht A. Alternative drug delivery approaches for the therapy of inflammatory bowel disease. J Pharm Sci 2008;97(8):2878-2891.
3. Jain SK, Jain A, Gupta Y, Ahirwar M. Design and Development of Hydrogel Beads for Targeted Drug Delivery to the Colon. AAPS Pharm Sci Tech 2007;8(3):Article 56.
4. Friend DR. Colon specific drug delivery, Adv Drug Del Rev 1991;7(1):149-199.
5. Makhlof A, Tozuka YT. pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model. Eur J Pharmaceut Biopharm 2009;72(1):1-8.
6. Controlled drug delivery. In: Bruck SD, editor. Vol. 2. CRC Press; 1982;p. 190.
7. Uekama M, Horikawa T, Yamanaka M, Hiramaya F. Peracylated b-cyclodextrins as novel sustained release carries for a water soluble drug, molsidomine. J Pharm Pharmacol 1994;46:714-717.
8. Patel HK, Nagle A, Murthy R. Characterization of calcium alginate beads of 5-fluorouracil for colon delivery. Asian J Pharm 2008;2:241-5.
9. Mooter GVD, Samyn C, Kinget R. In vivo evaluation of a colon-specific drug delivery system: An absorption study of Theophylline from capsules coated with Azo polymers in Rats. Pharm Res 1995;12(2):244-47.
10. Thanoo BC, Sunny MC, Jayakrishnan A. Cross-linked chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals. J Pharm Pharmacol 1992;44:283-286.
11. Gohel MC, Amin AF, Studies in the preparation of diclofenac sodium microspheres by emulsion solvent evaporation technique by response surface analysis. Ind J Pharm Sci 1999;61(1):48-53.
12. Paharia A, Yadav AK, Rai G, Jain SK, Pancholi SS, Agrawal GP. Eudragit-coated Pectin Microspheres of 5-Fluorouracil for Colon Targeting. AAPS Pharm Sci Tech 2007;8(1):E1:E7:Article 12.
13. Adel NM, Shirazi FH, Cripps CM, Shereeni V, Molepo MJ, Obrocea M, Diedre R, Bates S, Fry D, Stewart DJ, Goel R. An HPLC method for the measurement of 5-fluorouracil in human plasma with a low detection limit and a high extraction yield. Int J Mol Med 2002;10(4):513-6.
14. Wan NWS, Endud CS, Mayamar R. Effect of crosslinking agents on chitosan microspheres in controlled release of diclofenac sodium. Reac Func Polymers 2002;50:181-190.
15. Gonçalves VL, Laranjeira MCM, Fávere VT, Pedrosa RC. Effect of crosslinking agents on chitosan microspheres in controlled release of diclofenac sodium. Polímeros: Ciência e Tecnologia 2005;15(1):6-12.