Novel colon-specific microspheres with highly dispersed hydroxycamptothecin cores: Their preparation, release behavior, and therapeutic efficiency against colonic cancer

Journal of Pharmaceutical Sciences

Volumn 95, Issue 12, 2006, Pages 2619-2630

  Lu, Bin ^a   Zhang, Zhengquan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Air suspension spray drying; Cancer chemotherapy; Colonic drug delivery; Hydroxycamptothecin; Microencapsulation; Site specific delivery

Indexed keywords

CAMPTOTHECIN DERIVATIVE; EUDRAGIT; HYDROXYCAMPTOTHECIN; MACROGOL 6000; MACROGOL STEARATE; MICROSPHERE; PLACEBO; POLOXAMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING DISORDER; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; DIARRHEA; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG MEGADOSE; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; DRUG TISSUE LEVEL; FEMALE; GASTRITIS; GASTROINTESTINAL TOXICITY; HUMAN; HUMAN CELL; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; SMALL INTESTINE ABSORPTION; STOMACH ABSORPTION;

EID: 33846186854     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20635     Document Type: Article

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