Colon targeting of 5-fluorouracil using polyethylene glycol cross-linked chitosan microspheres enteric coated with cellulose acetate phthalate

Industrial and Engineering Chemistry Research

Volumn 50, Issue 21, 2011, Pages 11797-11807

  Ganguly, Kuntal ^a   Aminabhavi, Tejraj M ^a   Kulkarni, Anandrao R ^a  

^a S E T S COLLEGE OF PHARMACY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

5-FLUOROURACIL; 5-FLUOROURACIL (5-FU); ACIDIC ENVIRONMENT; ACIDIC PH; ALKALINE PH; CASE II; CELLULOSE ACETATE PHTHALATE; CHITOSAN COATINGS; COLON TARGETING; CROSS LINKED CHITOSAN; DRUG RELEASE; EMPIRICAL EQUATIONS; ENCAPSULATION EFFICIENCY; GASTROINTESTINAL TRACT; IN-VITRO; SMOOTH SURFACE; SURFACE RIDGES; TARGETED DELIVERY; TRANSPORT MECHANISM;

ALKALINITY; CELLULOSE; CHITOSAN; EMULSIFICATION; ENCAPSULATION; ESTERS; GLYCOLS; POLYETHYLENE GLYCOLS; POLYETHYLENES; THERMOPLASTICS; VOLATILE FATTY ACIDS;

MICROSPHERES;

EID: 80055026097     PISSN: 08885885     EISSN: 15205045     Source Type: Journal    
DOI: 10.1021/ie201623d     Document Type: Article

References (46)

1. Kulkarni, A. R.; Kulkarni, V. H.; Keshavayya, J.; Hukkeri, V. I.; Sung, H. W. Anti-microbial activity and film characterization of thiazolidinone derivatives of chitosan Macromol. Biosci. 2005, 5, 490
2. Lin, Y. H.; Chen, C. T.; Liang, H. F.; Kulkarni, A. R.; Lee, P. W.; Chen, C. H.; Sung, H. W. Novel nanoparticles for oral insulin delivery via the paracellular pathway Nanotechnology 2007, 18 (105) 1
3. Shi, Q.; Wang, H.; Tran, C.; Qiu, X.; Winnik, F. M.; Zhang, X.; Dai., K.; Benderdour, M.; Fernandes, J. C. Hydrodynamic delivery of chitosan-folate-DNA nanoparticles in rats with adjuvant-induced arthritis. J. Biomed Biotechnol. 2011, doi: 10.1155/2011/148763.
4. Agnihotri, S. A.; Mallikarjuna, N. N.; Aminabhavi, T. M. Recent advances on chitosan-based micro and nanoparticles in drug delivery J. Controlled Release 2004, 100, 5
5. Zhang, Y.; Wei, W.; Lv, P.; Wang, L.; Ma, G. Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin Eur. J. Pharm. Biopharm. 2011, 7, 11
6. Reverchon, E.; Antonacci, A. Chitosan microparticles production by supercritical fluid processing Ind. Eng. Chem. Res. 2006, 45, 5722
7. Il'ina, A. V.; Varlamov, V. P. Chitosan-based polyelectrolyte complexes: A review Appl Biochem. Microbiol. 2005, 41, 5
8. Mao, S.; Sun, W.; Kissel, T. Chitosan-based formulations for delivery of DNA and siRNA Adv. Drug. Delivery Rev. 2010, 62, 12
9. Kim, T. H.; Jiang, H. L.; Jere, D.; Park, I. K.; Cho, M. H.; Nah, J. W.; Choi, Y. J.; Akaike, T.; Cho, C.S. Chemical modification of chitosan as a gene carrier in vitro and in vivo Prog. Polym. Sci. 2007, 32, 726
10. Rudzinski, W. E.; Aminabhavi, T. M. Chitosan as a carrier for targeted delivery of small interfering RNA Int. J. Pharm. 2010, 399, 1
11. Piskin, E. Biodegradable polymers as biomaterials J. Biomater. Sci., Polym. Ed. 1995, 6, 775
12. Dutta, P. K.; Dutta, J.; Tripathi, V. S. Chitin and chitosan: Chemistry, properties and applications J. Sci. Ind. Res. 2004, 63, 20
13. Khan, T. A.; Peh, K. K.; Chang, H. S. Mechanical, Bioadhesive Strength and Biological Evaluations of Chitosan films for Wound Dressing J. Pharm. Pharm. Sci. 2000, 3, 303
14. Jayakumar, R.; Prabaharan, M.; Kumar, P. T. S.; Nair, S. V.; Tamura, H. Biomaterials based on chitin and chitosan in wound dressing applications Biotechnol. Adv. 2011, 29, 322
15. Saboktakin, M. R.; Tabatabaee, R. M.; Maharramov, A.; Ramazanov, M. A. Design and characterization of chitosan nanoparticles as delivery systems for paclitaxel Carbohydr. Polym. 2010, 82, 466
16. Muzzarelli, R. A. A. Chitosan-based dietary foods Carbohydr. Polym. 1996, 29, 309
17. Wei, W.; Ma, G. H.; Wang, L. Y.; Wu, J.; Su, Z. G. Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin Acta Biomater. 2010, 6, 205
18. Ubaidulla, U.; Sultana, Y.; Ahmed, F. J.; Khar, R. K.; Panda, A. K. Chitosan phthalate microspheres for oral delivery of insulin: preparation, characterization, and in vitro evaluation Drug Delivery 2007, 14, 19
19. Zhang, H.; Alsarra, I. A.; Neau, S. H. An in vitro evaluation of a chitosan containing multiparticulate system for macromolecule delivery to the colon Int. J. Pharm. 2002, 239, 197
20. Varshoaz, J.; Jaffarian, D. A.; Golafshan, S. Colon specific delivery of mesalazine chitosan microsphere J. Microencapsulation 2006, 23, 329
21. Tozaki, H.; Odoriba, T.; Okada, N.; Fujita, T.; Terabe, A.; Suzuki, T.; Okabe, S.; Muranishi, S.; Yamamato, A. Chitosan capsules for colon specific drug delivery: enhanced localization of 5-amino salicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats J. Controlled Release 2002, 82, 51
22. Kaushik, D.; Sardana, S.; Mishra, D. N. In-vitro characterization and cytotoxicity analysis of 5-fluorouracil loaded chitosan microspheres for targeting colon cancer Indian J. Pharm. Educ. Res. 2010, 44, 274
23. Xu, Y.; Zhan, C.; Fan, L.; Wang, L.; Zheng, H. Preparation of dual crosslinked alginate chitosan blend gel beads and in vitro controlled release in oral site- specific drug delivery system Int. J. Pharm. 2007, 336, 329
24. Miladenovska, K.; Raicki, R. S.; Janevik, E. I.; Ristoski, T.; Pavlova, M. J.; Kavrakovski, Z.; Dodov, M. G.; Goracinova, K. Colon specific delivery of 5-amino salicylic acid from chitosan - Ca alginate microparticles Int. J. Pharm. 2007, 342, 124
25. Bigucci, F.; Luppi, B.; Cerchiara, T.; Sorrenti, M.; Bettinetti, G.; Rodriquez, L.; Zecchi, V. Chitosan/pectin polyelectrolyte complexes: Selection of suitable preparative conditions for colon-specific delivery of vancomycin Eur. J. Pharm. Sci. 2008, 35, 435
26. Assaad, E.; Wang, Y. J.; Zhu, X. X.; Mateescu, M. A. Polyelectrolyte complex of carboxymethyl starch and chitosan as drug carrier for oral administration Carbohydr. Polym. 2011, 84, 1399
27. Du, J.; Dai, J.; Liu, J.; Dankovich, T. Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers React. Funct. Polym. 2006, 66, 1055
28. Liu, Z.; Jiao, Y.; Liu, F.; Zhang, Z. Heparin/chitosan nanoparticle carriers prepared by polyelectrolyte complexation J. Biomed. Mater. Res., Part A 2007, 83A, 806
29. Zhang, D. Y.; Shen, X. Z.; Wang, J. Y.; Dong, L.; Zheng, Y. L.; Wu, L. L. Preparation of chitosan-polyaspartic acid-5-fluorouracil nanoparticles and its anti-carcinoma effect on tumor growth in nude mice World J. Gastroenterol. 2008, 14, 3554
30. Li, P.; Wang, Y.; Zeng, F.; Chen, L.; Peng, Z.; Kong, L. X. Synthesis and characterization of folate conjugated chitosan and cellular uptake of its nanoparticles in HT-29 cells Carbohydr. Res. 2011, 346, 801
31. Kaur, G.; Jain, S.; Tiwary, A. K. Chitosan-Carboxymethyl Tamarind Kernel Powder Interpolymer Complexation: Investigations for Colon Drug Delivery Sci. Pharm. 2010, 78, 57
32. Chen, S. C.; Wu, Y. C.; Mi, F. L.; Lin, Y. H.; Yu, L. C.; Sung, H. W. A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery J. Controlled Release 2004, 96, 285
33. Kulkarni, A. R.; Hukkeri, V. I.; Sung, H. W.; Liang, H. F. A novel method for the synthesis of the PEG-crosslinked chitosan with a pH-independent swelling behavior Macromol. Biosci. 2005, 5, 925
34. Bakan, J. A. Microencapsulation In The theory and practice of industrial pharmacy; 3 rd ed.; Lachman, L.; Lieberman, H. A.; Kanig, J. L., Eds.; Lea & Febiger: Philadelphia, 1986; p 412.
35. Kolhe, P.; Kannan, R. M. Improvement in Ductility of Chitosan through Blending and Copolymerization with PEG: FTIR Investigation of Molecular Interactions Biomacromolecules 2003, 4, 173
36. Okonogi, S.; Puttipipatkhachorn, S. Dissolution Improvement of High Drug-loaded Solid Dispersion AAPS Pharm. Sci. Technol. 2006, 7 (52) E1
37. Bhumkar, D. R.; Pokharkar, V. B. Studies on Effect of pH on Cross-linking of Chitosan With Sodium Tripolyphosphate: A Technical Note AAPS Pharm. Sci. Technol. 2006, 7, 50
38. Lee, J. S.; Chae, G. S.; An, T. K.; Khang, G. Preparation of 5-fluorouracil-loaded poly(l-lactide-co-glycolide) wafer and evaluation of in vitro release behavior Macromol. Res. 2003, 11, 183
39. Goycoolea, F. M.; Heras, A.; Aranaz, I.; Galed, G.; Fernandez-Valle, M. E.; Arguilles-Monal, W. Effect of Chemical Crosslinking on the Swelling and Shrinking Properties of Thermal and pH-Responsive Chitosan Hydrogels Macromol. Biosci. 2003, 3, 612
40. Babu, V. R.; Sairam, M.; Aminabhavi, T. M. Development of 5-fluorouracil loaded poly(acrylamide-co-methyl methacrylate) novel core -shell microspheres: in vitro release studies Int. J. Pharm. 2006, 325, 55
41. Gudasi, K. B.; Vadavi, R. S.; Shelke, N. B.; Sairam, M.; Aminabhavi, T. M. Synthesis and characterization of novel polyorganophosphazenes substituted with 4-methoxybenzylamine and 4-methoxyphenethylamine for in vitro release of indomethacin and 5-fluorouracil React. Funct. Polym. 2006, 66, 1149
42. Reddy, K. M.; Babu, V. R.; Rao, K. S. V. K.; Subha, M. C. S.; Rao, K. C.; Sairam, M.; Aminabhavi, T. M. Temperature sensitive semi-IPN microspheres from sodium alginate and N-isopropylacrylamide for controlled release of 5-fluorouracil J. Appl. Polym. Sci. 2008, 107, 2820
43. Rokhade, A. P.; Shelke, N. B.; Patil, S. A.; Aminabhavi, T. M. Novel hydrogel microspheres of chitosan and pluoronic F-127 for controlled release of 5-fluorouracil J. Microencapsulation 2007, 24, 274
44. Agnihotri, S. A.; Aminabhavi, T. M. Controlled release of clozapine through chitosan microparticles prepared by a novel method J. Controlled Release 2004, 96, 245
45. Yassin, A. E. B.; Alsarra, I. A.; Alanazi, F. K.; Al-Mohizea, A. M.; Al-Robayan, A. A.; Al-Obeed, O. A. New targeted-colon delivery system: in vitro and in vivo evaluation using X-ray imaging J. Drug Targeting 2010, 18, 59
46. Shivani, N.; Hetal, P.; Rajesh, K.; Murthy, R. R. Colon delivery of 5-fluorouracil using cross-linked chitosan microspheres coated with Eudragit S 100 Int. J. Drug Delivery 2011, 3, 260