Formulation and evaluation porous microspheres of 5- fluorouracil for colon targeting

International Journal of PharmTech Research

Volumn 2, Issue 2, 2010, Pages 1112-1118

  Dhawale, S C ^a   Bankar, A S ^a   Patro, M N ^a  

^a Govt College of Pharmacy   (India)

Author keywords

5 fu; Colon delivery; Colorectal cancer; Microspheres

Indexed keywords

EUDRAGIT; FLUOROURACIL; MICROSPHERE; POLYMER;

ARTICLE; COLON; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PURITY; DRUG SCREENING; DRUG STRUCTURE; EMULSION; ENCAPSULATION; HYDROPHILICITY; PH; POROSITY; SCANNING ELECTRON MICROSCOPY; SOLVENT EXTRACTION; TARGET ORGAN;

EID: 77954696862     PISSN: None     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Labianca R, Pessi MA, Zamparelli G, Treatment of colorectal cancer. Current guidelines and future prospects for drug therapy, Drugs 53 (1997) 593-607.
2. Van Cutsem E, Peeters M, Verslype C, The medical treatment of colorectal cancer: actual status and new developments, Hepatogastroenterology., 1999, 46, 709-716.
3. Labianca RF, Beretta GD, Pessi MA, Disease management considerations: disease management considerations, Drugs., 2001, 61, 1751-1764.
4. Krishnaiah YS, Satyanarayana V, Dinesh Kumar B, Karthikeyan RS, In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil, Eur. J. Pharm. Sci., 2002, 16, 185-192.
5. Madajewicz S, Petrelli N, Rustum YM, Phase III trial of high-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer, Cancer Res., 1984, 44, 4667-4669.
6. Cortesi E, Aschelter AM, Gioacchini N, Pellegrini A, Frati L, Ficorella C, Mazzei N, Marchetti P, Efficacy and toxicity of 5-fluorouracil and folates in advanced colon cancer, J. Chemother. 1990, 2, 47-50.
7. O'Connell MJ, Mailliard JA, Kami MJ, Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer, J. Clin. Oncol. 1997, 15, 246-250.
8. Watts P J, Barrow L, Steed KP, Wilson CG, R.C. Spiller, C.D. Melia, M.C. Davies, The transit rate of different-sized model dosage forms through the human colon and the effects of a lactulose-induced catharsis, Int. J. Pharm. 1992, 87, 215-221.
9. Lin SY, Ayres JW, Calcium alginate beads as core carriers of 5-aminosalicylic acid, Pharm. Res., 1992, 9, 1128-1131.
10. Lorenzo-Lamosa ML, Remunan-Lopez C, Vila-Jato JL, Alonso MJ, Design of microencapsulated chitosan microspheres for colonic drug delivery, J. Controlled Release. 1998, 52, 109-118.
11. Rodriguez M, Vila-Jato JL, Torres D, Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region, J. Controlled Release. 1998, 55, 67-77.
12. Jeong YI, Prasad YR, Ohno T, Application of Eudragit P-4135F for the delivery of ellagic acid to the rat lower small intestine, J. Pharm. Pharmacol. 2001, 53, 1079-1085.
13. Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y, Microsphere design for the colonic delivery of 5-fluorouracil, J. of Cont. Rel, 2003, 90, 313-322.
14. Zinutti C, Kedzierewicz F, Hoffman M, Maincent P, Preparation and characterization of ethylcellulose microspheres containing 5-fluorouracil', J. of Microencap.,1994, 11(5), 555-563
15. Lamprechta A, Yamamotoa BH, Takeuchia H, Kawashimaa TY, A pH-sensitive microsphere system for the colon delivery of tacrolimus containing nanoparticles, J. of Cont. Rel., 2005, 104, 337-346.
16. Bahl D, Robin HB, Amorphization of Indomethacin by Co-Grinding with Neusilin US2: Amorphization Kinetics, Physical Stability and Mechanism. Pharm. Res., 2006, 23, 2317-2325.
17. Li J, Yang L, Ferguson MS, Hudson TJ, In Vitro Evaluation of Dissolution Behavior for a Colon-Specific Drug Delivery System (CODES™) in Multi-pH Media Using United States 21. Pharmacopeia Apparatus II and III, AAPS Pharm Sci Tech, 2002, 3, 33.
18. Sinha VR, Mittal BR, Kumria R, In vivo 22. evaluation of time and site of disintegration of polysaccharide tablet prepared for colon-specific drug delivery, Int. J. of Pharm 2005, 289, 79-85.
19. Sinha VR, Kumria R, Coating polymers for colon specific drug delivery: A comparative in vitro evaluation, Acta Pharm. 2003, 53, 41-47.
20. Nunthanid J, Huanbutta K, Luangtana-anan M, Development of time-, pH-, and enzyme-controlled colonic drug delivery using spraydried chitosan acetate and hydroxypropyl methylcellulose Eur. J. of Pharm Biopharm. 2007, 45, 234-244.
21. Reiberg SF, Zhu XX, Polymer microspheres for controlled drug release, Int. J. Pharm, 2004, 28, 1-18.
22. Jain D, Panda KA, Majumdar DK, Eudragit S100 Entrapped Insulin Microspheres for Oral Delivery, AAPS PharmSciTech, 2005, 16, 6-9.