Lectin from Canavalia brasiliensis (ConBr) protects hippocampal slices against glutamate neurotoxicity in a manner dependent of PI3K/Akt pathway

Neurochemistry International

Volumn 62, Issue 6, 2013, Pages 836-842

  Jacques, Amanda V ^a   Rieger, Débora K ^a   Maestri, Mariana ^a   Lopes, Mark W ^a   Peres, Tanara V ^a   Gonçalves, Filipe M ^a   Pedro, Daniela Z ^a   Tasca, Carla I ^a   López, Manuela G ^b   Egea, Javier ^b   Nascimento, Kyria S ^c   Cavada, Benildo S ^c   Leal, Rodrigo B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b INSTITUTO TEÓFILO HERNANDO   (Spain)

^c FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

ConBr; Glutamate; Lectin; Neuroprotection; NMDA; PI3K Akt

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CONCANAVALIN BR; GLUTAMIC ACID; LECTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 10; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 9; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CANAVALIA; CANAVALIA BRASILIENSIS; CELL VIABILITY; CONTROLLED STUDY; EXCITOTOXICITY; HIPPOCAMPUS; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CANAVALIA; CARBOHYDRATE METABOLISM; CELL SURVIVAL; CHROMONES; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HIPPOCAMPUS; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NEUROPROTECTIVE AGENTS; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PLANT LECTINS; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES;

CANAVALIA BRASILIENSIS; MUS;

EID: 84875071937     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.02.020     Document Type: Article

References (67)

1. J.L. Andrade, S. Arruda, T. Barbosa, L. Paim, M.V. Ramos, and B.S. Cavada Lectin-induced nitric oxide production Cell. Immunol. 194 1999 98 102
2. S.C. Barauna, M.P. Kaster, B.T. Heckert, K.S. do Nascimento, F.M. Rossi, E.H. Teixeira, B.S. Cavada, A.L. Rodrigues, and R.B. Leal Antidepressant-like effect of lectin from Canavalia brasiliensis (ConBr) administered centrally in mice Pharmacol. Biochem. Behav. 85 2006 160 169
3. T. Barbosa, S. Arruda, B.S. Cavada, T.B. Grangeiro, L.A. de Freitas, and M. Barral-Netto In vivo lymphocyte activation and apoptosis by lectins of the diocleinae subtribo Mem. Inst. Oswaldo Cruz 96 2001 673 678
4. O.J. Bjerrum, and N.H. Heegaard Has immunoblotting replaced electroimmunoprecipitation? Examples from the analysis of autoantigens and transglutaminase-induced polymers of the human erythrocyte membrane J. Chromatogr. 470 1989 351 367
5. S. Boehm, and S. Huck Presynaptic inhibition by concavalin A: are alpha-latrotoxin receptors involved in action potential-dependent transmitter release? J. Neurochem. 71 1998 2421 2430
6. M.A. Bogoyevitch, K.R. Ngoei, T.T. Zhao, Y.Y. Yeap, and D.C. Ng C-Jun N-terminal kinase (JNK) signaling: recent advances and challenges Biochim. Biophys. 1804 2010 463 475
7. E. Bonfoco, D. Krainc, M.D. Ankrakrona, P. Nicotera, and S.A. Lipton Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures Proc. Natl. Acad. Sci. USA 92 1995 7162 7166
8. D.P. Brazil, and B.A. Hemmings Ten years of protein kinase B signaling: a hard AKT to follow Trends Biochem. Sci. 26 2001 657 664
9. D.P. Brazil, Z.Z. Yang, and B.A. Hemmings Advances in protein kinase B signalling: AKTion on multiple fronts Trends Biochem. Sci. 29 2004 23 42
10. B.S. Cavada, T. Barbosa, S. Arruda, T.B. Grangeiro, and M. Barral-Netto Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the diocleinae subtribe lectins Curr. Protein Pept. Sci. 2 2001 1 13
11. N. Cedeño, M. Urbina, F. Obregón, and L. Lima Characterization of serotonin transporter in blood lymphocytes of rats. Modulation by in vivo administration of mitogens J. Neuroimmunol. 159 2005 31 40
12. Z. Chen, T.B. Gibson, F. Robinson, L. Silvestro, G. Pearson, B. Xu, A. Wright, C. Vanderbilt, and M.H. Cobb MAP kinases Chem. Rev. 101 2001 2449 2476
13. D.W. Choi Ionic dependence of glutamate neurotoxicity J. Neurosci. 7 1987 369 379
14. D.W. Choi Excitotoxic cell death J. Neurobiol. 23 1992 1261 1276
15. S.R. Choudhari, M.A. Khan, G. Harris, D. Picker, G.S. Jacob, T. Block, and K. Shailubhai Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent Atiprimod Mol. Cancer Ther. 6 2007 112 121
16. C.T. Chu, D.J. Levinthal, S.M. Kulich, E.M. Chalovich, and D.B. DeFranco Oxidative neuronal injury. The dark side of ERK1/2 Eur. J. Biochem. 271 2004 2060 2066
17. D.M. Chuang, Z. Wang, and C.T. Chiu GSK-3 as a target for lithium-induced neuroprotection against excitotoxicity in neuronal cultures and animal models of ischemic stroke Front. Mol. Neurosci. 4 2011 15
18. R.A. Clark, J.W. Gurd, N. Bissoon, N. Tricaud, E. Molnar, S.E. Zamze, R.A. Dwek, R.A. McIlhinney, and D.R. Wing Identification of lectin-purified neural glycoproteins, GPs 180, 116, and 110, with NMDA and AMPA receptor subunits: conservation of glycosylation at the synapse J. Neurochem. 70 1998 2594 2605
19. F.M. Cordova, A.L. Rodrigues, M.B. Giacomelli, C.S. Oliveira, T. Posser, P.R. Dunkley, and R.B. Leal Lead stimulates ERK1/2 and p38MAPK phosphorylation in the hippocampus of immature rats Brain Res. 998 2004 65 72
20. F.M. Cordova, A.S. Aguiar Jr., T.V. Peres, M.W. Lopes, F.M. Gonçalves, A.P. Remor, S.C. Lopes, C. Pilati, A.S. Latini, R.D. Prediger, K.M. Erikson, M. Aschner, and R.B. Leal In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motorfunction PLoS One 7 2012 1 14
21. + channels, phosphatidilinositol-3 kinase/protein kinase B pathway activation and glutamate uptake Neuroscience 183 2011 212 220
22. D.H. Dube, and C.R. Bertozzi Glycans in cancer and inflammation-potential for therapeutics and diagnostics Nat. Rev. Drug Discovery 4 2005 477 488
23. T. Endo Glycans and glycan-binding proteins in brain: galectin-1-induced expression of neurotrophic factors in astocytes Curr. Drug Targets 6 2005 427 436
24. I. Everts, C. Villmann, and M. Hollmann N-Glycosylation is not a prerequisite for glutamate receptor function but is essential for lectin modulation Mol. Pharmacol. 52 1997 861 873
25. A.M. Fay, and D. Bowie Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor J. Physiol. 572 2006 201 213
26. H. Ghazarian, B. Idoni, and S.B. Pooenheimer A glycobiology review: carbohydrates, lectins and implications in cancer therapeutics Elsevier 113 2010 236 247
27. X. Gonda Basic pharmacology of NMDA receptors Curr. Pharm. Des. 18 2012 1558 1567
28. P. Greengard The neurobiology of slow synaptic transmission Science 294 2001 1024 1030
29. J.W. Gurd Glycoproteins of the synapse, in neurobiology of glycoconjugates R.U. Margolis, R.K. Margolis, 1989 Plenum Press New York pp. 219-242
30. M. Hanada, J. Feng, and B.A. Hemmings Structure, regulation and function of PKB/AKT-a major therapeutic target Biochim. Biophys. Acta 1697 2004 3 16
31. Y. Jing, L.Z. Liu, Y. Jiang, Y. Zhu, N.L. Guo, J. Barnett, Y. Rojanasakul, F. Agani, and B.H. Jiang Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells Toxicol. Sci. 125 2012 10 19
32. Y. Kim, R. Seger, C.V. Suresh babu, S.Y. Hwang, and Y.S. Yoo A positive role of the PI3K/Akt signaling pathway in PC12 cell differentiation Mol. Cells 18 2004 353 359
33. E.K. Kim, and E.J. Choi Pathological roles of MAPK signaling pathways in human diseases Biochim. Biophys. Acta 1802 2010 396 405
34. A. Lau, and M. Tymianski Glutamate receptors, neurotoxicity an neurodegeneration Pflugers Arch. 460 2010 525 542
35. S. Lee, Y. Kim, E. Li, and S. Park Ghrelin protects spinal cord motoneurons against chronic glutamate excitotoxicity by inhibiting microglial activation Korean J. Physiol. Pharmacol. 16 2012 43 48
36. S.S. Lin, and I.B. Levitan Concanavalin A: a tool to investigate neuronal plasticity Trends Neurosci. 14 1991 273 277
37. Y. Liu, D.A. Peterson, H. Kimura, and D. Schubert Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction J. Neurochem. 69 1997 581 593
38. F.T. Liu, and G.A. Rabinovich Galectins as modulators of tumour progression Nat. Rev. Cancer 5 2005 29 41
39. F.C. Lopes, B.S. Cavada, V.P. Pinto, A.H. Sampaio, and J.C. Gomes Differential effect of plant lectins on mast cells of different origins on the histamine release induced by plant lectins Braz. J. Med. Biol. Res. 38 2005 935 941
40. D.R. Lynch, and R.P. Guttmann Excitotoxicity: perspectives based on NMDA receptor subtypes J. Pharmacol. Exp. Ther. 300 2002 717 723
41. P. Marschal, A. Reeber, J.R. Neeser, G. Vincendon, and J.P. Zanetta Carbohydrate and glycoprotein specificity of two endogenous cerebellar lectins Biochimie 71 1989 645 653
42. H. Matthies Jr., J. Kretlow, H. Matthies, K.H. Smalla, S. Staak, and M. Krug Glycosylation of proteins during a critical time window is necessary for the maintenance of long-term potentiation in the hippocampal CA1 region Neuroscience 91 1999 75 183
43. B.S. Meldrum Glutamate as a neurotransmitter in the brain: review of physiology and pathology J. Nutr. 130 2000 1007 1015
44. S. Molz, T. Dal-Cim, H. Decker, and C.I. Tasca GMP prevents excitotoxicity mediated by NMDA receptor activation but not by reversal activity of glutamate transporters in rat hippocampal slices Brain Res. 22 2008 113 120
45. S. Molz, H. Decker, T. Dal-Cim, C. Cremonez, F.M. Cordova, R.B. Leal, and C.I. Tasca Glutamate induced toxicity in hippocampal slices involves apoptotic features and-p38MAPK signaling Neurochem. Res. 33 2008 27 36
46. S. Molz, T. Dal-Cim, J. Budni, M.D. Martín-de-Saavedra, J. Egea, A. Romero, L. del Barrio, A.L. Rodrigues, M.G. López, and C.I. Tasca Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition J. Neurosci. Res. 89 2011 1400 1408
47. R.A. Moreira, and B.S. Cavada Lectin from Canavalia brasiliensis: isolation, charaterizatin and behavior during germination Biol. Plant. (Praha) 26 1984 113 120
48. K.M. Partin, D.K. Patneau, C.A. Winters, M.L. Mayer, and A. Buonanno Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A Neuron 11 1993 1069 1082
49. G.L. Peterson A simplification of the protein assay method of Lowry et al. which is more generally applicable Anal. Biochem. 83 1977 346 356
50. T.C. Piermartiri, S. Vandresen-Filho, B. de Araújo Herculano, W.C. Martins, D. Dal'agnolo, E. Stroeh, C.L. Carqueja, C.R. Boeck, and C.I. Tasca Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake Neurotoxicol. Res. 16 2009 106 115
51. W.S. Qu, Y.H. Wang, J.F. Ma, D.S. Tian, Q. Zhang, D.J. Pan, Z.Y. Yu, M.J. Xie, J.P. Wang, and W. Wang Galectin-1 attenuates astrogliosis-associated injuries and improves recovery of rats following focal cerebral ischemia J. Neurochem. 116 2011 217 226
52. A. Rambourg, and C.P. Leblond Electron microscope observations on the carbohydrate-rich cell coat present at the surface of cells in the rat J. Cell Biol. 32 1967 27 53
53. J.D. Rothstein Excitotoxicity hypothesis Neurology 47 4 Suppl. 2 1996 19 25
54. M.A. Russi, S. Vandresen-Filho, D.K. Rieger, A.P. Costa, M.W. Lopes, R.M. Cunha, E.H. Teixeira, K.S. Nascimento, B.S. Cavada, C.I. Tasca, and R.B. Leal ConBr, a lectin from Canavalia brasiliensis seeds, protects against quinolinic acid-induced seizures in mice Neurochem. Res. 37 2012 288 297
55. J. Sanz-Aparicio, J. Hermoso, T.B. Grangeiro, J.J. Calvete, and B.S. Cavada The crystal structure of Canavalia brasiliensis lectin suggests a correlation between its quaternary conformation and its distinct biological properties from Concanavalin A FEBS Lett. 405 1997 114 118
56. W.J. Scherer, and S.B. Udin Concanavalin A reduces habituation in the tectum of the frog Brain Res. 405 1994 114 118
57. M.A. Schwarzschild, R.L. Cole, and S.E. Hyman Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons J. Neurosci. 17 1997 3455 3466
58. C. Sun, D. Wang, and W. Zheng Hydrogen peroxide attenuates the prosurvival signaling of insulin-like growth factor-1 through two pathways Neuroreport 23 2012 768 773
59. J.D. Sweatt Mitogen-activated protein kinases in synaptic plasticity and memory Curr. Opin. Neurobiol. 14 2004 1 7
60. G.M. Thomas, and R.L. Huganir MAPK cascade signalling and synaptic plasticity Nat. Rev. Neurosci. 5 2004 173 183
61. L.P. Van der Heide, G.M. Ramakers, and M.P. Smidt Insulin signaling in the central nervous system: learning to survive Prog. Neurobiol. 79 2006 205 221
62. V. Waetzig, and T. Herdegen Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain Neurosci. Lett. 6 361 2004 64 67
63. D.R. Wing Glycoprotein specificity and diversity, in glycobiology and the brain M. Nicolini, P.F. Zatta, 1993 Pergamon Press Oxford pp. 7-121
64. W. Wong, and J.D. Scott AKAP signalling complexes: focal points in space and time Nat. Rev. Mol. Cell Biol. 5 2004 959 970
65. J. Yamane, M. Nakamura, A. Iwanami, M. Sakaguchi, H. Katoh, M. Yamada, S. Momoshima, S. Miyao, K. Ishii, N. Tamaoki, T. Nomura, H.J. Okano, Y. Kanemura, Y. Toyama, and H. Okano Transplatation of galectin-1 expressing human neural stem cells into injured spinal cord of adult common marmosets J. Neurosci. Res. 88 2010 1394 1405
66. D.D. Yang, C.Y. Kuan, A.J. Whitmarsh, M. Rincon, T.S. Zheng, R.J. Davis, P. Rakic, and R.A. Flavell Absence of excitotoxicity induced apoptosis in the hippocampus of mice lacking the Jnk3 gene Nature 389 1997 865 870
67. K.T. Yue, J.F. MacDonald, R. Pekhletski, and D.R. Hampson Differential effects of lectins on recombinant glutamate receptors Eur. J. Pharmacol. Mol. Pharmacol. 291 1995 229 235