메뉴 건너뛰기




Volumn 18, Issue 12, 2012, Pages 1558-1567

Basic pharmacology of NMDA receptors

Author keywords

Glutamate; Neuropsychiatric disorders; NMDA; Receptor subunits

Indexed keywords

DIMEBON; DIZOCILPINE; IFENPRODIL; IONOTROPIC RECEPTOR; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERAMEXANE; TRAXOPRODIL;

EID: 84860210195     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212799958521     Document Type: Article
Times cited : (58)

References (102)
  • 2
    • 25144447313 scopus 로고    scopus 로고
    • The neurobiology of persistent pain and its clinical implications
    • Dubner R. The neurobiology of persistent pain and its clinical implications. Suppl Clin Neurophysiol 2004; 57: 3-7.
    • (2004) Suppl Clin Neurophysiol , vol.57 , pp. 3-7
    • Dubner, R.1
  • 3
    • 0032694066 scopus 로고    scopus 로고
    • NMDA receptor hypofunction model of schizophrenia
    • Olney JW, Newcomer JW, Farber NB. NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res 1999; 33: 523-533.
    • (1999) J Psychiatr Res , vol.33 , pp. 523-533
    • Olney, J.W.1    Newcomer, J.W.2    Farber, N.B.3
  • 4
    • 13544268511 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor subtypes: Multiple roles in excitotoxicity and neurological disease
    • Waxman EA, Lynch DR. N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neurosci-entist 2005; 11: 37-49.
    • (2005) Neurosci-entist , vol.11 , pp. 37-49
    • Waxman, E.A.1    Lynch, D.R.2
  • 5
    • 0035949351 scopus 로고    scopus 로고
    • DeltaFosB: A sustained molecular switch for addiction
    • Nestler EJ, Barrot M, Self DW. DeltaFosB: a sustained molecular switch for addiction. Proc Natl Acad Sci USA 2001; 98: 11042-11046.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11042-11046
    • Nestler, E.J.1    Barrot, M.2    Self, D.W.3
  • 7
    • 85057925092 scopus 로고    scopus 로고
    • Pharmacology of NMDA receptors
    • In: VanDongen AM, Ed., Boca Raton: CRC Press
    • Monaghan DT, Jane DE. Pharmacology of NMDA receptors. In: VanDongen AM, Ed. Biology if the NMDA receptor. Boca Raton: CRC Press 2009; pp. 257-283.
    • (2009) Biology If the NMDA Receptor , pp. 257-283
    • Monaghan, D.T.1    Jane, D.E.2
  • 8
    • 0030078594 scopus 로고    scopus 로고
    • Ionotropic glutamate receptors. Their possible role in the expression of hippocampal synaptic plasticity
    • Asztely F, Gustafsson B. Ionotropic glutamate receptors. Their possible role in the expression of hippocampal synaptic plasticity. Mol Neurobiol 1996; 12: 1-11.
    • (1996) Mol Neurobiol , vol.12 , pp. 1-11
    • Asztely, F.1    Gustafsson, B.2
  • 10
    • 0024596865 scopus 로고
    • The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system
    • Monaghan DT, Bridges RJ, Cotman CW. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxicol 1989; 29: 365-402.
    • (1989) Annu Rev Pharmacol Toxicol , vol.29 , pp. 365-402
    • Monaghan, D.T.1    Bridges, R.J.2    Cotman, C.W.3
  • 12
    • 2942575981 scopus 로고    scopus 로고
    • Glutamate transporters bring competition to the synapse
    • Huang YH, Bergles DE. Glutamate transporters bring competition to the synapse. Curr Opin Neurobiol 2004; 14: 346-352.
    • (2004) Curr Opin Neurobiol , vol.14 , pp. 346-352
    • Huang, Y.H.1    Bergles, D.E.2
  • 13
    • 70349331070 scopus 로고    scopus 로고
    • Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
    • Wu LJ, Zhuo M. Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain. Neurotherapeutics 2009; 6: 693-702.
    • (2009) Neurotherapeutics , vol.6 , pp. 693-702
    • Wu, L.J.1    Zhuo, M.2
  • 14
    • 0024410966 scopus 로고
    • Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurones in culture
    • MacDonald JF, Mody I, Salter MW. Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurones in culture. J Physiol 1989; 414: 17-34.
    • (1989) J Physiol , vol.414 , pp. 17-34
    • Macdonald, J.F.1    Mody, I.2    Salter, M.W.3
  • 15
    • 0026437728 scopus 로고
    • Molecular diversity of glutamate receptors and implications for brain function
    • Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science 1992; 258: 597-603.
    • (1992) Science , vol.258 , pp. 597-603
    • Nakanishi, S.1
  • 16
    • 70350324907 scopus 로고    scopus 로고
    • Allosteric modulators of NR2B-containing NMDA receptors: Molecular mechanisms and therapeutic potential
    • Mony L, Kew JN, Gunthorpe MJ, Paoletti P. Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. Br J Pharmacol 2009; 157: 1301-1317.
    • (2009) Br J Pharmacol , vol.157 , pp. 1301-1317
    • Mony, L.1    Kew, J.N.2    Gunthorpe, M.J.3    Paoletti, P.4
  • 17
    • 33846920665 scopus 로고    scopus 로고
    • NMDA receptor subunits: Function and pharmacology
    • Paoletti P, Neyton J. NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 2007; 7: 39-47.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 39-47
    • Paoletti, P.1    Neyton, J.2
  • 18
    • 0032790229 scopus 로고    scopus 로고
    • Subunit- and site-specific pharmacology of the NMDA receptor channel
    • Yamakura T, Shimoji K. Subunit- and site-specific pharmacology of the NMDA receptor channel. Prog Neurobiol 1999; 59: 279-298.
    • (1999) Prog Neurobiol , vol.59 , pp. 279-298
    • Yamakura, T.1    Shimoji, K.2
  • 19
    • 0027295942 scopus 로고
    • The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
    • O'Hara PJ, Sheppard PO, Thogersen H, et al. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron 1993; 11: 41-52.
    • (1993) Neuron , vol.11 , pp. 41-52
    • O'Hara, P.J.1    Sheppard, P.O.2    Thogersen, H.3
  • 21
    • 0028559605 scopus 로고
    • Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins
    • Stern-Bach Y, Bettler B, Hartley M, Sheppard PO, O'Hara PJ, Heinemann SF. Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron 1994; 13: 1345-1357.
    • (1994) Neuron , vol.13 , pp. 1345-1357
    • Stern-Bach, Y.1    Bettler, B.2    Hartley, M.3    Sheppard, P.O.4    O'Hara, P.J.5    Heinemann, S.F.6
  • 22
    • 0029893942 scopus 로고    scopus 로고
    • The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: Identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region
    • Hirai H, Kirsch J, Laube B, Betz H, Kuhse J. The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region. Proc Natl Acad Sci USA 1996; 93: 6031-6036.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6031-6036
    • Hirai, H.1    Kirsch, J.2    Laube, B.3    Betz, H.4    Kuhse, J.5
  • 23
    • 0030991790 scopus 로고    scopus 로고
    • Molecular determinants of agonist discrimination by NMDA receptor subunits: Analysis of the glutamate binding site on the NR2B subunit
    • Laube B, Hirai H, Sturgess M, Betz H, Kuhse J. Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron 1997; 18: 493-503.
    • (1997) Neuron , vol.18 , pp. 493-503
    • Laube, B.1    Hirai, H.2    Sturgess, M.3    Betz, H.4    Kuhse, J.5
  • 24
    • 0028810883 scopus 로고
    • Structure and function of the NMDA receptor channel
    • Mori H, Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology 1995; 34: 1219-1237.
    • (1995) Neuropharmacology , vol.34 , pp. 1219-1237
    • Mori, H.1    Mishina, M.2
  • 25
    • 0037074985 scopus 로고    scopus 로고
    • Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
    • Chatterton JE, Awobuluyi M, Premkumar LS, et al. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 2002; 415: 793-798.
    • (2002) Nature , vol.415 , pp. 793-798
    • Chatterton, J.E.1    Awobuluyi, M.2    Premkumar, L.S.3
  • 26
    • 0031023519 scopus 로고    scopus 로고
    • An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor
    • Wood MW, VanDongen HM, VanDongen AM. An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor. J Biol Chem 1997; 272: 3532-3537.
    • (1997) J Biol Chem , vol.272 , pp. 3532-3537
    • Wood, M.W.1    Vandongen, H.M.2    Vandongen, A.M.3
  • 27
    • 0035369112 scopus 로고    scopus 로고
    • NMDA receptor subunits: Diversity, development and disease
    • Cull-Candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 2001; 11: 327-335.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 327-335
    • Cull-Candy, S.1    Brickley, S.2    Farrant, M.3
  • 28
    • 0026721811 scopus 로고
    • Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
    • Monyer H, Sprengel R, Schoepfer R, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 1992; 256: 1217-1221.
    • (1992) Science , vol.256 , pp. 1217-1221
    • Monyer, H.1    Sprengel, R.2    Schoepfer, R.3
  • 29
    • 2342637165 scopus 로고    scopus 로고
    • Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
    • Liu L, Wong TP, Pozza MF, et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 2004; 304: 1021-1024.
    • (2004) Science , vol.304 , pp. 1021-1024
    • Liu, L.1    Wong, T.P.2    Pozza, M.F.3
  • 30
    • 33845886090 scopus 로고    scopus 로고
    • Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    • Bartlett TE, Bannister NJ, Collett VJ, et al. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Neuropharma-cology 2007; 52: 60-70.
    • (2007) Neuropharma-cology , vol.52 , pp. 60-70
    • Bartlett, T.E.1    Bannister, N.J.2    Collett, V.J.3
  • 31
    • 0030463423 scopus 로고    scopus 로고
    • Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific
    • Krupp JJ, Vissel B, Heinemann SF, Westbrook GL. Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific. Mol Pharmacol 1996; 50: 1680-1688.
    • (1996) Mol Pharmacol , vol.50 , pp. 1680-1688
    • Krupp, J.J.1    Vissel, B.2    Heinemann, S.F.3    Westbrook, G.L.4
  • 32
    • 0032575065 scopus 로고    scopus 로고
    • Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
    • Das S, Sasaki YF, Rothe T, et al. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 1998; 393: 377-381.
    • (1998) Nature , vol.393 , pp. 377-381
    • Das, S.1    Sasaki, Y.F.2    Rothe, T.3
  • 33
    • 33644520285 scopus 로고    scopus 로고
    • NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
    • Micu I, Jiang Q, Coderre E, et al. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature 2006; 439: 988-992.
    • (2006) Nature , vol.439 , pp. 988-992
    • Micu, I.1    Jiang, Q.2    Coderre, E.3
  • 34
    • 0030864283 scopus 로고    scopus 로고
    • Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies
    • Laurie DJ, Bartke I, Schoepfer R, Naujoks K, Seeburg PH. Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies. Brain Res Mol Brain Res 1997; 51: 23-32.
    • (1997) Brain Res Mol Brain Res , vol.51 , pp. 23-32
    • Laurie, D.J.1    Bartke, I.2    Schoepfer, R.3    Naujoks, K.4    Seeburg, P.H.5
  • 35
    • 46849097142 scopus 로고    scopus 로고
    • NMDA receptors in clinical neurology: Excitatory times ahead
    • Kalia LV, Kalia SK, Salter MW. NMDA receptors in clinical neurology: excitatory times ahead. Lancet Neurol 2008; 7: 742-755.
    • (2008) Lancet Neurol , vol.7 , pp. 742-755
    • Kalia, L.V.1    Kalia, S.K.2    Salter, M.W.3
  • 36
    • 0019442884 scopus 로고
    • Pharmacology of excitatory amino acid transmitters
    • Watkins JC. Pharmacology of excitatory amino acid transmitters. Adv Biochem Psychopharmacol 1981; 29: 205-212.
    • (1981) Adv Biochem Psychopharmacol , vol.29 , pp. 205-212
    • Watkins, J.C.1
  • 38
    • 0024505521 scopus 로고
    • 1-Aminocyclopropane car-boxylic acid: A potent and selective ligand for the glycine modula-tory site of the N-methyl-D-aspartate receptor complex
    • Marvizon JC, Lewin AH, Skolnick P. 1-Aminocyclopropane car-boxylic acid: a potent and selective ligand for the glycine modula-tory site of the N-methyl-D-aspartate receptor complex. J Neuro-chem 1989; 52: 992-994.
    • (1989) J Neuro-chem , vol.52 , pp. 992-994
    • Marvizon, J.C.1    Lewin, A.H.2    Skolnick, P.3
  • 39
    • 0024509810 scopus 로고
    • 1-Aminocyclobutane-1-carboxylate (ACBC): A specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor
    • Hood WF, Sun ET, Compton RP, Monahan JB. 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor. Eur J Pharmacol 1989; 161: 281-282.
    • (1989) Eur J Pharmacol , vol.161 , pp. 281-282
    • Hood, W.F.1    Sun, E.T.2    Compton, R.P.3    Monahan, J.B.4
  • 40
    • 0024564076 scopus 로고
    • A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists
    • Kessler M, Terramani T, Lynch G, Baudry M. A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists. J Neurochem 1989; 52: 1319-1328.
    • (1989) J Neurochem , vol.52 , pp. 1319-1328
    • Kessler, M.1    Terramani, T.2    Lynch, G.3    Baudry, M.4
  • 41
    • 0027988561 scopus 로고
    • The glycine site on the NMDA receptor: Structure-activity relationships and therapeutic potential
    • Leeson PD, Iversen LL. The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential. J Med Chem 1994; 37: 4053-4067.
    • (1994) J Med Chem , vol.37 , pp. 4053-4067
    • Leeson, P.D.1    Iversen, L.L.2
  • 43
    • 0017367291 scopus 로고
    • Selective antagonism by Mg2+ of amino acid-induced depolarization of spinal neurones
    • Evans RH, Francis AA, Watkins JC. Selective antagonism by Mg2+ of amino acid-induced depolarization of spinal neurones. Experientia 1977; 33: 489-91.
    • (1977) Experientia , vol.33 , pp. 489-491
    • Evans, R.H.1    Francis, A.A.2    Watkins, J.C.3
  • 44
    • 0032892343 scopus 로고    scopus 로고
    • Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data
    • Parsons CG, Danysz W, Quack G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data. Neuropharmacology 1999; 38: 735-767.
    • (1999) Neuropharmacology , vol.38 , pp. 735-767
    • Parsons, C.G.1    Danysz, W.2    Quack, G.3
  • 45
    • 0020629581 scopus 로고
    • The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate
    • Anis NA, Berry SC, Burton NR, Lodge D. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br J Pharmacol 1983; 79: 565-575.
    • (1983) Br J Pharmacol , vol.79 , pp. 565-575
    • Anis, N.A.1    Berry, S.C.2    Burton, N.R.3    Lodge, D.4
  • 47
    • 0025350861 scopus 로고
    • Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
    • Traynelis SF, Cull-Candy SG. Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature 1990; 345: 347-350.
    • (1990) Nature , vol.345 , pp. 347-350
    • Traynelis, S.F.1    Cull-Candy, S.G.2
  • 48
    • 0029021010 scopus 로고
    • Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines
    • Traynelis SF, Hartley M, Heinemann SF. Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science 1995; 268: 873-876.
    • (1995) Science , vol.268 , pp. 873-876
    • Traynelis, S.F.1    Hartley, M.2    Heinemann, S.F.3
  • 49
    • 0024448447 scopus 로고
    • Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: Pharmacological evidence for the existence of a polyamine recognition site
    • Williams K, Romano C, Molinoff PB. Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol Pharmacol 1989; 36: 575-581.
    • (1989) Mol Pharmacol , vol.36 , pp. 575-581
    • Williams, K.1    Romano, C.2    Molinoff, P.B.3
  • 50
    • 0025063670 scopus 로고
    • Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor
    • Williams K, Dawson VL, Romano C, Dichter MA, Molinoff PB. Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor. Neuron 1990; 5: 199-208.
    • (1990) Neuron , vol.5 , pp. 199-208
    • Williams, K.1    Dawson, V.L.2    Romano, C.3    Dichter, M.A.4    Molinoff, P.B.5
  • 51
    • 0027174665 scopus 로고
    • Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippo-campal neurones
    • Benveniste M, Mayer ML. Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippo-campal neurones. J Physiol 1993; 464: 131-163.
    • (1993) J Physiol , vol.464 , pp. 131-163
    • Benveniste, M.1    Mayer, M.L.2
  • 52
    • 0028069856 scopus 로고
    • Mechanisms influencing stimulatory effects of sper-mine at recombinant N-methyl-D-aspartate receptors
    • Williams K. Mechanisms influencing stimulatory effects of sper-mine at recombinant N-methyl-D-aspartate receptors. Mol Pharmacol 1994; 46: 161-168.
    • (1994) Mol Pharmacol , vol.46 , pp. 161-168
    • Williams, K.1
  • 53
    • 0028170444 scopus 로고
    • 2+: An endogenous modulator of ligand- and voltage-gated ion channels
    • 2+: an endogenous modulator of ligand- and voltage-gated ion channels. Neuropharmacology 1994; 33: 935-952.
    • (1994) Neuropharmacology , vol.33 , pp. 935-952
    • Harrison, N.L.1    Gibbons, S.J.2
  • 54
    • 0023253615 scopus 로고
    • Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons
    • Peters S, Koh J, Choi DW. Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons. Science 1987; 236: 589-593.
    • (1987) Science , vol.236 , pp. 589-593
    • Peters, S.1    Koh, J.2    Choi, D.W.3
  • 55
    • 0030997418 scopus 로고    scopus 로고
    • Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition
    • Chen N, Moshaver A, Raymond LA. Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition. Mol Pharmacol 1997; 51: 1015-1023.
    • (1997) Mol Pharmacol , vol.51 , pp. 1015-1023
    • Chen, N.1    Moshaver, A.2    Raymond, L.A.3
  • 56
    • 0025951641 scopus 로고
    • Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism
    • Legendre P, Westbrook GL. Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism. Mol Pharmacol 1991; 40: 289-298.
    • (1991) Mol Pharmacol , vol.40 , pp. 289-298
    • Legendre, P.1    Westbrook, G.L.2
  • 57
    • 0031985248 scopus 로고    scopus 로고
    • State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist
    • Kew JN, Trube G, Kemp JA. State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br J Pharmacol 1998; 123: 463-472.
    • (1998) Br J Pharmacol , vol.123 , pp. 463-472
    • Kew, J.N.1    Trube, G.2    Kemp, J.A.3
  • 58
    • 0027405347 scopus 로고
    • Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
    • Williams K, Russell SL, Shen YM, Molinoff PB. Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron 1993; 10: 267-278.
    • (1993) Neuron , vol.10 , pp. 267-278
    • Williams, K.1    Russell, S.L.2    Shen, Y.M.3    Molinoff, P.B.4
  • 59
    • 30844451008 scopus 로고    scopus 로고
    • Glutamate-based therapeutic approaches: NR2B receptor antagonists
    • Gogas KR. Glutamate-based therapeutic approaches: NR2B receptor antagonists. Curr Opin Pharmacol 2006; 6: 68-74.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 68-74
    • Gogas, K.R.1
  • 60
    • 33646537447 scopus 로고    scopus 로고
    • NR2B selective NMDA antagonists: The evolution of the ifenprodil-type pharmacophore
    • Borza I, Domany G. NR2B selective NMDA antagonists: the evolution of the ifenprodil-type pharmacophore. Curr Top Med Chem 2006; 6: 687-695.
    • (2006) Curr Top Med Chem , vol.6 , pp. 687-695
    • Borza, I.1    Domany, G.2
  • 61
    • 77956434789 scopus 로고    scopus 로고
    • Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease
    • Tallaksen-Greene SJ, Janiszewska A, Benton K, Ruprecht L, Albin RL. Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease. Exp Neurol 2010; 225: 402-407.
    • (2010) Exp Neurol , vol.225 , pp. 402-407
    • Tallaksen-Greene, S.J.1    Janiszewska, A.2    Benton, K.3    Ruprecht, L.4    Albin, R.L.5
  • 62
    • 33947331063 scopus 로고    scopus 로고
    • NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo
    • Liu Y, Wong TP, Aarts M, et al. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci 2007; 27: 2846-2857.
    • (2007) J Neurosci , vol.27 , pp. 2846-2857
    • Liu, Y.1    Wong, T.P.2    Aarts, M.3
  • 63
    • 4143117789 scopus 로고    scopus 로고
    • Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease
    • Hynd MR, Scott HL, Dodd PR. Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease. J Neurochem 2004; 90: 913-919.
    • (2004) J Neurochem , vol.90 , pp. 913-919
    • Hynd, M.R.1    Scott, H.L.2    Dodd, P.R.3
  • 64
    • 1842614330 scopus 로고    scopus 로고
    • Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease
    • Hynd MR, Scott HL, Dodd PR. Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease. J Neurochem 2004; 89: 240-247.
    • (2004) J Neurochem , vol.89 , pp. 240-247
    • Hynd, M.R.1    Scott, H.L.2    Dodd, P.R.3
  • 65
    • 23044445669 scopus 로고    scopus 로고
    • Regulation of NMDA receptor trafficking by amyloid-beta
    • Snyder EM, Nong Y, Almeida CG, et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 2005; 8: 1051-1058.
    • (2005) Nat Neurosci , vol.8 , pp. 1051-1058
    • Snyder, E.M.1    Nong, Y.2    Almeida, C.G.3
  • 66
    • 34948842904 scopus 로고    scopus 로고
    • Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse
    • Parsons CG, Stoffler A, Danysz W. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse. Neuropharmacology 2007; 53: 699-723.
    • (2007) Neuropharmacology , vol.53 , pp. 699-723
    • Parsons, C.G.1    Stoffler, A.2    Danysz, W.3
  • 67
  • 68
    • 57049160908 scopus 로고    scopus 로고
    • Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and Parkinsonism
    • Nutt JG, Gunzler SA, Kirchhoff T, et al. Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and Parkinsonism. Mov Disord 2008; 23: 1860-1866.
    • (2008) Mov Disord , vol.23 , pp. 1860-1866
    • Nutt, J.G.1    Gunzler, S.A.2    Kirchhoff, T.3
  • 69
    • 85057916664 scopus 로고    scopus 로고
    • NMDA receptors and Huntington's Disease
    • In: VanDongen AM, Ed., Boca Raton: CRC Press
    • Fernandes HB, Raymond LA. NMDA receptors and Huntington's Disease. In: VanDongen AM, Ed. Biology if the NMDA receptor. Boca Raton: CRC Press 2009; pp. 17-41.
    • (2009) Biology If the NMDA Receptor , pp. 17-41
    • Fernandes, H.B.1    Raymond, L.A.2
  • 70
    • 0037075624 scopus 로고    scopus 로고
    • Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
    • Zeron MM, Hansson O, Chen N, et al. Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron 2002; 33: 849-860.
    • (2002) Neuron , vol.33 , pp. 849-860
    • Zeron, M.M.1    Hansson, O.2    Chen, N.3
  • 71
    • 0035816627 scopus 로고    scopus 로고
    • Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95
    • Sun Y, Savanenin A, Reddy PH, Liu YF. Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95. J Biol Chem 2001; 276: 24713-24718.
    • (2001) J Biol Chem , vol.276 , pp. 24713-24718
    • Sun, Y.1    Savanenin, A.2    Reddy, P.H.3    Liu, Y.F.4
  • 72
    • 33750515629 scopus 로고    scopus 로고
    • Evolving therapeutic approaches to treating acute ischemic stroke
    • Weinberger JM. Evolving therapeutic approaches to treating acute ischemic stroke. J Neurol Sci 2006; 249: 101-119.
    • (2006) J Neurol Sci , vol.249 , pp. 101-119
    • Weinberger, J.M.1
  • 73
    • 68549099832 scopus 로고    scopus 로고
    • Positive and negative symptoms in schizophrenia: The NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression
    • Bennett M. Positive and negative symptoms in schizophrenia: the NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression. Aust N Z J Psychiatry 2009; 43: 711-721.
    • (2009) Aust N Z J Psychiatry , vol.43 , pp. 711-721
    • Bennett, M.1
  • 74
    • 0037177552 scopus 로고    scopus 로고
    • Schizophrenia: Diverse approaches to a complex disease
    • Sawa A, Snyder SH. Schizophrenia: diverse approaches to a complex disease. Science 2002; 296: 692-695.
    • (2002) Science , vol.296 , pp. 692-695
    • Sawa, A.1    Snyder, S.H.2
  • 75
    • 0033588176 scopus 로고    scopus 로고
    • Mice with reduced NMDA Receptor expression display behaviors related to schizophrenia
    • Mohn AR, Gainetdinov RR, Caron MG, Koller BH. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 1999; 98: 427-436.
    • (1999) Cell , vol.98 , pp. 427-436
    • Mohn, A.R.1    Gainetdinov, R.R.2    Caron, M.G.3    Koller, B.H.4
  • 76
    • 33846185550 scopus 로고    scopus 로고
    • Schizophrenia: More evidence for less glutamate
    • Morrison PD, Pilowsky LS. Schizophrenia: more evidence for less glutamate. Expert Rev Neurother 2007; 7: 29-31.
    • (2007) Expert Rev Neurother , vol.7 , pp. 29-31
    • Morrison, P.D.1    Pilowsky, L.S.2
  • 78
    • 23944505476 scopus 로고    scopus 로고
    • Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression
    • Kristiansen LV, Meador-Woodruff JH. Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression. Schizophr Res 2005; 78: 87-93.
    • (2005) Schizophr Res , vol.78 , pp. 87-93
    • Kristiansen, L.V.1    Meador-Woodruff, J.H.2
  • 79
    • 36849005064 scopus 로고    scopus 로고
    • Glycine transport inhibitors and the treatment of schizophrenia
    • Javitt DC. Glycine transport inhibitors and the treatment of schizophrenia. Biol Psychiatry 2008; 63: 6-8.
    • (2008) Biol Psychiatry , vol.63 , pp. 6-8
    • Javitt, D.C.1
  • 80
    • 33846629921 scopus 로고    scopus 로고
    • A model of hippocampal neurogenesis in memory and mood disorders
    • Becker S, Wojtowicz JM. A model of hippocampal neurogenesis in memory and mood disorders. Trends Cogn Sci 2007; 11: 70-76.
    • (2007) Trends Cogn Sci , vol.11 , pp. 70-76
    • Becker, S.1    Wojtowicz, J.M.2
  • 81
    • 0042126365 scopus 로고    scopus 로고
    • Modulators of the gluta-matergic system: Implications for the development of improved therapeutics in mood disorders
    • Zarate CA, Quiroz J, Payne J, Manji HK. Modulators of the gluta-matergic system: implications for the development of improved therapeutics in mood disorders. Psychopharmacol Bull 2002; 36: 35-83.
    • (2002) Psychopharmacol Bull , vol.36 , pp. 35-83
    • Zarate, C.A.1    Quiroz, J.2    Payne, J.3    Manji, H.K.4
  • 82
    • 33746896935 scopus 로고    scopus 로고
    • A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    • Zarate CA, Jr., Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 2006; 63: 856-864.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 856-864
    • Zarate Jr., C.A.1    Singh, J.B.2    Carlson, P.J.3
  • 83
    • 30044450251 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of memantine in the treatment of major depression
    • Zarate CA, Jr., Singh JB, Quiroz JA, et al. A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry 2006; 163: 153-155.
    • (2006) Am J Psychiatry , vol.163 , pp. 153-155
    • Zarate Jr., C.A.1    Singh, J.B.2    Quiroz, J.A.3
  • 84
    • 33746902947 scopus 로고    scopus 로고
    • Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice
    • Boyce-Rustay JM, Holmes A. Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice. Neuropsychopharmacology 2006; 31: 2405-2414.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 2405-2414
    • Boyce-Rustay, J.M.1    Holmes, A.2
  • 85
    • 33746294074 scopus 로고    scopus 로고
    • Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats
    • Basselin M, Chang L, Bell JM, Rapoport SI. Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats. Neuropsycho-pharmacology 2006; 31: 1659-1674.
    • (2006) Neuropsycho-pharmacology , vol.31 , pp. 1659-1674
    • Basselin, M.1    Chang, L.2    Bell, J.M.3    Rapoport, S.I.4
  • 86
    • 29644438259 scopus 로고    scopus 로고
    • Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments
    • Chen C, Hardy M, Zhang J, LaHoste GJ, Bazan NG. Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments. Bio-chem Biophys Res Commun 2006; 340: 435-440.
    • (2006) Bio-chem Biophys Res Commun , vol.340 , pp. 435-440
    • Chen, C.1    Hardy, M.2    Zhang, J.3    Lahoste, G.J.4    Bazan, N.G.5
  • 87
    • 37349049304 scopus 로고    scopus 로고
    • The role of glutamate in mood disorders: Results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects
    • Maeng S, Zarate CA, Jr. The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects. Curr Psychiatry Rep 2007; 9: 467-474.
    • (2007) Curr Psychiatry Rep , vol.9 , pp. 467-474
    • Maeng, S.1    Zarate Jr., C.A.2
  • 88
    • 59049098262 scopus 로고    scopus 로고
    • An innovative design to establish proof of concept of the anti-depressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder
    • Preskorn SH, Baker B, Kolluri S, Menniti FS, Krams M, Landen JW. An innovative design to establish proof of concept of the anti-depressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder. J Clin Psychopharmacol 2008; 28: 631-637.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 631-637
    • Preskorn, S.H.1    Baker, B.2    Kolluri, S.3    Menniti, F.S.4    Krams, M.5    Landen, J.W.6
  • 89
    • 70350339387 scopus 로고    scopus 로고
    • Glutamate-based antidepressants: 20 years on Trends
    • Skolnick P, Popik P, Trullas R. Glutamate-based antidepressants: 20 years on. Trends Pharmacol Sci 2009; 30: 563-569.
    • (2009) Pharmacol Sci , vol.30 , pp. 563-569
    • Skolnick, P.1    Popik, P.2    Trullas, R.3
  • 90
    • 0034625770 scopus 로고    scopus 로고
    • Neuronal plasticity: Increasing the gain in pain
    • Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science 2000; 288: 1765-1769.
    • (2000) Science , vol.288 , pp. 1765-1769
    • Woolf, C.J.1    Salter, M.W.2
  • 91
    • 0037526206 scopus 로고    scopus 로고
    • N-methyl-D-aspartate glutamate receptors and alcoholism: Reward, dependence, treatment, and vulnerability
    • Krystal JH, Petrakis IL, Mason G, Trevisan L, D'Souza DC. N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol Ther 2003; 99: 79-94.
    • (2003) Pharmacol Ther , vol.99 , pp. 79-94
    • Krystal, J.H.1    Petrakis, I.L.2    Mason, G.3    Trevisan, L.4    D'Souza, D.C.5
  • 93
    • 0028149213 scopus 로고
    • Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms
    • Nie Z, Madamba SG, Siggins GR. Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms. J Pharmacol Exp Ther 1994; 271: 1566-1573.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1566-1573
    • Nie, Z.1    Madamba, S.G.2    Siggins, G.R.3
  • 94
    • 0030569408 scopus 로고    scopus 로고
    • Single-channel and whole-cell analysis of ethanol inhibition of NMDA-activated currents in cultured mouse cortical and hippocampal neurons
    • Wright JM, Peoples RW, Weight FF. Single-channel and whole-cell analysis of ethanol inhibition of NMDA-activated currents in cultured mouse cortical and hippocampal neurons. Brain Res 1996; 738: 249-256.
    • (1996) Brain Res , vol.738 , pp. 249-256
    • Wright, J.M.1    Peoples, R.W.2    Weight, F.F.3
  • 95
    • 0032252740 scopus 로고    scopus 로고
    • Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol
    • Calton JL, Wilson WA, Moore SD. Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol. J Pharmacol Exp Ther 1998; 287: 1015-1019.
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 1015-1019
    • Calton, J.L.1    Wilson, W.A.2    Moore, S.D.3
  • 96
    • 0028269524 scopus 로고
    • Acute tolerance to ethanol inhibition of NMDA-mediated EPSPs in the CA1 region of the rat hippocampus
    • Grover CA, Frye GD, Griffith WH. Acute tolerance to ethanol inhibition of NMDA-mediated EPSPs in the CA1 region of the rat hippocampus. Brain Res 1994; 642: 70-76.
    • (1994) Brain Res , vol.642 , pp. 70-76
    • Grover, C.A.1    Frye, G.D.2    Griffith, W.H.3
  • 97
    • 2642572544 scopus 로고    scopus 로고
    • Acute tolerance to ethanol inhibition of NMDA-induced responses in rat rostral ventrolateral medulla neurons
    • Lai CC, Chang MC, Lin HH. Acute tolerance to ethanol inhibition of NMDA-induced responses in rat rostral ventrolateral medulla neurons. J Biomed Sci 2004; 11: 482-492.
    • (2004) J Biomed Sci , vol.11 , pp. 482-492
    • Lai, C.C.1    Chang, M.C.2    Lin, H.H.3
  • 98
    • 33745193928 scopus 로고    scopus 로고
    • Neurobiology of alcohol withdrawal inhibitory and excitatory neurotransmitters
    • Esel E. Neurobiology of alcohol withdrawal inhibitory and excitatory neurotransmitters. Turk Psikiyatri Derg 2006; 17: 129-137.
    • (2006) Turk Psikiyatri Derg , vol.17 , pp. 129-137
    • Esel, E.1
  • 99
    • 0029865790 scopus 로고    scopus 로고
    • Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons
    • Hu XJ, Follesa P, Ticku MK. Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons. Brain Res Mol Brain Res 1996; 36: 211-218.
    • (1996) Brain Res Mol Brain Res , vol.36 , pp. 211-218
    • Hu, X.J.1    Follesa, P.2    Ticku, M.K.3
  • 100
    • 85057926746 scopus 로고    scopus 로고
    • NMDA and Dopa-mine: Diverse Mechanisms Applied to Interacting Receptor Systems
    • In: VanDongen AM, Ed., Boca Raton: CRC Press
    • Cepeda C, André VM, Jocoy EL, Levine MS. NMDA and Dopa-mine: Diverse Mechanisms Applied to Interacting Receptor Systems. In: VanDongen AM, Ed. Biology if the NMDA receptor. Boca Raton: CRC Press 2009; pp. 41-59.
    • (2009) Biology If the NMDA Receptor , pp. 41-59
    • Cepeda, C.1    André, V.M.2    Jocoy, E.L.3    Levine, M.S.4
  • 101
    • 16844386330 scopus 로고    scopus 로고
    • The role of the NMDA receptor in alcohol relapse: A pharmacological mapping study using the alcohol deprivation effect
    • Vengeliene V, Bachteler D, Danysz W, Spanagel R. The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology 2005; 48: 822-829.
    • (2005) Neuropharmacology , vol.48 , pp. 822-829
    • Vengeliene, V.1    Bachteler, D.2    Danysz, W.3    Spanagel, R.4
  • 102
    • 0031868767 scopus 로고    scopus 로고
    • Mechanism of action of acamprosate.Part I.Characterization of spermidine-sensitive acamprosate binding site in rat brain
    • Naassila M, Hammoumi S, Legrand E, Durbin P, Daoust M. Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain. Alcohol Clin Exp Res 1998; 22: 802-809.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 802-809
    • Naassila, M.1    Hammoumi, S.2    Legrand, E.3    Durbin, P.4    Daoust, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.