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Volumn 16, Issue 1, 2012, Pages 43-48

Ghrelin protects spinal cord motoneurons against chronic glutamate excitotoxicity by inhibiting microglial activation

Author keywords

Excitotoxicity; Ghrelin; Microglial activation; Motoneuron; Neuroinflammation

Indexed keywords

GHRELIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84863376097     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2012.16.1.43     Document Type: Article
Times cited : (37)

References (35)
  • 1
    • 33745223900 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis (motor neuron disease): Proposed mechanisms and pathways to treatment
    • DOI 10.1111/j.1467-9639.2006.00001.x, PII S1462399406010854
    • Goodall EF, Morrison KE. Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment. Expert Rev Mol Med. 2006;8:1-22. (Pubitemid 43904876)
    • (2006) Expert Reviews in Molecular Medicine , vol.8 , Issue.11 , pp. 1-22
    • Goodall, E.F.1    Morrison, K.E.2
  • 2
    • 33751229311 scopus 로고    scopus 로고
    • The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
    • Van Den Bosch L, Van Damme P, Bogaert E, Robberecht W. The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim Biophys Acta. 2006;1762:1068-1082.
    • (2006) Biochim Biophys Acta , vol.1762 , pp. 1068-1082
    • Van Den Bosch, L.1    Van Damme, P.2    Bogaert, E.3    Robberecht, W.4
  • 3
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein JD, Martin LJ, Kuncl RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med. 1992;326:1464-1468.
    • (1992) N Engl J Med , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 4
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • Rothstein JD, Van Kammen M, Levey AI, Martin LJ, Kuncl RW. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol. 1995;38:73-84.
    • (1995) Ann Neurol , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Van Kammen, M.2    Levey, A.I.3    Martin, L.J.4    Kuncl, R.W.5
  • 5
    • 79951704433 scopus 로고    scopus 로고
    • Neuroinflammation in amyotrophic lateral sclerosis: Role of glial activation in motor neuron disease
    • Philips T, Robberecht W. Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease. Lancet Neurol. 2011;10:253-263.
    • (2011) Lancet Neurol , vol.10 , pp. 253-263
    • Philips, T.1    Robberecht, W.2
  • 6
    • 9144230806 scopus 로고    scopus 로고
    • Increased cytotoxic potential of microglia from ALS-transgenic mice
    • DOI 10.1002/glia.20062
    • Weydt P, Yuen EC, Ransom BR, Möller T. Increased cytotoxic potential of microglia from ALS-transgenic mice. Glia. 2004;48:179-182. (Pubitemid 39545949)
    • (2004) GLIA , vol.48 , Issue.2 , pp. 179-182
    • Weydt, P.1    Yuen, E.C.2    Ransom, B.R.3    Moller, T.4
  • 9
    • 80755185727 scopus 로고    scopus 로고
    • Glial cells in amyotrophic lateral sclerosis
    • Lasiene J, Yamanaka K. Glial cells in amyotrophic lateral sclerosis. Neurol Res Int. 2011;2011:718987.
    • (2011) Neurol Res Int , vol.2011 , pp. 718987
    • Lasiene, J.1    Yamanaka, K.2
  • 10
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • DOI 10.1146/annurev.neuro.22.1.219
    • González-Scarano F, Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci. 1999;22:219-240. (Pubitemid 29144887)
    • (1999) Annual Review of Neuroscience , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 11
    • 0036209082 scopus 로고    scopus 로고
    • Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease
    • Tikka TM, Vartiainen NE, Goldsteins G, Oja SS, Andersen PM, Marklund SL, Koistinaho J. Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease. Brain. 2002;125:722-731. (Pubitemid 34279769)
    • (2002) Brain , vol.125 , Issue.4 , pp. 722-731
    • Tikka, T.M.1    Vartiainen, N.E.2    Goldsteins, G.3    Oja, S.S.4    Andersen, P.M.5    Marklund, S.L.6    Koistinaho, J.7
  • 12
    • 0035871840 scopus 로고    scopus 로고
    • Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    • Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci. 2001;21:2580-2588. (Pubitemid 32298200)
    • (2001) Journal of Neuroscience , vol.21 , Issue.8 , pp. 2580-2588
    • Tikka, T.1    Fiebich, B.L.2    Goldsteins, G.3    Keinanen, R.4    Koistinaho, J.5
  • 13
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • DOI 10.1152/physrev.00012.2004
    • Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005;85:495-522. (Pubitemid 40404635)
    • (2005) Physiological Reviews , vol.85 , Issue.2 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 14
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondai MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 2000;141:4255-4261.
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondai, M.S.5    Suganuma, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 15
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656-660. (Pubitemid 129516334)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 17
    • 33845910446 scopus 로고    scopus 로고
    • Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation
    • DOI 10.1210/en.2006-0991
    • Chung H, Kim E, Lee DH, Seo S, Ju S, Lee D, Kim H, Park S. Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology. 2007;148:148-159. (Pubitemid 46021447)
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 148-159
    • Chung, H.1    Kim, E.2    Dae, H.L.3    Seo, S.4    Ju, S.5    Lee, D.6    Kim, H.7    Park, S.8
  • 18
    • 53349175016 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells
    • Chung H, Seo S, Moon M, Park S. Phosphatidylinositol-3-kinase/Akt/ glycogen synthase kinase-3β and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. J Endocrinol. 2008;198:511-521.
    • (2008) J Endocrinol , vol.198 , pp. 511-521
    • Chung, H.1    Seo, S.2    Moon, M.3    Park, S.4
  • 19
    • 68449105015 scopus 로고    scopus 로고
    • Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4
    • Hwang S, Moon M, Kim S, Hwang L, Ahn KJ, Park S. Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. Endocr J. 2009;56:609-617.
    • (2009) Endocr J , vol.56 , pp. 609-617
    • Hwang, S.1    Moon, M.2    Kim, S.3    Hwang, L.4    Ahn, K.J.5    Park, S.6
  • 20
    • 70449527787 scopus 로고    scopus 로고
    • Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation
    • Moon M, Kim HG, Hwang L, Seo JH, Kim S, Hwang S, Kim S, Lee D, Chung H, Oh MS, Lee KT, Park S. Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation. Neurotox Res. 2009;15:332-347.
    • (2009) Neurotox Res , vol.15 , pp. 332-347
    • Moon, M.1    Kim, H.G.2    Hwang, L.3    Seo, J.H.4    Kim, S.5    Hwang, S.6    Kim, S.7    Lee, D.8    Chung, H.9    Oh, M.S.10    Lee, K.T.11    Park, S.12
  • 21
    • 79958050031 scopus 로고    scopus 로고
    • Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/ Akt/glycogen synthase kinase-3β pathways
    • Lim E, Lee S, Li E, Kim Y, Park S. Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β pathways. Exp Neurol. 2011;230:114-122.
    • (2011) Exp Neurol , vol.230 , pp. 114-122
    • Lim, E.1    Lee, S.2    Li, E.3    Kim, Y.4    Park, S.5
  • 23
    • 77952576252 scopus 로고    scopus 로고
    • Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus
    • Lee J, Lim E, Kim Y, Li E, Park S. Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J Endocrinol. 2010;205:263-270.
    • (2010) J Endocrinol , vol.205 , pp. 263-270
    • Lee, J.1    Lim, E.2    Kim, Y.3    Li, E.4    Park, S.5
  • 24
    • 7244232763 scopus 로고    scopus 로고
    • Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors
    • DOI 10.1016/j.mcn.2004.07.010, PII S1044743104001733
    • Lladó J, Haenggeli C, Maragalds NJ, Snyder EY, Rothstein JD. Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Mol Cell Neurosci. 2004;27:322-331. (Pubitemid 39433844)
    • (2004) Molecular and Cellular Neuroscience , vol.27 , Issue.3 , pp. 322-331
    • Llado, J.1    Haenggeli, C.2    Maragakis, N.J.3    Snyder, E.Y.4    Rothstein, J.D.5
  • 26
    • 78650869541 scopus 로고    scopus 로고
    • TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB
    • Tolosa L, Caraballo-Miralles V, Olmos G, Lladó J. TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB. Mol Cell Neurosci. 2011;46:176-186.
    • (2011) Mol Cell Neurosci , vol.46 , pp. 176-186
    • Tolosa, L.1    Caraballo-Miralles, V.2    Olmos, G.3    Lladó, J.4
  • 27
    • 77954898609 scopus 로고    scopus 로고
    • Inhibition of apoptotic cell death by ghrelin improves functional recovery after spinal cord injury
    • Lee JY, Chung H, Yoo YS, Oh YJ, Oh TH, Park S, Yune TY. Inhibition of apoptotic cell death by ghrelin improves functional recovery after spinal cord injury. Endocrinology. 2010;151:3815-3826.
    • (2010) Endocrinology , vol.151 , pp. 3815-3826
    • Lee, J.Y.1    Chung, H.2    Yoo, Y.S.3    Oh, Y.J.4    Oh, T.H.5    Park, S.6    Yune, T.Y.7
  • 28
    • 0027280317 scopus 로고
    • Art and artifice in the science of histology. 1933
    • del Rio-Hortega P. Art and artifice in the science of histology. 1933. Histopathology. 1993;22:515-525.
    • (1993) Histopathology , vol.22 , pp. 515-525
    • Del Rio-Hortega, P.1
  • 29
    • 70449656984 scopus 로고    scopus 로고
    • Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect
    • Huang CX, Yuan MJ, Huang H, Wu G, Liu Y, Yu SR Li HT, Wang T. Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect. Peptides. 2009;30:2286-2291.
    • (2009) Peptides , vol.30 , pp. 2286-2291
    • Huang, C.X.1    Yuan, M.J.2    Huang, H.3    Wu, G.4    Liu, Y.5    Yu, S.R.6    Li, H.T.7    Wang, T.8
  • 30
    • 70449521981 scopus 로고    scopus 로고
    • Anti-inflammatory activity of ghrelin in human carotid artery cells
    • Chow KB, Cheng CH, Wise H. Anti-inflammatory activity of ghrelin in human carotid artery cells. Inflammation. 2009;32:402-409.
    • (2009) Inflammation , vol.32 , pp. 402-409
    • Chow, K.B.1    Cheng, C.H.2    Wise, H.3
  • 34
    • 47349087292 scopus 로고    scopus 로고
    • Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra
    • Jiang H, Li LJ, Wang J, Xie JX. Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. Exp Neurol. 2008;212:532-537.
    • (2008) Exp Neurol , vol.212 , pp. 532-537
    • Jiang, H.1    Li, L.J.2    Wang, J.3    Xie, J.X.4
  • 35
    • 34249694588 scopus 로고    scopus 로고
    • Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats
    • DOI 10.1016/j.peptides.2007.04.003, PII S0196978107001222
    • Obay BD, Tasdemir E, Tümer C, Bilgin HM, Sermet A. Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. Peptides. 2007;28:1214-1219. (Pubitemid 46843389)
    • (2007) Peptides , vol.28 , Issue.6 , pp. 1214-1219
    • Obay, B.D.1    Tasdemir, E.2    Tumer, C.3    Bilgin, H.M.4    Sermet, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.