ConBr, a lectin from canavalia brasiliensis seeds, protects against quinolinic acid-induced seizures in mice

Neurochemical Research

Volumn 37, Issue 2, 2012, Pages 288-297

  Russi, Michael A ^a   Vandresen Filho, Samuel ^a   Rieger, Débora K ^a   Costa, Ana Paula ^a   Lopes, Mark W ^a   Cunha, Rodrigo M S ^b   Teixeira, Edson H ^c   Nascimento, Kyria S ^c   Cavada, Benildo S ^c   Tasca, Carla I ^a   Leal, Rodrigo B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSIDADE ESTADUAL VALE DO ACARAÚ   (Brazil)

^c FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

ConBr; Lectins; Neuroprotection; NMDA receptor; Quinolinic acid; Seizures

Indexed keywords

ANTICONVULSIVE AGENT; CARBOHYDRATE BINDING PROTEIN; CONBR LECTIN; CONCANAVALIN A; GLUTAMATE RECEPTOR 1; PLANT LECTIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; CANAVALIA BRASILIENSIS; CANAVALIA ENSIFORMIS; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; IN VIVO STUDY; LEGUME; MALE; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PLANT SEED; PRIORITY JOURNAL; REVIEW; TONIC CLONIC SEIZURE;

ANIMALS; BLOTTING, WESTERN; CANAVALIA; HIPPOCAMPUS; MALE; MICE; PLANT LECTINS; QUINOLINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; SEEDS; SEIZURES;

CANAVALIA BRASILIENSIS; MAMMALIA; MUS;

EID: 84856398003     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0608-x     Document Type: Review

References (71)

1. Varki A (1993) Biological roles of oligosaccharides: all of the theories are correct. Glycobiology 3:97-130 (Pubitemid 23132602)
2. Breen KC, Coughlan CM, Hayes FD (1998) The role of glycoproteins in neural development function, and disease. Mol Neurobiol 16:163-220 (Pubitemid 28372721)
3. Matthies H Jr, Kretlow J, Matthies H et al (1999) Glycosylation of proteins during a critical time window is necessary for the maintenance of long-term potentiation in the hippocampal CA1 region. Neuroscience 91:175-183 (Pubitemid 29170456)
4. Lau A, Tymianski M (2010) Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch 460:525-542
5. Hullebroeck MF, Hampson DR (1992) Characterization of the oligosaccharide side chains on kainate binding proteins and AMPA receptors. Brain Res 590:187-192
6. Standley S, Baudry M (2000) The role of glycosylation in ionotropic glutamate receptor ligand binding, function, and trafficking. Cell Mol Life Sci 57:1508-1516
7. Hardingham GE, Bading H (2010) Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci 11:682-696
8. Foster KA, McLaughlin N, Edbauer D et al (2010) Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. J Neurosci 30:2676-2678
9. Kawamoto S, Hattori S, Sakimura K et al (1995) N Linked glycosylation of the AMPA-selective glutamate receptor channel alpha2 subunit is essential for essential for the acquisition of ligand-binding activity. J Neurochem 64:1258-1266
10. Laurie DJ, Bartke I, Schoepfer R et al (1997) Regional, developmental and interspecies expression of the four NMDAR2 subunits examined using monoclonal antibodies. Mol Brain Res 51:23 (Pubitemid 27504028)
11. Cavada BS, Barbosa T, Arruda S et al (2001) Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins. Curr Prot Pep Sci 2:1-13 (Pubitemid 32499459)
12. Loris R (2002) Principles of structures of animal and plant lectins. Biochim Biophys Acta 1572:198-208 (Pubitemid 35246345)
13. Ambrosi M, Cameron NR, Davis BG (2005) Lectins: tools for the molecular understanding of the glycocode. Org Biomol Chem 3:1593-1608 (Pubitemid 40683078)
14. Sumner JB, Howell SF (1936) Identification of hemagglutinin of Jack Bean with Concanavalin A. J Bacteriol 32:227-237
15. Edelman GM, Cunningham BA, Reeke GN et al (1972) The covalent and three-dimensional structure of concanavalin A. Proc Natl Acad Sci USA 69:2580-2584
16. Hardman KD, Ainsworth CF (1972) Structure of concanavalin A at 2.4-A resolution. Biochemistry 11:4910-4919
17. Derewenda Z, Yariv J, Helliwell JR et al (1989) The structure of the saccharide-binding site of concanavalin A. EMBO J 8:2189-2193 (Pubitemid 19273295)
18. Lin SS, Levitan IB (1991) Concanavalin A: a tool to investigate neuronal plasticity. Trends Neurosci 14:273-277
19. Scherer WJ, Udin SB (1994) Concanavalin A reduces habituation in the tectum of the frog. Brain Res 667:209-215
20. Kirner A, Deutsch S, Weiler E et al (2003) Concanavalin A application to the olfactory epithelium reveals different sensory neuron populations for the odour pair D- and L-carvone. Behav Brain Res 138:201-206 (Pubitemid 36071358)
21. Suzuki T, Okumura-Noji K (1995) NMDA receptor subunits epsilon 1 (NR2A) and epsilon 2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain. Biochem Biophys Res Commun 216:582-588
22. Clark RA, Gurd JW, Bissoon N et al (1998) Identification of lectin-purified neural glycoproteins, GPs 180, 116, and 110, with NMDA and AMPA receptor subunits: conservation of glycosylation at the synapse. J Neurochem 70:2594-2605 (Pubitemid 28252387)
23. Partin KM, Patneau DK, Winters CA et al (1993) Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11:1069-1082 (Pubitemid 24015281)
24. Hoffman KB, Kessler M, Ta J et al (1998) Mannose-specific lectins modulate ligand binding to AMPA-type glutamate receptors. Brain Res 795:105-111 (Pubitemid 28337821)
25. Thalhammer A, Everts I, Hollmann M (2002) Inhibition by lectins of glutamate receptor desensitization is determined by the lectin's sugar specificity at kainate but not AMPA receptors. Mol Cell Neurosci 21:521-533 (Pubitemid 36062711)
26. Yue KT, MacDonald JF, Pekhletski R et al (1995) Differential effects of lectins on recombinant glutamate receptors. Eur J Pharmacol 291:229-235 (Pubitemid 3014594)
27. Everts I, Petroski R, Kizelsztein P et al (1999) Lectin-induced inhibition of desensitization of the kainate receptor GluR6 depends on the activation state and can be mediated by a single native or ectopic N-linked carbohydrate side chain. J Neurosci 19:916-927 (Pubitemid 29066154)
28. Fay AM, Bowie D (2006) Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor. J Physiol 572:201-213
29. Everts I, Villmann C, Hollmann M (1997) N-Glycosylation is not a prerequisite for glutamate receptor function but Is essential for lectin modulation. Mol Pharmacol 52:861-873 (Pubitemid 27484179)
30. Sanz-Aparicio J, Hermoso J, Granjeiro TB et al (1997) The crystal structure of Canavalia brasiliensis lectin suggests a correlation between its quaternary conformation and its distinct biological properties from Concanavalin A. FEBS Letters 405:114-118 (Pubitemid 27130385)
31. Barauna SC, Kaster MP, Heckert BT et al (2006) Antidepressant-like effect of lectin from Canavalia brasiliensis (ConBr) administered centrally in mice. Pharmacol Biochem Behav 85:160-169 (Pubitemid 44802740)
32. Hardingham GE (2009) Coupling of the NMDA receptor to neuroprotective and neurodestructive events. Biochem Soc Trans 37:1147-1160
33. Schwarcz R, Pellicciari R (2002) Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. J Pharmacol Exp Ther 303:1-10
34. Schwarcz R, Guidetti P, Sathyasaikumar KV et al (2010) Of mice, rats and men: revisiting the quinolinic acid hypothesis of Huntington's disease. Prog Neurobiol 90:230-245
35. Tavares RG, Schmidt AP, Tasca CI et al (2008) Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines. Neurochem Res 33:97-102 (Pubitemid 350242796)
36. Tavares RG, Schmidt AP, Abud J et al (2005) In vivo quinolinic acid increases synaptosomal glutamate release in rats: reversal by guanosine. Neurochem Res 30:439-444 (Pubitemid 40933651)
37. Moreira RA, Cavada BS (1984) Lectin from Canavalia brasiliensis Mart. Isolation, characterization and behavior during germination. Biol Plant Praga Checoslov 26:113-120
38. Schmidt AP, Lara DR, de FariaMaraschin J et al (2000) Guanosine and GMP prevent seizures induced by quinolinic acid in mice. Brain Res 864:40-43 (Pubitemid 30227595)
39. Cruz SL, Gauthereau MY, Camacho-Munoz C et al (2003) Effects of inhaled toluene and 1, 1, 1-trichloroethane on seizures and death produced by N-methyl-d-aspartic acid in mice. Behav Brain Res 140:195-202 (Pubitemid 36313254)
40. Marganella C, Bruno V, Matrisciano F et al (2005) Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice. Eur J Pharmacol 518:111-115 (Pubitemid 41133633)
41. Cordova FM, Rodrigues AL, Giacomelli MB et al (2004) Lead stimulates ERK1/2 and p38MAPK phosphorylation in the hippocampus of immature rats. Brain Res 998:65-72 (Pubitemid 38077127)
42. Molz S, Decker H, Dal-Cim T et al (2008) Glutamate-induced toxicity in hippocampal slices involves apoptotic features and p38 MAPK signaling. Neurochem Res 33:27-36 (Pubitemid 350242786)
43. Boeck CR, Ganzella M, Lottermann A et al (2004) NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice. Epilepsia 45:745-750 (Pubitemid 38890971)
44. Oliveira CS, Rigon AP, Leal RB et al (2008) The activation of ERK1/2 and p38 mitogen-activated protein kinases is dynamically regulated in the developing rat visual system. Int J Dev Neurosci 26:355-362
45. Peterson GL (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83:346-356 (Pubitemid 8269786)
46. Bjerrum OJ, Heegaard NHH (1988) CRC handbook of immunoblotting of proteins, vol I: Technical Descriptions. CRC Press, Boca Raton, FL
47. Rigon AP, Cordova FM, Oliveira CS et al (2008) Neurotoxicity of cadmium on immature hippocampus and a neuroprotective role for p38 MAPK. Neurotoxicology 29:727-734
48. Posser T, de Aguiar CB, Garcez RC et al (2007) Exposure of C6 glioma cells to Pb(II) increases the phosphorylation of p38(MAPK) and JNK1/2 but not of ERK1/2. Arch Toxicol 81:407-414 (Pubitemid 46991725)
49. Ferrer I, Blanco R, Carmona M (2001) Differential expression of active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates following quinolinic acid excitotoxicity in the rat. Mol Brain Res 94:48-58 (Pubitemid 32964745)
50. Pierozan P, Zamoner A, Soska AK et al (2010) Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats. Exp Neurol 224:188-196
51. Bento CAM, Cavada BS, Oliveira JTA et al (1993) Rat paw edema and leucocyte migration induced by plant lectins. Agents Actions 38:48-54 (Pubitemid 23100897)
52. Rodriguez D, Cavada BS, Abreu-de-Oliveira JT et al (1992) Differences in macrophage stimulation and leukocyte accumulation in response to intraperitoneal administration of glucose/mannose-binding plant lectins. Braz J Med Biol Res 25:823-826
53. Barbosa T, Arruda S, Cavada B et al (2001) In vivo lymphocyte activation and apoptosis by lectins of the diocleinaesubtribo. Mem Inst Oswaldo Cruz 96:673-678 (Pubitemid 33704172)
54. Ferreira RR, Cavada BS, Moreira RA et al (1996) Characteristics of the histamine release from hamster cheek pouch mast cells stimulated by lectins from Brazilian beans and concanavalin A. Inflamm Res 45:442-447 (Pubitemid 26326914)
55. Lopes FC, Cavada BS, Pinto VP et al (2005) Differential effect of plant lectins on mast cells of different origins. Braz J Med Biol Res 38:935-941 (Pubitemid 40932247)
56. Andrade JL, Arruda S, Barbosa T et al (1999) Lectin-induced nitric oxide production. Cell Immunol 194:98-102 (Pubitemid 29283981)
57. Pemberton KE, Belcher SM, Ripellino JA, et.al. (1998) High-affinity kainate-type ion channels in rat cerebellar granule cells. J Physiol 510(Pt 2):401-420
58. Machaidze GG, Mikeladze D (2001) Different effects of lectins on the ligand binding of the NMDA receptors and sigma sites in rat brain hippocampus synaptic membranes. Neurochem Res 26:457-462 (Pubitemid 32744293)
59. Lapin IP (1978) Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice. J Neural Trans 42:37-43 (Pubitemid 8271036)
60. Stone TW, Perkins MN (1981) Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol 72:411-412 (Pubitemid 11081065)
61. Kuroki Y, Fukushima K, Kanda Y, Mizuno K, Watanabe Y (2001) Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus. Eur J Neurosci 13:472-476 (Pubitemid 32158778)
62. Brecht S, Kirchhof R, Chromik A, Willesen M, Nicolaus T, Raivich G, Wessig J, Waetzig V, Goetz M, Claussen M, Pearse D, Kuan CY, Vaudano E, Behrens A, Wagner E, Flavell RA, Davis RJ, Herdegen T (2005) Specific pathophysiological functions of JNK isoforms in the brain. Eur J Neurosci 21:363-377 (Pubitemid 40204240)
63. Zhao Y, Herdegen T (2009) Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria. Mol Cell Neurosci 41:186-195
64. Waetzig V, Zhao Y, Herdegen T (2006) The bright side of JNKs-Multitalented mediators in neuronal sprouting, brain development and nerve fiber regeneration. Prog Neurobiol 80:84-97 (Pubitemid 44692017)
65. Kessels HW, Malinow R (2009) Synaptic AMPA receptor plasticity and behavior. Neuron 61:340-350
66. Santos SD, Carvalho AL, Caldeira MV et al (2009) Regulation of AMPA receptors and synaptic plasticity. Neuroscience 158:105-125
67. Zanetta JP, Meyer A, Kuchler S et al (1987) Isolation and immunochemical study of a soluble cerebellar lectin delineating its structure and function. J Neurochem 49:1250-1257 (Pubitemid 17139488)
68. Marschal P, Reeber A, Neeser JR et al (1989) Carbohydrate and glycoprotein specificity of two endogenous cerebellar lectins. Biochimie 71:645-653 (Pubitemid 19149751)
69. Lehmann S, Kuchler S, Theveniau M et al (1990) An endogenous lectin and one of its neuronal glycoprotein ligands are involved in contact guidance of neuron migration. Proc Natl Acad Sci USA 87:6455-6459 (Pubitemid 20259037)
70. Kuchler S, Lehmann S, Vincendon G et al (1992) Endogenous lectin cerebellar soluble lectin involved in myelination is absent from nonmyelinating Schwann cells. J Neurochem 58:1768-1772
71. Lekishvili T, Hesketh S, Brazier MW et al (2006) Mouse galectin-1 inhibits the toxicity of glutamate by modifying NR1 NMDA receptor expression. Eur J Neurosci 24:3017-3025 (Pubitemid 44952634)