In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor function

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Cordova, Fabiano M ^a,c   Aguiar, Aderbal S ^a   Peres, Tanara V ^a   Lopes, Mark W ^a   Gonçalves, Filipe M ^a   Remor, Aline P ^a   Lopes, Samantha C ^a   Pilati, Célso ^b   Latini, Alexandra S ^a   Prediger, Rui D S ^a   Erikson, Keith M ^d   Aschner, Michael ^e   Leal, Rodrigo B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b SANTA CATARINA STATE UNIVERSITY   (Brazil)

^c UNIVERSIDADE FEDERAL DO TOCANTINS   (Brazil)

^d UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; MANGANESE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEIN DARPP 32; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); TROLOX C; CASPASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; EXPOSURE; FEMALE; GROOMING; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; NEUROTOXICITY; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RAT; SHORT TERM EXPOSURE; ANALYSIS OF VARIANCE; ANIMAL; ATOMIC ABSORPTION SPECTROMETRY; BASAL GANGLION; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION REGULATION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHOSPHORYLATION; PSYCHOMOTOR PERFORMANCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

PARKINSONIA; RATTUS;

ANALYSIS OF VARIANCE; ANIMALS; BASAL GANGLIA; BLOTTING, WESTERN; CASPASES; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MANGANESE; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PSYCHOMOTOR PERFORMANCE; RATS; REACTIVE OXYGEN SPECIES; SPECTROPHOTOMETRY, ATOMIC;

EID: 84858129031     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033057     Document Type: Article

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