Epigenetics in cardiovascular disease

Current Opinion in Cardiology

Volumn 26, Issue 3, 2011, Pages 209-215

  Shirodkar, Apurva V ^a   Marsden, Philip A ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

cardiovascular disease; DNA methylation; epigenetics; histone posttranslational modifications

Indexed keywords

DNA; HISTONE; RNA;

ARTICLE; CARDIOVASCULAR DISEASE; CELL HYPOXIA; CHROMATIN; DNA METHYLATION; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; EPIGENETICS; GENE EXPRESSION REGULATION; HISTONE MODIFICATION; HUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROCESSING; SHEAR STRESS; VASCULAR ENDOTHELIUM;

CARDIOVASCULAR DISEASES; CHROMATIN; DNA METHYLATION; ENDOTHELIUM, VASCULAR; EPIGENESIS, GENETIC; EPIGENOMICS; GENE EXPRESSION; GENE REGULATORY NETWORKS; HEMODYNAMICS; HISTONES; HUMANS; HYPERTENSION; SHEAR STRENGTH;

EID: 79955055958     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/HCO.0b013e328345986e     Document Type: Article

References (69)

1. Manolio TA. Genomewide association studies and assessment of the risk of disease. N Engl J Med 2010; 363:166-176.
2. Musunuru K, Strong A, Frank-Kamenetsky M, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 2010; 466:714-719.
3. Petronis A. Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature 2010; 465:721-727.
4. Abbott A. Project set to map marks on genome. Nature 2010; 463:596-597.
5. Yan MS, Matouk CC, Marsden PA. Epigenetics of the vascular endothelium. J Appl Physiol 2010; 109:916-926.
6. Matouk CC, Marsden PA. Epigenetic regulation of vascular endothelial gene expression. Circ Res 2008; 102:873-887. (Pubitemid 351591544)
7. Bruneau BG. Epigenetic regulation of the cardiovascular system: introduction to a review series. Circ Res 2010; 107:324-326.
8. Pollack Y, Stein R, Razin A, Cedar H. Methylation of foreign DNA sequences in eukaryotic cells. Proc Natl Acad Sci U S A 1980; 77:6463-6467.
9. Stein R, Gruenbaum Y, Pollack Y, et al. Clonal inheritance of the pattern of DNA methylation in mouse cells. Proc Natl Acad Sci U S A 1982; 79:61-65. (Pubitemid 12181486)
10. Naveh-Many T, Cedar H. Active gene sequences are undermethylated. Proc Natl Acad Sci U S A 1981; 78:4246-4250. (Pubitemid 11010310)
11. Keshet I, Lieman-Hurwitz J, Cedar H. DNA methylation affects the formation of active chromatin. Cell 1986; 44:535-543. (Pubitemid 16083696)
12. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002; 16:6-21. (Pubitemid 34049633)
13. Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet 2000; 9:2395-2402.
14. Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 2006; 31:89-97. (Pubitemid 43221841)
15. Meehan RR, Lewis JD, McKay S, et al. Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 1989; 58:499-507. (Pubitemid 19203534)
16. Boyes J, Bird A. DNA methylation inhibits transcription indirectly via a methyl- CpG binding protein. Cell 1991; 64:1123-1134. (Pubitemid 121001199)
17. Lewis JD, Meehan RR, Henzel WJ, et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 1992; 69:905-914.
18. Nan X, Ng HH, Johnson CA, et al. Transcriptional repression by the methyl- CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 1998; 393:386-389. (Pubitemid 28269714)
19. Agarwal N, Hardt T, Brero A, et al. MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. Nucleic Acids Res 2007; 35:5402-5408. (Pubitemid 47423914)
20. Voo KS, Carlone DL, Jacobsen BM, et al. Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. Mol Cell Biol 2000; 20:2108-2121. (Pubitemid 30123826)
21. Thomson JP, Skene PJ, Selfridge J, et al. CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature 2010; 464:1082-1086.
22. Miranda TB, Jones PA. DNA methylation: the nuts and bolts of repression. J Cell Physiol 2007; 213:384-390. (Pubitemid 47509717)
23. Tahiliani M, Koh KP, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009; 324:930-935.
24. Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 2009; 324:929-930.
25. Wang GG, Allis CD, Chi P. Chromatin remodeling and cancer. Part I: Covalent histone modifications. Trends Mol Med 2007; 13:363-372. (Pubitemid 47385381)
26. Ruthenburg AJ, Li H, Patel DJ, Allis CD. Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol 2007; 8:983-994. (Pubitemid 350174643)
27. Guenther MG, Levine SS, Boyer LA, et al. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 2007; 130:77-88. (Pubitemid 47031323)
28. Mikkelsen TS, Ku M, Jaffe DB, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007; 448:553-560. (Pubitemid 47206934)
29. Guttman M, Amit I, Garber M, et al. Chromatin signature reveals over a thousand highly conserved large noncoding RNAs in mammals. Nature 2009; 458:223-227.
30. Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293: 1074-1080. (Pubitemid 32758077)
31. Erwin JA, Lee JT. New twists in X-chromosome inactivation. Curr Opin Cell Biol 2008; 20:349-355.
32. Khalil AM, Guttman M, Huarte M, et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A 2009; 106:11667-11672.
33. Rinn JL, Kertesz M, Wang JK, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 2007; 129:1311-1323. (Pubitemid 46962090)
34. Gupta RA, Shah N, Wang KC, et al. Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010; 464:1071-1076.
35. Wilcox JN, Subramanian RR, Sundell CL, et al. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Arterioscler Thromb Vasc Biol 1997; 17:2479-2488. (Pubitemid 28015984)
36. Oemar BS, Tschudi MR, Godoy N, et al. Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis. Circulation 1998; 97:2494-2498. (Pubitemid 28294493)
37. Teichert AM, Miller TL, Tai SC, et al. In vivo expression profile of an endothelial nitric oxide synthase promoter-reporter transgene. Am J Physiol Heart Circ Physiol 2000; 278:H1352-H1361. (Pubitemid 30235515)
38. Guillot PV, Liu L, Kuivenhoven JA, et al. Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression. Physiol Genomics 2000; 2:77-83.
39. Teichert AM, Scott JA, Robb GB, et al. Endothelial nitric oxide synthase gene expression during murine embryogenesis: commencement of expression in the embryo occurs with the establishment of a unidirectional circulatory system. Circ Res 2008; 103:24-33.
40. Chan Y, Fish JE, D'Abreo C, et al. The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation. J Biol Chem 2004; 279:35087-35100. (Pubitemid 39318145)
41. Fish JE, Matouk CC, Rachlis A, et al. The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. J Biol Chem 2005; 280:24824-24838. (Pubitemid 40934573)
42. Nussler AK, Di Silvio M, Liu ZZ, et al. Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes. Hepatology 1995; 21:1552-1560.
43. Orpana A, Ranta V, Mikkola T, et al. Inducible nitric oxide and prostacyclin productions are differently controlled by extracellular matrix and cell density in human vascular endothelial cells. J Cell Biochem 1997; 64:538-546. (Pubitemid 27154507)
44. Rosenkranz-Weiss P, Sessa WC, Milstien S, et al. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J Clin Invest 1994; 93:2236-2243.
45. Zhang X, Laubach VE, Alley EW, et al. Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/ interferon-gamma. J Leukoc Biol 1996; 59:575-585.
46. Chan GC, Fish JE, Mawji IA, et al. Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells. J Immunol 2005; 175:3846-3861. (Pubitemid 41292045)
47. Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128:683-692. (Pubitemid 46273572)
48. Kulis M, Esteller M. DNA methylation and cancer. Adv Genet 2010; 70:27-56.
49. Lund G, Andersson L, Lauria M, et al. DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E. J Biol Chem 2004; 279:29147-29154. (Pubitemid 38915787)
50. Morgan HD, Santos F, Green K, et al. Epigenetic reprogramming in mammals. Hum Mol Genet 2005; 14(Spec No. 1):R47-R58. (Pubitemid 40542620)
51. Ivanova NB, Dimos JT, Schaniel C, et al. A stem cell molecular signature. Science 2002; 298:601-604.
52. Bibikova M, Laurent LC, Ren B, et al. Unraveling epigenetic regulation in embryonic stem cells. Cell Stem Cell 2008; 2:123-134. (Pubitemid 351168715)
53. BibikovaM, Chudin E,Wu B, et al. Human embryonic stem cells have a unique epigenetic signature. Genome Res 2006; 16:1075-1083. (Pubitemid 44320394)
54. Boyer LA, Plath K, Zeitlinger J, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006; 441:349-353. (Pubitemid 44050199)
55. Kuzmichev A, Nishioka K, Erdjument-Bromage H, et al. Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of Zeste protein. Genes Dev 2002; 16:2893-2905. (Pubitemid 35334738)
56. Cao R, Wang L, Wang H, et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298:1039-1043. (Pubitemid 35247314)
57. Bernstein BE, Mikkelsen TS, Xie X, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006; 125:315-326.
58. Brawley L, Itoh S, Torrens C, et al. Dietary protein restriction in pregnancy induces hypertension and vascular defects in rat male offspring. Pediatr Res 2003; 54:83-90. (Pubitemid 36736811)
59. Torrens C, Brawley L, Anthony FW, et al. Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction. Hypertension 2006; 47:982-987. (Pubitemid 44297572)
60. Johnson AB, Denko N, Barton MC. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat Res 2008; 640:174-179.
61. Johnson AB, Barton MC. Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutat Res 2007; 618:149-162. (Pubitemid 46574738)
62. Chen H, Yan Y, Davidson TL, et al. Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res 2006; 66:9009-9016. (Pubitemid 44521119)
63. Fish JE, Yan MS, Matouk CC, et al. Hypoxic repression of endothelial nitricoxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem 2010; 285:810-826.
64. Gimbrone MA Jr, Resnick N, Nagel T, et al. Hemodynamics, endothelial gene expression, and atherogenesis. Ann N Y Acad Sci 1997; 811:1-10; discussion 10-11.
65. Dekker RJ, van Soest S, Fontijn RD, et al. Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2). Blood 2002; 100:1689-1698. (Pubitemid 34925146)
66. Khachigian LM, Anderson KR, Halnon NJ, et al. Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shearstress- response element in the PDGF A-chain promoter. Arterioscler Thromb Vasc Biol 1997; 17:2280-2286. (Pubitemid 28057133)
67. Illi B, Nanni S, Scopece A, et al. Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression. Circ Res 2003; 93:155-161. (Pubitemid 36919703)
68. Chen W, Bacanamwo M, Harrison DG. Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription. J Biol Chem 2008; 283:16293-16298.
69. Won D, Zhu SN, Chen M, et al. Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow. Am J Pathol 2007; 171:1691-1704. (Pubitemid 350158329)