Epigenetics and hypertension

Current Hypertension Reports

Volumn 13, Issue 1, 2011, Pages 21-28

  Millis, Richard M ^a  

^a HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

CpG island; Disrupter of telomeric silencing; DNA methylation; Epigenetics; Epithelial sodium channel; Essential hypertension; Gene silencing; Histone acetylation; Hydroxysteroid dehydrogenase 11 2; Intrauterine stress; Methyl CpG binding protein 2; Mineralocorticoid receptor; Mixed lineage leukemia (Af9) gene; Norepinephrine transporter; Phenylethanolamine methyltransferase; Placenta; Preeclampsia; Pregnancy; Prenatal protein deficiency; Prenatal water deprivation; Renin angiotensin system; Salt sensitive hypertension; Serine protease inhibitor A3 gene

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; ALDOSTERONE RECEPTOR; ANGIOTENSIN RECEPTOR; CONNECTIVE TISSUE GROWTH FACTOR; CORTISONE; DNA METHYLTRANSFERASE; HELICASE; HISTONE LYSINE METHYLTRANSFERASE; HYDROCORTISONE; METHYL CPG BINDING PROTEIN 2; MIXED LINEAGE LEUKEMIA PROTEIN; NORADRENALIN TRANSPORTER; PHENYLETHANOLAMINE N METHYLTRANSFERASE; PROTEIN AF9; PROTEIN DOT1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SERINE PROTEINASE INHIBITOR; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD VESSEL COMPLIANCE; CPG ISLAND; DISEASE ASSOCIATION; DNA METHYLATION; EPIGENETICS; ESSENTIAL HYPERTENSION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC ASSOCIATION; HISTONE ACETYLATION; HORMONE METABOLISM; HUMAN; ION PERMEABILITY; MENTAL STRESS; NONHUMAN; OXIDATIVE STRESS; PREECLAMPSIA; PROTEIN DEFICIENCY; PROTEIN PROTEIN INTERACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; SODIUM RESTRICTION; WATER DEPRIVATION;

DNA METHYLATION; EPIGENOMICS; GENE SILENCING; HISTONE ACETYLTRANSFERASES; HISTONES; HUMANS; HYPERTENSION; OXIDATIVE STRESS; RECEPTORS, ANGIOTENSIN; RENIN-ANGIOTENSIN SYSTEM; STRESS, PSYCHOLOGICAL; TELOMERE;

EID: 79551523339     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-010-0173-8     Document Type: Article

References (43)

1. EA Garcia S Newhouse MJ Caulfield PB Munroe 2003 Genes and hypertension Curr Pharm Des 9 1679 1689 1:CAS:528:DC%2BD3sXmt1Gnsro%3D 10.2174/ 1381612033454513 12871201 (Pubitemid 36958343)
2. R Kreutz N Hübner MR James, et al. 1995 Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10 Proc Natl Acad Sci U S A 12 8778 8782 10.1073/pnas.92.19.8778
3. GB Ehret 2010 Genome-wide association studies: contribution of genomics to understanding blood pressure and essential hypertension Curr Hypertens Rep 12 17 25 10.1007/s11906-009-0086-6 20425154
4. J Kunes J Zicha 2009 The interaction of genetic and environmental factors in the etiology of hypertension Physiol Res 58 Suppl 2 S33 S41 20131935
5. LM Bodnar JM Catov HN Simhan, et al. 2007 Maternal vitamin D deficiency increases the risk of preeclampsia J Clin Endocrinol Metab 92 3517 3522 1:CAS:528:DC%2BD2sXhtVGqsrnI 10.1210/jc.2007-0718 17535985 (Pubitemid 47435329)
6. M Parra R Rodrigo P Barja, et al. 2005 Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction Am J Obstet Gynecol 193 1486 1491 1:CAS:528:DC%2BD2MXhtVymsL3O 10.1016/j.ajog.2005.02.109 16202744 (Pubitemid 41395121)
7. RE Harskamp GG Zeeman 2007 Preeclampsia: at risk for remote cardiovascular disease Am J Med Sci 334 291 295 10.1097/MAJ.0b013e3180a6f094 18030186 (Pubitemid 351339288)
8. N Koleganova G Piecha E Ritz 2009 Prenatal causes of kidney disease Blood Purif 27 48 52 1:STN:280:DC%2BD1M%2FpvVSrtQ%3D%3D 10.1159/000167008 19169017
9. YW Jeske A So L Kelemen, et al. 2008 Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II Clin Exp Pharmacol Physiol 35 380 385 1:CAS:528:DC%2BD1cXjvFequro%3D 10.1111/j.1440-1681.2008.04882.x 18307725 (Pubitemid 351337333)
10. S Washietl IL Hofacker PF Stadler 2005 Fast and reliable prediction of noncoding RNAs Proc Natl Acad Sci U S A 102 2454 2459 1:CAS:528: DC%2BD2MXhvFKitLc%3D 10.1073/pnas.0409169102 15665081 (Pubitemid 40279397)
11. ST Chelbi F Mondon H Jammes, et al. 2007 Expressional and epigenetic alterations of placental serine protease inhibitors: SERPINA3 is a potential marker of preeclampsia Hypertension 49 76 83 1:CAS:528:DC%2BD28XhtlSrs7vF 10.1161/01.HYP.0000250831.52876.cb 17088445 (Pubitemid 46360344)
12. GC Chan JE Fish IA Mawji, et al. 2005 Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells J Immunol 175 3846 3861 1:CAS:528: DC%2BD2MXpslClsL4%3D 16148131
13. TJ Kang S Yuzawa H Suga 2008 Expression of histone H3 tails with combinatorial lysine modifications under the reprogrammed genetic code for the investigation on epigenetic markers Chem Biol 15 1166 1174 1:CAS:528: DC%2BD1cXhsVWmsrjN 10.1016/j.chembiol.2008.09.014 19022177
14. MK Irmak A Sizlan 2006 Essential hypertension seems to result from melatonin-induced epigenetic modifications in area postrema Med Hypotheses 66 1000 1007 1:CAS:528:DC%2BD28XhtlGgtb4%3D 10.1016/j.mehy.2005.10.016 16434146 (Pubitemid 43207663)
15. S Morimoto S Sasaki H Itoh, et al. 1999 Sympathetic activation and contribution of genetic factors in hypertension with neurovascular compression of the rostral ventrolateral medulla J Hypertens 17 1577 1582 1:STN:280:DC%2BD3c%2FnsVWksg%3D%3D 10.1097/00004872-199917110-00011 10608471
16. R Sharma T Ottenhof PA Rzeczkowska LP Niles 2008 Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells J Pineal Res 45 277 284 1:CAS:528:DC%2BD1cXht1ekurfI 10.1111/j.1600-079X.2008.00587.x 18373554 This reference is an in vitro study that provides strong evidence for epigenetic regulation of neural stem cells by histone acetylation, chromatin restructuring, and gene transcription. Epigenetic alteration of such stem cells could play a role in blood pressure control and hypertension by virtue of expressing melatonin receptors at brainstem vasomotor control centers
17. M Viswanathan JT Laitinen JM Saavedra 1992 Differential expression of melatonin receptors in spontaneously hypertensive rats Neuroendocrinology 56 864 870 1:CAS:528:DyaK3sXnvVeqsA%3D%3D 10.1159/000126318 1369596
18. M Esler N Eikelis M Schlaich, et al. 2008 Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder Ann N Y Acad Sci 1148 338 348 1:CAS:528:DC%2BD1MXht1WgsLk%3D 10.1196/annals.1410.064 19120127 This reference describes a novel hypothesis for epigenetic regulation resulting from induction of the phenylethanolamine N-methyltransferase (PNMT) gene; co-release of this gene's product, epinephrine; and silencing of the norepinephrine transporter gene by methylation-related inhibitory transcription factor-2 (MECP2). This sequence of events appears to be common to mental stress-related diseases such as panic disorder and essential hypertension
19. Z Yu Q Kong BC Kone 2010 CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells Am J Physiol Renal Physiol 298 F617 F624 1:CAS:528:DC%2BC3cXjsFGntbc%3D 10.1152/ajprenal.00636.2009 20053791 This reference describes an in vitro study in mouse mesangial cells that provides strong evidence for epigenetic regulation of the connective tissue growth factor (CTGF) gene by forskolin, a medicinal plant product. A complex mechanism is reported, which involves forskolin attaching to a cAMP response element binding (CREB), histone disruption of telomeric silencing (Dot), and hypermethylation of histone H3K79 at the CTGF promoter region, which could modify the expression of CTGF and play roles in blood vessel remodeling and renal fibrotic processes involved in hypertension
20. SA Wandji JE Gadsby JA Barber JM Hammond 2000 Messenger ribonucleic acids for MAC25 and connective tissue growth factor (CTGF) are inversely regulated during folliculogenesis and early luteogenesis Endocrinology 141 2648 2657 1:CAS:528:DC%2BD3cXlt1Cqtb8%3D 10.1210/en.141.7.2648 10875270 (Pubitemid 32269086)
21. B Rodriguez-Iturbe 2006 Arteriolar remodeling in essential hypertension: Are connective tissue growth factor and transforming growth factor involved? Kidney Int 69 1104 1105 1:CAS:528:DC%2BD28XivFOmtrw%3D 10.1038/sj.ki.5000222 16609677
22. ML Gumz LR Stow IJ Lynch, et al. 2009 The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice J Clin Invest 119 2423 2434 1:CAS:528:DC%2BD1MXpsFCksrs%3D 10.1172/JCI36908 19587447
23. DJ Steger MI Lefterova L Ying, et al. 2008 DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells Mol Cell Biol 28 2825 2839 1:CAS:528:DC%2BD1cXksFWqt7Y%3D 10.1128/MCB.02076-07 18285465 (Pubitemid 351542379)
24. D Zhang ZY Yu P Cruz, et al. 2009 Epigenetics and the control of epithelial sodium channel expression in collecting duct Kidney Int 75 260 267 1:CAS:528:DC%2BD1MXlvFCmtA%3D%3D 10.1038/ki.2008.475 18818687 This reference presents strong evidence for a novel hypothesis and a complex mechanism wherein aldosterone, the sodium-conserving product of the RAS, disrupts interaction of a telomere-silencing molecule (Dot1a) and a fused acute lymphoblastic leukemia-multiple lineage leukemia (ALL, MLL) gene on chromosome 9 (Af9). This mechanism can be induced by glucocorticoid kinase-1 phosphorylation of Af9, which inhibits expression of Dot1a and Af9 and results in histone H3K79 hypomethylation and disinhibition of an epithelial sodium channel promoter. Such a mechanism could contribute to the high sodium-channel permeability described in human populations with predilections for salt-sensitive hypertension
25. JY Lee RJ Prineas JW Eaton 2009 Heritability of erythrocyte sodium permeability: a possible genetic marker for hypertension Ann Clin Lab Sci 39 241 250 19667408
26. R Alikhani-Koopaei F Fouladkou FJ Frey BM Frey 2004 Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression J Clin Invest 114 1146 1157 1:CAS:528:DC%2BD2cXovVens7w%3D 15489962
27. S Friso F Pizzolo SW Choi, et al. 2008 Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension Atherosclerosis 199 323 327 1:CAS:528:DC%2BD1cXptVWkt7g%3D 10.1016/j.atherosclerosis.2007.11.029 18178212 This reference describes a human study providing strong evidence that epigenetic regulation of a gene that breaks down cortisol to cortisone metabolites contributes to exaggerated responsiveness of the RAS to salt and to salt-sensitive hypertension
28. JB Pippal PJ Fuller 2008 Structure-function relationships in the mineralocorticoid receptor J Mol Endocrinol 41 405 413 1:CAS:528: DC%2BD1cXhsFaktrrJ 10.1677/JME-08-0093 18805937
29. P Ferrari A Sansonnens B Dick FJ Frey 2001 In vivo 11beta-HSD-2 activity: variability, salt-sensitivity, and effect of licorice Hypertension 38 1330 1336 1:CAS:528:DC%2BD38XisVSitg%3D%3D 10.1161/hy1101.096112 11751713
30. HM Yang TE Lohmeier 1993 Influence of endogenous angiotensin on the renovascular response to norepinephrine Hypertension 21 695 703 1:CAS:528:DyaK3sXksVWku7c%3D 8491504
31. V Farah KM Elased M Morris 2007 Genetic and dietary interactions: role of angiotensin AT1a receptors in response to a high-fructose diet Am J Physiol Heart Circ Physiol 293 H1083 H1089 1:CAS:528:DC%2BD2sXptlyku7w%3D 10.1152/ajpheart.00106.2006 17449556 (Pubitemid 47254208)
32. CY Shim JW Ha S Park, et al. 2008 Exaggerated blood pressure response to exercise is associated with augmented rise of angiotensin II during exercise J Am Coll Cardiol 52 287 292 1:CAS:528:DC%2BD1cXoslWmtLo%3D 10.1016/j.jacc.2008. 03.052 18634984 (Pubitemid 351957850)
33. J Guan C Mao F Xu, et al. 2009 Prenatal dehydration alters renin-angiotensin system associated with angiotensin-increased blood pressure in young offspring Hypertens Res 32 1104 1111 1:CAS:528:DC%2BD1MXhsFSgsb3M 10.1038/hr.2009.155 19779489 This reference describes an experimental animal study providing strong evidence for epigenetic regulation of the RAS by demonstrating upregulation and exaggerated vasopressor responses in response to 3 days of prenatal exposure to limiting maternal water intake. Such exaggerated responses are found in humans with genetic predilections for hypertension
34. I Bogdarina S Welham PJ King, et al. 2007 Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension Circ Res 100 520 526 1:CAS:528:DC%2BD2sXitFylsbg%3D 10.1161/01.RES.0000258855.60637.58 17255528 (Pubitemid 46673261)
35. Z Zhang K Rhinehart G Solis, et al. 2005 Chronic ANG II infusion increases NO generation by rat descending vasa recta Am J Physiol Heart Circ Physiol 288 H29 H36 1:CAS:528:DC%2BD2MXhtVCqs70%3D 10.1152/ajpheart.00623.2004 15331364 (Pubitemid 40023824)
36. WJ Welch T Chabrashvili G Solis, et al. 2006 Role of extracellular superoxide dismutase in the mouse angiotensin slow pressor response Hypertension 48 934 941 1:CAS:528:DC%2BD28XhtVKjtL3I 10.1161/01.HYP.0000242928.57344.92 17015770 (Pubitemid 44611008)
37. TJ Guzik J Sadowski B Guzik, et al. 2006 Coronary artery superoxide production and nox isoform expression in human coronary artery disease Arterioscler Thromb Vasc Biol 26 333 339 1:CAS:528:DC%2BD28XksFKquw%3D%3D 10.1161/01.ATV.0000196651.64776.51 16293794 (Pubitemid 43732196)
38. D Wang T Chabrashvili L Borrego, et al. 2006 Angiotensin II infusion alters vascular function in mouse resistance vessels: roles of O and endothelium J Vasc Res 43 109 119 1:CAS:528:DC%2BD2MXhtlCksL7O 10.1159/000089969 16340215 (Pubitemid 41832713)
39. P Modlinger T Chabrashvili PS Gill, et al. 2006 RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response Hypertension 47 238 244 1:CAS:528:DC%2BD28XksFyjug%3D%3D 10.1161/01.HYP.0000200023.02195.73 16391171 (Pubitemid 43189769)
40. CG Marfella N Henninger SE LeBlanc, et al. 2008 A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype Kidney Blood Press Res 31 421 432 1:CAS:528:DC%2BD1MXhslynu7c%3D 10.1159/000190788 19142019
41. M Bader 2010 Tissue renin-angiotensin-aldosterone systems: targets for pharmacological therapy Annu Rev Pharmacol Toxicol 50 439 465 1:CAS:528:DC%2BC3cXisVelu78%3D 10.1146/annurev.pharmtox.010909.105610 20055710
42. C Le Clair T Abbi H Sandhu PS Tappia 2009 Impact of maternal undernutrition on diabetes and cardiovascular disease risk in adult offspring Can J Physiol Pharmacol 87 161 179 10.1139/Y09-006 19295658
43. R Goyal D Goyal A Leitzke, et al. 2010 Brain renin-angiotensin system: fetal epigenetic programming by maternal protein restriction during pregnancy Reprod Sci 17 227 238 10.1177/1933719109351935 19923380 This reference describes an experimental animal study providing strong evidence for epigenetic regulation of the brain RAS. A decrement in expression of an angiotensin-converting enzyme gene related to hypomethylation of the CpG islands at the promoter region is demonstrated. Such an effect could contribute to cognitive deficits associated with hypertension in humans