Role of the extracellular amino terminus and first membrane-spanning helix of dopamine D1 and D5 receptors in shaping ligand selectivity and efficacy

Cellular Signalling

Volumn 22, Issue 1, 2010, Pages 106-116

  D'Aoust, Jean Philippe ^a   Tiberi, Mario ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

D1; D5; Dopamine; GPCR; Mutagenesis; SKF83959

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 3 METHYL 1 PHENYL 1H 3 BENZAZEPINE; 3 ALLYL 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 3 METHYL 1 (3 METHYLPHENYL) 1H 3 BENZAZEPINE; 8 BROMO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BENZAZEPINE DERIVATIVE; BUTACLAMOL; CATECHOLAMINE; CYCLIC AMP; DIHYDREXIDINE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; FENOLDOPAM; FLUPHENAZINE; G PROTEIN COUPLED RECEPTOR; LIGAND; RADIOLIGAND; THIORIDAZINE; TIOTIXENE; TRIFLUOPERAZINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL STRAIN HEK293; CHIMERA; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; EXTRACELLULAR SPACE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIGAND BINDING; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY;

AMINO ACID SEQUENCE; CELL LINE; CELL MEMBRANE; CONSERVED SEQUENCE; DOPAMINE; EXTRACELLULAR SPACE; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D5; SEQUENCE ALIGNMENT;

EID: 70349994090     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2009.09.020     Document Type: Article

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