H11/HspB8 and Its herpes simplex virus type 2 homologue ICP10PK share functions that regulate cell life/death decisions and human disease

Autoimmune Diseases

Volumn 1, Issue 1, 2012, Pages

  Aurelian, Laure ^a   Laing, Jennifer M ^a   Lee, Ki Seok ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN B8; HEAT SHOCK PROTEIN H11; PROTEIN ICP10PK; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; BONE MORPHOGENETIC PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HEAT SHOCK PROTEIN 22; ICP10PK; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CANCER INHIBITION; CELL ACTIVATION; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DENDRITIC CELL; DNA METHYLATION; ENZYME ACTIVITY; EWING SARCOMA; HEMATOLOGIC MALIGNANCY; HERPES SIMPLEX VIRUS 2; HUMAN; INFLAMMATION; MELANOCYTE; MELANOMA; MOLECULAR CLONING; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR XENOGRAFT; UNFOLDED PROTEIN RESPONSE; VIROGENESIS; CELL CYCLE; CONFOCAL MICROSCOPY; CYTOKINE PRODUCTION; ENDOPLASMIC RETICULUM; GROWTH DISORDER; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING; PROTEIN EXPRESSION; PROTEIN STABILITY; TUMOR SUPPRESSOR GENE;

EID: 84874899951     PISSN: None     EISSN: 20900430     Source Type: Journal    
DOI: 10.1155/2012/395329     Document Type: Review

References (72)

1. Kappé G., Boelens W. C., de Jong W. W., Why proteins without an α -crystallin domain should not be included in the human small heat shock protein family HSPB. Cell Stress and Chaperones 2010 15 4 457 461 2-s2.0-77955665257 10.1007/s12192-009-0155-4
2. Hartl F. U., Chaperone-assisted protein folding: the path to discovery from a personal perspective. Nature Medicine 2011 17 1206 1210
3. Mchaourab H. S., Godar J. A., Stewart P. L., Structure and mechanism of protein stability sensors: chaperone activity of small heat shock proteins. Biochemistry 2009 48 18 3828 3837 2-s2.0-66149117827 10.1021/bi900212j
4. Mymrikov E. V., Seit-Nebi A. S., Gusev N. B., Large potentials of small heat shock proteins. Physiological Reviews 2011 91 1123 1159
5. Acunzo J., Katsogiannou M., Rocchi P., Small heat shock proteins HSP27 (HspB1), α B-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death. International Journal of Biochemistry & Cell Biology 2012 44 10 1622 1631
6. Yamauchi Y., Wada K., Goshima F., Daikoku T., Ohtsuka K., Nishiyama Y., Herpes simplex virus type 2 UL14 gene product has heat shock protein (HSP)-like functions. Journal of Cell Science 2002 115 12 2517 2527 2-s2.0-0037096164 (Pubitemid 34778069)
7. Chung T. D., Wymer J. P., Smith C. C., Kulka M., Aurelian L., Protein kinase activity associated with the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10). Journal of Virology 1989 63 8 3389 3398 2-s2.0-0024335047 (Pubitemid 19181399)
8. Hunter J. C. R., Smith C. C., Aurelian L., The HSV-2 LA-1 oncoprotein is a member of a novel family of serine/threonine receptor kinases. International Journal of Oncology 1995 7 3 515 522 2-s2.0-0029068634
9. Manning G., Whyte D. B., Martinez R., Hunter T., Sudarsanam S., The protein kinase complement of the human genome. Science 2002 298 5600 1912 1934 2-s2.0-0037032835 10.1126/science.1075762 (Pubitemid 35425239)
10. Zhang H., Photiou A., Grothey A., The role of pseudokinases in cancer. Cell Signal 2012 24 6 1173 1184
11. Nelson J. W., Zhu J., Smith C. C., Kulka M., Aurelian L., ATP and SH3 binding sites in the protein kinase of the large subunit of herpes simplex virus type 2 of ribonucleotide reductase (ICP10). Journal of Biological Chemistry 1996 271 29 17021 17027 2-s2.0-0030035137 10.1074/jbc.271.29.17021 (Pubitemid 26244247)
12. Smith C. C., The herpes simplex virus type 2 protein ICP10PK: a master of versatility. Frontiers in Bioscience 2005 10 2 2820 2831 2-s2.0-21344437335 (Pubitemid 40908913)
13. Smith C. C., Luo J. H., Hunter J. C. R., Ordonez J. V., Aurelian L., The transmembrane domain of the large subunit of HSV-2 ribonucleotide reductase (ICP10) is required for protein kinase activity and transformation-related signaling pathways that result in ras activation. Virology 1994 200 2 598 612 2-s2.0-0028220357 10.1006/viro.1994.1223
14. Gober M. D., Wales S. Q., Aurelian L., Herpes simplex virus type 2 encodes a heat shock protein homologue with apoptosis regulatory functions. Frontiers in Bioscience 2005 10 2 2788 2803 2-s2.0-21344465226 (Pubitemid 40905275)
15. Langelier Y., Champoux L., Hamel M., Guilbault C., Lamarche N., Gaudreau P., Massie B., The R1 subunit of herpes simplex virus ribonucleotide reductase is a good substrate for host cell protein kinases but is not itself a protein kinase. Journal of Biological Chemistry 1998 273 3 1435 1443 2-s2.0-0031916707 10.1074/jbc.273.3.1435 (Pubitemid 28133664)
16. Smith C. C., Nelson J., Aurelian L., Gober M., Goswami B. B., Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth. Journal of Virology 2000 74 22 10417 10429 2-s2.0-0033766284 10.1128/JVI.74.22.10417-10429.2000
17. Smith C. C., Peng T., Kulka M., Aurelian L., The PK domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for immediate-early gene expression and virus growth. Journal of Virology 1998 72 11 9131 9141 2-s2.0-0031684594 (Pubitemid 28471858)
18. Aurelian L., Smith C. C., Herpes simplex virus type 2 growth and latency reactivation by cocultivation are inhibited with antisense oligonucleotides complementary to the translation initiation site of the large subunit of ribonucleotide reductase (RR1). Antisense and Nucleic Acid Drug Development 2000 10 2 77 85 2-s2.0-0034015110 (Pubitemid 30255591)
19. Gober M. D., Wales S. Q., Hunter J. C., Sharma B. K., Aurelian L., Stress up-regulates neuronal expression of the herpes simplex virus type 2 large subunit of ribonucleotide reductase (R1; ICP10) by activating activator protein 1. Journal of NeuroVirology 2005 11 4 329 336 2-s2.0-27144512323 10.1080/13550280591002423 (Pubitemid 41614512)
20. Hunter J. C. R., Smith C. C., Bose D., Kulka M., Broderick R., Aurelian L., Intracellular internalization and signaling pathways triggered by the large subunit of HSV-2 ribonucleotide reductase (ICP10). Virology 1995 210 2 345 360 2-s2.0-0029095455 10.1006/viro.1995.1351
21. Perkins D., Pereira E. F. R., Aurelian L., The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein bag-1. Journal of Virology 2003 77 2 1292 1305 2-s2.0-0037228190 10.1128/JVI.77.2.1292-1305.2003 (Pubitemid 36055552)
22. Gober M. D., Laing J. M., Thompson S. M., Aurelian L., The growth compromised HSV-2 mutant ΔRR prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal cultures. Brain Research 2006 1119 1 26 39 2-s2.0-33750456567 10.1016/j.brainres.2006.08.078 (Pubitemid 44647224)
23. Wales S. Q., Li B., Laing J. M., Aurelian L., The herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and XIAP up-regulation. Journal of Neurochemistry 2007 103 1 365 379 2-s2.0-34548644394 10.1111/j.1471-4159.2007.04745.x (Pubitemid 47404212)
24. Golembewski E. K., Wales S. Q., Aurelian L., Yarowsky P. J., The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity. Experimental Neurology 2007 203 2 381 393 2-s2.0-33846520504 10.1016/j.expneurol.2006.08.022 (Pubitemid 46151764)
25. Wales S. Q., Laing J. M., Chen L., Aurelian L., ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+ICP10PK neuroprotection in MPP+. Gene Therapy 2008 15 20 1397 1409 2-s2.0-53649097671 10.1038/gt.2008.88
26. Laing J. M., Golembewski E. K., Wales S. Q., Liu J., Jafri M. S., Yarowsky P. J., Aurelian L., Growth-compromised HSV-2 vector ΔRR protects from N-methyl-D-aspartate-induced neuronal degeneration through redundant activation of the MEK/ERK and PI3-K/Akt survival pathways, either one of which overrides apoptotic cascades. Journal of Neuroscience Research 2008 86 2 378 391 2-s2.0-38849191849 10.1002/jnr.21486 (Pubitemid 351196743)
27. Laing J. M., Smith C. C., Aurelian L., Multi-targeted neuroprotection by the HSV-2 gene ICP10PK includes robust bystander activity through PI3-K/Akt and/or MEK/ERK-dependent neuronal release of vascular endothelial growth factor and fractalkine. Journal of Neurochemistry 2010 112 3 662 676 2-s2.0-73949107300 10.1111/j.1471-4159.2009.06475.x
28. McLean T. I., Bachenheimer S. L., Activation of cJUN N-terminal kinase by herpes simplex virus type 1 enhances viral replication. Journal of Virology 1999 73 10 8415 8426 2-s2.0-0032822610 (Pubitemid 29441704)
29. Perkins D., Gyure K. A., Pereira E. F. R., Aurelian L., Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase. Journal of NeuroVirology 2003 9 1 101 111 2-s2.0-0345268642 (Pubitemid 36372550)
30. Colunga A. G., Laing J. M., Aurelian L., The HSV-2 mutant ΔpK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins. Gene Therapy 2010 17 3 315 327 2-s2.0-77949423196 10.1038/gt.2009.126
31. Smith C. C., Yu Y. X., Kulka M., Aurelian L., A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells. Journal of Biological Chemistry 2000 275 33 25690 25699 2-s2.0-0034682806 10.1074/jbc.M002140200
32. Aurelian L., Smith C. C., Winchurch R., Kulka M., Gyotoku T., Zaccaro L., Chrest F. J., Burnett J. W., A novel gene expressed in human keratinocytes with long-term in vitro growth potential is required for cell growth. Journal of Investigative Dermatology 2001 116 2 286 295 2-s2.0-0035116940 10.1046/j.1523-1747.2001.00191.x (Pubitemid 32173734)
33. Benndorf R., Sun X., Gilmont R. R., Biederman K. J., Molloy M. P., Goodmurphy C. W., Cheng H., Andrews P. C., Welsh M. J., HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27). Journal of Biological Chemistry 2001 276 29 26753 26761 2-s2.0-0035920143 10.1074/jbc.M103001200
34. Charpentier A. H., Bednarek A. K., Daniel R. L., Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Research 2000 60 5977 5983
35. Yu Y. X., Heller A., Liehr T., Expression analysis and chromosome location of a novel gene (H11) associated with the growth of human melanoma cells. International Journal of Oncology 2001 18 5 905 911
36. Gober M. D., Smith C. C., Ueda K., Toretsky J. A., Aurelian L., Forced expression of the H11 heat shock protein can be regulated by DNA methylation and trigger apoptosis in human cells. Journal of Biological Chemistry 2003 278 39 37600 37609 2-s2.0-0141844530 10.1074/jbc.M303834200 (Pubitemid 37175283)
37. Li B., Smith C. C., Laing J. M., Gober M. D., Liu L., Aurelian L., Overload of the heat-shock protein H11/HspB8 triggers melanoma cell apoptosis through activation of transforming growth factor- β -activated kinase 1. Oncogene 2007 26 24 3521 3531 2-s2.0-34249337421 10.1038/sj.onc.1210145 (Pubitemid 46816763)
38. Smith C. C., Li B., Liu J., Lee K. S., Aurelian L., The levels of H11/HspB8 DNA methylation in human melanoma tissues and xenografts are a critical molecular marker for 5-Aza-2′-deoxycytidine therapy. Cancer Investigation 2011 29 6 383 395 2-s2.0-79958192790 10.3109/07357907.2011.584588
39. Cui X. Y., Wang N., Yang B. X., Gao W. F., HSPB8 is methylated in hematopoietic malignancies and overexpression of HSPB8 exhibits antileukemia effect. Experimental Hematology 2012 40 14 21
40. Chowdary T. K., Raman B., Ramakrishna T., Rao C. M., Interaction of mammalian Hsp22 with lipid membranes. Biochemical Journal 2007 401 2 437 445 2-s2.0-33846523468 10.1042/BJ20061046 (Pubitemid 46166426)
41. Chung T. D., Wymner J. P., Kulka M., Smith C. C., Aurelian L., Myristylation and polylysine-mediated activation of the protein kinase domain of the large subunit of herpes simplex type 2 ribonucleotide reductase (ICP10). Virology 1990 179 1 168 178 2-s2.0-0025036271 10.1016/0042-6822(90)90286-Z (Pubitemid 20354328)
42. Chowdary T. K., Raman B., Ramakrishna T., Rao C. M., Mammalian Hsp22 is a heat-inducible small heat-shock protein with chaperone-like activity. Biochemical Journal 2004 381 2 379 387 2-s2.0-3242776825 10.1042/BJ20031958 (Pubitemid 38969681)
43. Haeri M., Knox B. E., Endoplasmic reticulum stress and unfolded protein response pathways: potential for treating age-related retinal degeneration. Journal of Ophthalmic & Vision Research 2012 7 1 45 59
44. Fontaine J. M., Sun X., Benndorf R., Welsh M. J., Interactions of HSP22 (HSPB8) with HSP20, α b-crystallin, and HSPB3. Biochemical and Biophysical Research Communications 2005 337 3 1006 1011 2-s2.0-26844557815 10.1016/j.bbrc.2005.09.148 (Pubitemid 41447012)
45. Modem S., Chinnakannu K., Bai U., HSP22 (HSPB8/H11) knockdown induces Sam68 expression and stimulates proliferation of glioblastoma cells. Journal of Cellular Physiology 2011 226 11 2747 2751
46. Sun X., Fontaine J. M., Hoppe A. D., Carra S., Deguzman C., Martin J. L., Simon S., Vicart P., Welsh M. J., Landry J., Benndorf R., Abnormal interaction of motor neuropathy-associated mutant HspB8 (Hsp22) forms with the RNA helicase Ddx20 (gemin3). Cell Stress and Chaperones 2010 15 5 567 582 2-s2.0-77955711004 10.1007/s12192-010-0169-y
47. Sanbe A., Daicho T., Mizutani R., Endo T., Miyauchi N., Yamauchi J., Tanonaka K., Glabe C., Tanoue A., Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy. PLoS ONE 2009 4 4 2-s2.0-65449170415 10.1371/journal.pone.0005351 e5351
48. Carra S., Sivilotti M., Zobel A. T. C., Lambert H., Landry J., HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells. Human Molecular Genetics 2005 14 12 1659 1669 2-s2.0-21244489544 10.1093/hmg/ddi174 (Pubitemid 40895518)
49. Wilhelmus M. M. M., Boelens W. C., Otte-Höller I., Kamps B., Kusters B., Maat-Schieman M. L. C., de Waal R. M. W., Verbeek M. M., Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid- β protein aggregation and cerebrovascular amyloid- β toxicity. Acta Neuropathologica 2006 111 2 139 149 2-s2.0-33646190092 10.1007/s00401-005-0030-z
50. Irobi J., Van Impe K., Seeman P., Jordanova A., Dierick I., Verpoorten N., Michalik A., De Vriendt E., Jacobs A., Van Gerwen V., Vennekens K., Mazanec R., Tournev I., Hilton-Jones D., Talbot K., Kremensky I., Van Den Bosch L., Robberecht W., Vandekerckhove J., Van Broeckhoven C., Gettemans J., De Jonghe P., Timmerman V., Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. Nature Genetics 2004 36 6 597 601 2-s2.0-2642539919 10.1038/ng1328 (Pubitemid 38715986)
51. Crippa V., Sau D., Rusmini P., Boncoraglio A., Onesto E., Bolzoni E., Galbiati M., Fontana E., Marino M., Carra S., Bendotti C., de Biasi S., Poletti A., The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Human Molecular Genetics 2010 19 17 3440 3456 2-s2.0-77955365630 10.1093/hmg/ddq257
52. Doyle K., Kennedy D., Gorman A., Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. Journal of Cellular and Molecular Medicine 2011 15 2025 2039
53. Carra S., Seguin S. J., Lambert H., Landry J., HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. Journal of Biological Chemistry 2008 283 3 1437 1444 2-s2.0-38349105324 10.1074/jbc.M706304200
54. Chen J., Towards the physical basis of how intrinsic disorder mediates protein function. Archives of Biochemistry and Biophysics 2012 524 2 123 131
55. Modem S., Chinnakannu K., Bai U., Hsp22 (HspB8/H11) knockdown induces Sam68 expression and stimulates proliferation of glioblastoma cells. Journal of Cellular Physiology 2011 226 11 2747 2751
56. Sui X., Li D., Qiu H., Gaussin V., Depre C., Activation of the bone morphogenetic protein receptor by H11Kinase/Hsp22 promotes cardiac cell growth and survival. Circulation Research 2009 104 7 887 895 2-s2.0-65249153121 10.1161/CIRCRESAHA.108.192328
57. Depre C., Hase M., Gaussin V., Zajac A., Wang L., Hittinger L., Ghaleh B., Yu X., Kudej R. K., Wagner T., Sadoshima J., Vatner S. F., H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Circulation Research 2002 91 11 1007 1014 2-s2.0-0037195691 10.1161/01.RES.0000044380.54893.4B (Pubitemid 35416637)
58. Depre C., Wang L., Sui X., Qiu H., Hong C., Hedhli N., Ginion A., Shah A., Pelat M., Bertrand L., Wagner T., Gaussin V., Vatner S. F., H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart. Circulation Research 2006 98 2 280 288 2-s2.0-33644862630 10.1161/01.RES. 0000201284.45482.e8
59. Hase M., Depre C., Vatner S. F., Sadoshima J., H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes. Biochemical Journal 2005 388 2 475 483 2-s2.0-20544446917 10.1042/BJ20041314 (Pubitemid 40839924)
60. Sharma B. K., Smith C. C., Laing J. M., Rucker D. A., Burnett J. W., Aurelian L., Aberrant DNA methylation silences the novel heat shock protein H11 in melanoma but not benign melanocytic lesions. Dermatology 2006 213 3 192 199 2-s2.0-33750006223 10.1159/000095035 (Pubitemid 44567828)
61. Gollob J. A., Sciambi C. J., Peterson B. L., Richmond T., Thoreson M., Moran K., Dressman H. K., Jelinek J., Issa J. P. J., Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma. Clinical Cancer Research 2006 12 15 4619 4627 2-s2.0-33748046812 10.1158/1078-0432.CCR-06-0883 (Pubitemid 44297813)
62. Smith C. C., Lee K. S., Li B., Restored expression of the atypical heat shock protein H11/HspB8 inhibits the growth of genetically diverse melanoma tumors through activation of novel TAK1-dependent death pathways. Cell Death and Disease 2012 3, article e371 10.1038/cddis.2012.108
63. Davis B. K., Wen H., Ting J. P. Y., The Inflammasome NLRs in immunity, inflammation, and associated diseases. Annual Review of Immunology 2011 29 707 735 2-s2.0-79953046719 10.1146/annurev-immunol-031210-101405
64. Soliman G. A., Acosta-Jaquez H. A., Dunlop E. A., Ekim B., Maj N. E., Tee A. R., Fingar D. C., mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. Journal of Biological Chemistry 2010 285 11 7866 7879 2-s2.0-77950900079 10.1074/jbc.M109.096222
65. Roelofs M. F., Boelens W. C., Joosten L. A. B., Abdollahi-Roodsaz S., Geurts J., Wunderink L. U., Schreurs B. W., Van Den Berg W. B., Radstake T. R. D. J., Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. Journal of Immunology 2006 176 11 7021 7027 2-s2.0-33646882893 (Pubitemid 43787883)
66. Villeneuve J., Tremblay P., Vallières L., Tumor necrosis factor reduces brain tumor growth by enhancing macrophage recruitment and microcyst formation. Cancer Research 2005 65 9 3928 3936 2-s2.0-18144406858 10.1158/0008-5472.CAN-04-3612 (Pubitemid 40616375)
67. McCarthy J. V., Ni J., Dixit V. M., RIP2 is a novel NF- κ B-activating and cell death-inducing kinase. Journal of Biological Chemistry 1998 273 27 16968 16975 2-s2.0-0032479145 10.1074/jbc.273.27.16968 (Pubitemid 28311729)
68. Ye J., Wang L., Zhang X., Tantishaiyakul V., Rojanasakul Y., Inhibition of TNF- α gene expression and bioactivity by site-specific transcription factor-binding oligonucleotides. American Journal of Physiology 2003 284 2 L386 L394 2-s2.0-0037309547 (Pubitemid 36164374)
69. Chastain E. M., Miller S. D., Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease. Immunological Reviews 2012 245 1 227 238
70. Rashid T., Ebringer A., Autoimmunity in rheumatic diseases is induced by microbial infections via crossreactivity or molecular mimicry. Autoimmune Disease 2012 2012 539282
71. Holmes E. C., What does virus evolution tell us about virus origins? Journal of Virology 2011 85 11 5247 5251 2-s2.0-79956105255 10.1128/JVI.02203-10
72. Cornelis G., Heidmann O., Bernard-Stoecklin S., Ancestral capture of syncytin-Car1, a fusogenic endogenous retroviral envelope gene involved in placentation and conserved in Carnivora. Proceedings of the National Academy of Sciences of the United States of America 2012 109 7 E432 E441