Restored expression of the atypical heat shock protein H11/HspB8 inhibits the growth of genetically diverse melanoma tumors through activation of novel TAK1-dependent death pathways

Cell Death and Disease

Volumn 3, Issue 8, 2012, Pages

  Smith, C C ^a   Lee, K S ^a   Li, B ^a   Laing, J M ^a   Hersl, J ^a   Shvartsbeyn, M ^a,b   Aurelian, L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Apoptosis; ASC; Beclin 1; Caspase 1; Caspase 3 7; MTOR

Indexed keywords

BECLIN 1; CASPASE 3; CASPASE 7; HEAT SHOCK PROTEIN 22; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; TRANSFORMING GROWTH FACTOR BETA KINASE 1; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; DOXORUBICIN; HEAT SHOCK PROTEIN; HSPB8 PROTEIN, HUMAN; MAP KINASE KINASE KINASE 7; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; PYCARD PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; ANIMAL; DNA METHYLATION; DRUG EFFECT; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; UPREGULATION; XENOGRAFT;

MAMMALIA;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 1; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; DNA METHYLATION; DOXORUBICIN; HEAT-SHOCK PROTEINS; HUMANS; INFLAMMASOMES; MAP KINASE KINASE KINASES; MELANOMA; MEMBRANE PROTEINS; MICE; MICE, NUDE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TOR SERINE-THREONINE KINASES; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION;

EID: 84865796015     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.108     Document Type: Article

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