Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase

Journal of NeuroVirology

Volumn 9, Issue 1, 2003, Pages 101-111

  Perkins, Dana ^a   Gyure, Kymberly A ^a   Pereira, Edna F R ^a   Aurelian, Laure ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Encephalitis; ERK; HSV 1; JNK

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; APOPTOSIS INHIBITOR; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; POLYCLONAL ANTIBODY; STRESS ACTIVATED PROTEIN KINASE; VIRUS ANTIGEN;

ANIMAL CELL; APOPTOSIS; BRAIN TISSUE; CONTROLLED STUDY; ENZYME ACTIVATION; FETUS; HERPES SIMPLEX ENCEPHALITIS; HERPES SIMPLEX VIRUS 1; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; NERVE CELL CULTURE; NICK END LABELING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REVIEW;

ANIMALIA; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; SIMPLEXVIRUS;

EID: 0345268642     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280390173427     Document Type: Review

References (63)

1. Ando Y, Kimura H, Miwata H, Kudo T, Shibata M, Morishima T (1993). Quantitative analysis of herpes simplex virus DNA in cerebrospinal fluid of children with herpes simplex virus encephalitis. J Med Virol 41: 170-173.
2. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicoterra P (1995). Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961-973.
3. Aubert M, O'Toole J, Blaho JA (1999). Induction and prevention of apoptosis in human HEp-2 cells by herpes simplex virus type 1. J Virol 73: 10359-10370.
4. Aurelian L (2000). Herpes simplex viruses. In: Clinical virology manual, 3rd ed. Spector S, Hodinka RL, Young SA (eds). Plenum Press: Washington DC, pp 384-409.
5. Banker GA, Cowan WM (1977). Rat hippocampal neurons in dispersed cell culture. Brain Res 126: 397-342.
6. Beers DR, Henkel JS, Douglas MS, Schaeffer DC, Rose JW, Stroop WG (1993). Neuropathology of herpes simplex virus encephalitis in a rat seizure model. J Neuropathol Exp Neurol 52: 241-252.
7. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leistein JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW (2001). SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Nat Acad Sci USA 98: 13681-13686.
8. Bergstrom T, Svennerholm B, Conradi N, Horal P, Vahlne A (1991). Discrimination of herpes simplex virus types 1 and 2 cerebral infections in a rat model. Acta Neuropathol 82: 395-401.
9. Bergstrom T, Vahlne A, Alestig K, Jeansson S, Forsgren M, Lycke E (1990). Primary and recurrent herpes simplex virus type 2-induced meningitis. J Infect Dis 162: 322-330.
10. Bertollini L, Ciotti MT, Cherubini E, Cattaneo A (1997). Neurotrophin-3 promotes the survival of oligodendrocyte precursors in embryonic hippocampal cultures under chemically defined conditions. Brain Res 746: 19-24.
11. Bossy-Wetzel E, Bakiri L, Yaniv M (1997). Induction of apoptosis by the transcription factor c-Jun. EMBO J 16: 1695-1709.
12. Brazelton TR, Rossi FMV, Keshet GI, Blau HM (2000). From marrow to brain: expression of neuronal phenotypes in adult mice. Science 20: 1775-1779.
13. Charriaut-Marlangue C, Aggoun-Zouaoui D, Represa A, Ben-Ari Y (1996). Apoptotic features of selective neuronal death in ischemia, epilepsy and gp120 toxicity. Trends Neurosci 19: 105-114.
14. Chou SM, Cherry JD (1967). Ultrastructure of Cowdry type A inclusions. Neurology 17: 575-586.
15. Chung TD, Wymer JP, Smith CC, Kulka M, Aurelian L (1989). Protein kinase activity associated with the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10). J Virol 63: 3389-3398.
16. Cooper J, Conner J, Clements JB (1995). Characterization of the novel protein kinase activity present in the R1 sub-unit of herpes simplex virus ribonucleotide reductase. J Virol 69: 4979-4985.
17. Crowder RJ, Freeman RS (1998). Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci 18: 2933-2943.
18. Dennett C, Cleator GM, Klapper PE (1997). HSV-1 and HSV-2 in herpes simplex encephalitis: a study of sixty-four cases in the United Kingdom. J Med Virol 53: 1-3.
19. Eilers A, Whitfield J, Shah B, Spadoni C, Desmond H, Ham J (2001). Direct inhibition of c-Jun N-terminal kinase in sympathetic neurons prevents c-jun promoter activation and NGF withdrawal-induced death. J Neurochem 76: 1439-1454.
20. Erhardt P, Schremser EJ, Cooper GM (1999). B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol Cell Biol 19: 5308-5315.
21. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM (1998). Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632.
22. Ferreira A, Caceres A (1992). Expression of the class III beta-tubulin isotype in developing neurons in culture. J Neurosci Res 32: 516-529.
23. Fuchs SY, Adler V, Pincus MR, Ronai Z (1998). MEKK1/JNK signaling stabilizes and activates p53. Proc Natl Acad Sci USA 95: 10541-10546.
24. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992). Identification of programmed cell death via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501.
25. Gold R, Schmied M, Giegerich G, Beitschopf H, Hartung HP, Toyka KV, Lassman H (1994). Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab Invest 71: 219-225.
26. Graham DI, Lantos PL (1997). Pathological features of specific viral diseases. In: Greenfield's neuropathology, 6th ed. Arnold: New York, Oxford, pp 25-32.
27. Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS (2001). c-Jun N-terminal kinase is required for metalloproteinase expression and joint desctruction in inflammatory arthritis. J Clin Invest 108: 73-81.
28. Hardwick JM (1997). Virus-induced apoptosis. Adv Pharmacol 41: 295-335.
29. Hoffmeyer A, Grosse-Wilde A, Flory E, Neufeld B, Kunz M, Rapp UR, Ludwig S (1999). Different mitogen-activating protein kinase signaling pathways cooperate to regulate tumor necrosis factor 19 gene expression in T lymphocytes. J Biol Chem 274: 4319-4327.
30. Honig LS, Rosenberg RN (2000). Apoptosis and neurologic disease. Am J Med 108: 317-330.
31. Ishizuka T, Terada N, Gerwins P, Hamelmann E, Oshiba A, Fanger GR, Johnson GL, Gelfand EW (1997). Mast cell tumor necrosis factor-α is regulated by MEK kinases. Proc Natl Acad Sci USA 94: 6358-6363.
32. Johnson Webb S, Harrison DJ, Wyllie AH (1997). Apoptosis: an overview of the process and its relevance in disease. Adv Pharmacol 41: 1-31.
33. Kaplan DR, Miller FD (2000). Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 10: 381-391.
34. Koskiniemi M, Piiparinen H, Mannonen L, Rantalaiho T, Vaheri A (1996). Herpes encephalitis is a disease of middle aged and elderly people: polymerase chain reaction for detection of herpes simplex virus in the CSF of 516 patients with encephalitis. The Study Group. J Neurol Neurosur Psychiatry 60: 174-178.
35. Kleinschmidt-Demasters BK, Gilden DH (2001). The expanding spectrum of herpesvirus infections of the nervous system. Brain Pathol 11: 440-451.
36. Leist M, Nicotera P (1998). Apoptosis versus necrosis: the shape of neuronal cell death. In: Apoptosis: mechanisms and role in disease. Kumar S (ed). Springer: Berlin-New York, pp 105-135.
37. Leu CM, Chang C, Hu C (2000). Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway. Oncogene 19: 1665-1675.
38. Levresse V, Butterfield L, Zentrich E, Heasley LE (2000). Akt negatively regulates c-Jun N-terminal kinase pathway in PC12 cells. J Neurosci Res 62: 799-808.
39. Lin HJ, Eviner V, Prendergast GC, White E (1995). Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest. Mol Cell Biol 15: 4536-4544.
40. McLean TI, Bachenheimer SL (1999). Activation of cJun terminal kinase by herpes simplex virus type 1 enhances viral replication. J Virol 73: 8415-8426.
41. Milne DM, Campbell LE, Campbell DG, Meek DW (1995). P53 is phosphorylated in vitro and in vivo by an ultra-violet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1. J Biol Chem 270: 5511-5518.
42. Minden A, Karin N (1997). Regulation and function of the JNK subgroup of MAP kinases. Biochem Biophys Acta 1333: F85-F104.
43. Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, Davis RJ, Shirasaki Y, Greenberg ME (2001). Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-jun N-terminal kinase pathway and the induction of Fas ligand. J Neurosci 21: 7551-7560.
44. Nargi-Aizenman JL, Griffin DE (2001). Sindbis virus-induced neuronal death is both necrotic and apoptotic and is ameliorated by N-methyl-D-aspartate receptor antagonists. J Virol 75: 7114-7121.
45. Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y (1999). Regulation of c-Myc trough phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. J Biol Chem 274: 32580-32587.
46. Ouyang Y-B, Tan Y, Comb M, Liu C-L, Martone ME, Siesjo BK, Hu B-R (1999). Survival and death-promoting events after transient cerebral ischemia: phosphorylation of Akt, release of cytochrome c, and activation of caspase-like proteases. J Cereb Blood Flow Metab 19: 1126-1135.
47. Perkins D, Pereira EFR, Gober M, Yarowsky PJ, Aurelian L (2002a). The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons involving activation of the MEK/MAPK survival pathway. J Virol 76: 1435-1449.
48. Perkins D, Yu YX, Bambrick LL, Yarowsky PJ, Aurelian L (2002b). Expression of herpes simplex virus type 2 protein ICP10 PK rescues neurons from apoptosis due to serum deprivation or genetic defects. Exp Neurol 174: 118-122.
49. Perkins D, Pereira EFR, Aurelian L (2003). The HSV-2 R1 PK (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1. J Virol (in press).
50. Raftery MJ, Behrens CK, Muller A, Krammer PH, Walczak H, Schonrich G (1999). Herpes simplex virus type 1 infection of activated cytotoxic T cells: induction of fratricide as a mechanism of viral immune evasion. J Exp Med 190: 1103-1113.
51. Sauerbrei A, Eichhorn U, Hottenrott G, Wutzler P (2000). Virological diagnosis of herpes simplex encephalitis. J Clin Virol 17: 31-36.
52. Shoji M, Iwakami N, Takeuchi S, Waragai M, Suzuki M, Kanazawa I, Lippa CF, Ono S, Okazawa H (2001). JNK activation is associated with intracellular beta-amyloid accumulation. Mol Brain Res 85: 221-233.
53. Skoldenberg B (1996). Herpes simplex encephalitis. Scand J Infect Dis Suppl 100: 8-13.
54. Smith CC, Nelson J, Aurelian L, Gober M, Goswami BB (2000). Ras-GAP binding/phosphorylation by HSV-2 RR1PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth. J Virol 74: 10417-10429.
55. Studahl M, Bergstrom T, Hagberg L (1998). Acute viral encephalitis in adults - a prospective study. Scand J Infect Dis 30: 215-220.
56. Sobel RA, Collins AB, Colvin RB, Bhan AK (1986). The in situ cellular immune response in acute herpes simplex encephalitis. Am J Pathol 125: 332-338.
57. Thompson KA, Blessing WW, Wesselingh SL (2000). Herpes simplex replication and dissemination is not increased by corticosteroid treatment in a rat model of focal Herpes encephalitis. J NeuroVirol 6: 25-32.
58. Tropea F, Troiano L, Monti D, Lovato E, Malorni W, Rainaldi G, Mattana P, Viscomi G, Ingletti MC, Portolani M, Cermelli C, Cossarizza A, Franceschi C (1995). Sendai virus and herpes virus type 1 induce apoptosis in human peripheral blood mononuclear cells. Exp Cell Res 218: 63-70.
59. Weil AA, Glaser CA, Amad Z, Forghani B (2002). Patients with suspected herpes simplex encephalitis: rethinking an initial negative polymerase chain reaction result. Clin Infect Dis 34: 1154-1157.
60. Whitley RJ (1997). Herpes simplex viruses. In: Infections of the central nervous system, 2nd ed. Scheld WM, Whitley RJ, Durack DT (eds). Lippincott-Raven: Philadelphia, pp 73-89.
61. Wilson SE, Pedroza L, Beuerman R, Hill JM (1997). Herpes simplex virus type-1 infection of corneal epithelial cells induces apoptosis of the underlying keratocytes. Exp Eye Res 64: 775-779.
62. Xu Z, Maroney AC, Dobranski P, Kukekov NV, Greene LA (2001). The MLK mediated c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol 21: 4713-4724.
63. Zachos G, Clements B, Conner J (1999). Herpes simplex virus type 1 infection stimulates p38/c-jun N-terminal mitogen-activated protein kinase pathways and activates transcription factor AP-1. J Biol Chem 274: 5097-5103.