Multi-targeted neuroprotection by the HSV-2 gene ICP10PK includes robust bystander activity through PI3-K/Akt and/or MEK/ERK-dependent neuronal release of vascular endothelial growth factor and fractalkine

Journal of Neurochemistry

Volumn 112, Issue 3, 2010, Pages 662-676

  Laing, Jennifer M ^a   Smith, Cynthia C ^a   Aurelian, Laure ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Chemokines; Cytokines; Excitotoxicity; Growth factors; Microglia; SOD1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYTOKINE; FRACTALKINE; INTERLEUKIN 10; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UO 126; VASCULOTROPIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; BYSTANDER EFFECT; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HERPES SIMPLEX VIRUS 2; HIPPOCAMPUS; IMMUNE SYSTEM; MICROGLIA; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; STROKE; VERO CELL; VIRUS GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; CELL COMMUNICATION; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CEREBRAL CORTEX; CHEMOKINE CX3CL1; CULTURE MEDIA, CONDITIONED; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENETIC VECTORS; HIPPOCAMPUS; IN SITU NICK-END LABELING; INTERLEUKIN-10; MALE; MICE; MICROGLIA; MUTATION; N-METHYLASPARTATE; NEURONS; ONCOGENE PROTEIN V-AKT; ORGAN CULTURE TECHNIQUES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RIBONUCLEOTIDE REDUCTASES; TIME FACTORS; TRANSFECTION; TUBULIN; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VERO CELLS;

HUMAN HERPESVIRUS 2;

EID: 73949107300     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06475.x     Document Type: Article

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