Growth-compromised HSV-2 vector ΔRR protects from N-methyl-D-aspartate-induced neuronal degeneration through redundant activation of the MEK/ERK and PI3-K/Akt survival pathways, either one of which overrides apoptotic cascades

Journal of Neuroscience Research

Volumn 86, Issue 2, 2008, Pages 378-391

  Laing, Jennifer M ^a   Golembewski, Erin K ^a   Wales, Samantha Q ^a   Liu, Juan ^a   Jafri, M Samir ^a,b   Yarowsky, Paul J ^a,b   Aurelian, Laure ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Excitotoxicity; Gene therapy; ICP10PK; Neurodegeneration; Striatum

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; BAG 1 PROTEIN; CASPASE 3; ETHIDIUM; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; INFECTED CELL PROTEIN 10; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N METHYL DEXTRO ASPARTIC ACID; NEURON SPECIFIC NUCLEAR PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEIC ACID BINDING PROTEIN; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; UNCLASSIFIED DRUG; UO 126; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CHROMOSOME PAIRING; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVATION; FEMALE; HERPES SIMPLEX VIRUS 2; IMMUNOHISTOCHEMISTRY; MUTATION; NERVE DEGENERATION; NERVE GROWTH; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SURVIVAL; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CORPUS STRIATUM; EXCITATORY AMINO ACID AGONISTS; FLUORESCENT ANTIBODY TECHNIQUE; GENE THERAPY; GENETIC VECTORS; HERPESVIRUS 2, HUMAN; IMMUNOBLOTTING; IN SITU NICK-END LABELING; MITOGEN-ACTIVATED PROTEIN KINASES; N-METHYLASPARTATE; NERVE DEGENERATION; NEURONS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RIBONUCLEOTIDE REDUCTASES; VERO CELLS;

EID: 38849191849     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21486     Document Type: Article

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